Reproducible Differentiation of Human Pluripotent Stem Cells into Two-Dimensional Cortical Neuron Cultures with Checkpoints for Success
Curr Protoc. 2023 Dec;3(12):e948. doi: 10.1002/cpz1.948.ABSTRACTThe patterning of excitatory cortical neurons from human pluripotent stem cells (hPSCs) is a desired technique for the study of neurodevelopmental disorders, as neurons can be created and compared from control hPSC lines, hPSC lines generated from patients, and CRISPR-modified hPSC lines. Therefore, this technique allows for the examination of disease phenotypes and assists in the development of potential new therapeutics for neurodevelopmental disorders. Many protocols, however, are optimized for use with specific hPSC lines or within a single laboratory, and...
Source: Epilepsy Curr - December 27, 2023 Category: Neurology Authors: Elisa A Waxman Lea V Dungan Leah M DeFlitch Julie P Merchant Alyssa L Gagne Ethan M Goldberg Deborah L French Source Type: research
Reproducible Differentiation of Human Pluripotent Stem Cells into Two-Dimensional Cortical Neuron Cultures with Checkpoints for Success
Curr Protoc. 2023 Dec;3(12):e948. doi: 10.1002/cpz1.948.ABSTRACTThe patterning of excitatory cortical neurons from human pluripotent stem cells (hPSCs) is a desired technique for the study of neurodevelopmental disorders, as neurons can be created and compared from control hPSC lines, hPSC lines generated from patients, and CRISPR-modified hPSC lines. Therefore, this technique allows for the examination of disease phenotypes and assists in the development of potential new therapeutics for neurodevelopmental disorders. Many protocols, however, are optimized for use with specific hPSC lines or within a single laboratory, and...
Source: Epilepsy Curr - December 27, 2023 Category: Neurology Authors: Elisa A Waxman Lea V Dungan Leah M DeFlitch Julie P Merchant Alyssa L Gagne Ethan M Goldberg Deborah L French Source Type: research
Reproducible Differentiation of Human Pluripotent Stem Cells into Two-Dimensional Cortical Neuron Cultures with Checkpoints for Success
Curr Protoc. 2023 Dec;3(12):e948. doi: 10.1002/cpz1.948.ABSTRACTThe patterning of excitatory cortical neurons from human pluripotent stem cells (hPSCs) is a desired technique for the study of neurodevelopmental disorders, as neurons can be created and compared from control hPSC lines, hPSC lines generated from patients, and CRISPR-modified hPSC lines. Therefore, this technique allows for the examination of disease phenotypes and assists in the development of potential new therapeutics for neurodevelopmental disorders. Many protocols, however, are optimized for use with specific hPSC lines or within a single laboratory, and...
Source: Epilepsy Curr - December 27, 2023 Category: Neurology Authors: Elisa A Waxman Lea V Dungan Leah M DeFlitch Julie P Merchant Alyssa L Gagne Ethan M Goldberg Deborah L French Source Type: research
Reproducible Differentiation of Human Pluripotent Stem Cells into Two-Dimensional Cortical Neuron Cultures with Checkpoints for Success
Curr Protoc. 2023 Dec;3(12):e948. doi: 10.1002/cpz1.948.ABSTRACTThe patterning of excitatory cortical neurons from human pluripotent stem cells (hPSCs) is a desired technique for the study of neurodevelopmental disorders, as neurons can be created and compared from control hPSC lines, hPSC lines generated from patients, and CRISPR-modified hPSC lines. Therefore, this technique allows for the examination of disease phenotypes and assists in the development of potential new therapeutics for neurodevelopmental disorders. Many protocols, however, are optimized for use with specific hPSC lines or within a single laboratory, and...
Source: Epilepsy Curr - December 27, 2023 Category: Neurology Authors: Elisa A Waxman Lea V Dungan Leah M DeFlitch Julie P Merchant Alyssa L Gagne Ethan M Goldberg Deborah L French Source Type: research
Magnetoencephalography for Epilepsy Presurgical Evaluation
Curr Neurol Neurosci Rep. 2023 Dec 27. doi: 10.1007/s11910-023-01328-5. Online ahead of print.ABSTRACTPURPOSE OF THE REVIEW: Magnetoencephalography (MEG) is a functional neuroimaging technique that records neurophysiology data with millisecond temporal resolution and localizes it with subcentimeter accuracy. Its capability to provide high resolution in both of these domains makes it a powerful tool both in basic neuroscience as well as clinical applications. In neurology, it has proven useful in its ability to record and localize epileptiform activity. Epilepsy workup typically begins with scalp electroencephalography (EEG...
