Experimental and Clinical Psychopharmacology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Xylazine suppresses fentanyl consumption during self-administration and induces a unique sex-specific withdrawal syndrome that is not altered by naloxone in rats.
Experimental and Clinical Psychopharmacology, Vol 32(2), Apr 2024, 150-157; doi:10.1037/pha0000670Prescription and illicit opioid use are a public health crisis, with the landscape shifting to fentanyl use. Since fentanyl is 100-fold more potent than morphine, its use is associated with a higher risk of fatal overdose that can be remediated through naloxone (Narcan) administration. However, recent reports indicate that xylazine, an anesthetic, is increasingly detected in accidental fentanyl overdose deaths. Anecdotal reports suggest that xylazine may prolong the fentanyl “high,” alter the onset of fentanyl withdrawal, ...
Source: Experimental and Clinical Psychopharmacology - July 20, 2023 Category: Psychiatry & Psychology Source Type: research

Menstrual Phase Identification Questionnaire (MPIQ): Development and validation of a cross-sectional survey to identify follicular and luteal phases.
Experimental and Clinical Psychopharmacology, Vol 32(2), Apr 2024, 207-214; doi:10.1037/pha0000671Evidence continues to accumulate on the influence of the menstrual phase on several biobehavioral outcomes (e.g., substance misuse). Expansion of this knowledge is limited due to the burdensomeness of accurate menstrual phase assessment. Thus, we sought to create and validate a questionnaire that can be used as a stand-alone item within low-resource settings and numerous study designs (e.g., cross-sectional) to accurately identify both the follicular phase (FP) and the luteal phase (LP). Participants completed the self-adminis...
Source: Experimental and Clinical Psychopharmacology - July 13, 2023 Category: Psychiatry & Psychology Source Type: research

Support for incentive-sensitization theory in adolescent ad libitum smokers using ecological momentary assessment.
Experimental and Clinical Psychopharmacology, Vol 32(1), Feb 2024, 27-34; doi:10.1037/pha0000669The incentive-sensitization theory (IST) has emerged as a potentially useful theory in explaining substance addiction. IST postulates that the prolonged use of a substance can alter neural systems that are often involved in incentive motivation and reward processes, leading to an increased “sensitization” to the substance and associated stimuli. However, this increased sensitization is thought to mediate only the individual’s craving of the substance (e.g., their “wanting”), not their enjoyment of the substance (e.g., ...
Source: Experimental and Clinical Psychopharmacology - June 29, 2023 Category: Psychiatry & Psychology Source Type: research

Expectancy of alcohol analgesia moderates perception of pain relief following acute alcohol intake.
In this study, we tested expectancy of alcohol analgesia (EAA) as a moderator of subjective pain relief following oral alcohol challenge in individuals with and without chronic orofacial pain. Social drinkers (N = 48; 19 chronic pain; 29 pain-free controls) completed two testing sessions: alcohol administration (BrAC: 0.08 g/dL) and placebo. Alcohol expectancy (AE) was assessed using the EAA questionnaire and two 100-mm Visual Analogue Scales (VASs) regarding strength of belief that alcohol provides pain relief (AE VAS 1) or reduces pain sensitivity (AE VAS 2). Participants completed quantitative sensory testing (QST) invo...
Source: Experimental and Clinical Psychopharmacology - June 26, 2023 Category: Psychiatry & Psychology Source Type: research

Drinking alcohol appears to have no impact on self-perceptions of morality, aggressiveness, or intelligence.
Experimental and Clinical Psychopharmacology, Vol 32(1), Feb 2024, 104-111; doi:10.1037/pha0000666People generally perceive themselves as moral but does this tendency change after alcohol consumption? In the current research, we tested whether alcoholic intoxication affects self-assessments of morality (i.e., the self-importance of moral identity and the moral self-concept), and we also tested self-assessment of aggressiveness and intelligence. We conducted a preregistered laboratory experiment with participants divided into three groups: alcohol intoxication (n = 106), placebo (n = 114), and control condition (n = 109). W...
Source: Experimental and Clinical Psychopharmacology - June 26, 2023 Category: Psychiatry & Psychology Source Type: research

