Frailty Predicts Severe Postoperative Complication after Elective Hepatic Resection
Conclusion: CF, but not sarcopenia, is a robust predictor of severe postoperative complications for patients undergoing hepatectomy.Gastrointest Tumors (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - May 22, 2019 Category: Gastroenterology Source Type: research

Detection of Novel Fusion Transcript VTI1A-CFAP46 in Hepatocellular Carcinoma
Conclusions: The link between novel fusion transcript VTI1A-CFAP46 and autophagy as a potential therapeutic target in HCC patients deserves further investigation. Moreover, this study shows that fusion transcripts are worthy of additional exploration in HCC.Gastrointest Tumors (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - April 15, 2019 Category: Gastroenterology Source Type: research

Primary Jejunal Gastrointestinal Stromal Tumor: Diagnosis Delay of 3 Years but Successful Management in Early Stage (II) by Surgery and Adjuvant Therapy
We present the case of a 62-year-old Bangladeshi female with a history of GI bleeding 3 years earlier; the cause of the bleeding had not been fo und despite extensive investigations. In the meantime, the patient had developed occasional abdominal pain and lumpy feelings in the right side of the abdomen without any GI bleeding. Exploratory laparotomy was carried out in view of a small intestinal mesenteric mass in a computed tomography scan. On midline incision there was a 6 × 6 cm mass in the antimesenteric border of the jejunum approximately 30 cm from the duodenojejunal flexure, which was resected followed by anast...
Source: Gastrointestinal Tumors - April 3, 2019 Category: Gastroenterology Source Type: research

Nested Stromal-Epithelial Tumor of the Liver: A Review
Background: Nested stromal-epithelial tumor (NSET) is a rare liver tumor, which is most commonly seen in the pediatric age group. To the best of our knowledge, there has been no published review on this rare tumor in the English literature so far.Summary: In this review, we will discuss all the reported details of the published cases, including demography, clinical presentation, molecular histogenesis, imaging, gross pathology and histopathology, immunohistochemical findings, treatment modalities, and outcome of NSET of the liver.Key Message: Thirty-eight cases of NSET have been reported in the last 20 years in the English...
Source: Gastrointestinal Tumors - March 20, 2019 Category: Gastroenterology Source Type: research

Contents Vol. 5, 2018
Gastrointest Tumors 2018;5:I –IV (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - February 15, 2019 Category: Gastroenterology Source Type: research

High Serum CA19-9 Concentration Predicts Poor Prognosis in Elderly Patients with Stage IV Colorectal Cancer
Conclusions: A high pretreatment serum CA19-9 concentration (#x3e; 370 U/mL) was a reliable predictive factor for poor prognosis, and aggressive treatments should be performed carefully in these patients. Moreover, various treatments, including surgery and chemotherapy, might improve OS in elderly patients with stage IV CRC.Gastrointest Tumors (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - January 27, 2019 Category: Gastroenterology Source Type: research

Optimizing the Diagnostic Role of Alpha-Fetoprotein and Abdominal Ultrasound by Adding Overexpressed Blood mRNA Matrix Metalloproteinase-12 for Diagnosis of HCV-Related Hepatocellular Carcinoma
Conclusion: Blood mRNA MMP-12 has a good sensitivity and a bad specificity but is accurate in HCC diagnosis. Adding blood mRNA MMP-12 to AFP optimizes the current screening program to improve early diagnosis of HCC and hence better prognosis.Gastrointest Tumors (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - January 13, 2019 Category: Gastroenterology Source Type: research

Eye Opener to EtOH Ablation for Juxta-Cardiac Hepatocellular Carcinoma
Conclusion: Pericardial involvement or large vessels near the treatment area may limit the use of thermal ablation techniques for JC HCC. Percutaneous, intratumoral ethanol injection provides safe and effective alternative that is not subject to the “thermal sink” effect.Gastrointest Tumors (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - January 13, 2019 Category: Gastroenterology Source Type: research