Source: Epilepsy Curr - December 26, 2023 Category: Neurology Authors: Aaron S Geller Peter Teale Eugene Kronberg John S Ebersole Source Type: research
Machine Learning and Artificial Intelligence Applications to Epilepsy: a Review for the Practicing Epileptologist
Curr Neurol Neurosci Rep. 2023 Dec;23(12):869-879. doi: 10.1007/s11910-023-01318-7. Epub 2023 Dec 7.ABSTRACTPURPOSE OF REVIEW: Machine Learning (ML) and Artificial Intelligence (AI) are data-driven techniques to translate raw data into applicable and interpretable insights that can assist in clinical decision making. Some of these tools have extremely promising initial results, earning both great excitement and creating hype. This non-technical article reviews recent developments in ML/AI in epilepsy to assist the current practicing epileptologist in understanding both the benefits and limitations of integrating ML/AI tool...
Source: Epilepsy Curr - December 7, 2023 Category: Neurology Authors: Wesley T Kerr Katherine N McFarlane Source Type: research
Machine Learning and Artificial Intelligence Applications to Epilepsy: a Review for the Practicing Epileptologist
Curr Neurol Neurosci Rep. 2023 Dec;23(12):869-879. doi: 10.1007/s11910-023-01318-7. Epub 2023 Dec 7.ABSTRACTPURPOSE OF REVIEW: Machine Learning (ML) and Artificial Intelligence (AI) are data-driven techniques to translate raw data into applicable and interpretable insights that can assist in clinical decision making. Some of these tools have extremely promising initial results, earning both great excitement and creating hype. This non-technical article reviews recent developments in ML/AI in epilepsy to assist the current practicing epileptologist in understanding both the benefits and limitations of integrating ML/AI tool...
Source: Epilepsy Curr - December 7, 2023 Category: Neurology Authors: Wesley T Kerr Katherine N McFarlane Source Type: research
Machine Learning and Artificial Intelligence Applications to Epilepsy: a Review for the Practicing Epileptologist
Curr Neurol Neurosci Rep. 2023 Dec;23(12):869-879. doi: 10.1007/s11910-023-01318-7. Epub 2023 Dec 7.ABSTRACTPURPOSE OF REVIEW: Machine Learning (ML) and Artificial Intelligence (AI) are data-driven techniques to translate raw data into applicable and interpretable insights that can assist in clinical decision making. Some of these tools have extremely promising initial results, earning both great excitement and creating hype. This non-technical article reviews recent developments in ML/AI in epilepsy to assist the current practicing epileptologist in understanding both the benefits and limitations of integrating ML/AI tool...
Source: Epilepsy Curr - December 7, 2023 Category: Neurology Authors: Wesley T Kerr Katherine N McFarlane Source Type: research
Machine Learning and Artificial Intelligence Applications to Epilepsy: a Review for the Practicing Epileptologist
Curr Neurol Neurosci Rep. 2023 Dec;23(12):869-879. doi: 10.1007/s11910-023-01318-7. Epub 2023 Dec 7.ABSTRACTPURPOSE OF REVIEW: Machine Learning (ML) and Artificial Intelligence (AI) are data-driven techniques to translate raw data into applicable and interpretable insights that can assist in clinical decision making. Some of these tools have extremely promising initial results, earning both great excitement and creating hype. This non-technical article reviews recent developments in ML/AI in epilepsy to assist the current practicing epileptologist in understanding both the benefits and limitations of integrating ML/AI tool...
Source: Epilepsy Curr - December 7, 2023 Category: Neurology Authors: Wesley T Kerr Katherine N McFarlane Source Type: research
Machine Learning and Artificial Intelligence Applications to Epilepsy: a Review for the Practicing Epileptologist
Curr Neurol Neurosci Rep. 2023 Dec;23(12):869-879. doi: 10.1007/s11910-023-01318-7. Epub 2023 Dec 7.ABSTRACTPURPOSE OF REVIEW: Machine Learning (ML) and Artificial Intelligence (AI) are data-driven techniques to translate raw data into applicable and interpretable insights that can assist in clinical decision making. Some of these tools have extremely promising initial results, earning both great excitement and creating hype. This non-technical article reviews recent developments in ML/AI in epilepsy to assist the current practicing epileptologist in understanding both the benefits and limitations of integrating ML/AI tool...
