Correction to: Art Therapy in Advanced Cancer. A Mapping Review of the Evidence
(Source: Current Oncology Reports)
Source: Current Oncology Reports - September 21, 2022 Category: Cancer & Oncology Source Type: research
Role of Interventional Radiology in Pediatric Cancer Patients
AbstractPurpose of ReviewPediatric interventional radiology (IR) is a growing subspecialty. Here, we review the current role of IR in children with cancer, which uses imaging such as ultrasound, fluoroscopy, and computed tomography to perform minimally invasive procedures. These include biopsy, needle localization, central venous access, thermal ablation, transarterial chemoembolization, transarterial radioembolization with yttrium-90, non-tunneled/tunneled drainage catheter placement, and lymphatic interventions.Recent FindingsAlthough locoregional therapies for the treatment of cancer in adults are common, they are less ...
Source: Current Oncology Reports - September 3, 2022 Category: Cancer & Oncology Source Type: research
Art Therapy in Advanced Cancer. A Mapping Review of the Evidence
AbstractPurpose of ReviewThe benefits of arts in improving well-being in end-of-life patients have been stated by the WHO. To inspire clinical practice and future research, we performed a mapping review of the current evidence on the effectiveness of art therapy interventions in stage III and IV cancer patients and their relatives.Recent FindingsWe identified 14 studies. Benefits reported by the authors were grouped as improved emotional and spiritual condition, symptom relief, perception of well-being, satisfaction, and helpfulness. As a body of evidence, notable limitations were observed: Only 1 study was a randomized co...
Source: Current Oncology Reports - August 23, 2022 Category: Cancer & Oncology Source Type: research
New Advances in Supportive Care: Chemoprotective Agents as Novel Opportunities in Geriatric Oncology
AbstractPurpose of ReviewTo explore the effectiveness of trilaciclib and ALRN-6924 in the prevention of cancer chemotherapy-induced toxicity in older patients. New chemoprotective agents are necessary because age is the main risk factor for chemotherapy complications that account largely for the poorer outcome of cancer in the elderly. Trilaciclib and ALRN-6924 cause a reversible block of the proliferation of normal cells through cell cycle arrest (CCA). With this mechanism, they may prevent the toxicity of cycle-active cancer treatment including neutropenia, anemia, thrombocytopenia, lymphopenia, mucositis, and alopecia.R...
Source: Current Oncology Reports - August 20, 2022 Category: Cancer & Oncology Source Type: research
Primary or Interval Debulking Surgery in Advanced Ovarian Cancer: a Personalized Decision —a Literature Review
AbstractPurpose of ReviewSummarize the writings published in the last 5 years on the management of surgery in the first line of treatment for advanced ovarian cancer.Recent FindingsFor patients with a significant tumor burden, the neoadjuvant chemotherapy therapy (NACT) with interval debulking surgery (IDS) strategy shows comparable efficacy than primary debulking surgery (PDS) in terms of survival in randomized studies with less morbidity.SummaryAdvanced epithelial ovarian cancer generates more than half cases a recurrence. First-line treatment is based on a chemotherapy regimen combining a platinum-based and a taxane-b...
Source: Current Oncology Reports - August 15, 2022 Category: Cancer & Oncology Source Type: research
Advancements in Low-Grade Serous Carcinoma of the Ovary and Peritoneum
AbstractPurpose of ReviewLow-grade serous ovarian cancer (LGSOC) is a rare form of epithelial ovarian cancer that generally exhibits a protracted course and is less sensitive to chemotherapy than high-grade serous ovarian cancer. Over the past decade, it has become clear that patients with LGSOC have a clinically distinct course and are molecularly and histologically unique from patients with high-grade serous ovarian cancer.Recent FindingsEndocrine therapy is frequently used for the treatment of patients with recurrent LGSOC and is now also part of the standard upfront treatment of this disease, with an ongoing phase III ...
Source: Current Oncology Reports - August 13, 2022 Category: Cancer & Oncology Source Type: research
Fertility-Sparing and Less Radical Surgery for Cervical Cancer
AbstractPurpose of ReviewPatients with early-stage cervical cancer who desire future fertility may be candidates for less radical surgery. We review the literature supporting this approach in early-stage disease.Recent FindingsRetrospective data have shown that in carefully selected patients, the risk of parametrial involvement is less than 1%. This has led to interest in moving away from radical surgery towards more conservative approaches. Data from the newly published ConCerv trial, a prospective study evaluating the feasibility of conservative surgery in women with early-stage, low-risk cervical carcinoma, suggest that...
Source: Current Oncology Reports - August 12, 2022 Category: Cancer & Oncology Source Type: research
Interventional Management of Portal Hypertension in Cancer Patients
AbstractPurpose of ReviewTo provide an overview of the classifications and clinical hallmarks of common cancer-related conditions that contribute to the high incidence of portal hypertension in this population and provide an update on currently available interventional radiology therapeutic approaches.Recent FindingsIn the last few decades, there have been significant advancements in understanding the pathophysiology of portal hypertension. This knowledge has led to the development of safer and more effective minimally invasive approaches. The main objective is to provide alternatives to prevent life-threatening complicati...
