The epigenome under pressure: On regulatory adaptation to chronic stress in the brain
Curr Opin Neurobiol. 2023 Dec 22;84:102832. doi: 10.1016/j.conb.2023.102832. Online ahead of print.ABSTRACTChronic stress (CS) can have long-lasting consequences on behavior and cognition, that are associated with stable changes in gene expression in the brain. Recent work has examined the role of the epigenome in the effects of CS on the brain. This review summarizes experimental evidence in rodents showing that CS can alter the epigenome and the expression of epigenetic modifiers in brain cells, and critically assesses their functional effect on genome function. It discusses the influence of the developmental time of str...
Source: Current Opinion in Neurobiology - December 23, 2023 Category: Neurology Authors: Rodrigo G Arzate-Mejia Nancy V N Carullo Isabelle M Mansuy Source Type: research
The epigenome under pressure: On regulatory adaptation to chronic stress in the brain
Curr Opin Neurobiol. 2023 Dec 22;84:102832. doi: 10.1016/j.conb.2023.102832. Online ahead of print.ABSTRACTChronic stress (CS) can have long-lasting consequences on behavior and cognition, that are associated with stable changes in gene expression in the brain. Recent work has examined the role of the epigenome in the effects of CS on the brain. This review summarizes experimental evidence in rodents showing that CS can alter the epigenome and the expression of epigenetic modifiers in brain cells, and critically assesses their functional effect on genome function. It discusses the influence of the developmental time of str...
Source: Current Opinion in Neurobiology - December 23, 2023 Category: Neurology Authors: Rodrigo G Arzate-Mejia Nancy V N Carullo Isabelle M Mansuy Source Type: research
The epigenome under pressure: On regulatory adaptation to chronic stress in the brain
Curr Opin Neurobiol. 2023 Dec 22;84:102832. doi: 10.1016/j.conb.2023.102832. Online ahead of print.ABSTRACTChronic stress (CS) can have long-lasting consequences on behavior and cognition, that are associated with stable changes in gene expression in the brain. Recent work has examined the role of the epigenome in the effects of CS on the brain. This review summarizes experimental evidence in rodents showing that CS can alter the epigenome and the expression of epigenetic modifiers in brain cells, and critically assesses their functional effect on genome function. It discusses the influence of the developmental time of str...
Source: Current Opinion in Neurobiology - December 23, 2023 Category: Neurology Authors: Rodrigo G Arzate-Mejia Nancy V N Carullo Isabelle M Mansuy Source Type: research
From cellular to fear memory: An epigenetic toolbox to remember
Curr Opin Neurobiol. 2023 Dec 20;84:102829. doi: 10.1016/j.conb.2023.102829. Online ahead of print.ABSTRACTThroughout development, the neuronal epigenome is highly sensitive to external stimuli, yet capable of safeguarding cellular memory for a lifetime. In the adult brain, memories of fearful experiences are rapidly instantiated, yet can last for decades, but the mechanisms underlying such longevity remain unknown. Here, we showcase how fear memory formation and storage - traditionally thought to exclusively affect synapse-based events - elicit profound and enduring changes to the chromatin, proposing epigenetic regulatio...
Source: Current Opinion in Neurobiology - December 21, 2023 Category: Neurology Authors: Davide Martino Coda Johannes Gr äff Source Type: research
From cellular to fear memory: An epigenetic toolbox to remember
Curr Opin Neurobiol. 2023 Dec 20;84:102829. doi: 10.1016/j.conb.2023.102829. Online ahead of print.ABSTRACTThroughout development, the neuronal epigenome is highly sensitive to external stimuli, yet capable of safeguarding cellular memory for a lifetime. In the adult brain, memories of fearful experiences are rapidly instantiated, yet can last for decades, but the mechanisms underlying such longevity remain unknown. Here, we showcase how fear memory formation and storage - traditionally thought to exclusively affect synapse-based events - elicit profound and enduring changes to the chromatin, proposing epigenetic regulatio...
