Metastatic Hepatic Epitheloid Hemangioendothelioma in a Young Male: A Rare Presentation
We report the case of a 23-year-old male, known case of chronic liver disease, who presented with incisional hernia following exploratory laparotomy 8 months back, performed for intestinal obstruction. Contrast-enhanced computed tomography abdomen revealed an incisional hernia with a large defect along with multiple lesions in the liver (suspected metastases) and peritoneal deposits and a few discrete lung nodules. Some areas of interloop collections were also noted. Biopsies were taken from the liver which revealed benign cirrhotic lesion. Relevant to the findings, multiple biopsies were performed and fluid was sent for e...
Source: Gastrointestinal Tumors - February 18, 2021 Category: Gastroenterology Source Type: research

Common Presentation of an Uncommon Small Intestinal Lymphoma: A Rare Case Entity
Primary gastrointestinal NHL accounts for 30 –40% of all extranodal NHL. Primary gastrointestinal lymphomas constitute 5% of total gut neoplasms. Bowel perforation is a severe life-threatening complication and sometimes initial presentation of gastrointestinal lymphoma. A 60-year-old man presented with complaints of abdominal pain, distensio n, nausea and vomiting. There was clinical suspicion of acute intestinal perforation, which was confirmed by radiology. The patient underwent emergency laparotomy. The resected bowel on histopathological examination and immunohistochemistry was diagnosed as the high-grade transfo...
Source: Gastrointestinal Tumors - February 17, 2021 Category: Gastroenterology Source Type: research

Trends and In-Hospital Outcomes of Splanchnic Vein Thrombosis Associated with Gastrointestinal Malignancies: A Nationwide Analysis
Conclusions: Digestive cancer-associated SVTs constitute 10% of all SVT related hospitalizations and are significantly increasing in the past decade. We report the baseline characteristics and predictors of inpatient mortality in this study.Gastrointest Tumors (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - February 9, 2021 Category: Gastroenterology Source Type: research

Common and Rare Histological Variants of Hepatoblastoma in Children: A Pathological Diagnosis and Review of the Literature
Hepatoblastoma (HB) is a rare tumor, but it is the most common primary liver malignancy in children and comprised of approximately 1% of all pediatric malignancies. Mostly, this tumor is sporadic in nature but can show a syndrome association. Upregulation in Wnt/ β-catenin pathway can be there in 70–80% cases of HB. Most often present as abdominal mass and has a raised alpha-fetoprotein levels. Distant metastasis usually occurs in the lungs. HB is classified into 2 broad categories: epithelial and mesenchymal type. The majority of HB are epithelial type. The HB must be distinguished from focal nodular hyperplasi...
Source: Gastrointestinal Tumors - February 4, 2021 Category: Gastroenterology Source Type: research

Clear-Cell Adenocarcinoma of the Gallbladder with Alpha-Fetoprotein Production: A Case Report and Review of the Literature
Gallbladder tumors are the fifth most common cancers of the gastrointestinal tract with poor prognosis and low survival. The most common type is adenocarcinoma of which the clear cell type is an unusual histologic variant with alpha-fetoprotein (AFP)-producing gallbladder carcinoma, reported extremely rarely, which makes the index case an uncommon entity. AFP secretion by gallbladder carcinomas may occur given the similar embryological origin of liver and gallbladder. Herein we report a case of an incidental carcinoma of the gallbladder in a 60-year-old woman with an elevated serum AFP concentration at presentation, who un...
Source: Gastrointestinal Tumors - January 27, 2021 Category: Gastroenterology Source Type: research

The Effect of Laparoscopic Technique on the Surgical Outcome of Colorectal Cancer in a Small-Volume Rural Finnish Lapland Central Hospital
Conclusion: Our results showed that the introduction of laparoscopic colorectal surgery for treating cancer in a rural, small-volume hospital provided short- and long-term results comparable to findings from previous studies conducted in high-volume centers. Therefore, laparoscopy should be considered the treatment of choice for colorectal cancer in small, rural clinics.Gastrointest Tumors (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - November 18, 2020 Category: Gastroenterology Source Type: research

Short- and Long-Term Outcomes of Simultaneous Hepatic Artery Resection and Reconstruction for Perihilar Cholangiocarcinoma
Conclusions: Simultaneous HA resection and reconstruction is technically possible and may provide long-term survival in selected patients with locally advanced PHC.Gastrointest Tumors (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - November 10, 2020 Category: Gastroenterology Source Type: research

