Correction to: Risk factors predictive of adverse drug events and drug-related falls in aged care residents: secondary analysis from the ReMInDAR trial
(Source: Drugs and Aging)
Source: Drugs and Aging - December 20, 2022 Category: Geriatrics Source Type: research
Implications of Adverse Outcomes Associated with Antipsychotics in Older Patients with Dementia: A 2011 –2022 Update
AbstractNeuropsychiatric symptoms affect most patients with dementia over the course of the disease. They include a wide variety of symptoms from apathy and depression to psychosis, irritability, impulsivity and agitation. These symptoms are associated with significant distress to the patient and caregivers, as well as more rapid progression of dementia, institutionalisation and higher mortality. The first-line management of the neuropsychiatric symptoms of dementia should be non-pharmacological. If medications are required, antipsychotics are commonly chosen. Second-generation antipsychotics such as risperidone, olanzapin...
Source: Drugs and Aging - December 14, 2022 Category: Geriatrics Source Type: research
Importance of NAD+ Anabolism in Metabolic, Cardiovascular and Neurodegenerative Disorders
AbstractThe role of nicotinamide adenine dinucleotide (NAD+) in ageing has emerged as a critical factor in understanding links to a wide range of chronic diseases. Depletion of NAD+, a central redox cofactor and substrate of numerous metabolic enzymes, has been detected in many major age-related diseases. However, the mechanisms behind age-associated NAD+ decline remains poorly understood. Despite limited conclusive evidence, supplements aimed at increasing NAD+ levels are becoming increasingly popular. This review provides renewed insights regarding the clinical utility and benefits of NAD+ precursors, namely nicotinamide...
Source: Drugs and Aging - December 13, 2022 Category: Geriatrics Source Type: research
Hallucinations, Antipsychotic Use, and Mortality in Older Adults with Dementia: Retrospective Cohort Study of Two Medicare-Linked National Health Surveys
ConclusionHallucinations are associated with an increased risk of death that is greater than the risk associated with antipsychotic use, though this is partially confounded by dementia severity and comorbidities. (Source: Drugs and Aging)
Source: Drugs and Aging - December 2, 2022 Category: Geriatrics Source Type: research
Considerations for Choosing First-Line Urate-Lowering Treatment in Older Patients with Comorbid Conditions
AbstractGout is the most common inflammatory arthritis in adults. The prevalence of gout increases with age. Urate-lowering treatment (ULT) among older patients is often challenging in that patients frequently suffer insufficient effectiveness or adverse events due to comorbidities, concurrent medications, and altered pharmacokinetics. The large-scale randomized controlled trials (RCTs) directly investigating gout patients regarding cardiovascular (CV) safety have only recently been introduced; CARES and FAST compared the CV safety of the two xanthine oxidase inhibitors (XOis), febuxost at versus allopurinol, in patients...
Source: Drugs and Aging - November 28, 2022 Category: Geriatrics Source Type: research
Risk factors predictive of adverse drug events and drug-related falls in aged care residents: secondary analysis from the ReMInDAR trial
ConclusionOur results suggest residents with a previous fall, reduced cognition, and prescription of sedative or hypnotic medicines were at higher risk of adverse drug events and should be considered for proactive prevention. (Source: Drugs and Aging)
Source: Drugs and Aging - November 23, 2022 Category: Geriatrics Source Type: research
Deprescribing Medications that Increase the Risk of Falls in Older People: Exploring Doctors' Perspectives Using the Theoretical Domains Framework (TDF)
ConclusionDeprescribing FRIDs in older adults in the hospital setting is challenging. Implementation of the process in practice requires combined effort from stakeholders to tackle everyday work environment challenges. Future studies are required examining the clinical effect of the suggested interventions and exploring patients' involvement in deprescribing decisions. (Source: Drugs and Aging)
Source: Drugs and Aging - November 21, 2022 Category: Geriatrics Source Type: research
Estimating the Time to Benefit for Therapies in Heart Failure with Reduced Ejection Fraction: A Case Study of Sacubitril-Valsartan Using Reconstructed Data from a Randomized Controlled Trial
ConclusionUsing multiple approaches, the earliest benefit of sacubitril-valsartan compared to enalapril in stable HFrEF was found at about 1 month after initiation. (Source: Drugs and Aging)
Source: Drugs and Aging - November 21, 2022 Category: Geriatrics Source Type: research
Treating Hypertension in Older Adults in Light of the Recent STEP Trial: Can We Implement the Findings in Geriatric Practice?
