The potential impact of CYP and UGT drug-metabolizing enzymes on brain target site drug exposure

In conclusion, this review enhances our understanding of drug metabolism's significance in the brain, with a specific focus on CYPs and UGTs. Insights into the expression, activity, and influential factors of these enzymes within the CNS have crucial implications for drug development, the design of safe drug treatment strategies, and the comprehension of drug actions within the CNS. To that end, CNS pharmacokinetic (PK) models can be improved to further advance drug development and personalized therapy.PMID:38126313 | DOI:10.1080/03602532.2023.2297154
Source: Drug Metabolism Reviews - Category: Drugs & Pharmacology Authors: Source Type: research