Treating LUTS in Men with Benign Prostatic Obstruction: A Review Article
AbstractBenign prostatic obstruction (BPO) is a prevalent condition that affects men, primarily toward their old age. The condition is often accompanied by lower urinary tract symptoms (LUTS), which can significantly impair a patient ’s quality of life and lead to other medical complications. Accurate diagnosis of BPO is essential for effective management of complications secondary to BPO, and treatment plans should be tailored patients, and occasionally according to surgeon experience. As such, this literature review aims to analyze the current available data on male LUTS secondary to BPO by providing a comprehensive ov...
Source: Drugs and Aging - August 9, 2023 Category: Geriatrics Source Type: research
Trajectories of Benzodiazepine Use among Older Adults from a Concordance-with-Guidelines Perspective: A Nationwide Cohort Study
ConclusionsConcordance with guidelines varied over time during benzodiazepine use in older adults. A third of these adults will hypothetically follow one of the identified non-guideline-concordant trajectories, consisting of initial and/or late non-guideline concordance. This was associated with modifiable and nonmodifiable factors that clinicians should be aware of for tailoring the monitoring of patients. (Source: Drugs and Aging)
Source: Drugs and Aging - August 8, 2023 Category: Geriatrics Source Type: research
Repurposing Drugs for Diabetes Mellitus as Potential Pharmacological Treatments for Sarcopenia – A Narrative Review
AbstractSarcopenia, the age-related loss of muscle strength and mass or quality, is a common condition with major adverse consequences. Although the pathophysiology is incompletely understood, there are common mechanisms between sarcopenia and the phenomenon of accelerated ageing seen in diabetes mellitus. Drugs currently used to treat type 2 diabetes mellitus may have mechanisms of action that are relevant to the prevention and treatment of sarcopenia, for those with type 2 diabetes and those without diabetes. This review summarises shared pathophysiology between sarcopenia and diabetes mellitus, including the effects of ...
Source: Drugs and Aging - July 24, 2023 Category: Geriatrics Source Type: research
The Prognostic Utility of Anticholinergic Burden Scales: An Integrative Review and Gap Analysis
ConclusionsFuture research recommendations to bridge knowledge gaps include developing a risk assessment framework, refining ABS scales, establishing a standardized consensus scale, and creating a longitudinal measure of cumulative anticholinergic risk. Strategies to minimize bias, consider frailty, and promote multidisciplinary and multinational collaborations are also necessary to improve patient outcomes. (Source: Drugs and Aging)
Source: Drugs and Aging - July 18, 2023 Category: Geriatrics Source Type: research
Guideline-Directed Medical Therapies for Heart Failure with a Reduced Ejection Fraction in Older Adults: A Narrative Review on Efficacy, Safety and Timeliness
In conclusion, older adults suffering from heart failure with a reduced ejection fraction should not be denied treatment based on their age. (Source: Drugs and Aging)
Source: Drugs and Aging - July 14, 2023 Category: Geriatrics Source Type: research
Management of Type 2 Diabetes in Frail Older Adults
AbstractAging is one of the most important factors associated with the dramatic increase in the prevalence of type 2 diabetes mellitus (T2DM) globally. In addition to traditional micro- and macrovascular complications, diabetes mellitus (DM) in older adults is of great importance due to its independent relationship with frailty, which is defined as a decline in functional reserves and vulnerability to stressors. Frailty assessment enables the determination of biological age, thus predicting potential complications in older adults and identifying tailored treatment strategies. Although the latest guidelines have acknowledge...
Source: Drugs and Aging - July 11, 2023 Category: Geriatrics Source Type: research
Age is No Barrier: CAR-T Therapy in Older Adults
AbstractIn the last decade, chimeric antigen receptor-T (CAR-T) cells have revolutionized the treatment of hematological malignancies. With six different products for five diseases in various settings, CAR-T use has increased, and the comfort level of prescribers continues to expand. These therapies carry substantial toxicities that may limit their applicability to all patient populations. In the registrational trials, older adults are represented as part of a whole and risks specific to older age may not be clearly outlined. The aim of this review is to summarize the data from clinical trials, as well as real-life evidenc...
