Pharmacotherapies in Older Adults with COPD: Challenges and Opportunities
AbstractOlder adults have a higher prevalence of chronic obstructive pulmonary disease (COPD), which will likely increase substantially in the coming decades owing to aging populations and increased long-term exposure to risk factors for this disease. COPD in older adults is characterized by low-grade chronic systemic inflammation, known as inflamm-aging. It contributes substantially to age-associated pulmonary changes that are clinically expressed by reduced lung function, poor health status, and limitations in activities of daily living. In addition, inflamm-aging has been associated with the onset of many comorbidities ...
Source: Drugs and Aging - June 14, 2023 Category: Geriatrics Source Type: research
Polypharmacy and Aging in People Living with HIV: 6 Years of Experience in a Multidisciplinary Outpatient Clinic
ConclusionsThe high prevalence of polypharmacy in PLWH, especially among older adults, place these patients at high risk for clinically relevant drug –drug interactions (DDIs). A multidisciplinary approach involving physicians and clinical pharmacologists could help to optimize medication regimens associated with reduced risk. (Source: Drugs and Aging)
Source: Drugs and Aging - June 13, 2023 Category: Geriatrics Source Type: research
The Role of Multidimensional Prognostic Index to Identify Hospitalized Older Adults with COVID-19 Who Can Benefit from Remdesivir Treatment: An Observational, Prospective, Multicenter Study
ConclusionsMPI could help to identify less frail older adults hospitalized for COVID-19 who could benefit more from remdesivir treatment in terms of long-term survival. (Source: Drugs and Aging)
Source: Drugs and Aging - June 13, 2023 Category: Geriatrics Source Type: research
Benzodiazepine Receptor Agonists Use and Cessation Among Multimorbid Older Adults with Polypharmacy: Secondary Analysis from the OPERAM Trial
ConclusionBZRA prevalence was high among included multimorbid older adults, and BZRA cessation occurred in almost a quarter of them within 6 months after hospitalization. Targeted BZRA deprescribing programs could further enhance cessation. Specific attention is needed for females, central nervous system-acting co-medication, and COPD co-morbidity.RegistrationClinicalTrials.gov identifier: NCT02986425. December 8, 2016. (Source: Drugs and Aging)
Source: Drugs and Aging - May 23, 2023 Category: Geriatrics Source Type: research
Time-Varying Use of Proton Pump Inhibitors and Cognitive Impairment and Dementia: A Real-World Analysis from Germany
ConclusionOur large study supports existing evidence that PPI use is related to an increased risk of dementia. (Source: Drugs and Aging)
Source: Drugs and Aging - May 13, 2023 Category: Geriatrics Source Type: research
Intranasal Dexmedetomidine for Pain Management in Older Patients: A Cross-Over, Randomized, Double-Blinded, Active-Controlled Trial
ConclusionsIntranasal dexmedetomidine is feasible in elderly patients and may be an alternative to opioids to ensure comfort during nursing care. Future studies are needed to confirm the efficacy and safety of this procedure. (Source: Drugs and Aging)
Source: Drugs and Aging - May 11, 2023 Category: Geriatrics Source Type: research
Impact of a Comprehensive Intervention Bundle Including the Drug Burden Index on Deprescribing Anticholinergic and Sedative Drugs in Older Acute Inpatients: A Non-randomised Controlled Before-and-After Pilot Study
ConclusionIntegrating a comprehensive intervention bundle and accompanying stewardship program is a promising strategy to facilitate deprescribing of sedative and anticholinergic medications in older inpatients. (Source: Drugs and Aging)
Source: Drugs and Aging - May 9, 2023 Category: Geriatrics Source Type: research
Dosage Optimization of Digoxin in Older Patients with Heart Failure and Chronic Kidney Disease: A Population Pharmacokinetic Analysis
ConclusionsA population pharmacokinetic model of digoxin in older patients with heart failure and CKD was established in this study. A novel digoxin dosage strategy was recommended in this vulnerable population. (Source: Drugs and Aging)
