Endobiliary Radiofrequency Ablation for Malignant Biliary Obstruction over 32-Month Follow-Up
In this report, we present the case of a 58-year-old woman with a history of unresectable hilar cholangiocarcinoma. Initially she was treated with intraductal dilatation of malignancy and placement of a plastic stent and chemotherapy (Gemcitabin ® and Platinol®). Two years later she underwent a second-line chemotherapy with Gemcitabin® and Oxyplatin® because of tumor progression. Despite a second line chemotherapy and placement of an uncovered self-expandible metal stent (ucSEMS) that was extended later on by stent-in stent technique, t here was tumor progression which led to a complex course with relapsing obstructive...
Source: Gastrointestinal Tumors - February 2, 2022 Category: Gastroenterology Source Type: research
Endobiliary Radiofrequency Ablation for Malignant Biliary Obstruction over 32-Month Follow-Up
Gastrointest Tumors (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - February 2, 2022 Category: Gastroenterology Source Type: research
Endobiliary Radiofrequency Ablation (ELRA) for Malignant Biliary Obstruction over 32 months follow-up
In this report, we present the case of a 58-year-old woman with a history of unresectable hilar cholangiocarcinoma. Initially she was treated with intraductal dilatation of malignancy and placement of a plastic stent and chemotherapy (Gemcitabin ® and Platinol®). Two years later she underwent a second-line chemotherapy with Gemcitabin® and Oxyplatin® because of tumor progression. Despite a second line chemotherapy and placement of an uncovered self-expandible metal stent (ucSEMS) that was extended later on by stent-in stent technique, t here was tumor progression which led to a complex course with relapsing obstructive...
Source: Gastrointestinal Tumors - February 2, 2022 Category: Gastroenterology Source Type: research
Trends of Clinical Outcomes of Patients with Advanced Hepatocellular Carcinoma Treated with First-Line Sorafenib in Randomized Controlled Trials
Conclusion: The median OS of patients with advanced HCC treated with sorafenib has improved significantly over 15 years. At the same time, the median duration of therapy with sorafenib has decreased. The reason for these findings was not explained by changing demographics of patients enrolled in these trials and has implications for ongoing clinical trials.Gastrointest Tumors 2022;9:19 –26 (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - December 22, 2021 Category: Gastroenterology Source Type: research
Trends of Clinical Outcomes of Patients with Advanced Hepatocellular Carcinoma Treated with First-line Sorafenib in Randomized Controlled Trials
Conclusion: The median OS of patients with advanced HCC treated with sorafenib has improved significantly over 15 years . At the same time, the median duration of therapy with sorafenib has decreased. The reason for these findings was not explained by changing demographics of patients enrolled in these trials and has implications for ongoing clinical trials. (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - December 22, 2021 Category: Gastroenterology Source Type: research
Gallbladder Neuroendocrine Tumors: Is There a Need for a Specific Approach?
Neuroendocrine tumors (NETs) of the gallbladder or the biliary tree are rare. Most of the current guidelines and protocols are derived from the experience of managing lung small cell neuroendocrine carcinoma or gastrointestinal NETs. But, the overall outcome of gallbladder NETs (GB-NETs) seems worse than similarly staged lung NETs and adenocarcinoma of the gallbladder. This may be due to its rarity and lack of literature for a focused approach toward its treatment. Hence, the need for a specifically designed approach might help improve results of treatment for these rare tumors. We share our experience of 2 patients with G...
Source: Gastrointestinal Tumors - November 18, 2021 Category: Gastroenterology Source Type: research
Gallbladder Neuroendocrine Tumors: Is There a Need for a Specific Approach?
Neuroendocrine tumors (NETs) of the gallbladder or the biliary tree are rare. Most of the current guidelines and protocols are derived from the experience of managing lung small cell neuroendocrine carcinoma or gastrointestinal NETs. But, the overall outcome of gallbladder NETs (GB-NETs) seems worse than similarly staged lung NETs and adenocarcinoma of the gallbladder. This may be due to its rarity and lack of literature for a focused approach toward its treatment. Hence, the need for a specifically designed approach might help improve results of treatment for these rare tumors. We share our experience of 2 patients with G...