Lysyl Oxidase Mechanisms to Mediate Gastrointestinal Cancer Progression
Background: Malignancy is a complex process resulting from different changes such as extracellular matrix (ECM) remodeling and stiffness. One of the important enzymes that contribute to ECM remodeling is lysyl oxidase (Lox) that is overexpressed in different types of human cancers. Because of the high prevalence and poor survival of gastrointestinal (GI) malignancies in this review, we discuss the association between Lox activity and the progression of GI cancers. Lox proteins are a group of extracellular enzymes that catalyzed the cross-linking of collagen and elastin, so they have important roles in the control of struct...
Source: Gastrointestinal Tumors - November 10, 2020 Category: Gastroenterology Source Type: research

Gastrointestinal Luminal Stenting: The Early US Experience with the Duodenal HANAROSTENT
Self-expandable metal stents (SEMSs) are frequently utilized for palliation of malignant gastric and/or duodenal outlet obstruction (GDOO). Re-establishing luminal patency with accurate SEMS positioning while limiting migration and adjacent tissue injury is an important technical consideration and aim. The duodenal HANAROSTENT® was introduced in the USA in 2019 and developed with these challenges in mind. As the first center in the USA to deploy the duo ­denal HANAROSTENT® in clinical practice, we herein examine our early experience with its use. Specifically, we describe 7 consecutive cases of malignant GDOO i...
Source: Gastrointestinal Tumors - October 9, 2020 Category: Gastroenterology Source Type: research

Colonic Carcinosarcoma: Report of a Rare Colorectal Malignancy and Review of Literature
Colonic carcinosarcoma is an extremely rare tumor composed of mixed malignant epithelial and mesenchymal cells. Due to its rarity, its pathogenesis is poorly understood, and there are no specific guidelines for its treatment.Gastrointest Tumors (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - October 6, 2020 Category: Gastroenterology Source Type: research

Expression of < b > < i > AdipoR1 < /i > < /b > and < b > < i > AdipoR2 < /i > < /b > and Serum Level of Adiponectin in Gastric Cancer
Conclusion: We found that expression level ofAdipoR1 andAdipoR2 is strongly higher; however, the level of circulating adiponectin is lower in gastric cancer. Our study suggests that the expression ofAdipoR1 andAdipoR2, besides the low level of adiponectin, may play an important role in the development and/or progression of gastric cancer.Gastrointest Tumors (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - September 16, 2020 Category: Gastroenterology Source Type: research

Recurrence of Hepatocellular Carcinoma in Hepatitis C Virus (HCV) Liver Transplant Recipients Treated with Pretransplant Direct-Acting Antiviral (DAA) Therapy
Conclusions: A strong trend was observed on both Kaplan-Meier and multivariate analyses toward increased post-LT HCC recurrence in patients who achieved SVR prior to LT with DAAs compared to patients who were viremic at LT. Caution is required when considering pre-LT treatment of HCV with DAAs in patients with HCC.Gastrointest Tumors (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - September 14, 2020 Category: Gastroenterology Source Type: research

Long-Term Survival under Arterial Chemoembolization and Sorafenib of a Patient with Hepatocellular Carcinoma and Tumor Atrial Thrombus: A Case Report and Literature Review
We present a rare case of a male patient with HCC and IVC TT extending to the RA. The atrial thrombus was the first manifestation of HCC diagnosed by cardiac ultrasound. So far, the patient has undergone 4 courses of transarterial chemoembolization in combination with systemic therapy with sorafenib, and under this therapeutic approach long-term survival has been achieved.Gastrointest Tumors (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - August 18, 2020 Category: Gastroenterology Source Type: research

Why Cannot BCLC 0- or A-Stage Patients Receive Curative Treatment?
Conclusion: Our finding indicates that a significant fraction of the BCLC 0/A HCC patients is unable to have initial curative treatment as recommended by BCLC guidelines. These early stages of HCC patients represent a distinctive subpopulation and are in need of further investigation to improve their survival outcomes.Gastrointest Tumors (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - August 13, 2020 Category: Gastroenterology Source Type: research

