Potential Micronutrient Deficiencies in the First 1000 Days of Life: The Pediatrician on the Side of the Weakest
This study is to examine potential micronutrient deficiencies and any need for supplementation in children following specific diet plans in the first 1000 days of life.RECENT FINDINGS: Optimal nutrition in the first 1000 days of life has a lifelong positive impact on child development. Specific intrauterine and perinatal factors, pathological conditions, and dietary restrictions can represent potential risk factors for micronutrient deficiencies in the first 1000 days of life, which can have negative systemic consequences. Preterm and low-birth-weight infants are intrinsically at risk because of immature body systems. Chil...
Source: Epilepsy Curr - March 21, 2024 Category: Neurology Authors: Carol à Panzeri Luca Pecoraro Alice Dianin Andrea Sboarina Olivia C Arnone Giorgio Piacentini Angelo Pietrobelli Source Type: research
Potential Micronutrient Deficiencies in the First 1000 Days of Life: The Pediatrician on the Side of the Weakest
This study is to examine potential micronutrient deficiencies and any need for supplementation in children following specific diet plans in the first 1000 days of life.RECENT FINDINGS: Optimal nutrition in the first 1000 days of life has a lifelong positive impact on child development. Specific intrauterine and perinatal factors, pathological conditions, and dietary restrictions can represent potential risk factors for micronutrient deficiencies in the first 1000 days of life, which can have negative systemic consequences. Preterm and low-birth-weight infants are intrinsically at risk because of immature body systems. Chil...
Source: Epilepsy Curr - March 21, 2024 Category: Neurology Authors: Carol à Panzeri Luca Pecoraro Alice Dianin Andrea Sboarina Olivia C Arnone Giorgio Piacentini Angelo Pietrobelli Source Type: research
Technological advances in pediatric epilepsy surgery
Curr Probl Pediatr Adolesc Health Care. 2024 Mar 16:101588. doi: 10.1016/j.cppeds.2024.101588. Online ahead of print.NO ABSTRACTPMID:38494391 | DOI:10.1016/j.cppeds.2024.101588 (Source: Epilepsy Curr)
Source: Epilepsy Curr - March 17, 2024 Category: Neurology Authors: Michael E Baumgartner Liming Qiu Lucas R Philipp Kathleen Galligan Casey Halpern Benjamin C Kennedy Source Type: research
Technological advances in pediatric epilepsy surgery
Curr Probl Pediatr Adolesc Health Care. 2024 Mar 16:101588. doi: 10.1016/j.cppeds.2024.101588. Online ahead of print.NO ABSTRACTPMID:38494391 | DOI:10.1016/j.cppeds.2024.101588 (Source: Epilepsy Curr)
Source: Epilepsy Curr - March 17, 2024 Category: Neurology Authors: Michael E Baumgartner Liming Qiu Lucas R Philipp Kathleen Galligan Casey Halpern Benjamin C Kennedy Source Type: research
Technological advances in pediatric epilepsy surgery
Curr Probl Pediatr Adolesc Health Care. 2024 Mar 16:101588. doi: 10.1016/j.cppeds.2024.101588. Online ahead of print.NO ABSTRACTPMID:38494391 | DOI:10.1016/j.cppeds.2024.101588 (Source: Epilepsy Curr)
Source: Epilepsy Curr - March 17, 2024 Category: Neurology Authors: Michael E Baumgartner Liming Qiu Lucas R Philipp Kathleen Galligan Casey Halpern Benjamin C Kennedy Source Type: research
Technological advances in pediatric epilepsy surgery
Curr Probl Pediatr Adolesc Health Care. 2024 Mar 16:101588. doi: 10.1016/j.cppeds.2024.101588. Online ahead of print.NO ABSTRACTPMID:38494391 | DOI:10.1016/j.cppeds.2024.101588 (Source: Epilepsy Curr)
Source: Epilepsy Curr - March 17, 2024 Category: Neurology Authors: Michael E Baumgartner Liming Qiu Lucas R Philipp Kathleen Galligan Casey Halpern Benjamin C Kennedy Source Type: research
A pediatrician's guide to epilepsy surgery
Curr Probl Pediatr Adolesc Health Care. 2024 Mar 13:101578. doi: 10.1016/j.cppeds.2024.101578. Online ahead of print.ABSTRACTSurgical intervention for epilepsy emerged in the second half of the 20th century as an important option for pediatric patients with medically refractory epilepsy. Both the number of patients undergoing epilepsy surgery and the available surgical procedures for epilepsy have expanded in the last 3 decades, and now range from surgical resection to neuromodulatory device placement1,2 Studies showing that many patients who would be excellent candidates for surgery are still not being offered appropriate...
Source: Epilepsy Curr - March 14, 2024 Category: Neurology Authors: Ania Dabrowski Caren Armstrong Source Type: research
A pediatrician's guide to epilepsy surgery
Curr Probl Pediatr Adolesc Health Care. 2024 Mar 13:101578. doi: 10.1016/j.cppeds.2024.101578. Online ahead of print.ABSTRACTSurgical intervention for epilepsy emerged in the second half of the 20th century as an important option for pediatric patients with medically refractory epilepsy. Both the number of patients undergoing epilepsy surgery and the available surgical procedures for epilepsy have expanded in the last 3 decades, and now range from surgical resection to neuromodulatory device placement1,2 Studies showing that many patients who would be excellent candidates for surgery are still not being offered appropriate...
