Sensory alterations in post-traumatic stress disorder
Curr Opin Neurobiol. 2023 Dec 13;84:102821. doi: 10.1016/j.conb.2023.102821. Online ahead of print.ABSTRACTPTSD is characterized by difficulties in accurately evaluating the threat value of sensory stimuli. While the role of canonical fear and threat neural circuitry in this ability has been well studied, recent lines of evidence suggest a need to include more emphasis on sensory processing in the conceptualization of PTSD symptomology. Specifically, studies have demonstrated a strong association between variability in sensory processing regions and the severity of PTSD symptoms. In this review, we summarize recent finding...
Source: Current Opinion in Neurobiology - December 14, 2023 Category: Neurology Authors: Leland L Fleming Nathaniel G Harnett Kerry J Ressler Source Type: research
Neurobiology of schizophrenia
Curr Opin Neurobiol. 2023 Dec 12;84:102820. doi: 10.1016/j.conb.2023.102820. Online ahead of print.NO ABSTRACTPMID:38091860 | DOI:10.1016/j.conb.2023.102820 (Source: Current Opinion in Neurobiology)
Source: Current Opinion in Neurobiology - December 13, 2023 Category: Neurology Authors: Vikaas S Sohal Source Type: research
Neurobiology of schizophrenia
Curr Opin Neurobiol. 2023 Dec 12;84:102820. doi: 10.1016/j.conb.2023.102820. Online ahead of print.NO ABSTRACTPMID:38091860 | DOI:10.1016/j.conb.2023.102820 (Source: Current Opinion in Neurobiology)
Source: Current Opinion in Neurobiology - December 13, 2023 Category: Neurology Authors: Vikaas S Sohal Source Type: research
Editorial overview: Metabolic underpinnings of normal and diseased neural function
Curr Opin Neurobiol. 2023 Dec 11;84:102819. doi: 10.1016/j.conb.2023.102819. Online ahead of print.NO ABSTRACTPMID:38086171 | DOI:10.1016/j.conb.2023.102819 (Source: Current Opinion in Neurobiology)
Source: Current Opinion in Neurobiology - December 12, 2023 Category: Neurology Authors: Russell H Swerdlow Inna Slutsky Source Type: research
Editorial overview: Metabolic underpinnings of normal and diseased neural function
Curr Opin Neurobiol. 2023 Dec 11;84:102819. doi: 10.1016/j.conb.2023.102819. Online ahead of print.NO ABSTRACTPMID:38086171 | DOI:10.1016/j.conb.2023.102819 (Source: Current Opinion in Neurobiology)
Source: Current Opinion in Neurobiology - December 12, 2023 Category: Neurology Authors: Russell H Swerdlow Inna Slutsky Source Type: research
Network attractors and nonlinear dynamics of neural computation
Curr Opin Neurobiol. 2023 Dec 8;84:102818. doi: 10.1016/j.conb.2023.102818. Online ahead of print.ABSTRACTThe importance of understanding the nonlinear dynamics of neural systems, and the relation to cognitive systems more generally, has been recognised for a long time. Approaches that analyse neural systems in terms of attractors of autonomous networks can be successful in explaining system behaviours in the input-free case. Nonetheless, a computational system usually needs inputs from its environment to effectively solve problems, and this necessitates a non-autonomous framework where typically the effects of a changing ...
Source: Current Opinion in Neurobiology - December 9, 2023 Category: Neurology Authors: Peter Ashwin Muhammed Fadera Claire Postlethwaite Source Type: research
Network attractors and nonlinear dynamics of neural computation
Curr Opin Neurobiol. 2023 Dec 8;84:102818. doi: 10.1016/j.conb.2023.102818. Online ahead of print.ABSTRACTThe importance of understanding the nonlinear dynamics of neural systems, and the relation to cognitive systems more generally, has been recognised for a long time. Approaches that analyse neural systems in terms of attractors of autonomous networks can be successful in explaining system behaviours in the input-free case. Nonetheless, a computational system usually needs inputs from its environment to effectively solve problems, and this necessitates a non-autonomous framework where typically the effects of a changing ...
Source: Current Opinion in Neurobiology - December 9, 2023 Category: Neurology Authors: Peter Ashwin Muhammed Fadera Claire Postlethwaite Source Type: research
Network attractors and nonlinear dynamics of neural computation
Curr Opin Neurobiol. 2023 Dec 8;84:102818. doi: 10.1016/j.conb.2023.102818. Online ahead of print.ABSTRACTThe importance of understanding the nonlinear dynamics of neural systems, and the relation to cognitive systems more generally, has been recognised for a long time. Approaches that analyse neural systems in terms of attractors of autonomous networks can be successful in explaining system behaviours in the input-free case. Nonetheless, a computational system usually needs inputs from its environment to effectively solve problems, and this necessitates a non-autonomous framework where typically the effects of a changing ...
