Ancestral alleles defined for 70 million cattle variants using a population-based likelihood ratio test

CONCLUSIONS: Considering the high concordance of ancestral alleles across studies, the ancestral alleles determined in this study including those not previously listed, particularly those with high-probability estimates, may be used for further genetic analyses with reasonable accuracy. Our approach that used predetermined variants in species and the likelihood ratio test to determine ancestral alleles is applicable to other species for which sequence level genotypes are available.PMID:38321371 | PMC:PMC10848479 | DOI:10.1186/s12711-024-00879-6

Source: Genet Sel Evol - February 6, 2024 Category: Genetics & Stem Cells Authors: Jigme Dorji Antonio Reverter Pamela A Alexandre Amanda J Chamberlain Christy J Vander-Jagt James Kijas Laercio R Porto-Neto Source Type: research