Helicobacter pylori Eradication Treatment in Older Patients
AbstractHelicobacter pylori is the main etiopathogenetic factor of chronic gastritis, peptic ulcer disease and gastric cancer. The world ’s population is shifting towards older people, who have the highest prevalence ofH. pylori. Aging-related peculiarities could have an impact on the treatment ofH. pylori and there is still a lack of research data in the older population. The aim of this review was to summarize the findings of the most recent information, publications and studies on the issues relating toH. pylori infection in older patients.H. pylori eradication offers gastrointestinal and extra gastrointestinal benefi...
Source: Drugs and Aging - February 10, 2024 Category: Geriatrics Source Type: research
Development and Pilot Testing of an Algorithm-Based Approach to Anticholinergic Deprescribing in Older Patients
ConclusionsThe approach was well received by the participating physicians and might support standardized anticholinergic deprescribing. (Source: Drugs and Aging)
Source: Drugs and Aging - February 6, 2024 Category: Geriatrics Source Type: research
The Current Landscape of Pharmacotherapies for Sarcopenia
AbstractSarcopenia is a skeletal muscle disorder characterized by progressive and generalized decline in muscle mass and function. Although it is mostly known as an age-related disorder, it can also occur secondary to systemic diseases such as malignancy or organ failure. It has demonstrated a significant relationship with adverse outcomes, e.g., falls, disabilities, and even mortality. Several breakthroughs have been made to find a pharmaceutical therapy for sarcopenia over the years, and some have come up with promising findings. Yet still no drug has been approved for its treatment. The key factor that makes finding an ...
Source: Drugs and Aging - February 5, 2024 Category: Geriatrics Source Type: research
Unlocking Deprescribing Potential in Nursing Homes: Insights from a Focus Group Study with Healthcare Professionals
ConclusionsThis study provides insight into the various barriers and enablers faced by NHPs and pharmacists when deprescribing in nursing homes. Specific for this population, deprescribing barriers focus on communication (with residents and their relatives, and also with medical specialists) and resources, while knowledge and expertise are mentioned as enablers. (Source: Drugs and Aging)
Source: Drugs and Aging - January 29, 2024 Category: Geriatrics Source Type: research
Are Lists of Potentially Inappropriate Medications Associated with Hospital Readmissions? A Systematic Review
ConclusionThis systematic review shows that the association between list of PIMs and 30-day unplanned readmissions remains unclear and seems dependent on the PIM detection tool. Further studies are needed to clarify this association.PROSPERO registration number CRD42021252107. (Source: Drugs and Aging)
Source: Drugs and Aging - January 25, 2024 Category: Geriatrics Source Type: research
Evaluating Provider and Pharmacy Discordance in Potential Calcium Channel Blocker –Loop Diuretic Prescribing Cascade
ConclusionOur findings suggest that discordant providers and discordant pharmacies were more commonly involved in the potential prescribing cascade when compared with a similar control dyad of medications. Opportunities for enhanced care coordination and medication reconciliation should be explored to prevent unnecessary polypharmacy. (Source: Drugs and Aging)
Source: Drugs and Aging - January 22, 2024 Category: Geriatrics Source Type: research
Diagnosis and Pharmacological Management of Microscopic Colitis in Geriatric Care
AbstractMicroscopic colitis, a diagnosis under the umbrella term of inflammatory bowel disease, is a prevalent cause of watery diarrhea, often with symptoms of urgency and bloating, typically observed in older adults aged ≥ 60 years. Its incidence has been reported to exceed those of ulcerative colitis and Crohn’s disease in some geographical areas. Although nonpathognomonic endoscopic abnormalities, including changes of the vascular mucosal pattern; mucosal erythema; edema; nodularity; or mucosal defects, e.g. , “cat scratches” have been reported, a colonoscopy is typically macroscopically normal. As reliable bi...
Source: Drugs and Aging - January 17, 2024 Category: Geriatrics Source Type: research
Authors ’ Reply to Langford et al.: “Patient Perceptions of Opioids and Benzodiazepines and Attitudes Toward Deprescribing”
(Source: Drugs and Aging)
Source: Drugs and Aging - January 2, 2024 Category: Geriatrics Source Type: research
Comment on: “Patient Perceptions of Opioids and Benzodiazepines and Attitudes Toward Deprescribing”
(Source: Drugs and Aging)
Source: Drugs and Aging - January 2, 2024 Category: Geriatrics Source Type: research
Correction to: Prevalence and factors associated with inappropriate dosing of apixaban and rivaroxaban in hospitalized older adults with atrial fibrillation: a cross ‑sectional study
(Source: Drugs and Aging)
Source: Drugs and Aging - December 21, 2023 Category: Geriatrics Source Type: research
Individualized Dosing Patterns in the Treatment of Older Patients with Gastrointestinal Stromal Tumors: Results of a Registry-Based Observational National Cohort Study Including 871 Patients
ConclusionOlder patients showed higher imatinib trough plasma concentrations compared with younger patients and also had earlier and more often adverse events as the reason for first adjustment of treatment with imatinib followed by dose reduction. However, in a landmark analysis, patients with imatinib dose reductions had no poorer outcomes compared with patients not requiring a dose reduction. (Source: Drugs and Aging)
Source: Drugs and Aging - December 20, 2023 Category: Geriatrics Source Type: research
Do Proton Pump Inhibitors Reduce Upper Gastrointestinal Bleeding in Older Patients with Atrial Fibrillation Treated with Oral Anticoagulants? A Nationwide Cohort Study in France
ConclusionsThis study suggests that PPIs were associated with reduced risk of gastrointestinal bleeding after initiation of oral anticoagulation in older patients with atrial fibrillation, particularly within 6 months after initiation of an antivitamin K antagonist. (Source: Drugs and Aging)
Source: Drugs and Aging - December 20, 2023 Category: Geriatrics Source Type: research
Potentially Inappropriate Psychotropic Drugs in Nursing Homes: An Italian Observational Study
ConclusionsDifferent criteria for appropriate drug prescription identify very different percentages of patients in NHs exposed to psychotropics considered potentially inappropriate. The Beers and STOPP/START criteria identified a larger percentage of patients exposed in NHs than FORTA. (Source: Drugs and Aging)
Source: Drugs and Aging - November 30, 2023 Category: Geriatrics Source Type: research
A Trial-Based Cost-Utility Analysis of a Medication Optimization Intervention Versus Standard Care in Older Adults
ConclusionsAccording to societal willingness-to-pay thresholds, the medication optimization intervention was not cost effective compared to standard care for the full population. The intervention dominated standard care for the non-long stayers, with a high probability of cost effectiveness.Clinical Trial RegistrationThe IMMENSE trial was registered in ClinicalTrials.gov on 28 June, 2016 before enrolment started (NCT02816086). (Source: Drugs and Aging)
Source: Drugs and Aging - November 22, 2023 Category: Geriatrics Source Type: research
Cutaneous Lupus Erythematosus: Review and Considerations for Older Populations
AbstractThough more common earlier in life, increasing attention is being focused on the development of cutaneous lupus erythematosus (CLE) in patients with advancing age. Studies show that CLE is more common in older populations than previously thought, and all CLE subtypes are possible in this group. Just like patients in the third or fourth decade of life, CLE may appear alongside or independent of systemic lupus erythematosus. Older populations manifesting CLE for the first time seem to have a lower risk of progression to systemic disease than younger peers, and are more commonly White. CLE must be carefully distinguis...
Source: Drugs and Aging - November 22, 2023 Category: Geriatrics Source Type: research
