Human reaching control in dynamic environments
Curr Opin Neurobiol. 2023 Nov 9;83:102810. doi: 10.1016/j.conb.2023.102810. Online ahead of print.ABSTRACTClosed-loop models of movement control have attracted growing interest in how the nervous system transforms sensory information into motor commands, and several brain structures have been identified as neural substrates for these computational operations. Recently, several studies have focused on how these models need to be updated when environmental parameters change. Current evidence suggests that when the task changes, rapid control updates enable flexible modifications of current actions and online decisions. At th...
Source: Current Opinion in Neurobiology - November 11, 2023 Category: Neurology Authors: Hari T Kalidindi Fr édéric Crevecoeur Source Type: research
Structural insights into gating mechanism and allosteric regulation of NMDA receptors
Curr Opin Neurobiol. 2023 Nov 8;83:102806. doi: 10.1016/j.conb.2023.102806. Online ahead of print.ABSTRACTN-methyl-d-aspartate receptors (NMDARs) belong to the ionotropic glutamate receptors (iGluRs) superfamily and act as coincidence detectors that are crucial to neuronal development and synaptic plasticity. They typically assemble as heterotetramers of two obligatory GluN1 subunits and two alternative GluN2 (from 2A to 2D) and/or GluN3 (3A and 3B) subunits. These alternative subunits mainly determine the diverse biophysical and pharmacological properties of different NMDAR subtypes. Over the past decade, the unprecedente...
Source: Current Opinion in Neurobiology - November 11, 2023 Category: Neurology Authors: Enjiang Wu Jilin Zhang Jiwei Zhang Shujia Zhu Source Type: research
Human reaching control in dynamic environments
Curr Opin Neurobiol. 2023 Nov 9;83:102810. doi: 10.1016/j.conb.2023.102810. Online ahead of print.ABSTRACTClosed-loop models of movement control have attracted growing interest in how the nervous system transforms sensory information into motor commands, and several brain structures have been identified as neural substrates for these computational operations. Recently, several studies have focused on how these models need to be updated when environmental parameters change. Current evidence suggests that when the task changes, rapid control updates enable flexible modifications of current actions and online decisions. At th...
Source: Current Opinion in Neurobiology - November 11, 2023 Category: Neurology Authors: Hari T Kalidindi Fr édéric Crevecoeur Source Type: research
Structural insights into gating mechanism and allosteric regulation of NMDA receptors
Curr Opin Neurobiol. 2023 Nov 8;83:102806. doi: 10.1016/j.conb.2023.102806. Online ahead of print.ABSTRACTN-methyl-d-aspartate receptors (NMDARs) belong to the ionotropic glutamate receptors (iGluRs) superfamily and act as coincidence detectors that are crucial to neuronal development and synaptic plasticity. They typically assemble as heterotetramers of two obligatory GluN1 subunits and two alternative GluN2 (from 2A to 2D) and/or GluN3 (3A and 3B) subunits. These alternative subunits mainly determine the diverse biophysical and pharmacological properties of different NMDAR subtypes. Over the past decade, the unprecedente...
Source: Current Opinion in Neurobiology - November 11, 2023 Category: Neurology Authors: Enjiang Wu Jilin Zhang Jiwei Zhang Shujia Zhu Source Type: research
Diversity of neuropeptidergic modulation in decapod crustacean cardiac and feeding systems
Curr Opin Neurobiol. 2023 Nov 1;83:102802. doi: 10.1016/j.conb.2023.102802. Online ahead of print.ABSTRACTAll nervous systems are multiply modulated by polypeptides. However, a bulk of transmitter and modulation research has historically focused on small molecule transmitters released at synaptic sites. The stomatogastric nervous system (controls digestive movements of the foregut) and cardiac nervous system of decapod crustaceans have long been used to understand the processes that underlie neuromodulation. The circuits governing the rhythmic output from these nervous systems are comprised of a relatively small number of ...
