Cholangiocarcinoma: An Emerging Target for Molecular Therapy
Background: Cholangiocarcinoma has been traditionally considered a tumor with poor prognosis. Until now, surgical treatment has been the only more or less effective approach.Summary: Over 10 years, chemotherapy with a combination of gemcitabine and cisplatin remains the standard first-line therapy for patients with locally advanced or metastatic cholangiocarcinoma, which leads to a median overall survival of 11.7 months. Several inhibitors of HER (ERBB), HGF/c-MET, Hedgehog, KRAS-BRAF-MEK-ERK, and PI3K/AKT/mTOR signaling pathways did not show their superiority to standard chemotherapy. The rise of hope is associated with t...
Source: Gastrointestinal Tumors - July 21, 2021 Category: Gastroenterology Source Type: research
CircRNAs: Insights into Gastric Cancer
This study is an amalgamation of the implications and future prospects of circRNAs for the detection and potential treatment of GC.Gastrointest Tumors (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - July 16, 2021 Category: Gastroenterology Source Type: research
Hepatic Arterial Infusion Chemotherapy Is a Feasible Treatment Option for Hepatocellular Carcinoma: A New Update
Background: Hepatic arterial infusion chemotherapy (HAIC) is one option for treating massive tumors and unresectable hepatocellular carcinoma (HCC). However, there is a lack of remedial treatment after these treatments are ineffective or failed.Summary: Some studies have discovered that HAIC has greater survival in patients with advanced HCC. A previous study has shown that HAIC is effective in the treatment of advanced HCC, and the data on randomized clinical trials are limited and unclear.Key Message: More clinical trials and research are needed in order to make HAIC a standard and recommended therapy for advanced HCC. O...
Source: Gastrointestinal Tumors - July 15, 2021 Category: Gastroenterology Source Type: research
Perforated High-Grade Mixed Neuroendocrine Nonneuroendocrine Neoplasm of Cecum: Unusual Presentation of Rare Disease
Mixed neuroendocrine nonneuroendocrine neoplasms (MiNENs) are rare neoplasms of the gastrointestinal tract, where the neuroendocrine as well as the nonneuroendocrine components each comprise at least 30% of the tumor. Of all cases of colorectal malignancies, MiNENs constitute around 3 –9.6%, with only a few cases reported to be arising in the cecum. Since majority present with nonspecific clinical and radiological findings, its diagnosis preoperatively is almost impossible and these are usually diagnosed after histopathological examination of the resected specimen. Owing to the rarity of these tumors as well as lack of c...
Source: Gastrointestinal Tumors - April 20, 2021 Category: Gastroenterology Source Type: research
Etiological Analysis of Reactive Gastropathy in an Urban Population
Conclusion: Our study indicated that NSAID usage is the most common cause of RG, followed by bile reflux-mediated mucosal injury, in an ethnically diverse urban US-based population. Of note, few patients had intestinal metaplasia, suggesting it to be a slow or negligent sequela of RG.Gastrointest Tumors (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - April 14, 2021 Category: Gastroenterology Source Type: research
Inferior Vena Cava Syndrome as a Manifestation of Metastatic Carcinoid Tumor
Small bowel-origin carcinoid tumor is indolent but may metastasize relentlessly to various sites, including the liver. Over the past 9 years, we have treated a 69-year-old woman who has undergone 5 percutaneous liver ablations, 5 hepatic intra-arterial chemoembolizations, an ovarian cryoablation, and a trans-ventral hernia mesenteric cryoablation. These interventions are all related to her inoperable carcinoid malignancy. After the patient presented with swelling of the abdomen and both lower extremities, computed tomography (CT) angiography was performed, revealing a circumferential hepatic metastatic mass encasing the in...
Source: Gastrointestinal Tumors - April 13, 2021 Category: Gastroenterology Source Type: research
Gastrointestinal Stromal Tumor of the Ampulla of Vater: A Narrative Review
Background: Gastrointestinal stromal tumor (GIST) of the ampulla of Vater is a rare occurrence. To the best of our knowledge, there has been no published review on this rare tumor in the English literature so far.Summary: In this review, we will discuss all the reported details of the published cases, including demography, clinical presentation, imaging, gross pathology and histopathology, immunohistochemical findings, treatment modalities, and outcome of cases with the diagnosis GIST from the ampulla of Vater in the last 20 years.Key Message: Twenty-five cases of GIST in the ampulla of Vater have been reported in the last...
