Attitudes to Drug Use in Residential Aged Care Facilities: A Cross-Sectional Survey of Nurses and Care Staff
ConclusionsTo successfully and sustainably optimise medication use in RACF residents, it is important to consider the variation in views of nurses and care staff. (Source: Drugs and Aging)
Source: Drugs and Aging - June 25, 2021 Category: Geriatrics Source Type: research
Current Insights into Treating Vertigo in Older Adults
AbstractThe number of older people has been increasing over recent decades in Western populations. Dizziness, imbalance, and vertigo constitute some of the most common complaints in older patients, and risk of falling is the most frequent and worrying consequence. It has been reported that 15 –20% of the adult population experiences these debilitating symptoms. Among the diseases that may be associated with vertigo, the three classes of otological, central, and functional (psychological) dizziness may be distinguished. Overall, vestibular disorders account for 48% of vertiginous compla ints in the older population. The m...
Source: Drugs and Aging - June 23, 2021 Category: Geriatrics Source Type: research
Risk of Fractures in Older Adults with Chronic Non-cancer Pain Receiving Concurrent Benzodiazepines and Opioids: A Nested Case –Control Study
ConclusionThe concurrent use of benzodiazepines and opioids was associated with an increased risk of fractures in older patients with chronic non-cancer pain. Therefore, patients continuously receiving benzodiazepines in whom opioids are newly initiated need careful monitoring, and such combined therapy should be limited to the shortest duration possible. (Source: Drugs and Aging)
Source: Drugs and Aging - June 23, 2021 Category: Geriatrics Source Type: research
Systemic Treatment for Older Patients with Unresectable Hepatocellular Carcinoma
AbstractThe incidence rate of hepatocellular carcinoma is growing and age at diagnosis is increasing; however, despite the unprecedented wealth of therapeutic options for advanced HCC, its optimal management in some categories, such as older adults, is yet to be defined. Even though age is not an exclusion criterion per se, most of the landmark trials enrolled a limited number of senior patients, raising some concerns on the potential benefit of active treatments in this group. The identification of more vulnerable patients remains a crucial issue in clinical practice. In fact, the suitability assessment for systemic thera...
Source: Drugs and Aging - June 21, 2021 Category: Geriatrics Source Type: research
Management of Metastatic Colorectal Carcinoma in Older Adults: Balancing Risks and Benefits of Novel Therapies
AbstractThe prevalence of older patients with metastatic colorectal cancer (mCRC) will continue to increase with our aging population. Treatment of mCRC has changed significantly in the last few decades as we have learned how to personalize the treatment of mCRC to the biology of the tumor, utilizing new treatment approaches. With an ever-changing treatment paradigm, managing the population of older adults becomes paramount. This review highlights the pivotal clinical trials that defined the use of systemic therapy, immunotherapy and targeted therapies for mCRC, and how those are applied to the older patient population. In...
Source: Drugs and Aging - June 18, 2021 Category: Geriatrics Source Type: research
Vaccination in Older Adults: An Underutilized Opportunity to Promote Healthy Aging in India
AbstractOver the last 50 years, the Indian population aged 50 years and above (older adults) has quadrupled and is expected to comprise 404 million people in 2036, representing 27% of the country ’s projected population. Consequently, the contribution of chronic disease to older adults’ total burden of diseases in India is likely to escalate. Disease burden is notably amplified by immunosenescence, a deterioration of the immune system that develops with age, leading to increasing suscept ibility to infectious diseases and other comorbidities. Older adults with infectious diseases have a higher incidence and likelihood ...
Source: Drugs and Aging - June 14, 2021 Category: Geriatrics Source Type: research
Correction to: A Structured Literature Review and International Consensus Validation of FORTA Labels of Oral Anticoagulants for Long-Term Treatment of Atrial Fibrillation in Older Patients (OAC-FORTA 2019)
A correction to this paper has been published: https://doi.org/10.1007/s40266-021-00873-3 (Source: Drugs and Aging)
Source: Drugs and Aging - June 14, 2021 Category: Geriatrics Source Type: research
Gout Flare Burden, Diagnosis, and Management: Navigating Care in Older Patients with Comorbidity
AbstractGout is the most common form of inflammatory arthritis, and its incidence is highest in middle-aged and older patients. Adding to the diagnostic complexity, up to 50% of patients aged> 65 years present atypically, with subacute oligo- or polyarticular flares. Comorbidity and polypharmacy, common in older populations, affect real-world treatment decisions in gout management, and no specific guidelines are available to address these issues in these at-risk groups. Despite the gro wing public health burden posed by gout, suboptimal management has led to increased morbidity and substantial healthcare utilization ...