Coexistence of Gastric Cancer and Multiple Small Gastrointestinal Stromal Tumors: Report of a Unique Case and Review of the Literature
We present a case of a 79-year-old male patient who underwent surgery for an advanced gastric carcinoma, where multiple nodules of GIST were incidentally discovered during the work-up of his gastrectomy specimen.Key Message: GISTs range from small “low-risk” tumors to sarcomas. Small GISTs are found incidentally during unrelated surgery or autopsy. Multiple GISTs are extremely rare and usually associated with hereditary diseases.Practical Implications: In any case of gastrointestinal neoplasm, the surgeon and pathologist should be alert to perform a thorough investigation. Our case could provide further awarene...
Source: Gastrointestinal Tumors - December 21, 2018 Category: Gastroenterology Source Type: research

Three-Dimensional Remnant Pancreatic Volumetry Predicts Postoperative Pancreatic Fistula in Pancreatic Cancer Patients after Pancreaticoduodenectomy
Conclusion: The present study indicates that preoperative 3D-measured RPV is predictive of POPF after PD.Gastrointest Tumors (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - December 14, 2018 Category: Gastroenterology Source Type: research

Adherence to European Polypectomy Guidelines: Retrospective Experience from a Tertiary Irish Hospital
Conclusions: This study found an 84% compliance with polypectomy resection guidelines which is an improvement on previous studies. However, endoscopist grade significantly affected compliance and may reflect overall competency, highlighting the need for specific training in snare polypectomy techniques.Gastrointest Tumors (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - November 22, 2018 Category: Gastroenterology Source Type: research

Low Incidence of Pelvic Sepsis after Hartmann ’s Procedure: Radiation Therapy May Be a Risk Factor
Conclusion: Hartmann ’s procedure is a safe operation when an anastomosis is contraindicated since the incidence of pelvic sepsis is low. Preoperative radiotherapy and Hinchey grade III and IV may be risk factors for the development of pelvic sepsis.Gastrointest Tumors (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - November 7, 2018 Category: Gastroenterology Source Type: research

Comparison of Different Techniques of Pancreatic Stump Management in Robot-Assisted Pancreaticoduodenectomy
Conclusions: Reconstruction with PJ and TPG had better results compared to pancreatic duct occlusion with CG and PPG. However, TPG was the technique of choice and showed comparable results to PJ.Gastrointest Tumors (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - August 27, 2018 Category: Gastroenterology Source Type: research

Finally, a Minimally Invasive Option for Intrahepatic Inferior Vena Cava Invasion by Hepatocellular Carcinoma
Conclusion: Quality of life during this time was maximized, as recovery time from this procedure is minimal.Gastrointest Tumors (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - August 17, 2018 Category: Gastroenterology Source Type: research

Beyond the Beyond: A Case of an Extraordinary Response to Multiple Lines of Therapy in a de novo Metastatic HER2-Negative Gastric Cancer Patient
We present the case of a patient diagnosed with a de novo metastatic gastric cancer who experienced an extraordinary long response to multiple lines of chemotherapy (FOLFOX6, paclitaxel plus ramucirumab, FOLFIRI, rechallenge with FOLFOX6).Key Message: Gastric cancer therapy should be considered as the result of a strategy based on the patient ’s condition, and tolerance and response to various therapies. The emerging evidence of the role of subsequent lines of therapy, along with the recognition of the pivotal role of nutritional support and the availability of new drugs, should help clinicians in the management of p...
Source: Gastrointestinal Tumors - July 27, 2018 Category: Gastroenterology Source Type: research

Network Meta-Analysis of Adjuvant Chemotherapy following Resection of Colorectal Liver Metastases
Conclusion: Both SCT and HAI plus SCT showed superior efficacy and safety. Clinical trials in homogeneous populations with strict selection criteria are needed to compare these two ACTs.Gastrointest Tumors (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - July 25, 2018 Category: Gastroenterology Source Type: research

No Evidence for an Association between JC Polyomavirus Infection and Gastroduodenal Diseases
Conclusion: This study suggests no association between JCPyV infection and GC or other gastroduodenal diseases. The very low frequency of JCPyV LTag sequences in GC is an important aspect that weakens the hypothesis of the pathogenic role of JCPyV in gastric tumor induction.Gastrointest Tumors (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - July 11, 2018 Category: Gastroenterology Source Type: research