Longitudinal associations between anxiety sensitivity and substance use in adolescents: Mediation by depressive affect.
Experimental and Clinical Psychopharmacology, Vol 32(1), Feb 2024, 90-103; doi:10.1037/pha0000668Though anxiety sensitivity (AS)—fear of anxiety-related experiences—is primarily tied to anxiety vulnerability, AS has also been prospectively associated with general negative affect and depression. Furthermore, depression has been longitudinally associated with different forms of substance use, and some AS subfactors (e.g., cognitive concerns) have been associated more consistently with depression and substance use than others. However, no previous study has investigated if longitudinal associations of AS with substance us...
Source: Experimental and Clinical Psychopharmacology - June 26, 2023 Category: Psychiatry & Psychology Source Type: research

Baseline affective symptomatology moderates acute subjective effects of high potency THC and CBD cannabis concentrates.
Experimental and Clinical Psychopharmacology, Vol 31(6), Dec 2023, 1039-1049; doi:10.1037/pha0000667Highly potent cannabis concentrates are widely available and associated with affective disturbance and cannabis use disorder. Little is known about the effects of concentrated Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) and their relationship to long-term affect. We explored how baseline affective symptoms (anxiety and depression) relate to acute (i.e., immediate or short-term) subjective mood and intoxication effects during naturalistic use of cannabis concentrates. Fifty-four cannabis users (48% female; Mage = 29....
Source: Experimental and Clinical Psychopharmacology - June 8, 2023 Category: Psychiatry & Psychology Source Type: research

Posttraumatic stress and distress tolerance in relation to opioid misuse and dependence among trauma-exposed adults with chronic pain.
Experimental and Clinical Psychopharmacology, Vol 31(5), Oct 2023, 953-962; doi:10.1037/pha0000661Posttraumatic stress symptoms have been associated with opioid misuse and dependence among adults with chronic pain. Lower levels of perceived distress tolerance (i.e., perceived ability to withstand negative emotional states) have been independently associated with posttraumatic stress symptoms and opioid-related problems among nonchronic pain samples. However, there has not been a test of whether distress tolerance interacts with posttraumatic stress in terms of opioid misuse among trauma-exposed persons with chronic pain. T...
Source: Experimental and Clinical Psychopharmacology - June 1, 2023 Category: Psychiatry & Psychology Source Type: research

Loss aversion predicts cigarette smoking status across levels of sociodemographic characteristics.
Experimental and Clinical Psychopharmacology, Vol 32(2), Apr 2024, 189-196; doi:10.1037/pha0000665Loss aversion (LA) is a tendency to be more sensitive to potential losses relative to similar gains. Low LA is associated with increased risk for cigarette smoking and use of other substances. Previous studies of LA and smoking risk controlled for potentially confounding influences of sociodemographic characteristics associated with smoking risk. The present study replicates these earlier observations while also examining the generality of the association between low LA and smoking risk within different levels of each of the f...
Source: Experimental and Clinical Psychopharmacology - May 25, 2023 Category: Psychiatry & Psychology Source Type: research

Lumateperone for treatment of psychotic symptoms in Lewy body disease: A case report.
We present the first case of an LBD patient, showing favorable response in psychotic symptoms with lumateperone, a novel atypical neuroleptic. Our report revealed improvements in cognition, psychosis, and sleep following the initiation of lumateperone without concurrent emergence of extrapyramidal side effects, autonomic instability, parkinsonian features, or cognitive decline, which are typically seen when treated with available antipsychotic medications. Clinicians may wish to consider potential usefulness of lumateperone when managing patients with this disabling condition. (PsycInfo Database Record (c) 2024 APA, all ri...
Source: Experimental and Clinical Psychopharmacology - May 25, 2023 Category: Psychiatry & Psychology Source Type: research

