Dose-effect meta-analysis for psychopharmacological interventions using randomised data
Conclusions
The dose–effect meta-analysis enables clinicians to understand how the effect of a drug changes as a function of its dose. Such analysis should be conducted in practice using the one-stage model that incorporates evidence from all available studies. (Source: Evidence-Based Mental Health)
Source: Evidence-Based Mental Health - January 20, 2022 Category: Psychiatry & Psychology Authors: Hamza, T., Furukawa, T. A., Orsini, N., Cipriani, A., Salanti, G. Tags: Editor's choice, EBMH Statistics in Practice Source Type: research
Impact of COVID-19 on telepsychiatry at the service and individual patient level across two UK NHS mental health Trusts
Conclusions and clinical implications
The rapid shift to remote service delivery has not reached some groups of patients who may require more tailored management with telepsychiatry. (Source: Evidence-Based Mental Health)
Source: Evidence-Based Mental Health - October 21, 2021 Category: Psychiatry & Psychology Authors: Hong, J. S., Sheriff, R., Smith, K., Tomlinson, A., Saad, F., Smith, T., Engelthaler, T., Phiri, P., Henshall, C., Ede, R., Denis, M., Mitter, P., D'Agostino, A., Cerveri, G., Tomassi, S., Rathod, S., Broughton, N., Marlowe, K., Geddes, J., Cipriani, A. Tags: Open access, COVID-19 Digital mental health Source Type: research
Comparative efficacy and acceptability of psychotherapies for post-traumatic stress disorder in children and adolescents: a systematic review and network meta-analysis
Conclusions
CPT, BT and individual TF-CBT appear to be the best choices of psychotherapy for PTSD in young patients. Other types and different ways of delivering psychological treatment can be alternative options. Clinicians should consider the importance of each outcome and the patients’ preferences in real clinical practice. (Source: Evidence-Based Mental Health)
Source: Evidence-Based Mental Health - October 21, 2021 Category: Psychiatry & Psychology Authors: Xiang, Y., Cipriani, A., Teng, T., Del Giovane, C., Zhang, Y., Weisz, J. R., Li, X., Cuijpers, P., Liu, X., Barth, J., Jiang, Y., Cohen, D., Fan, L., Gillies, D., Du, K., Ravindran, A. V., Zhou, X., Xie, P. Tags: Open access Child and adolescent mental health Source Type: research
Prediction of treatment dosage and duration from free-text prescriptions: an application to ADHD medications in the Swedish prescribed drug register
Conclusions
The algorithm provides a flexible approach to estimate prescribed daily dosage and treatment duration from free-text prescriptions using register data. The algorithm showed a good performance for predicting daily dosage in external validation.
Clinical implications
The structured output of the algorithm could serve as basis for future pharmacoepidemiological studies evaluating utilization, effectiveness, and safety of medication use, which would facilitate evidence-based treatment decision-making. (Source: Evidence-Based Mental Health)
Source: Evidence-Based Mental Health - October 21, 2021 Category: Psychiatry & Psychology Authors: Zhang, L., Lagerberg, T., Chen, Q., Ghirardi, L., D'Onofrio, B. M., Larsson, H., Viktorin, A., Chang, Z. Tags: Open access Digital mental health Source Type: research
Prevalences of comorbid anxiety disorder and daily smartphone-based self-reported anxiety in patients with newly diagnosed bipolar disorder
Background
Around 40% of patients with bipolar disorder (BD) additionally have anxiety disorder. The prevalence of anxiety in patients with newly diagnosed BD and their first-degree relatives (UR) has not been investigated.
Objective
To investigate (1) the prevalence of a comorbid anxiety diagnosis in patients with newly diagnosed BD and their UR, (2) sociodemographic and clinical differences between patients with and without a comorbid anxiety diagnosis and (3) the association between smartphone-based patient-reported anxiety and observer-based ratings of anxiety and functioning, respectively.
Methods
We recruited 372 pa...
