An Update on the Management of Bone Metastases
AbstractPurpose of ReviewIncreasing life expectancy among patients with advanced cancer has placed a greater emphasis on optimizing pain control and quality of life. Concurrently, significant advancements in radiotherapy for bone metastases have permitted for dose escalation strategies such as stereotactic radiotherapy. This review aims to provide updated information on the management of bone metastases in light of these developments.Recent FindingsWe reviewed recent studies regarding the role and details of external beam radiotherapy for bone metastases, with emphasis on differences by treatment site as well as intention ...
Source: Current Oncology Reports - March 28, 2024 Category: Cancer & Oncology Source Type: research
Novel Clinical Trials and Approaches in the Management of Glioblastoma
AbstractPurpose of ReviewThe purpose of this review is to discuss a wide variety of novel therapies recently studied or actively undergoing study in patients with glioblastoma. This review also discusses current and future strategies for improving clinical trial design in patients with glioblastoma to maximize efficacy in discovering effective treatments.Recent FindingsOver the years, there has been significant expansion in therapy modalities studied in patients with glioblastoma. These therapies include, but are not limited to, targeted molecular therapies, DNA repair pathway targeted therapies, immunotherapies, vaccine t...
Source: Current Oncology Reports - March 28, 2024 Category: Cancer & Oncology Source Type: research
Head and Neck Mucosal Melanoma: Where Are We Now?
AbstractPurpose of ReviewTo highlight recent and relevant treatment considerations while managing mucosal melanoma.Recent FindingsEvidence is building to support the use of targeted therapy and immunotherapy while managing mucosal melanoma.SummarySurgical resection with postoperative radiotherapy plays a major role in managing resectable disease. Recent studies evaluate the addition of targeted, and immunotherapies with an attempt to determine the most efficacious sequence of treatment. (Source: Current Oncology Reports)
Source: Current Oncology Reports - March 21, 2024 Category: Cancer & Oncology Source Type: research
Oral Complications and Management Strategies for Cancer Patients: Principles of Supportive Oncology in Dentistry
The objective of this work is to provide a scientific evidence-based protocol for oral care in cancer patients. Cancer resection surgery, chemotherapy, and radiotherapy can cause important complications that impact patients ’ quality of life.Recent FindingsCancer patients, from the moment of diagnosis to the end of treatment and subsequent follow-up, have diverse care needs, both from a systemic and local point of view. The implementation of oral care protocols before, during, and after cancer therapy is essential because it helps to identify risk factors for the development of predictable oral complications.SummaryIt is...
Source: Current Oncology Reports - March 19, 2024 Category: Cancer & Oncology Source Type: research
Novel Therapeutic Targets in Acute Myeloid Leukemia (AML)
AbstractPurpose of ReviewThis review seeks to identify and describe novel genetic and protein targets and their associated therapeutics currently being used or studied in the treatment of acute myeloid leukemia (AML).Recent FindingsOver the course of the last 5 –6 years, several targeted therapies have been approved by the FDA, for the treatment of both newly diagnosed as well as relapsed/refractory AML. These novel therapeutics, as well as several others currently under investigation, have demonstrated activity in AML and have improved outcomes for man y patients.SummaryPatient outcomes in AML have slowly improved over...
Source: Current Oncology Reports - March 19, 2024 Category: Cancer & Oncology Source Type: research
Cerebrospinal Fluid Liquid Biopsies in the Evaluation of Adult Gliomas
AbstractPurpose of ReviewThis review aims to discuss recent research regarding the biomolecules explored in liquid biopsies and their potential clinical uses for adult-type diffuse gliomas.Recent FindingsEvaluation of tumor biomolecules via cerebrospinal fluid (CSF) is an emerging technology in neuro-oncology. Studies to date have already identified various circulating tumor DNA, extracellular vesicle, micro-messenger RNA and protein biomarkers of interest. These biomarkers show potential to assist in multiple avenues of central nervous system (CNS) tumor evaluation, including tumor differentiation and diagnosis, treatment...
Source: Current Oncology Reports - March 15, 2024 Category: Cancer & Oncology Source Type: research
Metronomic Chemotherapy in Elderly Patients
AbstractPurpose of ReviewThis review describes the most relevant studies found in the scientific literature regarding metronomic chemotherapy (MCT) in the geriatric oncology population to support its use as a feasible treatment of care in the frail elderly patients.Recent FindingsRecent years have seen a reevaluation of cancer chemotherapeutic drugs and MCT is an emerging schedule in phase II and III clinical trials.SummaryAgeing is one of the risk factors for the development of cancer, the incidence of whom increases dramatically in people who live longer. To date, standard oncological protocols involve chemotherapeutic d...
Source: Current Oncology Reports - March 7, 2024 Category: Cancer & Oncology Source Type: research
Lymph Node Dissection in Testicular Cancer: The State of the Art and Future Perspectives
AbstractPurpose of ReviewThis narrative review provides a comprehensive overview of the evolving role of retroperitoneal lymph node dissection (RPLND) in the management of testicular cancer (TC). It explores the significance of RPLND as both a diagnostic and therapeutic tool, highlighting its contribution to accurate staging, its impact on oncological outcomes, and its influence on subsequent treatment decisions.Recent FindingsRPLND serves as an essential diagnostic procedure, aiding in the precise assessment of lymph node involvement and guiding personalized treatment strategies. It has demonstrated therapeutic value, par...