Source: Gastrointestinal Tumors - November 18, 2021 Category: Gastroenterology Source Type: research
Gallbladder Neuroendocrine Tumors (NETs): Is there a need for a specific approach?
Neuroendocrine tumors (NETS) of the Gallbladder or the biliary tree are rare. Most of the current guidelines and protocols are derived from the experience of managing Lung small cell neuroendocrine carcinoma (SCNEC) or gastrointestinal (GI) NETS. But the overall outcome of Gallbladder NETS (GB NETS) seems worse than similarly staged lung NETS and adenocarcinoma of the gallbladder. This may be due to its rarity and lack of literature for a focused approach towards its treatment. Hence the need for a specifically designed approach might help improve the results of treatment for these rare tumours. We share our experience of ...
Source: Gastrointestinal Tumors - November 18, 2021 Category: Gastroenterology Source Type: research
Lower Extremity Varicose Veins: An Unusual Presentation of Small Bowel Leiomyosarcoma
We report a case of a 67-year-old male who presented with bulging lower extremity veins, abdominal bloating, and weight loss. A CT of the abdomen and pelvis revealed a pelvic mass arising from the small bowel and a metastatic hepatic lesion, which was found to be compressing the inferior vena cava. A biopsy of the hepatic lesion confirmed the diagnosis of metastatic leiomyosarcoma. (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - November 18, 2021 Category: Gastroenterology Source Type: research
Thyroid Disease and Hepatocellular Carcinoma Survival: A Danish Nationwide Cohort Study
Conclusions: In this large nationwide cohort study, thyrotoxicosis and nontoxic goiter were associated with prolonged HCC survival. (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - November 4, 2021 Category: Gastroenterology Source Type: research
Thyroid disease and hepatocellular carcinoma survival.
A Danish nationwide cohort study
Conclusions
In this large nationwide cohort study, thyrotoxicosis and nontoxic goitre were associated with prolonged HCC survival. (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - November 4, 2021 Category: Gastroenterology Source Type: research
Acknowledgement to Reviewers
Gastrointest Tumors 2021;8:193 (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - October 5, 2021 Category: Gastroenterology Source Type: research
Abdominal Viscera Migration Performing Hemodynamic Instability after Esophagectomy: A Case Report
Hiatal hernia is a rare postoperative complication of esophagectomy in the treatment of esophageal cancer. Although rare, its incidence increased after the establishment of minimally invasive surgical techniques. The patient is usually oligosymptomatic, and the diagnosis is made in the late postoperative period, during outpatient follow-up. The initial presentation of hiatus hernia with hemodynamic instability is a rare condition that has never been described in the literature before. In the following report, we address the clinical picture, diagnosis, and treatment for this condition, discussing the main nuances of the li...
Source: Gastrointestinal Tumors - September 8, 2021 Category: Gastroenterology Source Type: research
The Potential Role of Changes in the Glucose and Lipid Metabolic Pathways in Gastrointestinal Cancer Progression: Strategy in Cancer Therapy
Background: Changes in cell metabolism are a well-known feature of some cancers, and this may be involved in the etiology of tumor formation and progression, as well as tumor heterogeneity. These changes may affect fatty acid metabolism and glycolysis and are required to provide the increase in energy necessary for the high rate of proliferation of cancer cells. Gastrointestinal cancers remain a difficult-to-treat cancer, particularly as they are usually diagnosed at a late stage of disease and are associated with poor outcomes.Summary: Recently, the changes in the metabolic pathways, including the expression of the rate-l...
Source: Gastrointestinal Tumors - August 5, 2021 Category: Gastroenterology Source Type: research
Prognostic and Clinicopathologic Significance of Discoidin Domain Receptors in Different Human Malignancies: A Meta-Analysis
Conclusion: Our meta-analysis results suggest that high DDRs expression has the potential to be used as a biomarker of poor prognosis in cancers.Gastrointest Tumors (Source: Gastrointestinal Tumors)
Source: Gastrointestinal Tumors - August 5, 2021 Category: Gastroenterology Source Type: research
