Artificial Intelligence for Clinical Flow Cytometry
In this review, the authors discuss the fundamental principles of machine learning. They explore recent studies and approaches in implementing machine learning into flow cytometry workflows. These applications are promising but not without their shortcomings. Explainability may be the biggest barrier to adoption, as they contain “black boxes” in which a complex network of mathematical processes learns features of data that are not translatable into real language. The authors discuss the current limitations of machine learning models and the possibility that, without a multiinstitutional development process, these appli...
Source: Clinics in Laboratory Medicine - May 29, 2023 Category: Laboratory Medicine Authors: Robert P. Seifert, David A. Gorlin, Andrew A. Borkowski Source Type: research
The Enduring and Expanding Importance of Clinical Cytometry
Clinical cytometry is changing. Building upon decades of proven utility in diagnostic medicine, the field is now expanding to provide actionable clinical information beyond the initial diagnosis for an ever-expanding number of diseases. This advancement is driven in part by new technologies that make cytometry more sensitive, more precise, and easier to use for a wider population of providers. However, as the issue shows, the progress is equally due to the enduring ingenuity of physicians and scientists who push the boundaries of cytometry's capability, looking deeply into available data to unearth new clinical application...
Source: Clinics in Laboratory Medicine - May 15, 2023 Category: Laboratory Medicine Authors: Christopher B. Hergott Source Type: research
Update on Ovarian Sex Cord –Stromal Tumors
This article focuses on the recent advances in ovarian sex cord –stromal tumors, predominantly in the setting of their molecular underpinnings. The integration of genetic information with morphologic and immunohistochemical findings in this rare subset of tumors is of clinical significance from refining the diagnostic and prognostic stratifications to genetic counseling. (Source: Clinics in Laboratory Medicine)
Source: Clinics in Laboratory Medicine - May 10, 2023 Category: Laboratory Medicine Authors: Zehra Ordulu Source Type: research
Metaplastic Breast Carcinoma Revisited; Subtypes Determine Outcomes
Metaplastic breast carcinoma (MpBC) is a heterogeneous group of tumors that clinically could be divided into low risk and high risk. It is important to recognize the different types of MpBC, as the high-risk subtypes have worse clinical outcomes than triple-negative breast cancer. It is important for the pathologist to be aware of the MpBC entities and use the proposed algorithms (morphology and immunohistochemistry) to assist in rendering the final diagnosis. Few pitfalls are discussed, including misinterpretation of immunohistochemistry and certain histomorphologies, particularly spindle lesions associated with complex s...
Source: Clinics in Laboratory Medicine - May 10, 2023 Category: Laboratory Medicine Authors: Thaer Khoury Source Type: research
Kidney Tumors
This review summarizes current knowledge on several novel and emerging renal entities, including eosinophilic solid and cystic renal cell carcinoma (RCC), RCC with fibromyomatous stroma, anaplastic lymphoma kinase-rearranged RCC, low-grade oncocytic renal tumor, eosinophilic vacuolated tumor, thyroidlike follicular RCC, and biphasic hyalinizing psammomatous RCC. Their clinical features, gross and microscopic morphology, immunohistochemistry, and molecular and genetic features are described. The diagnosis of most of them rests on recognizing their morphologic features using immunohistochemistry. Accurate diagnosis of these ...
Source: Clinics in Laboratory Medicine - May 10, 2023 Category: Laboratory Medicine Authors: Farshid Siadat, Mehdi Mansoor, Ondrej Hes, Kiril Trpkov Source Type: research
A New Landscape of Testing and Therapeutics in Metastatic Breast Cancer
Predictive biomarker testing on metastatic breast cancer is essential for determining patient eligibility for targeted therapeutics. The National Comprehensive Cancer Network currently recommends assessment of specific biomarkers on metastatic tumor subtypes, including hormone receptors, HER2, and BRCA1/2 mutations, on all newly metastatic breast cancers subtypes; programmed death-ligand 1 on metastatic triple-negative carcinomas; and PIK3CA mutation status on estrogen receptor-positive carcinomas. In select circumstances mismatch repair protein deficiency and/or microsatellite insufficiency, tumor mutation burden, and NTR...