Source: Drugs and Aging - June 9, 2021 Category: Geriatrics Source Type: research
Differences in Health-Related Quality of Life Among Adults with a Potential Dihydropyridine Calcium Channel Blocker –Loop Diuretic Prescribing Cascade
ConclusionsNew loop diuretic use was associated with lower physical functioning among DH CCB users. These findings suggest that this potential prescribing cascade may result in both significant and clinically meaningful decreases in health-related quality of life. It is important for clinicians to avoid or intervene on this inappropriate prescribing cascade when possible. (Source: Drugs and Aging)
Source: Drugs and Aging - June 7, 2021 Category: Geriatrics Source Type: research
Adjunctive Perampanel in Older Patients With Epilepsy: A Multicenter Study of Clinical Practice
ConclusionsAdjunctive perampanel was associated with improvement in seizure control and good tolerability in a real-life setting and can represent a viable therapeutic option in older patients with epilepsy. (Source: Drugs and Aging)
Source: Drugs and Aging - June 2, 2021 Category: Geriatrics Source Type: research
Ghent Older People ’s Prescriptions Community Pharmacy Screening (GheOP3S)-Tool Version 2: Update of a Tool to Detect Drug-Related Problems in Older People in Primary Care
ConclusionGheOP3S-criteria were revised and updated according to experts ’ agreement on their clinical relevance and recent scientific evidence. Future studies should investigate the impact of pharmacist-led medication reviews with GheOP3S-tool version 2 on clinical, humanistic and economic outcomes in primary care. (Source: Drugs and Aging)
Source: Drugs and Aging - June 1, 2021 Category: Geriatrics Source Type: research
Antimuscarinic Cascade Across Individual Cholinesterase Inhibitors in Older Adults with Dementia
ConclusionThis study found that donepezil use is more likely to lead to antimuscarinic cascade than rivastigmine. Future studies are needed to determine the potential consequences of this cascade in dementia. (Source: Drugs and Aging)
Source: Drugs and Aging - May 24, 2021 Category: Geriatrics Source Type: research
Ghent Older People ’s Prescriptions Community Pharmacy Screening (GheOP 3 S)-Tool Version 2: Update of a Tool to Detect Drug-Related Problems in Older People in Primary Care
ConclusionGheOP3S-criteria were revised and updated according to experts ’ agreement on their clinical relevance and recent scientific evidence. Future studies should investigate the impact of pharmacist-led medication reviews with GheOP3S-tool version 2 on clinical, humanistic and economic outcomes in primary care. (Source: Drugs and Aging)
Source: Drugs and Aging - May 3, 2021 Category: Geriatrics Source Type: research
Major Depressive Disorder in Older Patients as an Inflammatory Disorder: Implications for the Pharmacological Management of Geriatric Depression
AbstractDepression is a common and highly disabling condition in older adults. It is a heterogenous disorder and there is emerging evidence of a link between inflammation and depression in older patients, with a possible inflammatory subtype of depression. Persistent low-level inflammation, from several sources including psychological distress and chronic disease, can disrupt monoaminergic and glutaminergic systems to create dysfunctional brain networks. Despite the evidence for the role of inflammation in depression, there is insufficient evidence to recommend use of any putative anti-inflammatory agent in the treatment o...
Source: Drugs and Aging - April 29, 2021 Category: Geriatrics Source Type: research
Correction to: The Influence of Age on Central Effects of Methylnaltrexone in Patients with Opioid-Induced Constipation
A correction to this paper has been published: https://doi.org/10.1007/s40266-021-00860-8 (Source: Drugs and Aging)
Source: Drugs and Aging - April 23, 2021 Category: Geriatrics Source Type: research