Source: Current Opinion in Neurobiology - December 21, 2023 Category: Neurology Authors: Davide Martino Coda Johannes Gr äff Source Type: research
From cellular to fear memory: An epigenetic toolbox to remember
Curr Opin Neurobiol. 2023 Dec 20;84:102829. doi: 10.1016/j.conb.2023.102829. Online ahead of print.ABSTRACTThroughout development, the neuronal epigenome is highly sensitive to external stimuli, yet capable of safeguarding cellular memory for a lifetime. In the adult brain, memories of fearful experiences are rapidly instantiated, yet can last for decades, but the mechanisms underlying such longevity remain unknown. Here, we showcase how fear memory formation and storage - traditionally thought to exclusively affect synapse-based events - elicit profound and enduring changes to the chromatin, proposing epigenetic regulatio...
Source: Current Opinion in Neurobiology - December 21, 2023 Category: Neurology Authors: Davide Martino Coda Johannes Gr äff Source Type: research
Descending control of motor sequences in Drosophila
Curr Opin Neurobiol. 2023 Dec 13;84:102822. doi: 10.1016/j.conb.2023.102822. Online ahead of print.ABSTRACTThe descending neurons connecting the fly's brain to its ventral nerve cord respond to sensory stimuli and evoke motor programs of varying complexity. Anatomical characterization of the descending neurons and their synaptic connections suggests how these circuits organize movements, while optogenetic manipulation of their activity reveals what behaviors they can induce. Monitoring their responses to sensory stimuli or during behavior performance indicates what information they may encode. Recent advances in all three ...
Source: Current Opinion in Neurobiology - December 14, 2023 Category: Neurology Authors: Julie H Simpson Source Type: research
Sensory alterations in post-traumatic stress disorder
Curr Opin Neurobiol. 2023 Dec 13;84:102821. doi: 10.1016/j.conb.2023.102821. Online ahead of print.ABSTRACTPTSD is characterized by difficulties in accurately evaluating the threat value of sensory stimuli. While the role of canonical fear and threat neural circuitry in this ability has been well studied, recent lines of evidence suggest a need to include more emphasis on sensory processing in the conceptualization of PTSD symptomology. Specifically, studies have demonstrated a strong association between variability in sensory processing regions and the severity of PTSD symptoms. In this review, we summarize recent finding...
Source: Current Opinion in Neurobiology - December 14, 2023 Category: Neurology Authors: Leland L Fleming Nathaniel G Harnett Kerry J Ressler Source Type: research
Descending control of motor sequences in Drosophila
Curr Opin Neurobiol. 2023 Dec 13;84:102822. doi: 10.1016/j.conb.2023.102822. Online ahead of print.ABSTRACTThe descending neurons connecting the fly's brain to its ventral nerve cord respond to sensory stimuli and evoke motor programs of varying complexity. Anatomical characterization of the descending neurons and their synaptic connections suggests how these circuits organize movements, while optogenetic manipulation of their activity reveals what behaviors they can induce. Monitoring their responses to sensory stimuli or during behavior performance indicates what information they may encode. Recent advances in all three ...
Source: Current Opinion in Neurobiology - December 14, 2023 Category: Neurology Authors: Julie H Simpson Source Type: research
Sensory alterations in post-traumatic stress disorder
Curr Opin Neurobiol. 2023 Dec 13;84:102821. doi: 10.1016/j.conb.2023.102821. Online ahead of print.ABSTRACTPTSD is characterized by difficulties in accurately evaluating the threat value of sensory stimuli. While the role of canonical fear and threat neural circuitry in this ability has been well studied, recent lines of evidence suggest a need to include more emphasis on sensory processing in the conceptualization of PTSD symptomology. Specifically, studies have demonstrated a strong association between variability in sensory processing regions and the severity of PTSD symptoms. In this review, we summarize recent finding...
