Next Generation Sequencing and Electromyography Reveal the Involvement of the < em > P2RX6 < /em > Gene in Myopathy
Curr Issues Mol Biol. 2024 Jan 29;46(2):1150-1163. doi: 10.3390/cimb46020073.ABSTRACTIon channelopathies result from impaired ion channel protein function, due to mutations affecting ion transport across cell membranes. Over 40 diseases, including neuropathy, pain, migraine, epilepsy, and ataxia, are associated with ion channelopathies, impacting electrically excitable tissues and significantly affecting skeletal muscle. Gene mutations affecting transmembrane ionic flow are strongly linked to skeletal muscle disorders, particularly myopathies, disrupting muscle excitability and contraction. Electromyography (EMG) analysis ...
Source: Epilepsy Curr - February 23, 2024 Category: Neurology Authors: Mirella Vinci Girolamo Aurelio Vitello Donatella Greco Simone Treccarichi Alda Ragalmuto Antonino Musumeci Antonio Fallea Concetta Federico Francesco Cal ì Salvatore Saccone Maurizio Elia Source Type: research
Advanced approaches in Pediatric Epilepsy surgery
Curr Probl Pediatr Adolesc Health Care. 2024 Feb 22:101575. doi: 10.1016/j.cppeds.2024.101575. Online ahead of print.ABSTRACTWhile recent technological advancements are reshaping the landscape of surgical epilepsy management, the established techniques of resective and disconnective surgeries guided by electrographic monitoring remain the workhorse interventions for the management of refractory seizures and have the highest likelihood of achieving complete seizure resolution. Here we discuss examples of recent developments in surgical approaches and techniques for resective and disconnective surgeries with discussion of th...
Source: Epilepsy Curr - February 23, 2024 Category: Neurology Authors: Michael E Baumgartner Kathleen Galligan Benjamin C Kennedy Source Type: research
Next Generation Sequencing and Electromyography Reveal the Involvement of the < em > P2RX6 < /em > Gene in Myopathy
Curr Issues Mol Biol. 2024 Jan 29;46(2):1150-1163. doi: 10.3390/cimb46020073.ABSTRACTIon channelopathies result from impaired ion channel protein function, due to mutations affecting ion transport across cell membranes. Over 40 diseases, including neuropathy, pain, migraine, epilepsy, and ataxia, are associated with ion channelopathies, impacting electrically excitable tissues and significantly affecting skeletal muscle. Gene mutations affecting transmembrane ionic flow are strongly linked to skeletal muscle disorders, particularly myopathies, disrupting muscle excitability and contraction. Electromyography (EMG) analysis ...
Source: Epilepsy Curr - February 23, 2024 Category: Neurology Authors: Mirella Vinci Girolamo Aurelio Vitello Donatella Greco Simone Treccarichi Alda Ragalmuto Antonino Musumeci Antonio Fallea Concetta Federico Francesco Cal ì Salvatore Saccone Maurizio Elia Source Type: research
Anti-seizure Effects and Mechanisms of Berberine: A Systematic Review
CONCLUSION: BBR indicated promising anti-seizure effects with remarkable antioxidant, antiinflammatory, anti-apoptotic, and neuroprotective activity. Future studies should be based on well-designed clinical trial studies that are integrated with new methods related to increasing bioavailability.PMID:38385486 | DOI:10.2174/0113892010283237240107121749 (Source: Epilepsy Curr)
Source: Epilepsy Curr - February 22, 2024 Category: Neurology Authors: Nahid Jivad Saeid Heidari-Soureshjani Hesamaldin Bagheri Catherine Mt Sherwin Sahar Rostamian Source Type: research
Anti-seizure Effects and Mechanisms of Berberine: A Systematic Review
CONCLUSION: BBR indicated promising anti-seizure effects with remarkable antioxidant, antiinflammatory, anti-apoptotic, and neuroprotective activity. Future studies should be based on well-designed clinical trial studies that are integrated with new methods related to increasing bioavailability.PMID:38385486 | DOI:10.2174/0113892010283237240107121749 (Source: Epilepsy Curr)
Source: Epilepsy Curr - February 22, 2024 Category: Neurology Authors: Nahid Jivad Saeid Heidari-Soureshjani Hesamaldin Bagheri Catherine Mt Sherwin Sahar Rostamian Source Type: research
Antiepileptic Strategies for Patients with Primary and Metastatic Brain Tumors
Curr Treat Options Oncol. 2024 Feb 14. doi: 10.1007/s11864-024-01182-8. Online ahead of print.ABSTRACTSeizure activity is common in patients with primary and metastatic brain tumors, affecting more than 50% of cases over the course of their disease. Several mechanisms contribute to brain tumor-related epilepsy (BTRE), including a pro-inflammatory environment, excessive secretion of glutamate and an increase in neuronal excitatory tone, reduction of GABAergic inhibitory activity, and an increase in 2-hydroxygluturate production in isocitrate dehydrogenase mutant tumors. After a verified seizure in a brain tumor patient, the...