Source: Current Opinion in Neurobiology - December 9, 2023 Category: Neurology Authors: Peter Ashwin Muhammed Fadera Claire Postlethwaite Source Type: research
Grounding neuroscience in behavioral changes using artificial neural networks
Curr Opin Neurobiol. 2023 Dec 4;84:102816. doi: 10.1016/j.conb.2023.102816. Online ahead of print.ABSTRACTConnecting neural activity to function is a common aim in neuroscience. How to define and conceptualize function, however, can vary. Here I focus on grounding this goal in the specific question of how a given change in behavior is produced by a change in neural circuits or activity. Artificial neural network models offer a particularly fruitful format for tackling such questions because they use neural mechanisms to perform complex transformations and produce appropriate behavior. Therefore, they can be a means of caus...
Source: Current Opinion in Neurobiology - December 5, 2023 Category: Neurology Authors: Grace W Lindsay Source Type: research
Grounding neuroscience in behavioral changes using artificial neural networks
Curr Opin Neurobiol. 2023 Dec 4;84:102816. doi: 10.1016/j.conb.2023.102816. Online ahead of print.ABSTRACTConnecting neural activity to function is a common aim in neuroscience. How to define and conceptualize function, however, can vary. Here I focus on grounding this goal in the specific question of how a given change in behavior is produced by a change in neural circuits or activity. Artificial neural network models offer a particularly fruitful format for tackling such questions because they use neural mechanisms to perform complex transformations and produce appropriate behavior. Therefore, they can be a means of caus...
Source: Current Opinion in Neurobiology - December 5, 2023 Category: Neurology Authors: Grace W Lindsay Source Type: research
Grounding neuroscience in behavioral changes using artificial neural networks
Curr Opin Neurobiol. 2023 Dec 4;84:102816. doi: 10.1016/j.conb.2023.102816. Online ahead of print.ABSTRACTConnecting neural activity to function is a common aim in neuroscience. How to define and conceptualize function, however, can vary. Here I focus on grounding this goal in the specific question of how a given change in behavior is produced by a change in neural circuits or activity. Artificial neural network models offer a particularly fruitful format for tackling such questions because they use neural mechanisms to perform complex transformations and produce appropriate behavior. Therefore, they can be a means of caus...
Source: Current Opinion in Neurobiology - December 5, 2023 Category: Neurology Authors: Grace W Lindsay Source Type: research
Grounding neuroscience in behavioral changes using artificial neural networks
Curr Opin Neurobiol. 2023 Dec 4;84:102816. doi: 10.1016/j.conb.2023.102816. Online ahead of print.ABSTRACTConnecting neural activity to function is a common aim in neuroscience. How to define and conceptualize function, however, can vary. Here I focus on grounding this goal in the specific question of how a given change in behavior is produced by a change in neural circuits or activity. Artificial neural network models offer a particularly fruitful format for tackling such questions because they use neural mechanisms to perform complex transformations and produce appropriate behavior. Therefore, they can be a means of caus...
Source: Current Opinion in Neurobiology - December 5, 2023 Category: Neurology Authors: Grace W Lindsay Source Type: research
Impacts of sex differences on optogenetic, chemogenetic, and calcium-imaging tools
Curr Opin Neurobiol. 2023 Dec 1;84:102817. doi: 10.1016/j.conb.2023.102817. Online ahead of print.ABSTRACTTechnical innovation in neuroscience introduced powerful tools for measuring and manipulating neuronal activity via optical, chemogenetic, and calcium-imaging tools. These tools were initially tested primarily in male animals but are now increasingly being used in females as well. In this review, we consider how these tools may work differently in males and females. For example, we review sex differences in the metabolism of chemogenetic ligands and their downstream signaling effects. Optical tools more directly alter ...
Source: Current Opinion in Neurobiology - December 2, 2023 Category: Neurology Authors: Valentina I Cea Salazar Melvin Perez A J Robison Brian C Trainor Source Type: research
Impacts of sex differences on optogenetic, chemogenetic, and calcium-imaging tools
Curr Opin Neurobiol. 2023 Dec 1;84:102817. doi: 10.1016/j.conb.2023.102817. Online ahead of print.ABSTRACTTechnical innovation in neuroscience introduced powerful tools for measuring and manipulating neuronal activity via optical, chemogenetic, and calcium-imaging tools. These tools were initially tested primarily in male animals but are now increasingly being used in females as well. In this review, we consider how these tools may work differently in males and females. For example, we review sex differences in the metabolism of chemogenetic ligands and their downstream signaling effects. Optical tools more directly alter ...
Source: Current Opinion in Neurobiology - December 2, 2023 Category: Neurology Authors: Valentina I Cea Salazar Melvin Perez A J Robison Brian C Trainor Source Type: research
Impacts of sex differences on optogenetic, chemogenetic, and calcium-imaging tools
Curr Opin Neurobiol. 2023 Dec 1;84:102817. doi: 10.1016/j.conb.2023.102817. Online ahead of print.ABSTRACTTechnical innovation in neuroscience introduced powerful tools for measuring and manipulating neuronal activity via optical, chemogenetic, and calcium-imaging tools. These tools were initially tested primarily in male animals but are now increasingly being used in females as well. In this review, we consider how these tools may work differently in males and females. For example, we review sex differences in the metabolism of chemogenetic ligands and their downstream signaling effects. Optical tools more directly alter ...
Source: Current Opinion in Neurobiology - December 2, 2023 Category: Neurology Authors: Valentina I Cea Salazar Melvin Perez A J Robison Brian C Trainor Source Type: research