Successful Surgical Treatment of a Patient with Synchronic Intraductal Papillary Mucinous Carcinoma and Solid Pseudopapillary Neoplasm of the Pancreas
We present a case of synchronous solid SPN and IPMN – carcinoma in a 44-year-old female patient. An uncommon surgical treatment was performed – pancreatoduodenectomy with the resection of the pancreas body, resection of the mesentericoportal trunk + distal pancreatectomy, and splenectomy. Part of the pancreatic tissue was preserved.Gastrointest Tumors (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - August 12, 2020 Category: Gastroenterology Source Type: research

The Safety and Efficacy of Primary Duct Closure without Endoscopic Nasobiliary Drainage after Laparoscopic Common Bile Duct Exploration
Conclusions: In patients who meet the screening criteria, PDC without ENBD after LCBDE is safe and effective and worthy of clinical application.Gastrointest Tumors (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - August 12, 2020 Category: Gastroenterology Source Type: research

Yttrium-90 Radioembolization Therapy for Combined Hepatocellular and Cholangiocarcinoma
Conclusions: While outcomes of combined HCC-CC are poor and optimal treatment remains undefined, TARE appears to represent an effective locoregional treatment with survival outcomes similar to that of HCC treated by TARE.Gastrointest Tumors (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - July 28, 2020 Category: Gastroenterology Source Type: research

Evaluation of a Phone Call Reminder Strategy in the Surveillance of Patients with Gastric Precancerous Lesions Lost to Follow-Up
Conclusion: Despite several telephone calls, only one-third of the contacted patients could be brought to surveillance endoscopy. Most of the patients showed stability of GPL, but 1 progressed to GC and could be successfully treated.Gastrointest Tumors (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - July 17, 2020 Category: Gastroenterology Source Type: research

Publisher's Note
Gastrointest Tumors (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - July 14, 2020 Category: Gastroenterology Source Type: research

Non-Invasive Colorectal Cancer Screening: An Overview
Background: Colorectal cancer (CRC) follows a protracted stepwise progression, from benign adenomas to malignant adenocarcinomas. If detected early, 90% of deaths are preventable. However, CRC is asymptomatic in its early-stage and arises sporadically within the population. Therefore, CRC screening is a public health priority.Summary: Faecal immunochemical test (FIT) is gradually replacing guaiac faecal occult blood test and is now the most commonly used screening tool for CRC screening program globally. However, FIT is still limited by the haemoglobin degradation and the intermittent bleeding patterns, so that one in four...
Source: Gastrointestinal Tumors - May 20, 2020 Category: Gastroenterology Source Type: research

The Early Decline of α-Fetoprotein and Des-γ-Carboxy Prothrombin Predicts the Response of Hepatic Arterial Infusion Chemotherapy in Hepatocellular Carcinoma Patients
Conclusion: Optimal cutoff values for AFP and DCP ratios enable prediction of nonresponders to HAIC with LFP. This simple and early assessment method allows the use of HAIC and molecular targeting drugs for HCC treatment.Gastrointest Tumors 2020;7:83 –92 (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - April 21, 2020 Category: Gastroenterology Source Type: research

Primary Rectal Non-Hodgkin ’s Lymphoma Treated with Urgent Radiotherapy and Chemotherapy: A Case Report and Literature Review
We describe the case of a 49-year-old male from Bangladesh with the same presentation. His treatment was delayed for more than a month as immunohistochemistry and staging delayed the final diagnosis . The disease was diagnosed as stage IE with the help of a positron emission tomography (PET)-CT scan, and due to the local progression the patient had a massive rectal bleeding that needed an urgent intervention. Radiotherapy was applied to stop the bleeding. Hypofraction followed by a conventional fraction of external beam radiotherapy (EBRT) with a total of 40 Gy was applied. Post-EBRT digital rectal examination showed no re...
Source: Gastrointestinal Tumors - March 30, 2020 Category: Gastroenterology Source Type: research

Polyp Detection Rate as a Surrogate for Adenoma and Sessile Serrated Adenoma/Polyp Detection Rates
Conclusions: ADQ and SSA/P-DQ values were consistent when over 500 procedures were analyzed. ADQ had an excellent correlation with ADR when #x3e;177 procedures per endoscopist were evaluated.Gastrointest Tumors 2020;7:74 –82 (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - February 11, 2020 Category: Gastroenterology Source Type: research