Examining the validity of the addictions neuroclinical assessment domains in a crowdsourced sample of adults with current alcohol use.
Experimental and Clinical Psychopharmacology, Vol 32(1), Feb 2024, 68-83; doi:10.1037/pha0000648Several dimensional frameworks for characterizing heterogeneity in alcohol use disorder (AUD) have been proposed, including the Addictions Neuroclinical Assessment (ANA). The ANA is a framework for assessing individual variability within AUD across three domains corresponding to the proposed stages of the addiction cycle: reward (binge-intoxication stage), negative emotionality (withdrawal-negative affect stage), and cognitive control (preoccupation-anticipation stage). Recent work has evaluated the ANA’s three-factor structur...
Source: Experimental and Clinical Psychopharmacology - May 25, 2023 Category: Psychiatry & Psychology Source Type: research

Conditioned taste avoidance and conditioned place preference induced by the third-generation synthetic cathinone eutylone in female sprague-dawley rats.
Experimental and Clinical Psychopharmacology, Vol 31(6), Dec 2023, 1069-1079; doi:10.1037/pha0000657Recently, use of the synthetic cathinone (aka “bath salt”) eutylone has risen in the United States and globally. Due to its novelty in drug markets, its affective properties remain largely uninvestigated. In this context, drugs of abuse have both rewarding and aversive effects and understanding these effects, their relative balance, and factors that impact each are important to understanding the likelihood of drug use and abuse. This investigation attempted to characterize eutylone’s rewarding and aversive effects in a...
Source: Experimental and Clinical Psychopharmacology - May 25, 2023 Category: Psychiatry & Psychology Source Type: research

Novel methods for the remote investigation of emerging substances: Application to kratom.
Experimental and Clinical Psychopharmacology, Vol 32(2), Apr 2024, 215-227; doi:10.1037/pha0000656The botanical product commonly called “kratom” is still relatively novel to the United States. Like other natural products marketed as supplements, kratom is highly variable, both in terms of the alkaloids naturally occurring in kratom leaves and in terms of processing and formulation. Kratom products sold in the United States are not well-characterized, nor are daily use patterns among regular users. Surveys and case reports have comprised most of the literature on kratom use among humans. To advance our understanding of ...
Source: Experimental and Clinical Psychopharmacology - May 22, 2023 Category: Psychiatry & Psychology Source Type: research

Current suicide risk, but not lifetime history of attempted suicide, predicts treatment response to low-dose ketamine infusion: Post Hoc analysis of adjunctive ketamine study of Taiwanese patients with treatment-resistant depression.
Experimental and Clinical Psychopharmacology, Vol 32(1), Feb 2024, 84-89; doi:10.1037/pha0000658Whether current suicide risk or a history of attempted suicide is related to the antidepressant effect of a low-dose ketamine infusion remains unclear. In total, 47 patients with treatment-resistant depression (TRD), including 32 with low current suicide risk and 15 with moderate or high current suicide risk, were randomized to groups receiving a low-dose ketamine infusion of either 0.2 or 0.5 mg/kg. Among the patients, 21 had a lifetime history of attempted suicide. Suicide risk was assessed based on the Suicidal scale of the M...
Source: Experimental and Clinical Psychopharmacology - May 18, 2023 Category: Psychiatry & Psychology Source Type: research

Behavioral mechanisms of oxycodone’s effects in female and male rats: Reinforcement delay and impulsive choice.
Experimental and Clinical Psychopharmacology, Vol 31(6), Dec 2023, 1050-1068; doi:10.1037/pha0000646μ-Opioid agonists (e.g., morphine) typically increase impulsive choice, which has been interpreted as an opioid-induced increase in sensitivity to reinforcement delay. Relatively little research has been done with opioids other than morphine (e.g., oxycodone), or on sex differences in opioid effects, on impulsive choice. The present study investigated the effects of acute (0.1–1.0 mg/kg) and chronic (1.0 mg/kg twice/day) administration of oxycodone on choice controlled by reinforcement delay, a primary mechanism implicate...
Source: Experimental and Clinical Psychopharmacology - May 18, 2023 Category: Psychiatry & Psychology Source Type: research