New Strategy for Rational Use of Antihypertensive Drugs in Clinical Practice in High-altitude Hypoxic Environments
Drug Metab Rev. 2023 Aug 22:1-22. doi: 10.1080/03602532.2023.2250930. Online ahead of print.ABSTRACTHigh-altitude hypoxic environments have critical implications on cardiovascular system function as well as blood pressure regulation. Such environments place patients with hypertension at risk by activating the sympathetic nervous system, which leads to an increase in blood pressure. In addition, the high-altitude hypoxic environment alters the in vivo metabolism and antihypertensive effects of antihypertensive drugs, which changes the activity and expression of drug-metabolizing enzymes and drug transporters. The present st...
Source: Drug Metabolism Reviews - August 22, 2023 Category: Drugs & Pharmacology Authors: Delong Duo Yabin Duan Junbo Zhu Xue Bai Jianxin Yang Guiqin Liu Qian Wang Xiangyang Li Source Type: research
Pregnane X receptor as a therapeutic target for cholestatic liver injury
Drug Metab Rev. 2023 Aug 18:1-24. doi: 10.1080/03602532.2023.2248680. Online ahead of print.ABSTRACTCholestatic liver injury (CLI) is caused by toxic bile acids (BAs) accumulation in the liver and can lead to inflammation and liver fibrosis. The mechanisms underlying CLI development remain unclear, and this disease has no effective cure. However, regulating BA synthesis and homeostasis represents a promising therapeutic strategy for CLI treatment. Pregnane X receptor (PXR) plays an essential role in the metabolism of endobiotics and xenobiotics via the transcription of metabolic enzymes and transporters, which can ultimate...
Source: Drug Metabolism Reviews - August 18, 2023 Category: Drugs & Pharmacology Authors: Huan Lan Ying Zhang Minqi Fan Bingxin Wu Caiyan Wang Source Type: research
Physiological and pathophysiological roles of hepoxilins and their analogs
Drug Metab Rev. 2023 Aug;55(3):254-266. doi: 10.1080/03602532.2023.2219035. Epub 2023 Jun 1.ABSTRACTThe metabolism of arachidonic acid (AA) occurs via different pathways leading to the production of a great number of metabolites with a wide range of biological effects. Hepoxilins (HXs) are physiologically active AA metabolites produced through the lipoxygenase pathway. Since their discovery, several researchers have investigated their biological effects. They were proven to have pro-inflammatory, anti-apoptotic, and skin-protective effects. HXs also contribute to the processes of neutrophil activation and migration and inf...
Source: Drug Metabolism Reviews - June 2, 2023 Category: Drugs & Pharmacology Authors: Sara A Helal Fadumo Ahmed Isse Samar H Gerges Ayman O S El-Kadi Source Type: research