Carbohydrate Antigen 19-9, Carcinoembryonic Antigen, and Carbohydrate Antigen 72-4 in Gastric Cancer: Is the Old Band Still Playing?
Background: Gastric cancer (GC) is characterized by aggressive behavior and a high mortality rate. The diagnosis of GC is challenging because the GC is often diagnosed in an advanced stage. The use of tumor markers is a putative way to improve the detection and treatment in patients with GC.Summary: In this article, we review the significance of serum carbohydrate antigen (CA) 19-9, carcinoembryonic antigen (CEA), and CA 72-4 in GC. The results from different studies regarding the diagnostic and prognostic role of CA 19-9, CEA, and CA 72-4 in GC are encouraging, but inadequate sensitivity and specificity obstruct their use...
Source: Gastrointestinal Tumors - April 24, 2018 Category: Gastroenterology Source Type: research

Survival of Hepatocellular Carcinoma Patients Treated with Sorafenib beyond Progression
Conclusion: In HCC patients, continuing sorafenib beyond progression for #x3e; 3 months is associated with improved survival compared to discontinuing sorafenib within 3 months. Furthermore, patients with a poor prognosis who continue sorafenib beyond progression in general show significantly prolonged survival.Gastrointest Tumors (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - April 11, 2018 Category: Gastroenterology Source Type: research

Contents Volume 4, 2017
Gastrointest Tumors 2017;4:I –II (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - February 23, 2018 Category: Gastroenterology Source Type: research

Erratum
Gastrointest Tumors 2017;4:104 (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - February 22, 2018 Category: Gastroenterology Source Type: research

Intraplatelet Vascular Endothelial Growth Factor and Platelet-Derived Growth Factor: New Biomarkers in Carcinoembryonic Antigen-Negative Colorectal Cancer?
Conclusion: Elevated preoperative intraplatelet VEGF and PDGF levels in CRC patients suggest new possibilities for postoperative monitoring in CRC patients, especially when CEA is negative.Gastrointest Tumors (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - February 16, 2018 Category: Gastroenterology Source Type: research

Waiting Time following Neoadjuvant Chemoradiotherapy for Rectal Cancer: Does It Really Matter
Conclusion: In this small exploratory study there was no evident difference in outcome according to timing of surgery, which suggests that further research in larger cohorts is warranted.Gastrointest Tumors (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - December 15, 2017 Category: Gastroenterology Source Type: research

Waiting Time following Neoadjuvant Chemoradiotherapy for Rectal Cancer: Does It Really Matter?
Conclusion: In this small exploratory study there was no evident difference in outcome according to timing of surgery, which suggests that further research in larger cohorts is warranted.Gastrointest Tumors (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - December 14, 2017 Category: Gastroenterology Source Type: research

Impact of Three-Dimensional Surgical Simulation on Pancreatic Surgery
Background/Aims: Anatomical variations are frequently encountered during hepato-biliary-pancreatic surgeries, requiring surgeons to have a precise understanding of the surgical anatomy in order to perform a safe surgery. We evaluated the impact of novel three-dimensional (3D) surgical simulation on pancreatic surgeries to enhance surgical residents' understanding.Methodology: Between January 2013 and May 2014, 61 preoperative 3D surgical simulations were performed. The consistency (0-10, with 10 representing 100% consistency) among the 15 surgical residents' anatomical drawings from multidetector computed tomography images...
Source: Gastrointestinal Tumors - December 6, 2017 Category: Gastroenterology Source Type: research

Short-Term Outcomes of Extended Pancreatectomy: A Single-Surgeon Experience
Conclusion: Although patients who underwent EP experienced significantly increased operative time, blood loss, and postoperative stay, they did not experience significantly higher postoperative morbidity or mortality compared to patients who underwent SP.Gastrointest Tumors (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - November 29, 2017 Category: Gastroenterology Source Type: research

Effects of Enteral Immunonutrition in Esophageal Cancer
Background: Immunonutrition (IN) significantly reduces the incidence of postoperative infectious complications and the length of hospitalization in patients undergoing major elective surgery for gastrointestinal malignances. However, the clinical benefit of IN in patients who have undergone esophagectomy for esophageal cancer is unclear. Moreover, the effect of enteral IN in patients during preoperative adjuvant chemoradiotherapy and in patients treated with concurrent chemoradiotherapy for advanced esophageal cancer is unknown.Summary: This review analyzes the evidence supporting the enteral administration of IN in patien...
Source: Gastrointestinal Tumors - November 22, 2017 Category: Gastroenterology Source Type: research

