Arkypallidal neurons in basal ganglia circuits: Unveiling novel pallidostriatal loops?
Curr Opin Neurobiol. 2023 Nov 27;84:102814. doi: 10.1016/j.conb.2023.102814. Online ahead of print.ABSTRACTJust over a decade ago, a novel GABAergic input originating from a subpopulation of external globus pallidus neurons known as Arkypallidal and projecting exclusively to the striatum was unveiled. At the single-cell level, these pallidostriatal Arkypallidal projections represent one of the largest extrinsic sources of GABA known to innervate the dorsal striatum. This discovery has sparked new questions regarding their role in striatal information processing, the circuit that recruit these neurons, and their influence o...
Source: Current Opinion in Neurobiology - November 28, 2023 Category: Neurology Authors: Lise Guilhemsang Nicolas P Mallet Source Type: research
Arkypallidal neurons in basal ganglia circuits: Unveiling novel pallidostriatal loops?
Curr Opin Neurobiol. 2023 Nov 27;84:102814. doi: 10.1016/j.conb.2023.102814. Online ahead of print.ABSTRACTJust over a decade ago, a novel GABAergic input originating from a subpopulation of external globus pallidus neurons known as Arkypallidal and projecting exclusively to the striatum was unveiled. At the single-cell level, these pallidostriatal Arkypallidal projections represent one of the largest extrinsic sources of GABA known to innervate the dorsal striatum. This discovery has sparked new questions regarding their role in striatal information processing, the circuit that recruit these neurons, and their influence o...
Source: Current Opinion in Neurobiology - November 28, 2023 Category: Neurology Authors: Lise Guilhemsang Nicolas P Mallet Source Type: research
Mechanisms of NMDA receptor regulation
Curr Opin Neurobiol. 2023 Nov 20;83:102815. doi: 10.1016/j.conb.2023.102815. Online ahead of print.ABSTRACTN-methyl-D-aspartate receptors (NMDARs) are glutamate-gated ion channels widely expressed in the central nervous system that play key role in brain development and plasticity. On the downside, NMDAR dysfunction, be it hyperactivity or hypofunction, is harmful to neuronal function and has emerged as a common theme in various neuropsychiatric disorders including autism spectrum disorders, epilepsy, intellectual disability, and schizophrenia. Not surprisingly, NMDAR signaling is under a complex set of regulatory mechanis...
Source: Current Opinion in Neurobiology - November 21, 2023 Category: Neurology Authors: Laetitia Mony Pierre Paoletti Source Type: research
Mechanisms of NMDA receptor regulation
Curr Opin Neurobiol. 2023 Nov 20;83:102815. doi: 10.1016/j.conb.2023.102815. Online ahead of print.ABSTRACTN-methyl-D-aspartate receptors (NMDARs) are glutamate-gated ion channels widely expressed in the central nervous system that play key role in brain development and plasticity. On the downside, NMDAR dysfunction, be it hyperactivity or hypofunction, is harmful to neuronal function and has emerged as a common theme in various neuropsychiatric disorders including autism spectrum disorders, epilepsy, intellectual disability, and schizophrenia. Not surprisingly, NMDAR signaling is under a complex set of regulatory mechanis...
Source: Current Opinion in Neurobiology - November 21, 2023 Category: Neurology Authors: Laetitia Mony Pierre Paoletti Source Type: research
Mechanisms of NMDA receptor regulation
Curr Opin Neurobiol. 2023 Nov 20;83:102815. doi: 10.1016/j.conb.2023.102815. Online ahead of print.ABSTRACTN-methyl-D-aspartate receptors (NMDARs) are glutamate-gated ion channels widely expressed in the central nervous system that play key role in brain development and plasticity. On the downside, NMDAR dysfunction, be it hyperactivity or hypofunction, is harmful to neuronal function and has emerged as a common theme in various neuropsychiatric disorders including autism spectrum disorders, epilepsy, intellectual disability, and schizophrenia. Not surprisingly, NMDAR signaling is under a complex set of regulatory mechanis...
