BAK to the Future? Preserved and Preservative-Free Topical Glaucoma Medications
No abstract available (Source: Eye and Contact Lens: Science and Clinical Practice)
Source: Eye and Contact Lens: Science and Clinical Practice - March 22, 2022 Category: Opthalmology Tags: Editorial Source Type: research

Mechanisms Underlying Contact Lens-Related Keratitis Caused by Pseudomonas aeruginosa
Abstract: Infectious keratitis is a severe complication associated with contact lens (CL) wear, and can progress rapidly with suppurative infiltration, resulting in the loss of vision. Contact lens wearers with poor and improper care are susceptible to develop infectious keratitis. Gram-negative bacilli such as Pseudomonas aeruginosa, have an ability to form biofilms on CL cases and CLs. Moreover, P. aeruginosa has various virulence factors such as type III secretion system (TTSS) which is an important factor for pathogenicity in keratitis. The effector proteins of TTSS have been identified, namely ExoU, ExoS, ExoT, an...
Source: Eye and Contact Lens: Science and Clinical Practice - February 22, 2022 Category: Opthalmology Tags: Review Article Source Type: research

Epidemiology, Microbiology, and Genetics of Contact Lens–Related and Non–Contact Lens-Related Infectious Keratitis
Abstract: Infectious keratitis is a rare but severe condition associated with a range of ocular and systemic predisposing conditions, including ocular trauma, prior surgery, surface disease, and contact lens (CL) wear. This review explores the epidemiology of infectious keratitis, specifically the differences in disease incidence and risk factors, causative organism profile and virulence characteristics and host microbiome, genetics, gene expression, proteomics, and metabolomic characteristics in CL-related and non–CL-related diseases. Differences exist in the epidemiology, demographics, causative organisms, and thei...
Source: Eye and Contact Lens: Science and Clinical Practice - February 22, 2022 Category: Opthalmology Tags: Review Article Source Type: research

Polymeric Drug Delivery Devices: Role in Cornea and External Disease
Abstract: The field of ophthalmic drug delivery is undergoing rapid changes not only in the evolution of pharmacologic agents but also in the novel drug delivery vehicles. The ocular surface has limitations to drug penetration because of the presence of tight junctions between basal epithelial cells, which limits the amount of drug that can be absorbed after topical instillation. In addition, nasolacrimal drainage reduces the precorneal residence time significantly. Contact lenses (CLs) have been considered as possible carriers for topical medications because they reside on the ocular surface for a sufficient length of...
Source: Eye and Contact Lens: Science and Clinical Practice - February 22, 2022 Category: Opthalmology Tags: Review Article Source Type: research

Contact Lenses for Ocular Surface Disease
Abstract: Ocular surface disease can be difficult to manage, causing patients discomfort and vision loss. Therapeutic contact lenses are an important treatment option that is often neglected because it is conventional wisdom that eyes that are dry or irritated are not good candidates for contact lens. In this focused review, we consider the substantial literature on the use of bandage soft contact lenses (BSCL), scleral lenses, and customized prosthetic devices in the management of ocular graft-vs-host disease. Reports on BSCLs for recurrent corneal erosion are reviewed, as is literature on scleral lenses and prostheti...
Source: Eye and Contact Lens: Science and Clinical Practice - February 22, 2022 Category: Opthalmology Tags: Review Article Source Type: research

Management of Keratoconus With Corneal Rigid Gas-Permeable Contact Lenses
Abstract: Vision correction using a corneal rigid gas-permeable contact lens, which is relatively safe, easy to replace, and economical, is still the basis of the management for keratoconus. For eyes with keratoconus, two fitting strategies have traditionally been used in Japan: apical touch fitting with spherical lenses and parallel fitting with multicurve lenses. These two techniques have different success rates depending on the type and severity of keratoconus. Therefore, it is important to classify eyes with keratoconus into four types according to the shape of the cornea and select the prescription techniques acco...
Source: Eye and Contact Lens: Science and Clinical Practice - February 22, 2022 Category: Opthalmology Tags: Review Article Source Type: research

Update on Myopia Control: The US Perspective
This study reviews the current management options including contact lenses, spectacles, atropine, and environmental and behavioral modifications. Particular attention is given to the US perspective. (Source: Eye and Contact Lens: Science and Clinical Practice)
Source: Eye and Contact Lens: Science and Clinical Practice - February 22, 2022 Category: Opthalmology Tags: Review Source Type: research