Is Colonoscopy Indicated in Young Patients with Hematochezia
Conclusion: Performing colonoscopy in patients presenting with hematochezia should be strongly considered for those aged 41-50 years in view of the significant likelihood of underlying neoplastic polyps compared to those aged ≤40 years.Gastrointest Tumors (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - November 3, 2017 Category: Gastroenterology Source Type: research

Is Colonoscopy Indicated in Young Patients with Hematochezia?
Conclusion: Performing colonoscopy in patients presenting with hematochezia should be strongly considered for those aged 41-50 years in view of the significant likelihood of underlying neoplastic polyps compared to those aged ≤40 years.Gastrointest Tumors (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - November 2, 2017 Category: Gastroenterology Source Type: research

Enucleation versus Anatomic Resection for Giant Hepatic Hemangioma: A Meta-Analysis
Background: Hepatic hemangiomas are the most common benign liver tumors, and the management of giant hepatic hemangioma (GHH) is still in controversial. The aim of this meta-analysis was to compare the postoperative outcomes of enucleation versus anatomic resection for GHH.Methods: PubMed, Embase, Web of Science, and the Cochrane Library were searched from January 1988 to December 2015 to identify studies comparing the outcomes of enucleation versus anatomic resection for GHH. Finally, we performed this meta-analysis using the Review Manager 5.3 software, and the results were presented as risk ratio (RR) or mean difference...
Source: Gastrointestinal Tumors - October 25, 2017 Category: Gastroenterology Source Type: research

Accuracy of Multidetector-Row Computed Tomography in the Preoperative Diagnosis of Lymph Node Metastasis in Patients with Gastric Cancer
Conclusion: The accuracy of CT in the preoperative diagnosis of lymph node metastasis in patients with gastric cancer remains poor. Therefore, surgeons should pay attention to the visibility of lymph nodes on CT. Detection of lymph nodes on CT can be utilized for a more accurate diagnosis such as fine-needle aspiration biopsy.Gastrointest Tumors 2016;3:163-170 (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - October 25, 2017 Category: Gastroenterology Source Type: research

Contents Vol. 3, 2016
Gastrointest Tumors 2016;3:I-IV (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - October 25, 2017 Category: Gastroenterology Source Type: research

Diffuse-Type Hepatoma: A Grave Prognostic Marker
This study was planned to compare nodular- and diffuse-type HCC in this cohort.Methods: CT scans of 227 patients with HCC negative for infective hepatitis were analyzed and grouped as nodular and diffuse from July 2011 to July 2014. Diffuse-type cancer was defined as a tumor without convex/distinct margin, diffusely infiltrating the hepatic parenchyma. There were 45 (20%) cases. The baseline liver functions, etiology, treatment, and the outcome were compared with nodular-type cancers. Stage III diffuse cancers were matched with 2 stage III nodular cancers looking at the T stage and background liver.Results: There was no di...
Source: Gastrointestinal Tumors - October 25, 2017 Category: Gastroenterology Source Type: research

Left Gastric Artery Reconstruction after Distal Pancreatectomy with Celiac Axis En-Bloc Resection: How We Do It
Conclusion: We present LGA reconstruction by MCA-LGA bypass after LGA-resecting DP-CAR. We conducted a perioperative assessment of ischemic gastropathy to confirm the feasibility and safety of this procedure.Gastrointest Tumors 2017;4:28-35 (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - October 25, 2017 Category: Gastroenterology Source Type: research

Mortality and Survival after Surgical Treatment of Colorectal Cancer in Patients Aged over 80 Years
Conclusions: After good surgical selection, low early mortality and acceptable long-term survival can be achieved even in the oldest old patients with colorectal cancer. However, low early mortality seems to underestimate the effects of surgery during the first postoperative year.Gastrointest Tumors 2017;4:36-44 (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - October 25, 2017 Category: Gastroenterology Source Type: research