Changing Patterns of Hepatocellular Carcinoma after Treatment with Direct Antiviral Agents
Conclusion: The changing HCC pattern after DAA treatment may suggest the need for new HCC staging and treatment protocols.Gastrointest Tumors 2020;7:50 –59 (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - January 17, 2020 Category: Gastroenterology Source Type: research

Rare Treatment for a Rare Tumor: Cryoablation of a Granular Cell Tumor
Conclusion: Cryoablation can be used as an alternative to surgical intervention to treat malignant GCTs. This procedure is minimally invasive, less painful, and potentially effective in promoting antitumor immunity.Gastrointest Tumors 2020;7:41 –49 (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - December 18, 2019 Category: Gastroenterology Source Type: research

Presence of JC Polyomavirus in Nonneoplastic Inflamed Colon Mucosa and Primary and Metastatic Colorectal Cancer
Conclusions: The detection of JCPyV DNA at low copy numbers (lower than 1 viral copy per cell equivalent) and the absence of viral sequences in the corresponding primary tumors of the JCPyV-positive metastatic samples weaken the hypothesis of an etiological role of JCPyV in primary CRC induction.Gastrointest Tumors 2020;7:30 –40 (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - November 18, 2019 Category: Gastroenterology Source Type: research

The Efficacy and Safety of a Promising Single-Channel Endoscopic Closure Technique for Endoscopic Treatment-Related Artificial Ulcers: A Pilot Study
Conclusion: The SCCT could be applied in the treatment of artificial ulcers in several parts of the GI tract with a high clinical success rate and no complications. The SCCT appears to be a good option for closing artificial mucosal ulcers.Gastrointest Tumors 2020;7:21 –29 (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - November 6, 2019 Category: Gastroenterology Source Type: research

Cost Analysis of Biliary Drainage Using Metal versus Plastic Stents in Hepatocellular Carcinoma Patients with Obstructive Jaundice
Conclusions: Based on this analysis, the use of metal stents rather than plastic stents in biliary drainage is more cost effective for this group of patients.Gastrointest Tumors 2020;7:1 –10 (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - November 1, 2019 Category: Gastroenterology Source Type: research

Aberrant Expression of Peroxisome Proliferator-Activated Receptors in Colorectal Cancer and Their Association with Cancer Progression and Prognosis
Conclusions: It was found that PPAR α and PPARδ were overexpressed while PPARγ was suppressed in CRC tumor tissues, and these deregulations are associated with cancer progression and poor prognosis.Gastrointest Tumors 2020;7:11 –20 (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - November 1, 2019 Category: Gastroenterology Source Type: research

Hepatocellular Carcinoma of Fibrolamellar Type in an Adolescent: Case Report and Literature Review
We present a female patient, 13 years old, with diagnosis of hepatocellular carcinoma of fibrolamellar type, which was rapidly evolving. The fibrolamellar hepatocellular carcinoma invaded more than 80% of the hepatic parenchyma without surgical possibility or liver transplantation. Measures applied corresponded to chemotherapy of 1 cycle of cisplatin 40 mg/s/5 days + vincristine 1.5 mg/m2/day, 5-fluorouracil, doxorubicin, and dexrazoxane. The case presented aggressive evolution of hepatocellular carcinoma, which led to acute liver failure, with hyperammonemia, sepsis, pulmonary focus plus septic shock, grade III-IV encepha...
Source: Gastrointestinal Tumors - May 27, 2019 Category: Gastroenterology Source Type: research

Frailty Predicts Severe Postoperative Complication after Elective Hepatic Resection
Conclusion: CF, but not sarcopenia, is a robust predictor of severe postoperative complications for patients undergoing hepatectomy.Gastrointest Tumors (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - May 22, 2019 Category: Gastroenterology Source Type: research

Detection of Novel Fusion Transcript VTI1A-CFAP46 in Hepatocellular Carcinoma
Conclusions: The link between novel fusion transcript VTI1A-CFAP46 and autophagy as a potential therapeutic target in HCC patients deserves further investigation. Moreover, this study shows that fusion transcripts are worthy of additional exploration in HCC.Gastrointest Tumors (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - April 15, 2019 Category: Gastroenterology Source Type: research

