Back to the Basics in Predictive Modeling-Predicting Surgical Success
Epilepsy Curr. 2023 Nov 6;24(1):19-21. doi: 10.1177/15357597231205437. eCollection 2024 Jan-Feb.ABSTRACTPMID:38327535 | PMC:PMC10846520 | DOI:10.1177/15357597231205437 (Source: Epilepsy Curr)
Source: Epilepsy Curr - February 8, 2024 Category: Neurology Authors: Samuel W Terman Source Type: research

Only Hit the Bad Guys: A Gene Therapy Approach to Selectively Silence Highly Active Neurons Reduces Chronic Seizures in Epileptic Mice
Epilepsy Curr. 2023 Dec 12;24(1):56-58. doi: 10.1177/15357597231210253. eCollection 2024 Jan-Feb.ABSTRACTPMID:38327536 | PMC:PMC10846513 | DOI:10.1177/15357597231210253 (Source: Epilepsy Curr)
Source: Epilepsy Curr - February 8, 2024 Category: Neurology Authors: Tristan Shuman Source Type: research

MicroRNA 335-5p: The Sodium Channel Silencer
Epilepsy Curr. 2023 Nov 22;24(1):50-52. doi: 10.1177/15357597231212373. eCollection 2024 Jan-Feb.ABSTRACTPMID:38327537 | PMC:PMC10846517 | DOI:10.1177/15357597231212373 (Source: Epilepsy Curr)
Source: Epilepsy Curr - February 8, 2024 Category: Neurology Authors: Jennifer C Wong Source Type: research

Seizure Detection Devices in Children: One Step Closer
Epilepsy Curr. 2023 Nov 16;24(1):31-33. doi: 10.1177/15357597231211710. eCollection 2024 Jan-Feb.ABSTRACTPMID:38327538 | PMC:PMC10846510 | DOI:10.1177/15357597231211710 (Source: Epilepsy Curr)
Source: Epilepsy Curr - February 8, 2024 Category: Neurology Authors: Charuta Joshi Source Type: research

Determining the Spread: Potential Biomarkers and Treatment for Seizure-Induced-Spreading Depolarization in a Mouse Model of Genetic Epilepsy
Epilepsy Curr. 2023 Nov 22;24(1):47-49. doi: 10.1177/15357597231212763. eCollection 2024 Jan-Feb.ABSTRACTPMID:38327539 | PMC:PMC10846522 | DOI:10.1177/15357597231212763 (Source: Epilepsy Curr)
Source: Epilepsy Curr - February 8, 2024 Category: Neurology Authors: Katelyn G Joyal Gordon F Buchanan Source Type: research

Exploring Dendritic and Spine Structural Profiles in Epilepsy: Insights From Human Studies and Experimental Animal Models
Epilepsy Curr. 2023 Dec 27;24(1):40-46. doi: 10.1177/15357597231218603. eCollection 2024 Jan-Feb.ABSTRACTDendrites are tree-like structures with tiny spines specialized to receive excitatory synaptic transmission. Spino-dendritic plasticity, driven by neural activity, underlies the maintenance of neuronal connections crucial for proper circuit function. Abnormalities in dendritic morphology are frequently seen in epilepsy. However, the exact etiology or functional implications are not yet known. Therefore, to better comprehend the structure-function significance of this dendritic pathology in epilepsy, it is necessary to i...
Source: Epilepsy Curr - February 8, 2024 Category: Neurology Authors: Shikha Kumari Amy L Brewster Source Type: research

Unspooling the Thread: VIP Interneurons Linked With Autism Spectrum Disorder Behaviors but Not Seizures in Dravet Syndrome
Epilepsy Curr. 2023 Dec 27;24(1):62-64. doi: 10.1177/15357597231218876. eCollection 2024 Jan-Feb.ABSTRACTPMID:38327541 | PMC:PMC10846521 | DOI:10.1177/15357597231218876 (Source: Epilepsy Curr)
Source: Epilepsy Curr - February 8, 2024 Category: Neurology Authors: Raquel Miralles Manoj K Patel Source Type: research

The "Curious Case of Postictal Oxygen Dissipation": Could ROS Be the Culprit?
Epilepsy Curr. 2023 Dec 12;24(1):59-61. doi: 10.1177/15357597231216921. eCollection 2024 Jan-Feb.ABSTRACTPMID:38327542 | PMC:PMC10846519 | DOI:10.1177/15357597231216921 (Source: Epilepsy Curr)
Source: Epilepsy Curr - February 8, 2024 Category: Neurology Authors: Ashwini Sri Hari Cameron S Metcalf Source Type: research