Source: Current Opinion in Neurobiology - November 21, 2023 Category: Neurology Authors: Laetitia Mony Pierre Paoletti Source Type: research
Mechanisms of NMDA receptor regulation
Curr Opin Neurobiol. 2023 Nov 20;83:102815. doi: 10.1016/j.conb.2023.102815. Online ahead of print.ABSTRACTN-methyl-D-aspartate receptors (NMDARs) are glutamate-gated ion channels widely expressed in the central nervous system that play key role in brain development and plasticity. On the downside, NMDAR dysfunction, be it hyperactivity or hypofunction, is harmful to neuronal function and has emerged as a common theme in various neuropsychiatric disorders including autism spectrum disorders, epilepsy, intellectual disability, and schizophrenia. Not surprisingly, NMDAR signaling is under a complex set of regulatory mechanis...
Source: Current Opinion in Neurobiology - November 21, 2023 Category: Neurology Authors: Laetitia Mony Pierre Paoletti Source Type: research
Mechanisms of NMDA receptor regulation
Curr Opin Neurobiol. 2023 Nov 20;83:102815. doi: 10.1016/j.conb.2023.102815. Online ahead of print.ABSTRACTN-methyl-D-aspartate receptors (NMDARs) are glutamate-gated ion channels widely expressed in the central nervous system that play key role in brain development and plasticity. On the downside, NMDAR dysfunction, be it hyperactivity or hypofunction, is harmful to neuronal function and has emerged as a common theme in various neuropsychiatric disorders including autism spectrum disorders, epilepsy, intellectual disability, and schizophrenia. Not surprisingly, NMDAR signaling is under a complex set of regulatory mechanis...
Source: Current Opinion in Neurobiology - November 21, 2023 Category: Neurology Authors: Laetitia Mony Pierre Paoletti Source Type: research
Mechanisms of NMDA receptor regulation
Curr Opin Neurobiol. 2023 Nov 20;83:102815. doi: 10.1016/j.conb.2023.102815. Online ahead of print.ABSTRACTN-methyl-D-aspartate receptors (NMDARs) are glutamate-gated ion channels widely expressed in the central nervous system that play key role in brain development and plasticity. On the downside, NMDAR dysfunction, be it hyperactivity or hypofunction, is harmful to neuronal function and has emerged as a common theme in various neuropsychiatric disorders including autism spectrum disorders, epilepsy, intellectual disability, and schizophrenia. Not surprisingly, NMDAR signaling is under a complex set of regulatory mechanis...
Source: Current Opinion in Neurobiology - November 21, 2023 Category: Neurology Authors: Laetitia Mony Pierre Paoletti Source Type: research
Fast Hebbian plasticity and working memory
Curr Opin Neurobiol. 2023 Nov 17;83:102809. doi: 10.1016/j.conb.2023.102809. Online ahead of print.ABSTRACTTheories and models of working memory (WM) were at least since the mid-1990s dominated by the persistent activity hypothesis. The past decade has seen rising concerns about the shortcomings of sustained activity as the mechanism for short-term maintenance of WM information in the light of accumulating experimental evidence for so-called activity-silent WM and the fundamental difficulty in explaining robust multi-item WM. In consequence, alternative theories are now explored mostly in the direction of fast synaptic pla...
Source: Current Opinion in Neurobiology - November 19, 2023 Category: Neurology Authors: Anders Lansner Florian Fiebig Pawel Herman Source Type: research
Dendrites and efficiency: Optimizing performance and resource utilization
Curr Opin Neurobiol. 2023 Nov 17;83:102812. doi: 10.1016/j.conb.2023.102812. Online ahead of print.ABSTRACTThe brain is a highly efficient system that has evolved to optimize performance under limited resources. In this review, we highlight recent theoretical and experimental studies that support the view that dendrites make information processing and storage in the brain more efficient. This is achieved through the dynamic modulation of integration versus segregation of inputs and activity within a neuron. We argue that under conditions of limited energy and space, dendrites help biological networks to implement complex f...