Source: Drugs and Aging - May 8, 2023 Category: Geriatrics Source Type: research
Classifying Polypharmacy According to Pharmacotherapeutic and Clinical Risks in Older Adults: A Latent Class Analysis in Quebec, Canada
ConclusionsWe distinguished three types of polypharmacy with varying pharmacotherapeutic and clinical appropriateness. Our results highlight the value of looking beyond the number of medications to assess polypharmacy. (Source: Drugs and Aging)
Source: Drugs and Aging - May 6, 2023 Category: Geriatrics Source Type: research
Identifying Residents Who May Benefit from an Analgesic Review: Applying Analgesic Indicators in Residential Aged Care Services
ConclusionsUp to one in three residents may benefit from a review of their analgesic regimen, including 1 in 13 who may benefit from a specific review of their opioid regimen. Analgesic indicators represent a new approach to target analgesic stewardship interventions. (Source: Drugs and Aging)
Source: Drugs and Aging - May 6, 2023 Category: Geriatrics Source Type: research
The Information-Seeking Behavior and Unmet Knowledge Needs of Older Medicinal Cannabis Consumers in Canada: A Qualitative Descriptive Study
This study explored the perspectives of older cannabis consumers, prospective consumers, healthcare professionals, and cannabis retailers on older adults ’ information-seeking behavior and unmet knowledge needs.MethodsA qualitative descriptive design was used. Semi-structured telephone interviews were conducted with a purposeful sample of 36 older cannabis consumers and prospective consumers, as well as 4 healthcare professionals and 5 cannabis retailers from across Canada, for a total sample of 45 participants. Data were thematically analyzed.ResultsThree main themes characterizing older cannabis consumers ’ informati...
Source: Drugs and Aging - May 5, 2023 Category: Geriatrics Source Type: research
Prospective Observational Study Evaluating the Prognostic Value of the G8 Screening Tool for Extensive-Stage Small Cell Lung Cancer Patients Who Received Programmed Death-Ligand 1 Inhibitor plus Platinum –Etoposide Chemotherapy
ConclusionsG8 score evaluation before treatment initiation was useful as a prognostic factor for ES-SCLC patients who received PD-L1 inhibitors and platinum –etoposide chemotherapy, even with good PS. (Source: Drugs and Aging)
Source: Drugs and Aging - May 5, 2023 Category: Geriatrics Source Type: research
The EURO-FORTA (Fit fOR The Aged) List Version 2: Consensus Validation of a Clinical Tool for Improved Pharmacotherapy in Older Adults
ConclusionIn this study, seven new country/region specific FORTA lists, as well as a new overarching EURO-FORTA List, were developed. An overall increase in the mean consensus coefficient and increases for all disease-specific mean consensus coefficients show a wider consensus among participants. The new lists have the potential to improve drug therapy in older people internationally. (Source: Drugs and Aging)
Source: Drugs and Aging - May 2, 2023 Category: Geriatrics Source Type: research
Association between the Use of Suvorexant and Hip Fracture in Older Adults in Japan Using a Nationwide Administrative Claims Database: A Matched Case –Control Study
ConclusionsUsing RWD in Japanese older adults, we showed that sleep therapy with suvorexant was not associated with an increased risk of hip fracture. The results provide evidence-based drug safety information for the selection of hypnotics for sleep disorders, which increase with age. (Source: Drugs and Aging)
Source: Drugs and Aging - April 30, 2023 Category: Geriatrics Source Type: research
Impact of Age on Poly(ADP-Ribose) Polymerase Inhibitor (PARPi)-Induced Lymphopenia: A Scoping Review of the Literature and Internal Analysis of a Retrospective Database
ConclusionLymphopenia events were much more frequent in real-life than in previously reported studies, particularly in older patients. Future work is needed to improve patient follow-up and discuss prophylactic strategies. (Source: Drugs and Aging)
Source: Drugs and Aging - April 20, 2023 Category: Geriatrics Source Type: research