Ambulatory seizure detection
Curr Opin Neurol. 2024 Feb 8. doi: 10.1097/WCO.0000000000001248. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: To review recent advances in the field of seizure detection in ambulatory patients with epilepsy.RECENT FINDINGS: Recent studies have shown that wrist or arm wearable sensors, using 3D-accelerometry, electrodermal activity or photoplethysmography, in isolation or in combination, can reliably detect focal-to-bilateral and generalized tonic-clonic seizures (GTCS), with a sensitivity over 90%, and false alarm rates varying from 0.1 to 1.2 per day. A headband EEG has also demonstrated a high sensitivity for detecti...
Source: Epilepsy Curr - February 8, 2024 Category: Neurology Authors: Adriano Bernini Jonathan Dan Philippe Ryvlin Source Type: research

Convection-enhanced Diffusion: A Novel Tactics to Crack the BBB
Curr Drug Deliv. 2024 Jan 24. doi: 10.2174/0115672018266501231207095127. Online ahead of print.ABSTRACTAlthough the brain is very accessible to nutrition and oxygen, it can be difficult to deliver medications to malignant brain tumours. To get around some of these issues and enable the use of therapeutic pharmacological substances that wouldn't typically cross the blood-brain barrier (BBB), convection-enhanced delivery (CED) has been developed. It is a cutting-edge strategy that gets beyond the blood-brain barrier and enables targeted drug administration to treat different neurological conditions such as brain tumours, Par...
Source: Epilepsy Curr - January 26, 2024 Category: Neurology Authors: Meenakshi Dhanawat None Garima Kashish Wilson Sumeet Gupta Rishabh Chalotra Nidhi Gupta Source Type: research

Getting Under the Skin of Seizure Monitoring: A Subcutaneous EEG Tool to Keep a Tally Over the Long Haul
Epilepsy Curr. 2023 Aug 29;23(6):351-353. doi: 10.1177/15357597231197093. eCollection 2023 Nov-Dec.ABSTRACTPMID:38269339 | PMC:PMC10805096 | DOI:10.1177/15357597231197093 (Source: Epilepsy Curr)
Source: Epilepsy Curr - January 25, 2024 Category: Neurology Authors: Ioannis Karakis Source Type: research

A Water Nymph's Curse and the Serotonergic Mechanism of Postictal Breathing Dysfunction
Epilepsy Curr. 2023 Oct 31;23(6):369-371. doi: 10.1177/15357597231199340. eCollection 2023 Nov-Dec.ABSTRACTPMID:38269340 | PMC:PMC10805091 | DOI:10.1177/15357597231199340 (Source: Epilepsy Curr)
Source: Epilepsy Curr - January 25, 2024 Category: Neurology Authors: Ian C Wenker Manoj K Patel Source Type: research

Cenobamate: Real-World Experience Matches Clinical Trials
Epilepsy Curr. 2023 Aug 29;23(6):348-350. doi: 10.1177/15357597231197105. eCollection 2023 Nov-Dec.ABSTRACTPMID:38269341 | PMC:PMC10805087 | DOI:10.1177/15357597231197105 (Source: Epilepsy Curr)
Source: Epilepsy Curr - January 25, 2024 Category: Neurology Authors: Gewalin Aungaroon Source Type: research

Update in Progress: Cognitive Phenotypes in Temporal Lobe Epilepsy
Epilepsy Curr. 2023 Nov 30;23(6):363-365. doi: 10.1177/15357597231211446. eCollection 2023 Nov-Dec.ABSTRACTPMID:38269342 | PMC:PMC10805095 | DOI:10.1177/15357597231211446 (Source: Epilepsy Curr)
Source: Epilepsy Curr - January 25, 2024 Category: Neurology Authors: Rani A Sarkis Source Type: research

Revoking the Seize Order: Preventing Spontaneous Seizures With AAV in a CLN2 Mouse Model
Epilepsy Curr. 2023 Oct 9;23(6):386-388. doi: 10.1177/15357597231200702. eCollection 2023 Nov-Dec.ABSTRACTPMID:38269343 | PMC:PMC10805085 | DOI:10.1177/15357597231200702 (Source: Epilepsy Curr)
Source: Epilepsy Curr - January 25, 2024 Category: Neurology Authors: Gordon F Buchanan Source Type: research