Source: Current Opinion in Neurobiology - December 14, 2023 Category: Neurology Authors: Leland L Fleming Nathaniel G Harnett Kerry J Ressler Source Type: research
Descending control of motor sequences in Drosophila
Curr Opin Neurobiol. 2023 Dec 13;84:102822. doi: 10.1016/j.conb.2023.102822. Online ahead of print.ABSTRACTThe descending neurons connecting the fly's brain to its ventral nerve cord respond to sensory stimuli and evoke motor programs of varying complexity. Anatomical characterization of the descending neurons and their synaptic connections suggests how these circuits organize movements, while optogenetic manipulation of their activity reveals what behaviors they can induce. Monitoring their responses to sensory stimuli or during behavior performance indicates what information they may encode. Recent advances in all three ...
Source: Current Opinion in Neurobiology - December 14, 2023 Category: Neurology Authors: Julie H Simpson Source Type: research
Sensory alterations in post-traumatic stress disorder
Curr Opin Neurobiol. 2023 Dec 13;84:102821. doi: 10.1016/j.conb.2023.102821. Online ahead of print.ABSTRACTPTSD is characterized by difficulties in accurately evaluating the threat value of sensory stimuli. While the role of canonical fear and threat neural circuitry in this ability has been well studied, recent lines of evidence suggest a need to include more emphasis on sensory processing in the conceptualization of PTSD symptomology. Specifically, studies have demonstrated a strong association between variability in sensory processing regions and the severity of PTSD symptoms. In this review, we summarize recent finding...
Source: Current Opinion in Neurobiology - December 14, 2023 Category: Neurology Authors: Leland L Fleming Nathaniel G Harnett Kerry J Ressler Source Type: research
Descending control of motor sequences in Drosophila
Curr Opin Neurobiol. 2023 Dec 13;84:102822. doi: 10.1016/j.conb.2023.102822. Online ahead of print.ABSTRACTThe descending neurons connecting the fly's brain to its ventral nerve cord respond to sensory stimuli and evoke motor programs of varying complexity. Anatomical characterization of the descending neurons and their synaptic connections suggests how these circuits organize movements, while optogenetic manipulation of their activity reveals what behaviors they can induce. Monitoring their responses to sensory stimuli or during behavior performance indicates what information they may encode. Recent advances in all three ...
Source: Current Opinion in Neurobiology - December 14, 2023 Category: Neurology Authors: Julie H Simpson Source Type: research
Sensory alterations in post-traumatic stress disorder
Curr Opin Neurobiol. 2023 Dec 13;84:102821. doi: 10.1016/j.conb.2023.102821. Online ahead of print.ABSTRACTPTSD is characterized by difficulties in accurately evaluating the threat value of sensory stimuli. While the role of canonical fear and threat neural circuitry in this ability has been well studied, recent lines of evidence suggest a need to include more emphasis on sensory processing in the conceptualization of PTSD symptomology. Specifically, studies have demonstrated a strong association between variability in sensory processing regions and the severity of PTSD symptoms. In this review, we summarize recent finding...
Source: Current Opinion in Neurobiology - December 14, 2023 Category: Neurology Authors: Leland L Fleming Nathaniel G Harnett Kerry J Ressler Source Type: research
Descending control of motor sequences in Drosophila
Curr Opin Neurobiol. 2023 Dec 13;84:102822. doi: 10.1016/j.conb.2023.102822. Online ahead of print.ABSTRACTThe descending neurons connecting the fly's brain to its ventral nerve cord respond to sensory stimuli and evoke motor programs of varying complexity. Anatomical characterization of the descending neurons and their synaptic connections suggests how these circuits organize movements, while optogenetic manipulation of their activity reveals what behaviors they can induce. Monitoring their responses to sensory stimuli or during behavior performance indicates what information they may encode. Recent advances in all three ...
Source: Current Opinion in Neurobiology - December 14, 2023 Category: Neurology Authors: Julie H Simpson Source Type: research