Oncological Outcomes following Rectal Cancer Surgery with High or Low Ligation of the Inferior Mesenteric Artery
Conclusions: The ligation level of the IMA in rectal cancer may not influence oncological outcomes. However, further large-scale RCTs are needed to conclude this issue.Gastrointest Tumors 2017;4:45-52 (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - October 25, 2017 Category: Gastroenterology Source Type: research

Scaffold Proteins in Gastrointestinal Tumors as a Shortcut to Oncoprotein Activation
Background: The development of cancer involves uncontrolled cell proliferation, and multiple signaling pathways that regulate cell proliferation have been found to be dysregulated in cancers. Extracellular signal-regulated protein kinase (ERK) is one of three major subtypes in the mitogen-activated protein kinase (MAPK) families. The MAPK/ERK pathway (RAS/RAF1/MEK/ERK) plays an important part in promoting cell proliferation in response to growth factors, thereby serving as a driving signal in gastrointestinal (GI) tumors. In contrast, the p53 tumor suppressor functions as a “guardian of the genome” and stops ce...
Source: Gastrointestinal Tumors - October 25, 2017 Category: Gastroenterology Source Type: research

Freezing Fort Knox: Mesenteric Carcinoid Cryoablation
Conclusion: Percutaneous cryoablation with hydrodissection can be used to target intraabdominal malignancy in poor surgical candidates. This procedure is safe, effective, and minimally invasive.Gastrointest Tumors 2017;4:53-60 (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - October 25, 2017 Category: Gastroenterology Source Type: research

Effect of Adjuvant Chemotherapy on Elderly Colorectal Cancer Patients: Lack of Evidence
Background: Adjuvant chemotherapy has become the standard form of treatment for all patients with stage III colorectal cancer and is also recommended for patients with stage II disease and defined risk factors. However, clinical studies that evaluate the effect of adjuvant treatment regimens have a selection bias in favor of younger patients, so that even retrospective subgroup analyses cannot define the best therapeutic procedure in elderly patients with comorbidities.Summary: As long as the role of adjuvant chemotherapy in elderly colorectal cancer patients is not investigated in comprehensive trials, no clear recommenda...
Source: Gastrointestinal Tumors - October 25, 2017 Category: Gastroenterology Source Type: research

Freezing Fort Knox: Mesenteric Carcinoid Cryoablation
Conclusion: Percutaneous cryoablation with hydrodissection can be used to target intraabdominal malignancy in poor surgical candidates. This procedure is safe, effective, and minimally invasive.Gastrointest Tumors (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - August 30, 2017 Category: Gastroenterology Source Type: research

Effect of Adjuvant Chemotherapy on Elderly Colorectal Cancer Patients: Lack of Evidence
Background: Adjuvant chemotherapy has become the standard form of treatment for all patients with stage III colorectal cancer and is also recommended for patients with stage II disease and defined risk factors. However, clinical studies that evaluate the effect of adjuvant treatment regimens have a selection bias in favor of younger patients, so that even retrospective subgroup analyses cannot define the best therapeutic procedure in elderly patients with comorbidities.Summary: As long as the role of adjuvant chemotherapy in elderly colorectal cancer patients is not investigated in comprehensive trials, no clear recommenda...
Source: Gastrointestinal Tumors - August 30, 2017 Category: Gastroenterology Source Type: research

Scaffold Proteins in Gastrointestinal Tumors as a Shortcut to Oncoprotein Activation
Background: The development of cancer involves uncontrolled cell proliferation, and multiple signaling pathways that regulate cell proliferation have been found to be dysregulated in cancers. Extracellular signal-regulated protein kinase (ERK) is one of three major subtypes in the mitogen-activated protein kinase (MAPK) families. The MAPK/ERK pathway (RAS/RAF1/MEK/ERK) plays an important part in promoting cell proliferation in response to growth factors, thereby serving as a driving signal in gastrointestinal (GI) tumors. In contrast, the p53 tumor suppressor functions as a “guardian of the genome” and stops ce...
Source: Gastrointestinal Tumors - July 11, 2017 Category: Gastroenterology Source Type: research