AbstractRecently, major trials have explored blood pressure targets that would provide greater benefit and fewer adverse events in older adult population on antihypertensive treatment. The last study was the STEP study conducted in China, which included 8511 older people aged 60 –80 years. When systolic blood pressure below 130 mmHg was targeted in older individuals, there was a 26% risk reduction in cardiovascular outcomes compared with higher (< 150 mmHg) blood pressure values. At this point, it is necessary to evaluate how much the study group represents the older population because this population group is very...
Source: Drugs and Aging - November 19, 2022 Category: Geriatrics Source Type: research
Acknowledgement to Referees
(Source: Drugs and Aging)
Source: Drugs and Aging - November 15, 2022 Category: Geriatrics Source Type: research
Association of Psychotropic Education with Quality of Life: A Before-After Study in Residential Aged Care Facilities
ConclusionThe MMC was associated with improvement in QoL, NPS, staff distress, and reduction in monthly use of antipsychotics and antidepressants among RACF residents. There was no correlation between improved QoL and reduction in use of psychotropic medications, but due to the limitations of our study, this should be confirmed in additional studies. (Source: Drugs and Aging)
Source: Drugs and Aging - November 11, 2022 Category: Geriatrics Source Type: research
A Systematic Review of the Current Evidence from Randomised Controlled Trials on the Impact of Medication Optimisation or Pharmacological Interventions on Quantitative Measures of Cognitive Function in Geriatric Patients
ConclusionThis systematic review identified a small number of heterogenous RCTs investigating the impact of medication optimisation or pharmacological interventions on cognitive function. Five trials showed a positive impact on at least one aspect of cognitive function, with comprehensive medication optimisation not being more successful than focused drug interventions. More prospective trials are needed to specifically assess ways of limiting the negative impact of certain medication in particular and polypharmacy in general on cognitive function in older patients. (Source: Drugs and Aging)
Source: Drugs and Aging - October 26, 2022 Category: Geriatrics Source Type: research
Antihypertensive Use and the Risk of Alzheimer ’s Disease and Related Dementias among Older Adults in the USA
ConclusionsFindings of the study suggest the need for evidence-based drug therapy to manage hypertension in later adulthood and warrant further investigation into the mechanism underlying the protective effect of antihypertensives, particularly ACEIs, against the development of AD among older adults with hypertension. (Source: Drugs and Aging)
Source: Drugs and Aging - October 17, 2022 Category: Geriatrics Source Type: research
Medication Complexity Among Older Adults with HF: How Can We Assess Better?
AbstractMedical management of heart failure (HF) has evolved and has achieved significant survival benefits, resulting in highly complex medication regimens. Complex medication regimens create challenges for older adults, including nonadherence and increased adverse drug events, especially associated with cognitive impairment, physical limitations, or lack of social support. However, the association between medication complexity and patients ’ health outcomes among older adults with HF is unclear. The purpose of this review is to address how the complexity of HF medications has been assessed in the literature and what cl...
Source: Drugs and Aging - October 13, 2022 Category: Geriatrics Source Type: research
Interprofessional Interventions Involving Pharmacists and Targeting the Medicines Management Process Provided to Older People Residing in Nursing Homes: A Systematic Review and Meta-Analysis of Randomised Controlled Trials
ConclusionsThis systematic review provides a detailed description of the impact of interprofessional practice, involving pharmacists, which targets at least one stage of the medicine management process in the nursing home setting. The findings suggest that future research should prioritise improving prescribing inappropriateness rather than the number of long-term medications prescribed. It remains unknown if interventions are designed using theory and, therefore, it is not clear whether theory-derived interventions are more effective than those without a theoretical element.Clinical Trial RegistrationThe protocol was publ...
Source: Drugs and Aging - October 4, 2022 Category: Geriatrics Source Type: research
