What You Don't Know Can Hurt You: Psychiatric Effects of Prenatal Anti-Seizure Medications
Epilepsy Curr. 2023 Aug 7;23(6):366-368. doi: 10.1177/15357597231191953. eCollection 2023 Nov-Dec.ABSTRACTPMID:38269349 | PMC:PMC10805090 | DOI:10.1177/15357597231191953 (Source: Epilepsy Curr)
Source: Epilepsy Curr - January 25, 2024 Category: Neurology Authors: Samuel W Terman Source Type: research
Brake Early: RGS14 in CA2 Limits Seizures and Oxidative Stress After SE
Epilepsy Curr. 2023 Sep 28;23(6):372-374. doi: 10.1177/15357597231199343. eCollection 2023 Nov-Dec.ABSTRACTPMID:38269350 | PMC:PMC10805082 | DOI:10.1177/15357597231199343 (Source: Epilepsy Curr)
Source: Epilepsy Curr - January 25, 2024 Category: Neurology Authors: Cameron S Metcalf Source Type: research
Neurons Are GIRKed in GNB1 Encephalopathy: Unraveling Pathogenic Mechanisms in a Complex Neurodevelopmental Disorder
Epilepsy Curr. 2023 Nov 30;23(6):381-382. doi: 10.1177/15357597231202859. eCollection 2023 Nov-Dec.ABSTRACTPMID:38269351 | PMC:PMC10805083 | DOI:10.1177/15357597231202859 (Source: Epilepsy Curr)
Source: Epilepsy Curr - January 25, 2024 Category: Neurology Authors: Jacy L Wagnon Source Type: research
Open Sesame: Door to Enriched Somatic Variants Underlying Sporadic mTLE
Epilepsy Curr. 2023 Sep 28;23(6):383-385. doi: 10.1177/15357597231201127. eCollection 2023 Nov-Dec.ABSTRACTPMID:38269352 | PMC:PMC10805092 | DOI:10.1177/15357597231201127 (Source: Epilepsy Curr)
Source: Epilepsy Curr - January 25, 2024 Category: Neurology Authors: Shilpa D Kadam Source Type: research
Is MORE better? Accumulating Evidence for ANT DBS in Epilepsy
Epilepsy Curr. 2023 Sep 4;23(6):357-359. doi: 10.1177/15357597231197086. eCollection 2023 Nov-Dec.ABSTRACTPMID:38269353 | PMC:PMC10805093 | DOI:10.1177/15357597231197086 (Source: Epilepsy Curr)
Source: Epilepsy Curr - January 25, 2024 Category: Neurology Authors: Imran H Quraishi Source Type: research
Suppress Globally or Seize Locally: Cortical Network Activity Explains Seizure Diversity Among < em > Kcnt1 < /em > Mutants
Epilepsy Curr. 2023 Nov 30;23(6):389-391. doi: 10.1177/15357597231202671. eCollection 2023 Nov-Dec.ABSTRACTPMID:38269354 | PMC:PMC10805094 | DOI:10.1177/15357597231202671 (Source: Epilepsy Curr)
Source: Epilepsy Curr - January 25, 2024 Category: Neurology Authors: Scott Kilianski Mark Beenhakker Source Type: research
Somatic mosaicism in focal epilepsies
Curr Opin Neurol. 2024 Jan 19. doi: 10.1097/WCO.0000000000001244. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Over the past decade, it has become clear that brain somatic mosaicism is an important contributor to many focal epilepsies. The number of cases and the range of underlying pathologies with somatic mosaicism are rapidly increasing. This growth in somatic variant discovery is revealing dysfunction in distinct molecular pathways in different focal epilepsies.RECENT FINDINGS: We briefly summarize the current diagnostic yield of pathogenic somatic variants across all types of focal epilepsy where somatic mosaicism...
Source: Epilepsy Curr - January 18, 2024 Category: Neurology Authors: Samuel Gooley Piero Perucca Caitlin Tubb Michael S Hildebrand Samuel F Berkovic Source Type: research
An update on psychogenic nonepileptic seizures
Curr Opin Neurol. 2024 Jan 19. doi: 10.1097/WCO.0000000000001245. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: The understanding of psychogenic nonepileptic seizures (PNES) has advanced steadily over recent decades. This update summarizes new insights from the last three years.RECENT FINDINGS: The process of diagnosing PNES has shifted from the exclusion of epilepsy to one based on the recognition of typical clinical features. While the diagnosis cannot rely on any single feature in isolation, a range of semiological features characterising PNES are now recognised and a number of studies hint at the potential for machi...
Source: Epilepsy Curr - January 18, 2024 Category: Neurology Authors: Mithila Vijay Markus Reuber Source Type: research
Recent advances in clinical electroencephalography
Curr Opin Neurol. 2024 Jan 18. doi: 10.1097/WCO.0000000000001246. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Clinical electroencephalography (EEG) is a conservative medical field. This explains likely the significant gap between clinical practice and new research developments. This narrative review discusses possible causes of this discrepancy and how to circumvent them. More specifically, we summarize recent advances in three applications of clinical EEG: source imaging (ESI), high-frequency oscillations (HFOs) and EEG in critically ill patients.RECENT FINDINGS: Recently published studies on ESI provide further evid...