Source: Evidence-Based Mental Health - October 21, 2021 Category: Psychiatry & Psychology Authors: Stanislaus, S., Coello, K., Kjaerstad, H. L., Sletved, K. S. O., Seeberg, I., Frost, M., Bardram, J. E., Jensen, R. N., Vinberg, M., Faurholt-Jepsen, M., Kessing, L. V. Tags: Digital mental health Source Type: research
Guidelines to understand and compute the number needed to treat
Conclusion
This application will help researchers and clinicians assess the efficacy of treatment and consequently improve the quality and accuracy of decisions. (Source: Evidence-Based Mental Health)
Source: Evidence-Based Mental Health - October 21, 2021 Category: Psychiatry & Psychology Authors: Vancak, V., Goldberg, Y., Levine, S. Z. Tags: Editor's choice, EBMH Statistics in Practice Source Type: research
Increasing the clinical interpretability of PHQ-9 through equipercentile linking with health utility values by EQ-5D-3L
In our recent paper,1 we presented the results of the equipercentile linking analysis between the Patient Health Questionnaire (PHQ-9) and the Euro-Qol Five Dimentions Three Levels (EQ-5D-3L) in order to increase the clinical interpretability of the PHQ-9 scores and their changes. Our paper was based on the clinical approach to linking that has been applied to various scales in psychiatry.2 3 Drs Franklin and Young made some important comments on our approach and we will try our best to clarify the concerns they raise. Drs Franklin and Young cite the International Society for Pharmacoeconomics and Outcomes Research (ISPOR)...
Source: Evidence-Based Mental Health - October 21, 2021 Category: Psychiatry & Psychology Authors: Furukawa, T. A., Levine, S. Z., Buntrock, C., Cuijpers, P. Tags: Open access Letter Source Type: research
Correspondence on "How can we estimate QALYs based on PHQ-9 scores? Equipercentile linking analysis of PHQ-9 and EQ-5D" by Furukawa et al
Furukawa et al1 posed the question: how can we estimate quality-adjusted life years (QALYs) based on Patient Health Questionnaire-9 (PHQ-9) scores? They recommend equipercentile linking analysis between the depression severity PHQ-9 and preference-based EQ-5D three-level version (EQ-5D-3L; UK value set), the latter used to estimate utility data for QALYs. Furukawa et al1 refer to the process of ‘cross-walking’, whereby the practice of fitting a statistical model to health utility data has been referred to as ‘mapping’ and 'cross-walking’.2 Furukawa et al1 reference two mapping-related papers (...
Source: Evidence-Based Mental Health - October 21, 2021 Category: Psychiatry & Psychology Authors: Franklin, M., Young, T. Tags: Letter Source Type: research
Call for emergency action to limit global temperature increases, restore biodiversity and protect health
Wealthy nations must do much more, much faster. The United Nations General Assembly in September 2021 will bring countries together at a critical time for marshalling collective action to tackle the global environmental crisis. They will meet again at the biodiversity summit in Kunming, China, and the climate conference (Conference of the Parties (COP)26) in Glasgow, UK. Ahead of these pivotal meetings, we—the editors of health journals worldwide—call for urgent action to keep average global temperature increases below 1.5°C, halt the destruction of nature and protect health. Health is already being harmed ...
Source: Evidence-Based Mental Health - October 21, 2021 Category: Psychiatry & Psychology Authors: Atwoli, L., H Baqui, A., Benfield, T., Bosurgi, R., Godlee, F., Hancocks, S., Horton, R., Laybourn-Langton, L., Monteiro, C. A., Norman, I., Patrick, K., Praities, N., Rikkert, M. G. O., Rubin, E. J., Sahni, P., Smith, R., Talley, N. J., Turale, S., Vazqu Tags: Open access Editorials Source Type: research
Changing response rates in clinical trials of depression: how did the introduction of DSM-III and DSM-III-R influence the outcome?
It has been argued recently that the drug-placebo difference is diminishing in clinical trials of depression. Recently a paper suggested that the placebo response in trials of antidepressant agents increased abruptly after 1991 and remained stable afterwards at the level of 35–40%.1 A possible explanation for this change could be the introduction of Diagnostic and Statistical Manual Third Edition (DSM)-III and DSM-III-Revised (R) and the change in paradigm concerning depression, which came with them since the early 1980s.2 3 With the introduction of operationalised diagnostic criteria, the concept of depression both ...