Primary Jejunal Gastrointestinal Stromal Tumor: Diagnosis Delay of 3 Years but Successful Management in Early Stage (II) by Surgery and Adjuvant Therapy
We present the case of a 62-year-old Bangladeshi female with a history of GI bleeding 3 years earlier; the cause of the bleeding had not been fo und despite extensive investigations. In the meantime, the patient had developed occasional abdominal pain and lumpy feelings in the right side of the abdomen without any GI bleeding. Exploratory laparotomy was carried out in view of a small intestinal mesenteric mass in a computed tomography scan. On midline incision there was a 6 × 6 cm mass in the antimesenteric border of the jejunum approximately 30 cm from the duodenojejunal flexure, which was resected followed by anast...
Source: Gastrointestinal Tumors - April 3, 2019 Category: Gastroenterology Source Type: research

Nested Stromal-Epithelial Tumor of the Liver: A Review
Background: Nested stromal-epithelial tumor (NSET) is a rare liver tumor, which is most commonly seen in the pediatric age group. To the best of our knowledge, there has been no published review on this rare tumor in the English literature so far.Summary: In this review, we will discuss all the reported details of the published cases, including demography, clinical presentation, molecular histogenesis, imaging, gross pathology and histopathology, immunohistochemical findings, treatment modalities, and outcome of NSET of the liver.Key Message: Thirty-eight cases of NSET have been reported in the last 20 years in the English...
Source: Gastrointestinal Tumors - March 20, 2019 Category: Gastroenterology Source Type: research

Contents Vol. 5, 2018
Gastrointest Tumors 2018;5:I –IV (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - February 15, 2019 Category: Gastroenterology Source Type: research

High Serum CA19-9 Concentration Predicts Poor Prognosis in Elderly Patients with Stage IV Colorectal Cancer
Conclusions: A high pretreatment serum CA19-9 concentration (#x3e; 370 U/mL) was a reliable predictive factor for poor prognosis, and aggressive treatments should be performed carefully in these patients. Moreover, various treatments, including surgery and chemotherapy, might improve OS in elderly patients with stage IV CRC.Gastrointest Tumors (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - January 27, 2019 Category: Gastroenterology Source Type: research

Optimizing the Diagnostic Role of Alpha-Fetoprotein and Abdominal Ultrasound by Adding Overexpressed Blood mRNA Matrix Metalloproteinase-12 for Diagnosis of HCV-Related Hepatocellular Carcinoma
Conclusion: Blood mRNA MMP-12 has a good sensitivity and a bad specificity but is accurate in HCC diagnosis. Adding blood mRNA MMP-12 to AFP optimizes the current screening program to improve early diagnosis of HCC and hence better prognosis.Gastrointest Tumors (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - January 13, 2019 Category: Gastroenterology Source Type: research

Eye Opener to EtOH Ablation for Juxta-Cardiac Hepatocellular Carcinoma
Conclusion: Pericardial involvement or large vessels near the treatment area may limit the use of thermal ablation techniques for JC HCC. Percutaneous, intratumoral ethanol injection provides safe and effective alternative that is not subject to the “thermal sink” effect.Gastrointest Tumors (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - January 13, 2019 Category: Gastroenterology Source Type: research

Coexistence of Gastric Cancer and Multiple Small Gastrointestinal Stromal Tumors: Report of a Unique Case and Review of the Literature
We present a case of a 79-year-old male patient who underwent surgery for an advanced gastric carcinoma, where multiple nodules of GIST were incidentally discovered during the work-up of his gastrectomy specimen.Key Message: GISTs range from small “low-risk” tumors to sarcomas. Small GISTs are found incidentally during unrelated surgery or autopsy. Multiple GISTs are extremely rare and usually associated with hereditary diseases.Practical Implications: In any case of gastrointestinal neoplasm, the surgeon and pathologist should be alert to perform a thorough investigation. Our case could provide further awarene...
Source: Gastrointestinal Tumors - December 21, 2018 Category: Gastroenterology Source Type: research

Three-Dimensional Remnant Pancreatic Volumetry Predicts Postoperative Pancreatic Fistula in Pancreatic Cancer Patients after Pancreaticoduodenectomy
Conclusion: The present study indicates that preoperative 3D-measured RPV is predictive of POPF after PD.Gastrointest Tumors (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - December 13, 2018 Category: Gastroenterology Source Type: research

Adherence to European Polypectomy Guidelines: Retrospective Experience from a Tertiary Irish Hospital
Conclusions: This study found an 84% compliance with polypectomy resection guidelines which is an improvement on previous studies. However, endoscopist grade significantly affected compliance and may reflect overall competency, highlighting the need for specific training in snare polypectomy techniques.Gastrointest Tumors (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - November 22, 2018 Category: Gastroenterology Source Type: research