Source: Epilepsy Curr - March 14, 2024 Category: Neurology Authors: Ania Dabrowski Caren Armstrong Source Type: research
A pediatrician's guide to epilepsy surgery
Curr Probl Pediatr Adolesc Health Care. 2024 Mar 13:101578. doi: 10.1016/j.cppeds.2024.101578. Online ahead of print.ABSTRACTSurgical intervention for epilepsy emerged in the second half of the 20th century as an important option for pediatric patients with medically refractory epilepsy. Both the number of patients undergoing epilepsy surgery and the available surgical procedures for epilepsy have expanded in the last 3 decades, and now range from surgical resection to neuromodulatory device placement1,2 Studies showing that many patients who would be excellent candidates for surgery are still not being offered appropriate...
Source: Epilepsy Curr - March 14, 2024 Category: Neurology Authors: Ania Dabrowski Caren Armstrong Source Type: research
Genetic testing for unexplained epilepsy: A review of diagnostic approach, benefits, and referral algorithm
Curr Probl Pediatr Adolesc Health Care. 2024 Mar 13:101579. doi: 10.1016/j.cppeds.2024.101579. Online ahead of print.ABSTRACTIn the last several decades, advances in genetic testing have transformed the diagnostic and therapeutic approach to pediatric epilepsy. However, the interpretation of these genetic tests often requires expert analysis and counseling. For this reason, as our molecular understanding of the linkages between abnormal cerebral physiology and genetics has grown, so too has the field of clinical epilepsy genetics. Here we explore recent advances in genetic testing, describe the benefits of genetic testing ...
Source: Epilepsy Curr - March 13, 2024 Category: Neurology Authors: Alexis Karlin Sarah Ruggiero Mark Fitzgerald Source Type: research
Increased Cyclic Adenosine Monophosphate Responsive Element is Closely Associated with the Pathogenesis of Drug-resistant Epilepsy
CONCLUSION: Our study shows that enhanced CREB expression promotes the development of DRE and negatively regulates GABAA receptor levels and that the inhibition of CREB expression may reduce the incidence of DRE.PMID:38468526 | DOI:10.2174/0115672026290996240307072539 (Source: Epilepsy Curr)
Source: Epilepsy Curr - March 12, 2024 Category: Neurology Authors: Jing-Xuan Li Dai Shi Si-Ying Ren Guo-Feng Wu Source Type: research
Accelerating therapeutic development and clinical trial readiness for STXBP1 and SYNGAP1 disorders
Curr Probl Pediatr Adolesc Health Care. 2024 Mar 11:101576. doi: 10.1016/j.cppeds.2024.101576. Online ahead of print.ABSTRACTGene-targeted therapies for genetic neurodevelopmental disorders (NDDs) are becoming a reality. The Center for Epilepsy and Neurodevelopmental Disorders (ENDD) is currently focused on the development of therapeutics for STXBP1 and SYNGAP1 disorders. Here we review the known clinical features of these disorders, highlight the biological role of STXBP1 and SYNGAP1, and discuss our current understanding of pathogenic mechanisms and therapeutic development. Finally, we provide our perspective as scientis...
Source: Epilepsy Curr - March 12, 2024 Category: Neurology Authors: Nicolas Marotta Michael J Boland Benjamin L Prosser Source Type: research
Increased Cyclic Adenosine Monophosphate Responsive Element is Closely Associated with the Pathogenesis of Drug-resistant Epilepsy
CONCLUSION: Our study shows that enhanced CREB expression promotes the development of DRE and negatively regulates GABAA receptor levels and that the inhibition of CREB expression may reduce the incidence of DRE.PMID:38468526 | DOI:10.2174/0115672026290996240307072539 (Source: Epilepsy Curr)
Source: Epilepsy Curr - March 12, 2024 Category: Neurology Authors: Jing-Xuan Li Dai Shi Si-Ying Ren Guo-Feng Wu Source Type: research
Accelerating therapeutic development and clinical trial readiness for STXBP1 and SYNGAP1 disorders
Curr Probl Pediatr Adolesc Health Care. 2024 Mar 11:101576. doi: 10.1016/j.cppeds.2024.101576. Online ahead of print.ABSTRACTGene-targeted therapies for genetic neurodevelopmental disorders (NDDs) are becoming a reality. The Center for Epilepsy and Neurodevelopmental Disorders (ENDD) is currently focused on the development of therapeutics for STXBP1 and SYNGAP1 disorders. Here we review the known clinical features of these disorders, highlight the biological role of STXBP1 and SYNGAP1, and discuss our current understanding of pathogenic mechanisms and therapeutic development. Finally, we provide our perspective as scientis...
Source: Epilepsy Curr - March 12, 2024 Category: Neurology Authors: Nicolas Marotta Michael J Boland Benjamin L Prosser Source Type: research
Increased Cyclic Adenosine Monophosphate Responsive Element is Closely Associated with the Pathogenesis of Drug-resistant Epilepsy
CONCLUSION: Our study shows that enhanced CREB expression promotes the development of DRE and negatively regulates GABAA receptor levels and that the inhibition of CREB expression may reduce the incidence of DRE.PMID:38468526 | DOI:10.2174/0115672026290996240307072539 (Source: Epilepsy Curr)
Source: Epilepsy Curr - March 12, 2024 Category: Neurology Authors: Jing-Xuan Li Dai Shi Si-Ying Ren Guo-Feng Wu Source Type: research
