Investigating the Association between CYP2J2 Inhibitors and QT Prolongation: A Literature Review
Drug Metab Rev. 2024 Mar 13:1-29. doi: 10.1080/03602532.2024.2329928. Online ahead of print.ABSTRACTDrug withdrawal post-marketing due tocardiotoxicity is a major concern for drug developers, regulatory agencies, and patients. One common mechanism of cardiotoxicity isthroughinhibition of cardiac ion channels, leading to prolongation of the QT intervaland sometimes fatal arrythmias. Recently, oxylipinsignaling compounds have been shown to bind toand alter ion channel function,and disruption in their cardiac levels may contribute to QTprolongation. Cytochrome P450 2J2 (CYP2J2) is the predominant CYP isoform expressed in card...
Source: Drug Metabolism Reviews - March 13, 2024 Category: Drugs & Pharmacology Authors: Alexandra M Wiley Jade Yang Rivcka Madhani Abhinav Nath Rheem A Totah Source Type: research
Favipiravir, remdesivir, and lopinavir: metabolites, degradation products and their analytical methods
Drug Metab Rev. 2024 Mar 6:1-18. doi: 10.1080/03602532.2024.2326415. Online ahead of print.ABSTRACTSevere acute respiratory syndrome 2 (SARS-CoV-2) caused the emergence of the COVID-19 pandemic all over the world. Several studies have suggested that antiviral drugs such as favipiravir (FAV), remdesivir (RDV), and lopinavir (LPV) may potentially prevent the spread of the virus in the host cells and person-to-person transmission. Simultaneously with the widespread use of these drugs, their stability and action mechanism studies have also attracted the attention of many researchers. This review focuses on the action mechanism...
Source: Drug Metabolism Reviews - March 6, 2024 Category: Drugs & Pharmacology Authors: Mir Saleh Hoseininezhad-Namin Elaheh Rahimpour Abolghasem Jouyban Source Type: research