Source: Gastrointestinal Tumors - March 31, 2021 Category: Gastroenterology Source Type: research
The Potential Association between the Risk of Post-Surgical Adhesion and the Activated Local Angiotensin II Type 1 Receptors: Need for Novel Treatment Strategies
The objective of this article was to explore the role of the AngII/AT1R axis potential to induce PSAB and the therapeutic potential of angiotensin receptor blockers in the prevention and treatment of PSAB.Gastrointest Tumors (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - March 31, 2021 Category: Gastroenterology Source Type: research
Perioperative Predictive Markers for Recurrence of Esophageal Cancer after Esophagectomy
Conclusions: Low preoperative PNI and high postoperative inflammatory response were associated with postoperative EC progression after esophagectomy. Preoperative nutritional interventions or suppression of postoperative inflammatory response, including respiratory complications, may improve patient prognosis.Gastrointest Tumors (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - March 17, 2021 Category: Gastroenterology Source Type: research
Does Radiation Dose to Gastric Fundus during Neoadjuvant Chemoradiotherapy for Esophageal Carcinoma Have an Impact on Postoperative Anastomotic Leak?
Conclusion: There was no significant negative impact of the dose received by the GF in NACRT upon AL rates. Further studies with a larger sample size are required to clarify this issue.Gastrointest Tumors (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - March 17, 2021 Category: Gastroenterology Source Type: research
Hepatocellular Malignant Neoplasm, Not Otherwise Specified: A New Name in Liver Tumors: A Brief Narrative Review of Published Cases
Background: Hepatocellular malignant neoplasm, not otherwise specified (HEM, NOS), is a rare liver tumor that is most commonly seen in adolescents. To the best of our knowledge, there has been no published review on this rare tumor in the English literature so far.Summary: In this review, we will discuss all reported details, including demographic findings, clinical presentations, molecular histogenesis, imaging, gross pathology and histopathology, immunohistochemical findings, treatment modalities, and outcome, of the published cases of HEM, NOS, in the liver.Key Message: Twenty-two cases of HEM, NOS, have been reported i...
Source: Gastrointestinal Tumors - March 11, 2021 Category: Gastroenterology Source Type: research
Capecitabine as Maintenance Therapy for High-Risk, Resected Colorectal Cancer
Conclusion: The findings and analyses of this cohort of patients suggest that maintenance capecitabine therapy reduces the risk of disease progression and cancer-related death.Gastrointest Tumors (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - March 10, 2021 Category: Gastroenterology Source Type: research
Anal Cancer with Mediastinal Lymph Node Metastasis
We present a case of a patient with both a prior history of squamous cell carcinoma of the anal canal as well as breast cancer, who was without evidence of disease for 1 year. She was subsequently found to have FDG-avid mediastinal lymphadenopathy, initially assumed to be related to her more recent breast cancer. However, a biopsy confirmed recurrent anal cancer, with HPV infection. This represents a novel site of spread for anal cancer, one not yet reported in the literature.Gastrointest Tumors (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - March 8, 2021 Category: Gastroenterology Source Type: research
Screening Status as a Determinant of Choice of Colorectal Cancer Screening Method: A Population-Based Informed Survey
Conclusions: Not having up-to-date screening was independently associated with fecal blood testing as the preferred method for CRC screening. Proposing this method to this subpopulation, in a context of shared decision, could potentially increase screening uptake in settings where it is already high.Gastrointest Tumors (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - March 5, 2021 Category: Gastroenterology Source Type: research
Metastatic Hepatic Epitheloid Hemangioendothelioma in a Young Male: A Rare Presentation
We report the case of a 23-year-old male, known case of chronic liver disease, who presented with incisional hernia following exploratory laparotomy 8 months back, performed for intestinal obstruction. Contrast-enhanced computed tomography abdomen revealed an incisional hernia with a large defect along with multiple lesions in the liver (suspected metastases) and peritoneal deposits and a few discrete lung nodules. Some areas of interloop collections were also noted. Biopsies were taken from the liver which revealed benign cirrhotic lesion. Relevant to the findings, multiple biopsies were performed and fluid was sent for e...
Source: Gastrointestinal Tumors - February 18, 2021 Category: Gastroenterology Source Type: research