Source: Epilepsy Curr - January 17, 2024 Category: Neurology Authors: Birgit Frauscher Andrea O Rossetti S ándor Beniczky Source Type: research
Safety of noninvasive brain stimulation in children
Curr Opin Psychiatry. 2024 Jan 4. doi: 10.1097/YCO.0000000000000923. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Noninvasive brain stimulation (NIBS) is a promising method for altering cortical excitability with clinical implications. It has been increasingly used in children, especially in neurodevelopmental disorders. Yet, its safety and applications in the developing brain require further investigation. This review aims to provide an overview of the safety of commonly used NIBS techniques in children, including transcranial electrical stimulation (tES) and transcranial magnetic stimulation (TMS). Safety data for ot...
Source: Epilepsy Curr - January 16, 2024 Category: Neurology Authors: Mohammad Ali Salehinejad Michael Siniatchkin Source Type: research
Predictive models of epilepsy outcomes
Curr Opin Neurol. 2024 Jan 16. doi: 10.1097/WCO.0000000000001241. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Multiple complex medical decisions are necessary in the course of a chronic disease like epilepsy. Predictive tools to assist physicians and patients in navigating this complexity have emerged as a necessity and are summarized in this review.RECENT FINDINGS: Nomograms and online risk calculators are user-friendly and offer individualized predictions for outcomes ranging from safety of antiseizure medication withdrawal (accuracy 65-73%) to seizure-freedom, naming, mood, and language outcomes of resective epilep...
Source: Epilepsy Curr - January 15, 2024 Category: Neurology Authors: Shehryar Sheikh Lara Jehi Source Type: research
Reproducible Differentiation of Human Pluripotent Stem Cells into Two-Dimensional Cortical Neuron Cultures with Checkpoints for Success
Curr Protoc. 2023 Dec;3(12):e948. doi: 10.1002/cpz1.948.ABSTRACTThe patterning of excitatory cortical neurons from human pluripotent stem cells (hPSCs) is a desired technique for the study of neurodevelopmental disorders, as neurons can be created and compared from control hPSC lines, hPSC lines generated from patients, and CRISPR-modified hPSC lines. Therefore, this technique allows for the examination of disease phenotypes and assists in the development of potential new therapeutics for neurodevelopmental disorders. Many protocols, however, are optimized for use with specific hPSC lines or within a single laboratory, and...
Source: Epilepsy Curr - December 27, 2023 Category: Neurology Authors: Elisa A Waxman Lea V Dungan Leah M DeFlitch Julie P Merchant Alyssa L Gagne Ethan M Goldberg Deborah L French Source Type: research
Reproducible Differentiation of Human Pluripotent Stem Cells into Two-Dimensional Cortical Neuron Cultures with Checkpoints for Success
Curr Protoc. 2023 Dec;3(12):e948. doi: 10.1002/cpz1.948.ABSTRACTThe patterning of excitatory cortical neurons from human pluripotent stem cells (hPSCs) is a desired technique for the study of neurodevelopmental disorders, as neurons can be created and compared from control hPSC lines, hPSC lines generated from patients, and CRISPR-modified hPSC lines. Therefore, this technique allows for the examination of disease phenotypes and assists in the development of potential new therapeutics for neurodevelopmental disorders. Many protocols, however, are optimized for use with specific hPSC lines or within a single laboratory, and...
Source: Epilepsy Curr - December 27, 2023 Category: Neurology Authors: Elisa A Waxman Lea V Dungan Leah M DeFlitch Julie P Merchant Alyssa L Gagne Ethan M Goldberg Deborah L French Source Type: research
Reproducible Differentiation of Human Pluripotent Stem Cells into Two-Dimensional Cortical Neuron Cultures with Checkpoints for Success
Curr Protoc. 2023 Dec;3(12):e948. doi: 10.1002/cpz1.948.ABSTRACTThe patterning of excitatory cortical neurons from human pluripotent stem cells (hPSCs) is a desired technique for the study of neurodevelopmental disorders, as neurons can be created and compared from control hPSC lines, hPSC lines generated from patients, and CRISPR-modified hPSC lines. Therefore, this technique allows for the examination of disease phenotypes and assists in the development of potential new therapeutics for neurodevelopmental disorders. Many protocols, however, are optimized for use with specific hPSC lines or within a single laboratory, and...
Source: Epilepsy Curr - December 27, 2023 Category: Neurology Authors: Elisa A Waxman Lea V Dungan Leah M DeFlitch Julie P Merchant Alyssa L Gagne Ethan M Goldberg Deborah L French Source Type: research
Reproducible Differentiation of Human Pluripotent Stem Cells into Two-Dimensional Cortical Neuron Cultures with Checkpoints for Success
Curr Protoc. 2023 Dec;3(12):e948. doi: 10.1002/cpz1.948.ABSTRACTThe patterning of excitatory cortical neurons from human pluripotent stem cells (hPSCs) is a desired technique for the study of neurodevelopmental disorders, as neurons can be created and compared from control hPSC lines, hPSC lines generated from patients, and CRISPR-modified hPSC lines. Therefore, this technique allows for the examination of disease phenotypes and assists in the development of potential new therapeutics for neurodevelopmental disorders. Many protocols, however, are optimized for use with specific hPSC lines or within a single laboratory, and...
Source: Epilepsy Curr - December 27, 2023 Category: Neurology Authors: Elisa A Waxman Lea V Dungan Leah M DeFlitch Julie P Merchant Alyssa L Gagne Ethan M Goldberg Deborah L French Source Type: research