Source: Current Oncology Reports - August 12, 2022 Category: Cancer & Oncology Source Type: research
A Systematic Review and a Meta-analysis of Randomized Controlled Trials ’ Control Groups in Metastatic Hormone-Sensitive Prostate Cancer (mHSPC)
AbstractPurpose of ReviewDetermining the risk for progression or survival after standard androgen deprivation treatment (ADT) in metastatic hormone-sensitive prostate cancer (mHSPC) is essential for stratifying patients according to expected outcomes in future studies of treatment combination. This systematic review and meta-analysis aims to estimate the progression-free survival (PFS) and overall survival (OS) probabilities in the control group of randomized controlled trials (RCTs) of different regimens of standard androgen deprivation treatment (ADT) in mHSPC and to identify possible predictors of outcomes.Recent Findin...
Source: Current Oncology Reports - August 12, 2022 Category: Cancer & Oncology Source Type: research
Small Cell and Other Rare Histologic Types of Cervical Cancer
AbstractPurpose of ReviewThe goal of this paper was to summarize the recent evidence on rare subtypes of cervical cancer including small-cell carcinoma of the cervix (SCCC), gastric-type adenocarcinoma, and carcinosarcoma.Recent FindingsAll three cervical cancer subtypes are aggressive with poor treatment response and high recurrence rates. Molecular studies have identified various actionable mutations in both SCCC (PIK3CA, MYC, TP53, PTEN, ARID1A, KRAS, BRCA2) and gastric-type adenocarcinoma (KRAS, ARID1A, PTEN). While there are a limited number of case reports demonstrating a favorable response for recurrent SCCC to immu...
Source: Current Oncology Reports - August 10, 2022 Category: Cancer & Oncology Source Type: research
Effect of Post-diagnosis Physical Activity on Breast Cancer Recurrence: a Systematic Review and Meta-analysis
AbstractPurpose of ReviewBreast cancer (BC) recurrence dramatically decreases 5-year survival, which causes a fear of BC recurrence among a majority of BC survivors. Evidence is currently inconsistent on whether post-diagnosis recreational physical activity (rPA) can prevent BC recurrence due to the small number of included studies, as well as methodological heterogeneity among the studies. This systematic review aimed to clarify the association between post-diagnosis rPA and the risk of BC recurrence, by conducting a meta-analysis while controlling for the categories of rPA across the existing studies.Recent FindingsProsp...
Source: Current Oncology Reports - August 10, 2022 Category: Cancer & Oncology Source Type: research
Management of Peripheral T-cell Lymphomas and the Role of Transplant
AbstractPurpose of ReviewHere, we review the management of peripheral T-cell lymphoma, particularly focusing on the role of autologous and allogeneic stem cell transplant.Recent FindingsPeripheral T-cell lymphomas are a rare subset of non-Hodgkin ’s lymphomas that are treated with curative intent. While therapy has been based on other aggressive lymphoid malignancies, outcomes are generally poorer than B-cell lymphomas with 5-year overall and progression-free survival of 30–40% and 20–30%, respectively. In effort to improve outcomes, t ransplant has been used in both the frontline and salvage settings. Although not s...
Source: Current Oncology Reports - August 10, 2022 Category: Cancer & Oncology Source Type: research
Emerging Role of PARP Inhibitors in Metastatic Prostate Cancer
AbstractPurpose of ReviewWe highlight the clinical development of Poly (ADP-Ribose) polymerase (PARP) inhibitors in prostate cancer.Recent FindingsApproximately 10 to 30% of metastatic prostate cancer patients carry germline or somatic mutations in DNA repair pathways.BRCA2 is the most commonly mutated gene in DNA damage repair pathways. Because of its critical function in homologous recombination repair (HRR) machinery, deleteriousBRCA2 mutation enables synthetic lethality to a PARP inhibitor. Olaparib demonstrated clinical benefit in patients with deleterious mutations in HRR-related genes and most clearly in patients wi...
Source: Current Oncology Reports - August 6, 2022 Category: Cancer & Oncology Source Type: research
Brain Prehabilitation for Oncologic Surgery
AbstractPurpose of ReviewThis review aims to summarize the current research on postoperative cognitive complications, such as delirium and cognitive dysfunction. This includes discussion on preoperative preventive strategies, such as physical and nutritional prehabilitation as well as up-to-date information on neuroprehabilitation.Recent FindingsCurrent recommendations for prevention of postoperative delirium have focused on multicomponent interventions. The optimal composition of surgical prehabilitation programs targeting exercise and nutrition has not yet been established. The Neurobics Trial shows that cognitive prehab...
Source: Current Oncology Reports - July 28, 2022 Category: Cancer & Oncology Source Type: research
Older Patients with Lung Cancer: a Summary of Seminal Contributions to Optimal Patient Care
AbstractPurpose of ReviewThis review aspires to summarize the landmark advancements in the management of the non-small cell lung cancer (NSCLC), both historically and contemporarily with special focus in older adults.Recent FindingsThe past two decades have witnessed remarkable improvements in the diagnosis and management of lung cancer. Screening recommendations now facilitate earlier diagnosis in high-risk individuals, PET/CT scans have improved radiologic accuracy in identifying sites of disease, and surgical management with minimally invasive techniques has rendered surgery safer in those with limited physiologic reser...
Source: Current Oncology Reports - July 28, 2022 Category: Cancer & Oncology Source Type: research