Source: Current Opinion in Neurobiology - November 3, 2023 Category: Neurology Authors: Patsy S Dickinson Daniel J Powell Source Type: research
Diversity of neuropeptidergic modulation in decapod crustacean cardiac and feeding systems
Curr Opin Neurobiol. 2023 Nov 1;83:102802. doi: 10.1016/j.conb.2023.102802. Online ahead of print.ABSTRACTAll nervous systems are multiply modulated by polypeptides. However, a bulk of transmitter and modulation research has historically focused on small molecule transmitters released at synaptic sites. The stomatogastric nervous system (controls digestive movements of the foregut) and cardiac nervous system of decapod crustaceans have long been used to understand the processes that underlie neuromodulation. The circuits governing the rhythmic output from these nervous systems are comprised of a relatively small number of ...
Source: Current Opinion in Neurobiology - November 3, 2023 Category: Neurology Authors: Patsy S Dickinson Daniel J Powell Source Type: research
Diversity of neuropeptidergic modulation in decapod crustacean cardiac and feeding systems
Curr Opin Neurobiol. 2023 Nov 1;83:102802. doi: 10.1016/j.conb.2023.102802. Online ahead of print.ABSTRACTAll nervous systems are multiply modulated by polypeptides. However, a bulk of transmitter and modulation research has historically focused on small molecule transmitters released at synaptic sites. The stomatogastric nervous system (controls digestive movements of the foregut) and cardiac nervous system of decapod crustaceans have long been used to understand the processes that underlie neuromodulation. The circuits governing the rhythmic output from these nervous systems are comprised of a relatively small number of ...
Source: Current Opinion in Neurobiology - November 3, 2023 Category: Neurology Authors: Patsy S Dickinson Daniel J Powell Source Type: research
Diversity of neuropeptidergic modulation in decapod crustacean cardiac and feeding systems
Curr Opin Neurobiol. 2023 Nov 1;83:102802. doi: 10.1016/j.conb.2023.102802. Online ahead of print.ABSTRACTAll nervous systems are multiply modulated by polypeptides. However, a bulk of transmitter and modulation research has historically focused on small molecule transmitters released at synaptic sites. The stomatogastric nervous system (controls digestive movements of the foregut) and cardiac nervous system of decapod crustaceans have long been used to understand the processes that underlie neuromodulation. The circuits governing the rhythmic output from these nervous systems are comprised of a relatively small number of ...
Source: Current Opinion in Neurobiology - November 3, 2023 Category: Neurology Authors: Patsy S Dickinson Daniel J Powell Source Type: research
Diversity of neuropeptidergic modulation in decapod crustacean cardiac and feeding systems
Curr Opin Neurobiol. 2023 Nov 1;83:102802. doi: 10.1016/j.conb.2023.102802. Online ahead of print.ABSTRACTAll nervous systems are multiply modulated by polypeptides. However, a bulk of transmitter and modulation research has historically focused on small molecule transmitters released at synaptic sites. The stomatogastric nervous system (controls digestive movements of the foregut) and cardiac nervous system of decapod crustaceans have long been used to understand the processes that underlie neuromodulation. The circuits governing the rhythmic output from these nervous systems are comprised of a relatively small number of ...
Source: Current Opinion in Neurobiology - November 3, 2023 Category: Neurology Authors: Patsy S Dickinson Daniel J Powell Source Type: research
Making time and space for calcium control of neuron activity
Curr Opin Neurobiol. 2023 Oct 30;83:102804. doi: 10.1016/j.conb.2023.102804. Online ahead of print.ABSTRACTCalcium directly controls or indirectly regulates numerous functions that are critical for neuronal network activity. Intracellular calcium concentration is tightly regulated by numerous molecular mechanisms because spatial domains and temporal dynamics (not just peak amplitude) are critical for calcium control of synaptic plasticity and ion channel activation, which in turn determine neuron spiking activity. The computational models investigating calcium control are valuable because experiments achieving high spatial...