Source: Epilepsy Curr - December 7, 2023 Category: Neurology Authors: Wesley T Kerr Katherine N McFarlane Source Type: research
Machine Learning and Artificial Intelligence Applications to Epilepsy: a Review for the Practicing Epileptologist
Curr Neurol Neurosci Rep. 2023 Dec;23(12):869-879. doi: 10.1007/s11910-023-01318-7. Epub 2023 Dec 7.ABSTRACTPURPOSE OF REVIEW: Machine Learning (ML) and Artificial Intelligence (AI) are data-driven techniques to translate raw data into applicable and interpretable insights that can assist in clinical decision making. Some of these tools have extremely promising initial results, earning both great excitement and creating hype. This non-technical article reviews recent developments in ML/AI in epilepsy to assist the current practicing epileptologist in understanding both the benefits and limitations of integrating ML/AI tool...
Source: Epilepsy Curr - December 7, 2023 Category: Neurology Authors: Wesley T Kerr Katherine N McFarlane Source Type: research
Machine Learning and Artificial Intelligence Applications to Epilepsy: a Review for the Practicing Epileptologist
Curr Neurol Neurosci Rep. 2023 Dec;23(12):869-879. doi: 10.1007/s11910-023-01318-7. Epub 2023 Dec 7.ABSTRACTPURPOSE OF REVIEW: Machine Learning (ML) and Artificial Intelligence (AI) are data-driven techniques to translate raw data into applicable and interpretable insights that can assist in clinical decision making. Some of these tools have extremely promising initial results, earning both great excitement and creating hype. This non-technical article reviews recent developments in ML/AI in epilepsy to assist the current practicing epileptologist in understanding both the benefits and limitations of integrating ML/AI tool...
Source: Epilepsy Curr - December 7, 2023 Category: Neurology Authors: Wesley T Kerr Katherine N McFarlane Source Type: research
Machine Learning and Artificial Intelligence Applications to Epilepsy: a Review for the Practicing Epileptologist
Curr Neurol Neurosci Rep. 2023 Dec;23(12):869-879. doi: 10.1007/s11910-023-01318-7. Epub 2023 Dec 7.ABSTRACTPURPOSE OF REVIEW: Machine Learning (ML) and Artificial Intelligence (AI) are data-driven techniques to translate raw data into applicable and interpretable insights that can assist in clinical decision making. Some of these tools have extremely promising initial results, earning both great excitement and creating hype. This non-technical article reviews recent developments in ML/AI in epilepsy to assist the current practicing epileptologist in understanding both the benefits and limitations of integrating ML/AI tool...
Source: Epilepsy Curr - December 7, 2023 Category: Neurology Authors: Wesley T Kerr Katherine N McFarlane Source Type: research
Machine Learning and Artificial Intelligence Applications to Epilepsy: a Review for the Practicing Epileptologist
Curr Neurol Neurosci Rep. 2023 Dec;23(12):869-879. doi: 10.1007/s11910-023-01318-7. Epub 2023 Dec 7.ABSTRACTPURPOSE OF REVIEW: Machine Learning (ML) and Artificial Intelligence (AI) are data-driven techniques to translate raw data into applicable and interpretable insights that can assist in clinical decision making. Some of these tools have extremely promising initial results, earning both great excitement and creating hype. This non-technical article reviews recent developments in ML/AI in epilepsy to assist the current practicing epileptologist in understanding both the benefits and limitations of integrating ML/AI tool...
Source: Epilepsy Curr - December 7, 2023 Category: Neurology Authors: Wesley T Kerr Katherine N McFarlane Source Type: research
Machine Learning and Artificial Intelligence Applications to Epilepsy: a Review for the Practicing Epileptologist
Curr Neurol Neurosci Rep. 2023 Dec 7. doi: 10.1007/s11910-023-01318-7. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Machine Learning (ML) and Artificial Intelligence (AI) are data-driven techniques to translate raw data into applicable and interpretable insights that can assist in clinical decision making. Some of these tools have extremely promising initial results, earning both great excitement and creating hype. This non-technical article reviews recent developments in ML/AI in epilepsy to assist the current practicing epileptologist in understanding both the benefits and limitations of integrating ML/AI tools into ...
Source: Epilepsy Curr - December 7, 2023 Category: Neurology Authors: Wesley T Kerr Katherine N McFarlane Source Type: research
