Enantioselectivity in some physiological and pathophysiological roles of hydroxyeicosatetraenoic acids
Drug Metab Rev. 2024 Feb;56(1):31-45. doi: 10.1080/03602532.2023.2284110. Epub 2023 Nov 21.ABSTRACTThe phenomenon of chirality has been shown to greatly impact drug activities and effects. Different enantiomers may exhibit different effects in a certain biological condition or disease state. Cytochrome P450 (CYP) enzymes metabolize arachidonic acid (AA) into a large variety of metabolites with a wide range of activities. Hydroxylation of AA by CYP hydroxylases produces hydroxyeicosatetraenoic acids (HETEs), which are classified into mid-chain (5, 8, 9, 11, 12, and 15-HETE), subterminal (16-, 17-, 18- and 19-HETE) and termi...
Source: Drug Metabolism Reviews - February 15, 2024 Category: Drugs & Pharmacology Authors: Sara A Helal Samar H Gerges Ayman O S El-Kadi Source Type: research