Oncological Outcomes following Rectal Cancer Surgery with High or Low Ligation of the Inferior Mesenteric Artery
Conclusions: The ligation level of the IMA in rectal cancer may not influence oncological outcomes. However, further large-scale RCTs are needed to conclude this issue.Gastrointest Tumors (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - July 4, 2017 Category: Gastroenterology Source Type: research

Mortality and Survival after Surgical Treatment of Colorectal Cancer in Patients Aged over 80 Years
Conclusions: After good surgical selection, low early mortality and acceptable long-term survival can be achieved even in the oldest old patients with colorectal cancer. However, low early mortality seems to underestimate the effects of surgery during the first postoperative year.Gastrointest Tumors (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - June 28, 2017 Category: Gastroenterology Source Type: research

Left Gastric Artery Reconstruction after Distal Pancreatectomy with Celiac Axis En-Bloc Resection: How We Do It
Conclusion: We present LGA reconstruction by MCA-LGA bypass after LGA-resecting DP-CAR. We conducted a perioperative assessment of ischemic gastropathy to confirm the feasibility and safety of this procedure.Gastrointest Tumors (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - April 11, 2017 Category: Gastroenterology Source Type: research

Diffuse-Type Hepatoma: A Grave Prognostic Marker
This study was planned to compare nodular- and diffuse-type HCC in this cohort.Methods: CT scans of 227 patients with HCC negative for infective hepatitis were analyzed and grouped as nodular and diffuse from July 2011 to July 2014. Diffuse-type cancer was defined as a tumor without convex/distinct margin, diffusely infiltrating the hepatic parenchyma. There were 45 (20%) cases. The baseline liver functions, etiology, treatment, and the outcome were compared with nodular-type cancers. Stage III diffuse cancers were matched with 2 stage III nodular cancers looking at the T stage and background liver.Results: There was no di...
Source: Gastrointestinal Tumors - March 15, 2017 Category: Gastroenterology Source Type: research

Contents Vol. 3, 2016
Gastrointest Tumors 2016;3:I-IV (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - March 2, 2017 Category: Gastroenterology Source Type: research

Clinicopathology of Early Gastric Carcinoma: An Update for Pathologists and Gastroenterologists
Background: The WHO defines early gastric carcinoma (EGC) as invasive carcinoma up to the submucosal layer, regardless of nodal metastasis. The recent study results indicate that EGC varies in location, histology, nodal metastasis, and prognosis.Summary: The heterogeneity in EGC may be related to various types of epithelial stem cells. The most important stem cells include Lgr5+ cells at the base of a gastric unit in the antrum-pylorus-cardia, Mist1+ cells at the isthmus/Troy+ cells at the base in the corpus-fundus, and Sox2+ cells at the base in almost all regions. Dysregulation of these cells along with environmental fac...
Source: Gastrointestinal Tumors - February 10, 2017 Category: Gastroenterology Source Type: research

Accuracy of Multidetector-Row Computed Tomography in the Preoperative Diagnosis of Lymph Node Metastasis in Patients with Gastric Cancer
Conclusion: The accuracy of CT in the preoperative diagnosis of lymph node metastasis in patients with gastric cancer remains poor. Therefore, surgeons should pay attention to the visibility of lymph nodes on CT. Detection of lymph nodes on CT can be utilized for a more accurate diagnosis such as fine-needle aspiration biopsy.Gastrointest Tumors (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - February 10, 2017 Category: Gastroenterology Source Type: research

Enucleation versus Anatomic Resection for Giant Hepatic Hemangioma: A Meta-Analysis
Background: Hepatic hemangiomas are the most common benign liver tumors, and the management of giant hepatic hemangioma (GHH) is still in controversial. The aim of this meta-analysis was to compare the postoperative outcomes of enucleation versus anatomic resection for GHH.Methods: PubMed, Embase, Web of Science, and the Cochrane Library were searched from January 1988 to December 2015 to identify studies comparing the outcomes of enucleation versus anatomic resection for GHH. Finally, we performed this meta-analysis using the Review Manager 5.3 software, and the results were presented as risk ratio (RR) or mean difference...
Source: Gastrointestinal Tumors - February 10, 2017 Category: Gastroenterology Source Type: research