Myopia Control With Orthokeratology: A Review
This article reviewed the peer-reviewed literature on the efficacy of OK for myopia control. Although it cannot halt myopia progression completely, the inhibitory effect on axial elongation for 2 years has been reported to be from 32% to 63%, as compared with single-vision spectacles and contact lenses. In addition, the efficacy and acceptable safety have been confirmed even in several long-term studies up to 10 years. However, the possibility of a rebound phenomenon in myopia progression after OK discontinuation remains unknown. It is also unclear how long the treatment should be continued to attain the maximum benefit in...
Source: Eye and Contact Lens: Science and Clinical Practice - February 22, 2022 Category: Opthalmology Tags: Review Article Source Type: research

Contact Lenses: The Frenemies
No abstract available (Source: Eye and Contact Lens: Science and Clinical Practice)
Source: Eye and Contact Lens: Science and Clinical Practice - February 22, 2022 Category: Opthalmology Tags: Editorial Source Type: research

Total Anterior Staphyloma Secondary to Acanthamoeba Keratitis
This study reports the clinical and histopathological findings and subsequent management of a 27-year-old healthy female patient who developed total anterior staphyloma after poor compliance with treatment for clinically diagnosed acanthamoeba keratitis. She underwent a successful evisceration with good long-term results. This case highlights that total anterior staphyloma may also result from untreated keratitis which is not fungal in origin. In cases of fungal and acanthamoeba keratitis, patient compliance with both treatment and follow-up is paramount to avoid vision-threatening sequelae that present significant challen...
Source: Eye and Contact Lens: Science and Clinical Practice - January 27, 2022 Category: Opthalmology Tags: Case Report Source Type: research

Lipid Keratopathy Management With Therapeutic Scleral Lens Wear
Conclusions: This case illustrates the use of scleral lens wear in the therapeutic management of lipid keratopathy secondary to rigid gas permeable lens wear and ocular surface disease. For patients limited by lipid keratopathy and topographical irregularity, scleral lens wear may be used to achieve both visual and therapeutic outcomes. (Source: Eye and Contact Lens: Science and Clinical Practice)
Source: Eye and Contact Lens: Science and Clinical Practice - January 27, 2022 Category: Opthalmology Tags: Case Report Source Type: research

Frugal Method of Notch Modification of Scleral Contact Lenses in the Setting of Complex Ocular Surface Anatomy
We describe a frugal method of ScCL notch modification that can be performed by a practitioner using readily available tools in a single office visit. Two patients with abnormal ocular surface anatomy were fit with the practitioner-modified ScCL and achieved successful visual rehabilitation. We offer this method as a potentially economical and effective technique to achieve successful ScCL fitting in this challenging patient population with pathologies that may preclude standard ScCL usage. (Source: Eye and Contact Lens: Science and Clinical Practice)
Source: Eye and Contact Lens: Science and Clinical Practice - January 27, 2022 Category: Opthalmology Tags: Case Report Source Type: research

Evaluation of the Lubricating Effect of Hyaluronic Acid on Contact Lenses Using a Pendulum-Type Friction Tester Under Mimicking Physiological Conditions
Objective: To evaluate the lubricating effect of hyaluronic acid (HA) on soft contact lenses (SCLs) measured using a pendulum-type friction tester. Methods: We measured the coefficient of friction (CoF) of narafilcon A, delefilcon A, and etafilcon A with polyvinylpyrrolidone (PVP), daily disposable SCL material, using a modified pendulum-type friction tester. Sample SCLs were set on an acrylic plastic half-ball and placed into the polyethylene terephthalate hemisphere cup filled with 0.4 mL of test lubricants that included saline and 0.05%, 0.1%, 0.2%, 0.3%, 0.4%, and 0.5% (wt/vol) HA (molecular weight, 850 kDa)...
Source: Eye and Contact Lens: Science and Clinical Practice - January 27, 2022 Category: Opthalmology Tags: Article Source Type: research

Evaluation of Orthokeratology Lens Fitting Assisted by Sagittal Height Simulation Software
Conclusions: The new sagittal height simulation software can accurately calculate the AC value of the orthokeratology lens suitable for the Chinese patients. (Source: Eye and Contact Lens: Science and Clinical Practice)
Source: Eye and Contact Lens: Science and Clinical Practice - January 27, 2022 Category: Opthalmology Tags: Article Source Type: research

Subjective Responses to Various Filling Solutions in the Posterior Fluid Reservoir of Miniscleral Lenses at Application
Conclusions: The use of postlens lubrication may be useful in enhancing adaptation to miniscleral lenses. (Source: Eye and Contact Lens: Science and Clinical Practice)
Source: Eye and Contact Lens: Science and Clinical Practice - January 27, 2022 Category: Opthalmology Tags: Article Source Type: research