Metabolic bioactivation of antidepressants: advance and underlying hepatotoxicity
Drug Metab Rev. 2024 Feb 4:1-38. doi: 10.1080/03602532.2024.2313967. Online ahead of print.ABSTRACTMany drugs that serve as first-line medications for the treatment of depression are associated with severe side effects, including liver injury. Of the 34 antidepressants discussed in this review, four have been withdrawn from the market due to severe hepatotoxicity, and others carry boxed warnings for idiosyncratic liver toxicity. The clinical and economic implications of antidepressant-induced liver injury are substantial, but the underlying mechanisms remain elusive. Drug-induced liver injury may involve the host immune sy...
Source: Drug Metabolism Reviews - February 5, 2024 Category: Drugs & Pharmacology Authors: Saleh M Khalil Kevin R MacKenzie Mirjana Maletic-Savatic Feng Li Source Type: research
The aminosalicylate - folate connection
Drug Metab Rev. 2024 Feb;56(1):80-96. doi: 10.1080/03602532.2024.2303507. Epub 2024 Jan 17.ABSTRACTTwo aminosalicylate isomers have been found to possess useful pharmacological behavior: p-aminosalicylate (PAS, 4AS) is an anti-tubercular agent that targets M. tuberculosis, and 5-aminosalicylate (5AS, mesalamine, mesalazine) is used in the treatment of ulcerative colitis (UC) and other inflammatory bowel diseases (IBD). PAS, a structural analog of pABA, is biosynthetically incorporated by bacterial dihydropteroate synthase (DHPS), ultimately yielding a dihydrofolate (DHF) analog containing an additional hydroxyl group in th...
Source: Drug Metabolism Reviews - January 17, 2024 Category: Drugs & Pharmacology Authors: Robert E London Source Type: research
Melatonin in cancer biology: pathways, derivatives, and the promise of targeted delivery
Drug Metab Rev. 2024 Feb;56(1):62-79. doi: 10.1080/03602532.2024.2305764. Epub 2024 Jan 30.ABSTRACTMelatonin, historically recognized for its primary role in regulating circadian rhythms, has expanded its influence particularly due to its wide range of biological activities. It has firmly established itself in cancer research. To highlight its versatility, we delved into how melatonin interacts with key signaling pathways, such as the Wnt/β-Catenin, PI3K, and NF-κB pathways, which play foundational roles in tumor development and progression. Notably, melatonin can intricately modulate these pathways, potentially affectin...
Source: Drug Metabolism Reviews - January 16, 2024 Category: Drugs & Pharmacology Authors: Yu-Juan Yi Hong Tang Peng-Lai Pi Han-Wen Zhang Si-Yu Du Wei-Ye Ge Qi Dai Zi-Yan Zhao Jia Li Zheng Sun Source Type: research
The potential impact of CYP and UGT drug-metabolizing enzymes on brain target site drug exposure
In conclusion, this review enhances our understanding of drug metabolism's significance in the brain, with a specific focus on CYPs and UGTs. Insights into the expression, activity, and influential factors of these enzymes within the CNS have crucial implications for drug development, the design of safe drug treatment strategies, and the comprehension of drug actions within the CNS. To that end, CNS pharmacokinetic (PK) models can be improved to further advance drug development and personalized therapy.PMID:38126313 | DOI:10.1080/03602532.2023.2297154 (Source: Drug Metabolism Reviews)
Source: Drug Metabolism Reviews - December 21, 2023 Category: Drugs & Pharmacology Authors: Mengxu Zhang Vivi Rottsch äfer Elizabeth C M de Lange Source Type: research
The potential impact of CYP and UGT drug metabolizing enzymes on brain target site drug exposure
In conclusion, this review enhances our understanding of drug metabolism's significance in the brain, with a specific focus on CYPs and UGTs. Insights into the expression, activity, and influential factors of these enzymes within the CNS have crucial implications for drug development, the design of safe drug treatment strategies, and the comprehension of drug actions within the CNS. To that end, CNS pharmacokinetic (PK) models can be improved to further advance drug development and personalized therapy.PMID:38126313 | DOI:10.1080/03602532.2023.2297154 (Source: Drug Metabolism Reviews)
Source: Drug Metabolism Reviews - December 21, 2023 Category: Drugs & Pharmacology Authors: Mengxu Zhang Vivi Rottsch äfer Elizabeth Cm de Lange Source Type: research