Source: Drugs and Aging - July 11, 2023 Category: Geriatrics Source Type: research
Associated Factors to Efficacy and Tolerance of Immunotherapy in Older Patients with Cancer Aged 70 Years and Over: Impact of Coprescriptions
ConclusionsIn older patients taking ICB for solid cancers, concomitant AP may influence efficacy and concomitant PPI may influence tolerance. Further studies are needed to confirm these results. (Source: Drugs and Aging)
Source: Drugs and Aging - July 10, 2023 Category: Geriatrics Source Type: research
Utility of Big Data to Explore Medication Adherence in M āori and Non-Māori Community-Dwelling Older Adults with Heart Failure in Aotearoa New Zealand: A Cross-sectional Study
ConclusionsThere was a significant disparity between M āori and non-Māori concerning medication adherence. Given the international use of the interRAI-HC assessment tool, these results have significant transferability to other countries and allow the identification of underserved ethnic groups for which culturally appropriate interventions can be targ eted. (Source: Drugs and Aging)
Source: Drugs and Aging - June 29, 2023 Category: Geriatrics Source Type: research
Association of Potentially Inappropriate Medication Classes with Mortality Risk Among Older Adults Initiating Hemodialysis
ConclusionsOnly a minority of Beers Criteria PIM classes may be associated with mortality in the older dialysis population; however, mortality risk increases with concomitant use of “high-risk” PIMs. Additional studies are needed to confirm these associations and their underlying mechanisms. (Source: Drugs and Aging)
Source: Drugs and Aging - June 28, 2023 Category: Geriatrics Source Type: research
Fall-Risk-Increasing Drugs and Gait Performance in Community-Dwelling Older Adults: Exploratory Results from the Gait and Brain Study
ConclusionThe association between diuretic use and reduced gait speed is consistent with existing evidence on diuretic use and increased fall risk. The association between statins and increased stride time variability is notable given inconclusive evidence in previous studies. Our results provide initial estimates of the association between FRIDs and gait performance in older adults for future longitudinal studies. (Source: Drugs and Aging)
Source: Drugs and Aging - June 22, 2023 Category: Geriatrics Source Type: research
Platelet-Rich Plasma for Knee Osteoarthritis: What Does the Evidence Say?
AbstractThe utilization of platelet-rich-plasma as a therapeutic intervention for knee osteoarthritis has gained immense attention since 2008. The increase in the number of scientific publications dedicated to this area can be attributed to the majority of favorable results reported in clinical trials and basic science studies. However, despite the growing evidence, the use of platelet-rich plasma in clinical practice still poses controversial aspects. The potential mechanisms of action described for platelet-rich-plasma so far indicate that it could serve as a disease-modifying drug, acting to counteract important aspects...
Source: Drugs and Aging - June 22, 2023 Category: Geriatrics Source Type: research
Menopausal Hormone Therapy in Older Women: Examining the Current Balance of Evidence
AbstractMenopause occurs in all women. During the menopause transition, 80% of women experience vasomotor symptoms that can last an average of 7 –10 years or longer, sometimes into the seventh and eighth decades of life. Understanding how to manage vasomotor symptoms (VMS) in older menopausal women is important since these symptoms can negatively impact quality of life. This review provides a practical guide on how to approach VMS treatme nt either with menopausal hormone therapy or non-hormone options. When initiating, as well as continuing hormone therapy, the factors clinicians should consider as they weigh risks and...
Source: Drugs and Aging - June 21, 2023 Category: Geriatrics Source Type: research
Elevating Safe Use of Over-The-Counter Medications in Older Adults: A Narrative Review of Pharmacy Involved Interventions and Recommendations for Improvement
AbstractOver-the-counter (OTC) medications are products that have been made easily accessible to allow patients to treat common ailments without a prescription and the cost of a doctor ’s visit. These medications are generally considered safe; however, there is still a potential for these medications to lead to adverse health outcomes. Older adults (ages 50+) are especially susceptible to these adverse health outcomes, due to age-related physiological changes, a higher prevalenc e of comorbidities, and prescription medication use. Many OTC medications are sold in pharmacies, which provides pharmacists and technicians wit...
Source: Drugs and Aging - June 20, 2023 Category: Geriatrics Source Type: research
Independent Association Between Use of Proton Pump Inhibitors and Muscle Wasting in Patients with Heart Failure: A Single-Center, Ambispective, Observational Study
ConclusionUse of PPIs is associated with a high risk of muscle wasting in HF patients. Caution is warranted when long-term PPI treatment is performed in sarcopenic HF patients and HF patients with several risk factors for muscle wasting. (Source: Drugs and Aging)
Source: Drugs and Aging - June 16, 2023 Category: Geriatrics Source Type: research
