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Experience With 0.1% Tacrolimus Eye Drop for Noninfectious, Non-necrotizing Anterior Scleritis
Objectives: To report experience with 0.1% tacrolimus eye drops in the treatment of noninfectious, non-necrotizing anterior scleritis. Methods: This prospective, single-arm study included nine patients (4 men and 5 women; mean age=59.4 years, SD=10.5) with anterior scleritis. All patients were first treated with steroids for 1 month and then switched to tacrolimus eye drops alone. We defined baseline as the initiation of tacrolimus eye drops. Hyperemia and pain were scored before each treatment, at 1 and 2 weeks, and at 1 month after initiation of each treatment using 5 grades (0=none; 1+=mild; 2+=moderate; 3+=s...
Source: Eye and Contact Lens: Science and Clinical Practice - April 1, 2021 Category: Opthalmology Tags: Article Source Type: research

Subconjunctival Aflibercept for the Treatment of Formed Corneal Neovascularization
Conclusions: A single subconjunctival aflibercept injection seems to be well tolerated. However, it is ineffective for regressing formed corneal neovascularization. (Source: Eye and Contact Lens: Science and Clinical Practice)
Source: Eye and Contact Lens: Science and Clinical Practice - April 1, 2021 Category: Opthalmology Tags: Article Source Type: research

A New Treatment Experience in Pseudomonas Keratitis: Topical Meropenem and Cefepime
Purpose: To compare the efficacy of topical meropenem and cefepime treatments with respect to moxifloxacin as new treatment options in an experimental Pseudomonas keratitis model. Methods: Twenty-four rabbits in which keratitis are induced using Pseudomonas aeruginosa were divided into four groups according to treatment options. A solution of 50 mg/mL meropenem was prepared and topically applied to the first group, 50 mg/mL cefepime solution to the second group, topical 0.5% moxifloxacin drop to the third group, and topical isotonic (0.9% saline) solution to the fourth (control) group. The eyes were examined bef...
Source: Eye and Contact Lens: Science and Clinical Practice - April 1, 2021 Category: Opthalmology Tags: Article Source Type: research

Ocular Surface and Conjunctival Cytology Findings in Patients With Confirmed COVID-19
Purpose: To assess the effect of severe acute respiratory syndrome coronavirus-2 infection on the conjunctiva and tear film. Methods: Thirty-eight patients with confirmed COVID-19 and 31 healthy controls were included in this prospective and observational study. Individuals with COVID-19 formed the patient group, and healthy individuals formed the control group. Conjunctival impression cytology (CIC), TBUT, Schirmer II test, and ocular surface disease index were evaluated in all participants. Results: No significant difference was observed regarding the mean age and gender between the groups (P=0.786 and ...
Source: Eye and Contact Lens: Science and Clinical Practice - April 1, 2021 Category: Opthalmology Tags: Article Source Type: research

Management of Post-DALK Recipient Posterior Stromal Scarring: A Novel Approach
Conclusion: This is a sutureless, relatively simple, inexpensive, and effective novel surgical technique that avoids complications of open sky procedure and can be replicated in any ophthalmologic operation theatre setup. (Source: Eye and Contact Lens: Science and Clinical Practice)
Source: Eye and Contact Lens: Science and Clinical Practice - April 1, 2021 Category: Opthalmology Tags: Article Source Type: research

Review of Gamma-Irradiated Sterile Cornea: Properties, Indications, and New Directions
Abstract: Gamma-irradiated sterile cornea (GISC) is a relatively new graft tissue that follows the 30-year success of irradiation to other tissues (bone and sclera) to lessen antigenic load and infection transmission. It can serve as a graft to cover glaucoma drainage devices, as graft tissue for frank or impending corneal perforations in tectonic keratoplasty, as graft tissue in lamellar keratoplasty, and as carrier tissue for keratoprosthesis. With the limited availability of fresh corneal tissue in less developed countries, GISC may fill a need for corneal tissue worldwide. It can be used in situations where corneal...
Source: Eye and Contact Lens: Science and Clinical Practice - April 1, 2021 Category: Opthalmology Tags: Review Article Source Type: research

On the Horizon: Biologics and Nutrients for Neurotrophic Keratitis
Abstract: Neurotrophic keratitis (NK), a potentially sight-threatening corneal disease, still does not have a specific treatment. The reduction or complete loss of corneal sensation, the most important factor in its pathogenesis, is one of the most important factors that complicate the treatment of corneal wound healing. In addition, the visual outcome may be adversely affected because of aggressive stromal fibrosis in severe NK cases. Basically, the current management of NK aims to accelerate wound healing and prevent the progression. However, new therapeutic agents, particularly developed depending on cell type-speci...
Source: Eye and Contact Lens: Science and Clinical Practice - February 24, 2021 Category: Opthalmology Tags: Review Source Type: research

