Correction to: Prevalence and factors associated with inappropriate dosing of apixaban and rivaroxaban in hospitalized older adults with atrial fibrillation: a cross ‑sectional study
(Source: Drugs and Aging)
Source: Drugs and Aging - December 21, 2023 Category: Geriatrics Source Type: research
Individualized Dosing Patterns in the Treatment of Older Patients with Gastrointestinal Stromal Tumors: Results of a Registry-Based Observational National Cohort Study Including 871 Patients
ConclusionOlder patients showed higher imatinib trough plasma concentrations compared with younger patients and also had earlier and more often adverse events as the reason for first adjustment of treatment with imatinib followed by dose reduction. However, in a landmark analysis, patients with imatinib dose reductions had no poorer outcomes compared with patients not requiring a dose reduction. (Source: Drugs and Aging)
Source: Drugs and Aging - December 20, 2023 Category: Geriatrics Source Type: research
Do Proton Pump Inhibitors Reduce Upper Gastrointestinal Bleeding in Older Patients with Atrial Fibrillation Treated with Oral Anticoagulants? A Nationwide Cohort Study in France
ConclusionsThis study suggests that PPIs were associated with reduced risk of gastrointestinal bleeding after initiation of oral anticoagulation in older patients with atrial fibrillation, particularly within 6 months after initiation of an antivitamin K antagonist. (Source: Drugs and Aging)
Source: Drugs and Aging - December 20, 2023 Category: Geriatrics Source Type: research
Potentially Inappropriate Psychotropic Drugs in Nursing Homes: An Italian Observational Study
ConclusionsDifferent criteria for appropriate drug prescription identify very different percentages of patients in NHs exposed to psychotropics considered potentially inappropriate. The Beers and STOPP/START criteria identified a larger percentage of patients exposed in NHs than FORTA. (Source: Drugs and Aging)
Source: Drugs and Aging - November 30, 2023 Category: Geriatrics Source Type: research
A Trial-Based Cost-Utility Analysis of a Medication Optimization Intervention Versus Standard Care in Older Adults
ConclusionsAccording to societal willingness-to-pay thresholds, the medication optimization intervention was not cost effective compared to standard care for the full population. The intervention dominated standard care for the non-long stayers, with a high probability of cost effectiveness.Clinical Trial RegistrationThe IMMENSE trial was registered in ClinicalTrials.gov on 28 June, 2016 before enrolment started (NCT02816086). (Source: Drugs and Aging)
Source: Drugs and Aging - November 22, 2023 Category: Geriatrics Source Type: research
Cutaneous Lupus Erythematosus: Review and Considerations for Older Populations
AbstractThough more common earlier in life, increasing attention is being focused on the development of cutaneous lupus erythematosus (CLE) in patients with advancing age. Studies show that CLE is more common in older populations than previously thought, and all CLE subtypes are possible in this group. Just like patients in the third or fourth decade of life, CLE may appear alongside or independent of systemic lupus erythematosus. Older populations manifesting CLE for the first time seem to have a lower risk of progression to systemic disease than younger peers, and are more commonly White. CLE must be carefully distinguis...
Source: Drugs and Aging - November 22, 2023 Category: Geriatrics Source Type: research
Evaluating the Safety of an Educational Deprescribing Intervention: Lessons from the Optimize Trial
ConclusionsPopulation-based deprescribing education is safe in the older adult population with cognitive impairment in our study. Pragmatic methods for safety monitoring are needed to further inform deprescribing interventions.Trial RegistrationNCT03984396. Registered on 13 June 2019 (Source: Drugs and Aging)
Source: Drugs and Aging - November 20, 2023 Category: Geriatrics Source Type: research
Potentially inappropriate prescribing in multimorbid and polymedicated older adults with AF: A Systematic Review and Meta-Analysis
ConclusionThis systematic review highlights the scarce evidence regarding the prevalence of PIP and its association with adverse health outcomes in multimorbid older adults with AF. Large, prospective and better-designed studies are needed. (Source: Drugs and Aging)
Source: Drugs and Aging - November 17, 2023 Category: Geriatrics Source Type: research
Prevalence and factors associated with inappropriate dosing of apixaban and rivaroxaban in hospitalized older adults with atrial fibrillation: a cross-sectional study
ConclusionThis study highlighted the high prevalence of inappropriate apixaban or rivaroxaban doses in older adults, particularly underdosing, which increases the risk of thromboembolism. (Source: Drugs and Aging)
Source: Drugs and Aging - November 13, 2023 Category: Geriatrics Source Type: research
Acknowledgement to Referees
(Source: Drugs and Aging)
Source: Drugs and Aging - November 13, 2023 Category: Geriatrics Source Type: research
Factors Associated with Psychotropic Medication Use in People Living with Dementia in the Community: A Systematic Review and Meta-Analysis
ConclusionsWhile it is clear from this review that there remains a significant lack of clarity as to the reasons why these medications are being utilized in this population, this review provides greater insight and understanding into the context of psychotropic use. The study has highlighted an opportunity for further targeted research to be conducted and provides a much-needed context for this to occur.PROSPERO Registration NumberCRD42021286322. (Source: Drugs and Aging)
Source: Drugs and Aging - November 9, 2023 Category: Geriatrics Source Type: research
Polypharmacy and Antibody Response to SARS-CoV-2 Vaccination in Residents of Long-Term Care Facilities: The GeroCovid Vax Study
ConclusionsThe humoral immune response to SARS-CoV-2 vaccination of older residents showed only slight changes as a function of the number of medications taken. Although it seemed less durable among older residents with hyperpolypharmacy, the booster dose administration equalized such a difference. (Source: Drugs and Aging)
Source: Drugs and Aging - November 8, 2023 Category: Geriatrics Source Type: research
Current Pharmacological Therapies for the Management of Spondyloarthritis: Special Considerations in Older Patients
AbstractSpondylarthritis (SpA) is generally observed in young male patients but can be diagnosed in older patients. These cases correspond to late-onset SpA (LoSpA) with two main clinical presentations, axial and peripheral SpA. Another increasingly common situation is that of older patients who have had SpA for many years. The therapeutic management of LoSpA is quite smilar to the management of patients with an early-onset disease, combining both non-pharmacological and pharmacological treatments. The treatments that can be used in LoSpA include non-steroidal anti-inflammatory drugs (NSAIDs) and biological agents targetin...
Source: Drugs and Aging - October 30, 2023 Category: Geriatrics Source Type: research
NSAIDs for Pain Control During the Peri-Operative Period of Hip Fracture Surgery: A Systematic Review
ConclusionsThe use of NSAIDs may be effective for pain control in the peri-operative period of HF surgery. However, safety data were conflicting with low levels of certainty. Further studies are needed to assess their benefit –risk balance in this context. The research protocol was previously registered on PROSPERO (registration number: CRD42021237649) (Source: Drugs and Aging)
Source: Drugs and Aging - October 25, 2023 Category: Geriatrics Source Type: research
Prevalence of and Risk Factors for Drug-Related Readmissions in Older Adults: A Systematic Review and Meta-Analysis
ConclusionsAlmost one in ten older adults discharged from hospital experienced a drug-related hospital readmission, with one fifth of these deemed preventable. Several comorbidities and the use of polypharmacy and high-risk drugs were identified as prominent risk factors for readmission. Further research is needed to explore possible causes of drug-related readmissions in older adults for a more guided approach to the development of effective medication management interventions. (Source: Drugs and Aging)
Source: Drugs and Aging - October 21, 2023 Category: Geriatrics Source Type: research