Source: Current Opinion in Neurobiology - November 1, 2023 Category: Neurology Authors: Joanna J ędrzejewska-Szmek Daniel B Dorman Kim T Blackwell Source Type: research
The coordination of chewing
Curr Opin Neurobiol. 2023 Oct 30;83:102805. doi: 10.1016/j.conb.2023.102805. Online ahead of print.ABSTRACTFeeding behavior involves a complex organization of neural circuitry and interconnected pathways between the cortex, the brainstem, and muscles. Elevated synchronicity is required starting from the moment the animal brings the food to its mouth, chews, and initiates subsequent swallowing. Moreover, orofacial sensory and motor systems are coordinated in a way to optimize movement patterns as a result of integrating information from premotor neurons. Recent studies have uncovered significant discoveries employing variou...
Source: Current Opinion in Neurobiology - November 1, 2023 Category: Neurology Authors: Dominic Falardeau Sophia Dubois Arlette Kolta Source Type: research
Making time and space for calcium control of neuron activity
Curr Opin Neurobiol. 2023 Oct 30;83:102804. doi: 10.1016/j.conb.2023.102804. Online ahead of print.ABSTRACTCalcium directly controls or indirectly regulates numerous functions that are critical for neuronal network activity. Intracellular calcium concentration is tightly regulated by numerous molecular mechanisms because spatial domains and temporal dynamics (not just peak amplitude) are critical for calcium control of synaptic plasticity and ion channel activation, which in turn determine neuron spiking activity. The computational models investigating calcium control are valuable because experiments achieving high spatial...
Source: Current Opinion in Neurobiology - November 1, 2023 Category: Neurology Authors: Joanna J ędrzejewska-Szmek Daniel B Dorman Kim T Blackwell Source Type: research
The coordination of chewing
Curr Opin Neurobiol. 2023 Oct 30;83:102805. doi: 10.1016/j.conb.2023.102805. Online ahead of print.ABSTRACTFeeding behavior involves a complex organization of neural circuitry and interconnected pathways between the cortex, the brainstem, and muscles. Elevated synchronicity is required starting from the moment the animal brings the food to its mouth, chews, and initiates subsequent swallowing. Moreover, orofacial sensory and motor systems are coordinated in a way to optimize movement patterns as a result of integrating information from premotor neurons. Recent studies have uncovered significant discoveries employing variou...
Source: Current Opinion in Neurobiology - November 1, 2023 Category: Neurology Authors: Dominic Falardeau Sophia Dubois Arlette Kolta Source Type: research
Making time and space for calcium control of neuron activity
Curr Opin Neurobiol. 2023 Oct 30;83:102804. doi: 10.1016/j.conb.2023.102804. Online ahead of print.ABSTRACTCalcium directly controls or indirectly regulates numerous functions that are critical for neuronal network activity. Intracellular calcium concentration is tightly regulated by numerous molecular mechanisms because spatial domains and temporal dynamics (not just peak amplitude) are critical for calcium control of synaptic plasticity and ion channel activation, which in turn determine neuron spiking activity. The computational models investigating calcium control are valuable because experiments achieving high spatial...
Source: Current Opinion in Neurobiology - November 1, 2023 Category: Neurology Authors: Joanna J ędrzejewska-Szmek Daniel B Dorman Kim T Blackwell Source Type: research
The coordination of chewing
Curr Opin Neurobiol. 2023 Oct 30;83:102805. doi: 10.1016/j.conb.2023.102805. Online ahead of print.ABSTRACTFeeding behavior involves a complex organization of neural circuitry and interconnected pathways between the cortex, the brainstem, and muscles. Elevated synchronicity is required starting from the moment the animal brings the food to its mouth, chews, and initiates subsequent swallowing. Moreover, orofacial sensory and motor systems are coordinated in a way to optimize movement patterns as a result of integrating information from premotor neurons. Recent studies have uncovered significant discoveries employing variou...
Source: Current Opinion in Neurobiology - November 1, 2023 Category: Neurology Authors: Dominic Falardeau Sophia Dubois Arlette Kolta Source Type: research