Source: Clinics in Laboratory Medicine - May 10, 2023 Category: Laboratory Medicine Authors: Geetha Jagannathan, Marissa J. White, Rena R. Xian, Leisha A. Emens, Ashley Cimino-Mathews Source Type: research
Point of Care Testing
CLINICS IN LABORATORY MEDICINE (Source: Clinics in Laboratory Medicine)
Source: Clinics in Laboratory Medicine - May 10, 2023 Category: Laboratory Medicine Authors: Linoj Samuel Source Type: research
Copyright
Elsevier (Source: Clinics in Laboratory Medicine)
Source: Clinics in Laboratory Medicine - May 10, 2023 Category: Laboratory Medicine Source Type: research
Contributors
MILENKO JOVAN TANASIJEVIC, MD, MBA (Source: Clinics in Laboratory Medicine)
Source: Clinics in Laboratory Medicine - May 10, 2023 Category: Laboratory Medicine Source Type: research
Contents
Linoj Samuel (Source: Clinics in Laboratory Medicine)
Source: Clinics in Laboratory Medicine - May 10, 2023 Category: Laboratory Medicine Source Type: research
Forthcoming Issues
Advances in Clinical Cytometry (Source: Clinics in Laboratory Medicine)
Source: Clinics in Laboratory Medicine - May 10, 2023 Category: Laboratory Medicine Source Type: research
Preface
In this issue of Clinics in Laboratory Medicine, the focus is on the increasing role of point-of-care (POC) testing in patient care and management. In a previous issue before the onset of the COVID-19 pandemic, Samuel and colleagues1 commented on the growing importance of POC testing and the need for appropriate oversight. The COVID-19 pandemic put an unprecedented strain on diagnostic laboratories across the world. Traditional centralized laboratory-based diagnostic testing was challenged by severe shortages in the supply chain. (Source: Clinics in Laboratory Medicine)
Source: Clinics in Laboratory Medicine - May 10, 2023 Category: Laboratory Medicine Authors: Linoj Samuel Source Type: research
Will Antigen Testing Remain Relevant in the Point-of-Care Testing Environment?
This article discusses the general considerations of antigen and molecular assays and the merits and factors to consider when implementing diagnostic assays for several common pathogens. (Source: Clinics in Laboratory Medicine)
Source: Clinics in Laboratory Medicine - April 4, 2023 Category: Laboratory Medicine Authors: Lindsey E. Nielsen, Steven Mahlen, Deena E. Sutter Source Type: research
Practical Challenges of Point-of-Care Testing
The practical challenges of point-of-care testing (POCT) include analytical performance and quality compared with testing performed in a central laboratory and higher cost per test compared with laboratory-based tests. These challenges can be addressed with new test technology, consensus, and practice guidelines for the use of POCT, instituting a quality management system and data connectivity in the POCT setting, and studies that demonstrate evidence of clinical and economic value of POCT. (Source: Clinics in Laboratory Medicine)
Source: Clinics in Laboratory Medicine - March 22, 2023 Category: Laboratory Medicine Authors: Daniel A. Ortiz, Michael J. Loeffelholz Source Type: research
Point-of-Care Testing for Sexually Transmitted Infections
Point-of-care testing for sexually transmitted infections is essential for controlling transmission and preventing sequelae in high-risk populations. Since the World Health Organization published the ASSURED criteria, point-of-care testing has improved for use in large population screening and rapid testing that prevents loss of clinical follow-up. Recent advancements have been advantageous for low-resource areas allowing testing at a minimal cost without reliable electricity or refrigeration. Point-of-care nucleic acid detection and amplification techniques are recommended, but are often inaccessible in low-resource areas...
Source: Clinics in Laboratory Medicine - March 22, 2023 Category: Laboratory Medicine Authors: Ashleigh N. Riegler, Natalie Larsen, Megan H. Amerson-Brown Source Type: research