Low Incidence of Pelvic Sepsis after Hartmann ’s Procedure: Radiation Therapy May Be a Risk Factor
Conclusion: Hartmann ’s procedure is a safe operation when an anastomosis is contraindicated since the incidence of pelvic sepsis is low. Preoperative radiotherapy and Hinchey grade III and IV may be risk factors for the development of pelvic sepsis.Gastrointest Tumors (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - November 7, 2018 Category: Gastroenterology Source Type: research

Comparison of Different Techniques of Pancreatic Stump Management in Robot-Assisted Pancreaticoduodenectomy
Conclusions: Reconstruction with PJ and TPG had better results compared to pancreatic duct occlusion with CG and PPG. However, TPG was the technique of choice and showed comparable results to PJ.Gastrointest Tumors (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - August 27, 2018 Category: Gastroenterology Source Type: research

Finally, a Minimally Invasive Option for Intrahepatic Inferior Vena Cava Invasion by Hepatocellular Carcinoma
Conclusion: Quality of life during this time was maximized, as recovery time from this procedure is minimal.Gastrointest Tumors (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - August 17, 2018 Category: Gastroenterology Source Type: research

Beyond the Beyond: A Case of an Extraordinary Response to Multiple Lines of Therapy in a de novo Metastatic HER2-Negative Gastric Cancer Patient
We present the case of a patient diagnosed with a de novo metastatic gastric cancer who experienced an extraordinary long response to multiple lines of chemotherapy (FOLFOX6, paclitaxel plus ramucirumab, FOLFIRI, rechallenge with FOLFOX6).Key Message: Gastric cancer therapy should be considered as the result of a strategy based on the patient ’s condition, and tolerance and response to various therapies. The emerging evidence of the role of subsequent lines of therapy, along with the recognition of the pivotal role of nutritional support and the availability of new drugs, should help clinicians in the management of p...
Source: Gastrointestinal Tumors - July 27, 2018 Category: Gastroenterology Source Type: research

Network Meta-Analysis of Adjuvant Chemotherapy following Resection of Colorectal Liver Metastases
Conclusion: Both SCT and HAI plus SCT showed superior efficacy and safety. Clinical trials in homogeneous populations with strict selection criteria are needed to compare these two ACTs.Gastrointest Tumors (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - July 25, 2018 Category: Gastroenterology Source Type: research

No Evidence for an Association between JC Polyomavirus Infection and Gastroduodenal Diseases
Conclusion: This study suggests no association between JCPyV infection and GC or other gastroduodenal diseases. The very low frequency of JCPyV LTag sequences in GC is an important aspect that weakens the hypothesis of the pathogenic role of JCPyV in gastric tumor induction.Gastrointest Tumors (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - July 11, 2018 Category: Gastroenterology Source Type: research

Carbohydrate Antigen 19-9, Carcinoembryonic Antigen, and Carbohydrate Antigen 72-4 in Gastric Cancer: Is the Old Band Still Playing?
Background: Gastric cancer (GC) is characterized by aggressive behavior and a high mortality rate. The diagnosis of GC is challenging because the GC is often diagnosed in an advanced stage. The use of tumor markers is a putative way to improve the detection and treatment in patients with GC.Summary: In this article, we review the significance of serum carbohydrate antigen (CA) 19-9, carcinoembryonic antigen (CEA), and CA 72-4 in GC. The results from different studies regarding the diagnostic and prognostic role of CA 19-9, CEA, and CA 72-4 in GC are encouraging, but inadequate sensitivity and specificity obstruct their use...
Source: Gastrointestinal Tumors - April 24, 2018 Category: Gastroenterology Source Type: research

Survival of Hepatocellular Carcinoma Patients Treated with Sorafenib beyond Progression
Conclusion: In HCC patients, continuing sorafenib beyond progression for #x3e; 3 months is associated with improved survival compared to discontinuing sorafenib within 3 months. Furthermore, patients with a poor prognosis who continue sorafenib beyond progression in general show significantly prolonged survival.Gastrointest Tumors (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - April 11, 2018 Category: Gastroenterology Source Type: research

Contents Volume 4, 2017
Gastrointest Tumors 2017;4:I –II (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - February 23, 2018 Category: Gastroenterology Source Type: research