Surgical Management of the Ocular Surface in Neurotrophic Keratopathy: Amniotic Membrane, Conjunctival Grafts, Lid Surgery, and Neurotization
Conclusion: A variety of surgical options exist to manage neurotrophic keratopathy when medical treatments alone fail to resolve epitheliopathy. Ongoing protection and optimization of the ocular surface health remains crucial to prevent recurrent epithelial breakdown. (Source: Eye and Contact Lens: Science and Clinical Practice)
Source: Eye and Contact Lens: Science and Clinical Practice - February 24, 2021 Category: Opthalmology Tags: Review Article Source Type: research

Scleral Lens Use in Neurotrophic Keratopathy: A Review of Current Concepts and Practice
Conclusions: Scleral lenses may be effective in reducing the need for surgical intervention and improving the quality of life in patients with NK. (Source: Eye and Contact Lens: Science and Clinical Practice)
Source: Eye and Contact Lens: Science and Clinical Practice - February 24, 2021 Category: Opthalmology Tags: Review Article Source Type: research

Overview of Neurotrophic Keratopathy and a Stage-Based Approach to Its Management
Abstract: Neurotrophic keratopathy (NK) occurs because of disruption of corneal sensory innervation. There are many etiologies that can lead to NK, such as infection, trauma, topical medication use, cornea surgery, and intracranial tumors among others. We review the current available treatment options and provide a stage-based approach to its management. (Source: Eye and Contact Lens: Science and Clinical Practice)
Source: Eye and Contact Lens: Science and Clinical Practice - February 24, 2021 Category: Opthalmology Tags: Review Article Source Type: research

Neurotrophic Keratopathy: Ophthalmology's Diabetic Foot Problem
This article summarizes key elements of the 2020 Harold A. Stein Lecture presented at the Eye and Contact Lens Special Symposium “Healing the Ocular Surface: What's New for Neurotrophic Keratitis.” The major point that I made in this talk is that we need to think about neurotrophic keratopathy as ophthalmology's diabetic foot problem; as a chronic condition that is, often best managed by prevention. Neurotrophic keratopathy is not primarily an inflammatory condition, as suggested by the term ‟neurotrophic keratitis.” The epitheliopathy in this condition is a consequence of the dysregulated epithelial cell migration...
Source: Eye and Contact Lens: Science and Clinical Practice - February 24, 2021 Category: Opthalmology Tags: Review Article Source Type: research

Neurotrophic Keratitis: Do Not Be Insensitive
No abstract available (Source: Eye and Contact Lens: Science and Clinical Practice)
Source: Eye and Contact Lens: Science and Clinical Practice - February 24, 2021 Category: Opthalmology Tags: Editorial Source Type: research

Deposition of Fluorescently Tagged Lysozyme on Contact Lenses in a Physiological Blink Model
Purpose: To visualize the deposition of fluorescein isothiocyanate (FITC) lysozyme on daily disposable contact lenses (CLs) using a novel blink model. Methods: Three daily disposable conventional hydrogel CLs (etafilcon A, omafilcon A, and nelfilcon A) and three silicone hydrogel CLs (delefilcon A, senofilcon A, and somofilcon A) were evaluated in the study. The CLs were mounted onto a novel blink model and exposed to an artificial tear solution containing FITC lysozyme for 2 and 10 hr. The flow rate and blink speed were set to 1 μL/min and 6 blinks/min, respectively. After the incubation period, a 5-mm-diamete...
Source: Eye and Contact Lens: Science and Clinical Practice - January 30, 2021 Category: Opthalmology Tags: Article Source Type: research

Risk Factors for Contact Lens–Related Microbial Keratitis and Associated Vision Loss in a South Indian Population
Conclusions: Identification of these risk factors may help inform safe contact lens wear habits and management strategies. (Source: Eye and Contact Lens: Science and Clinical Practice)
Source: Eye and Contact Lens: Science and Clinical Practice - January 30, 2021 Category: Opthalmology Tags: Article Source Type: research

Effect of Bandage Contact Lens Exchange on Pain and Healing After Photorefractive Keratectomy—A Randomized Control Trial
Objective: To evaluate the corneal re-epithelialization and patient-perceived pain after bandage contact lens (BCL) exchange on day one, after photorefractive keratectomy (PRK). Methods: A randomized controlled trial, of all patients who underwent bilateral transepithelial-PRK (trans-PRK) or bilateral alcohol debridement and PRK (A-PRK), between March and October 2019. One eye of each patient was randomly assigned to BCL exchange on the first postoperative day (exchange group) and the BCL was not exchanged in the fellow eye (control group). Patients were evaluated daily until healing was complete. At each visit,...
Source: Eye and Contact Lens: Science and Clinical Practice - January 30, 2021 Category: Opthalmology Tags: Article Source Type: research