Source: Epilepsy Curr - February 14, 2024 Category: Neurology Authors: Herbert B Newton Jenna Wojkowski Source Type: research
Antiepileptic Strategies for Patients with Primary and Metastatic Brain Tumors
Curr Treat Options Oncol. 2024 Feb 14. doi: 10.1007/s11864-024-01182-8. Online ahead of print.ABSTRACTSeizure activity is common in patients with primary and metastatic brain tumors, affecting more than 50% of cases over the course of their disease. Several mechanisms contribute to brain tumor-related epilepsy (BTRE), including a pro-inflammatory environment, excessive secretion of glutamate and an increase in neuronal excitatory tone, reduction of GABAergic inhibitory activity, and an increase in 2-hydroxygluturate production in isocitrate dehydrogenase mutant tumors. After a verified seizure in a brain tumor patient, the...
Source: Epilepsy Curr - February 14, 2024 Category: Neurology Authors: Herbert B Newton Jenna Wojkowski Source Type: research
Antiepileptic Strategies for Patients with Primary and Metastatic Brain Tumors
Curr Treat Options Oncol. 2024 Feb 14. doi: 10.1007/s11864-024-01182-8. Online ahead of print.ABSTRACTSeizure activity is common in patients with primary and metastatic brain tumors, affecting more than 50% of cases over the course of their disease. Several mechanisms contribute to brain tumor-related epilepsy (BTRE), including a pro-inflammatory environment, excessive secretion of glutamate and an increase in neuronal excitatory tone, reduction of GABAergic inhibitory activity, and an increase in 2-hydroxygluturate production in isocitrate dehydrogenase mutant tumors. After a verified seizure in a brain tumor patient, the...
Source: Epilepsy Curr - February 14, 2024 Category: Neurology Authors: Herbert B Newton Jenna Wojkowski Source Type: research
Antiepileptic Strategies for Patients with Primary and Metastatic Brain Tumors
Curr Treat Options Oncol. 2024 Feb 14. doi: 10.1007/s11864-024-01182-8. Online ahead of print.ABSTRACTSeizure activity is common in patients with primary and metastatic brain tumors, affecting more than 50% of cases over the course of their disease. Several mechanisms contribute to brain tumor-related epilepsy (BTRE), including a pro-inflammatory environment, excessive secretion of glutamate and an increase in neuronal excitatory tone, reduction of GABAergic inhibitory activity, and an increase in 2-hydroxygluturate production in isocitrate dehydrogenase mutant tumors. After a verified seizure in a brain tumor patient, the...
Source: Epilepsy Curr - February 14, 2024 Category: Neurology Authors: Herbert B Newton Jenna Wojkowski Source Type: research
Antiepileptic Strategies for Patients with Primary and Metastatic Brain Tumors
Curr Treat Options Oncol. 2024 Feb 14. doi: 10.1007/s11864-024-01182-8. Online ahead of print.ABSTRACTSeizure activity is common in patients with primary and metastatic brain tumors, affecting more than 50% of cases over the course of their disease. Several mechanisms contribute to brain tumor-related epilepsy (BTRE), including a pro-inflammatory environment, excessive secretion of glutamate and an increase in neuronal excitatory tone, reduction of GABAergic inhibitory activity, and an increase in 2-hydroxygluturate production in isocitrate dehydrogenase mutant tumors. After a verified seizure in a brain tumor patient, the...