Source: Evidence-Based Mental Health - April 24, 2017 Category: Psychiatry & Psychology Authors: Fountoulakis, K. N. Tags: Letter Source Type: research
Simpler therapy may successfully treat adolescents with anorexia nervosa
ABSTRACT FROM: Le Grange D, Hughes EK, Court A, et al. Randomized clinical trial of parent-focused treatment and family-based treatment for adolescent anorexia nervosa. J Am Acad Child Adolesc Psychiatry 2016;55:683–92. What is already known on this topic Family-based treatment (FBT) is an effective evidence-based therapy for adolescent anorexia nervosa (AN) and is the recommended approach to treatment at the present time.1 The effectiveness of other treatments such as individual psychotherapy (ego-oriented therapy) and generic family therapy (systemic family therapy) is based on less evidence and such treatments are...
Source: Evidence-Based Mental Health - April 24, 2017 Category: Psychiatry & Psychology Authors: Agras, S. Tags: Psychological interventions Source Type: research
Targeted psychological interventions may prevent depression in children and adolescents
ABSTRACT FROM: Hetrick SE, Cox GR, Witt KG, et al. Cognitive–behavioural therapy (CBT), third-wave CBT and interpersonal therapy (IPT) based interventions for preventing depression in children and adolescents. Cochrane Database Syst Rev 2016;(8):CD003380. What is already known on this topic Major depressive disorder is a leading global cause of lifelong disability, with the greatest increase in incidence occurring in mid-to-late adolescence into young adulthood. Onset in childhood predicts poor long-term educational, social and health outcomes. Therefore, interventions to prevent depression in children and adolescent...
Source: Evidence-Based Mental Health - April 24, 2017 Category: Psychiatry & Psychology Authors: Watkins, E. Tags: Psychological interventions Source Type: research
Short-term adjunct of topiramate to antipsychotics in schizophrenia improves the psychopathology and has weight maintenance
This study included RCTs of antipsychotic cotreatment with topiramate in patients with schizophrenia-spectrum disorders (schizophrenia, schizophreniform disorder, schizoaffective disorder). PubMed, PsycINFO, Embase, Cochrane Library databases, the Cochrane Controlled Trials Register and... (Source: Evidence-Based Mental Health)
Source: Evidence-Based Mental Health - April 24, 2017 Category: Psychiatry & Psychology Authors: Kishi, T. Tags: Pharmacological interventions Source Type: research
Relative to SSRI users, SSRI-statin users have fewer psychiatric hospital contacts and no increase in suicidal behaviour or all-cause mortality
ABSTRACT FROM: Kohler O, Gasse C, Petersen L, et al. The effect of concomitant treatment with SSRIs and statins: a population-based study. Am J Psychiatry 2016;173:807–15. What is already known on this topic Observational studies have identified inflammatory changes in depression,1 2 and randomised controlled trials (RCTs) suggest that depression may respond better when anti-inflammatory drugs are used to augment antidepressant drugs.3 Statins have anti-inflammatory properties. The present study is the first population-level investigation of the benefits and risks of a selective serotonin reuptake inhibitor (SSRI)&nd...
Source: Evidence-Based Mental Health - April 24, 2017 Category: Psychiatry & Psychology Authors: Andrade, C. Tags: Outcomes Source Type: research
Hypersomnia: an overlooked, but not overestimated, sleep disturbance in bipolar disorder
ABSTRACT FROM: Steinan MK, Scott J, Lagerberg TV, et al. Sleep problems in bipolar disorders: more than just insomnia. Acta Psychiatr Scand 2016;133:368–77. What is already known on this topic Sleep disturbances are common across bipolar spectrum disorders. Reduced need for sleep, insomnia and hypersomnia (excessive sleep or sleepiness) are diagnostic features of illness episodes; these sleep disturbances persist into the interepisode period and are associated with functional impairment and risk for relapse.1 Few studies have investigated subtypes of sleep disturbances within bipolar spectrum disorders, and these hav...
Source: Evidence-Based Mental Health - April 24, 2017 Category: Psychiatry & Psychology Authors: Kaplan, K. A., Williams, R. Tags: Outcomes Source Type: research