Source: Current Oncology Reports - March 2, 2024 Category: Cancer & Oncology Source Type: research
An Integrated Care Approach to Improve Well-Being in Breast Cancer Patients
ConclusionsIn the context of a patient-centered care, BC treatment cannot be separated from a patient ’s long-term follow-up and care, and an organized interdisciplinary collaboration is the future in this disease’s cure, to make sure that our patients will live longer and better.Trial RegistrationNCT05893368: New Model for Integrating Person-based Care (PbC) in the Treatment of Advanced HER2-negative Breast Cancer (PERGIQUAL). Registration date: 29th May 2023. (Source: Current Oncology Reports)
Source: Current Oncology Reports - February 24, 2024 Category: Cancer & Oncology Source Type: research
Addressing Residual Disease in HER2-Positive and Triple-Negative Breast Cancer: What Is Next?
AbstractPurpose of reviewTo summarize the treatment strategies for patients with human epidermal growth factor receptor 2 (HER2)-positive disease and triple-negative breast cancer (TNBC) who have residual disease after preoperative systemic therapy.Recent findingsThere has been a shift towards neoadjuvant systemic therapy for selected patients with HER2-positive and TNBC. Assessing the tumor ’s response to therapy provides prognostic information and allows individualization of the postoperative treatment for these patients based on the tumor response to neoadjuvant therapy. Patients with TNBC with residual disease after ...
Source: Current Oncology Reports - February 23, 2024 Category: Cancer & Oncology Source Type: research
Current Status and Future Direction in the Treatment of Advanced Adrenocortical Carcinoma
AbstractPurpose of ReviewTo provide a comprehensive overview of the current understanding and developments in the treatment options for adrenocortical carcinoma (ACC), focusing on the strategies utilized for advanced disease.Recent FindingsResearch has delved into the genomic landscape of ACC, revealing potential targets for therapy. Despite the failure of inhibitors aimed at the insulin like growth factor 1(IGF-1) receptor, other approaches, including vascular endothelial growth factor receptor (VEFGR) tyrosine kinase inhibitors and immune checkpoint inhibitors, are being investigated. There are also ongoing trials of com...
Source: Current Oncology Reports - February 21, 2024 Category: Cancer & Oncology Source Type: research
Integrated Molecular and Histological Insights for Targeted Therapies in Mesenchymal Sinonasal Tract Tumors
AbstractPurpose of ReviewThis review aims to provide a comprehensive overview of mesenchymal sinonasal tract tumors (STTs), a distinct subset of STTs. Despite their rarity, mesenchymal STTs represent a unique clinical challenge, characterized by their rarity, often slow progression, and frequently subtle or overlooked symptoms. The complex anatomy of the sinonasal area, which includes critical structures such as the orbit, brain, and cranial nerves, further complicates surgical treatment options. This underscores an urgent need for more advanced and specialized therapeutic approaches.Recent FindingsAdvancements in molecula...
Source: Current Oncology Reports - February 20, 2024 Category: Cancer & Oncology Source Type: research
Current Trends and Challenges of Microbiome Research in Bladder Cancer
AbstractPurpose of the ReviewMicrobiome research has provided valuable insights into the associations between microbial communities and bladder cancer. However, this field faces significant challenges that hinder the interpretation, generalization, and translation of findings into clinical practice. This review aims to elucidate these challenges and highlight the importance of addressing them for the advancement of microbiome research in bladder cancer.Recent FindingsRecent findings underscore the complexities involved in microbiome research, particularly in the context of bladder cancer. Challenges include low microbial b...
Source: Current Oncology Reports - February 20, 2024 Category: Cancer & Oncology Source Type: research
Perspectives on the Cardiovascular and Metabolic Effects of Androgen Deprivation Therapy in Prostate Cancer
AbstractPurpose of ReviewCardiovascular disease (CVD) is the leading cause of non-cancer mortality in men with prostate cancer. This review summarizes the existing and emerging literature examining the cardiometabolic effects of androgen deprivation therapy (ADT) in prostate cancer.Recent FindingsThe evidence behind the metabolic effects of ADT is derived from older studies and has not been validated in modern cohorts. Most of the newer studies focus on the risk of cardiovascular disease (CVD) with ADT. Recently published studies like the HERO and PRONOUNCE trials have once again sparked debate about the effects of differe...
Source: Current Oncology Reports - February 20, 2024 Category: Cancer & Oncology Source Type: research
Oral Health in Patients with History of Head and Neck Cancer: Complexity and Benefits of a Targeted Oral Healthcare Pathway
This article emphasizes the impo rtance of multidisciplinary care and highlights the need for further research elucidating the intricate relationships between oral health and HNCs, particularly through the microbiota. (Source: Current Oncology Reports)
Source: Current Oncology Reports - February 20, 2024 Category: Cancer & Oncology Source Type: research