Source: Epilepsy Curr - February 14, 2024 Category: Neurology Authors: Herbert B Newton Jenna Wojkowski Source Type: research
Antiepileptic Strategies for Patients with Primary and Metastatic Brain Tumors
Curr Treat Options Oncol. 2024 Feb 14. doi: 10.1007/s11864-024-01182-8. Online ahead of print.ABSTRACTSeizure activity is common in patients with primary and metastatic brain tumors, affecting more than 50% of cases over the course of their disease. Several mechanisms contribute to brain tumor-related epilepsy (BTRE), including a pro-inflammatory environment, excessive secretion of glutamate and an increase in neuronal excitatory tone, reduction of GABAergic inhibitory activity, and an increase in 2-hydroxygluturate production in isocitrate dehydrogenase mutant tumors. After a verified seizure in a brain tumor patient, the...
Source: Epilepsy Curr - February 14, 2024 Category: Neurology Authors: Herbert B Newton Jenna Wojkowski Source Type: research
Prevention of epileptogenesis - are we there yet?
Curr Opin Neurol. 2024 Feb 13. doi: 10.1097/WCO.0000000000001256. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: To review recent progress in preventing epileptogenesis in patients with epilepsy.RECENT FINDINGS: The recent success of epilepsy prevention and disease modification in tuberous sclerosis using simple EEG biomarkers to guide treatment initiation, and the identification of biomarkers to enrich the targeted patient population has made clinical trials of epilepsy prevention after acquired central nervous system (CNS) insults such as traumatic brain injury, stroke or infection both feasible and timely. Two such tr...
Source: Epilepsy Curr - February 12, 2024 Category: Neurology Authors: Matthias Koepp Eugen Trinka Wolfgang L öscher Pavel Klein Source Type: research
Local and Remote Chemogenetic Suppression of Hippocampal Seizures in Rats
CONCLUSION: This study shows the potency of chemogenetics to attenuate hippocampal seizures locally or remotely by activating the transfected hM4Di receptor with CNO or clozapine. ANT is suggested as a potentially safe chemogenetic application target in the epileptic network for focal hippocampal seizures.PMID:38333970 | DOI:10.2174/1570159X22999240131122455 (Source: Epilepsy Curr)
Source: Epilepsy Curr - February 9, 2024 Category: Neurology Authors: Donghong Li Xi Yan Yue Xing Jiaqing Yan Junling Wang Herui Zhang Jiaoyang Wang Xiaonan Li Zhumin Su Horace Hao Loh Xiaofeng Yang Xiaohong Chen Source Type: research
Evidence based noninvasive presurgical evaluation for patients with drug resistant epilepsies
Curr Opin Neurol. 2024 Feb 15. doi: 10.1097/WCO.0000000000001253. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: To review the current practices and evidence for the diagnostic accuracy and the benefits of presurgical evaluation.RECENT FINDINGS: Preoperative evaluation of patients with drug-resistant focal epilepsies and subsequent epilepsy surgery leads to a significant proportion of seizure-free patients. Even those who are not completely seizure free postoperatively often experience improved quality of life with better social integration. Systematic reviews and meta-analysis on the diagnostic accuracy are available fo...
Source: Epilepsy Curr - February 9, 2024 Category: Neurology Authors: Eugen Trinka Matthias Koepp Gudrun Kalss Teia Kobulashvili Source Type: research
One Ring to Bind Them: The Annulus of GABAergic Inhibitory Restraint Fades at Seizure Emergence
Epilepsy Curr. 2024 Jan 10;24(1):53-55. doi: 10.1177/15357597231223586. eCollection 2024 Jan-Feb.ABSTRACTPMID:38327527 | PMC:PMC10846514 | DOI:10.1177/15357597231223586 (Source: Epilepsy Curr)
Source: Epilepsy Curr - February 8, 2024 Category: Neurology Authors: Matthew A Stern Raymond Dingledine Source Type: research