Source: Current Opinion in Neurobiology - November 19, 2023 Category: Neurology Authors: Roman Makarov Michalis Pagkalos Panayiota Poirazi Source Type: research
Redefining stroke rehabilitation: Mobilizing the embodied goal-oriented brain
Curr Opin Neurobiol. 2023 Nov 17;83:102807. doi: 10.1016/j.conb.2023.102807. Online ahead of print.ABSTRACTAdvancements in stroke rehabilitation remain limited and call for a reorientation. Based on recent results, this study proposes a network-centric perspective on stroke, positing that it not only causes localized deficits but also affects the brain's intricate network of networks, transiting it into a pathological state. Translating these system-level insights into interventions requires brain theory, and the Distributed Adaptive Control (DAC) theory offers such a framework. When applied in the rehabilitation gaming sy...
Source: Current Opinion in Neurobiology - November 19, 2023 Category: Neurology Authors: Paul F M J Verschure Francisco P áscoa Dos Santos Vivek Sharma Source Type: research
Fast Hebbian plasticity and working memory
Curr Opin Neurobiol. 2023 Nov 17;83:102809. doi: 10.1016/j.conb.2023.102809. Online ahead of print.ABSTRACTTheories and models of working memory (WM) were at least since the mid-1990s dominated by the persistent activity hypothesis. The past decade has seen rising concerns about the shortcomings of sustained activity as the mechanism for short-term maintenance of WM information in the light of accumulating experimental evidence for so-called activity-silent WM and the fundamental difficulty in explaining robust multi-item WM. In consequence, alternative theories are now explored mostly in the direction of fast synaptic pla...
Source: Current Opinion in Neurobiology - November 19, 2023 Category: Neurology Authors: Anders Lansner Florian Fiebig Pawel Herman Source Type: research
Dendrites and efficiency: Optimizing performance and resource utilization
Curr Opin Neurobiol. 2023 Nov 17;83:102812. doi: 10.1016/j.conb.2023.102812. Online ahead of print.ABSTRACTThe brain is a highly efficient system that has evolved to optimize performance under limited resources. In this review, we highlight recent theoretical and experimental studies that support the view that dendrites make information processing and storage in the brain more efficient. This is achieved through the dynamic modulation of integration versus segregation of inputs and activity within a neuron. We argue that under conditions of limited energy and space, dendrites help biological networks to implement complex f...
Source: Current Opinion in Neurobiology - November 19, 2023 Category: Neurology Authors: Roman Makarov Michalis Pagkalos Panayiota Poirazi Source Type: research
Redefining stroke rehabilitation: Mobilizing the embodied goal-oriented brain
Curr Opin Neurobiol. 2023 Nov 17;83:102807. doi: 10.1016/j.conb.2023.102807. Online ahead of print.ABSTRACTAdvancements in stroke rehabilitation remain limited and call for a reorientation. Based on recent results, this study proposes a network-centric perspective on stroke, positing that it not only causes localized deficits but also affects the brain's intricate network of networks, transiting it into a pathological state. Translating these system-level insights into interventions requires brain theory, and the Distributed Adaptive Control (DAC) theory offers such a framework. When applied in the rehabilitation gaming sy...
Source: Current Opinion in Neurobiology - November 19, 2023 Category: Neurology Authors: Paul F M J Verschure Francisco P áscoa Dos Santos Vivek Sharma Source Type: research
Understanding molecular signaling cascades in neural disease using multi-resolution models
Curr Opin Neurobiol. 2023 Nov 14;83:102808. doi: 10.1016/j.conb.2023.102808. Online ahead of print.ABSTRACTIf the genome defines the program for the operations of a cell, signaling networks execute it. These cascades of chemical, cell-biological, structural, and trafficking events span milliseconds (e.g., synaptic release) to potentially a lifetime (e.g., stabilization of dendritic spines). In principle almost every aspect of neuronal function, particularly at the synapse, depends on signaling. Thus dysfunction of these cascades, whether through mutations, local dysregulation, or infection, leads to disease. The sheer comp...
Source: Current Opinion in Neurobiology - November 16, 2023 Category: Neurology Authors: Nisha Ann Viswan Upinder Singh Bhalla Source Type: research
