Massive Transfusion in Pediatric Patients
Massive transfusion in pediatric patients is infrequent but associated with much higher mortality than in adults. Blood transfusion and hematology has conceptualized ideas such as blood failure and the interplay of the blood-endothelium interface to understand coagulopathy in the context of hemorrhagic shock. Researchers are still searching for an appropriate definition of what constitutes a pediatric massive transfusion. There is no universally accepted protocol for massive transfusion and how to address the many complications that can arise. Pharmacologic adjuncts to resuscitation may prove beneficial in reducing coagulo...
Source: Clinics in Laboratory Medicine - December 15, 2020 Category: Laboratory Medicine Authors: Lucas P. Neff, Michael Aaron Beckwith, Robert T. Russell, Jeremy W. Cannon, Philip C. Spinella Source Type: research
Evaluation and Management of Coagulopathies and Thrombophilias in Pediatric Patients
The diagnosis of coagulopathy or thrombophilia in pediatric patients can be challenging. Congenital coagulopathies often present in the pediatric period and require appropriate work-up for diagnosis and ongoing management. Acquired coagulopathies of childhood are frequently encountered in hospitalized children and warrant appropriate coagulation testing for goal-directed therapy. The incidence of thrombosis is increasing in pediatric patients. After identifying the presence of thrombus, acute management includes initiating therapeutic anticoagulation. Choice of anticoagulant depends on patient ’s clinical status, along w...
Source: Clinics in Laboratory Medicine - December 14, 2020 Category: Laboratory Medicine Authors: HyoJeong Han, Lisa Hensch, Shiu-Ki Rocky Hui, Jun Teruya Source Type: research
Novel Blood Component Therapies in the Pediatric Setting
This article reviews the literature on use of whole blood, solvent/detergent-treated plasma, pathogen-reduced platelets, and fibrinogen concentrate in pediatric patients. Many countries have adopted pathogen-reduced blood product technology, and hospitals in the United States are slowly adopting these products. The pediatric transfusion medicine community needs to appraise the evidence for their use and continue to advocate the inclusion of children in the most robust randomized clinical trials for novel blood components. (Source: Clinics in Laboratory Medicine)
Source: Clinics in Laboratory Medicine - December 14, 2020 Category: Laboratory Medicine Authors: Shannon C. Walker, Jennifer Andrews Source Type: research
The Development of the Nascent Field of Pediatric Transfusion Medicine
The concept of childhood is a more recent construct of civilization from the seventeenth century. Previously in human history, once a person could walk and talk, there was no distinction, and more importantly, no protection for this vulnerable time in development. This transition in thinking of childhood as a distinct entity separate from adulthood with distinct developmental stages and special needs gave birth to the specialty of pediatrics in the late nineteenth century. There is now worldwide recognition of the special status of children in many cultures, and we are just beginning to understand the depth of these differ...
Source: Clinics in Laboratory Medicine - December 14, 2020 Category: Laboratory Medicine Authors: Sarah R. Vossoughi, Brie A. Stotler Tags: Preface Source Type: research
Update on Biosafety and Emerging Infections for the Clinical Microbiology Laboratory
This article focuses on the biosafety program that clinical laboratory leaders should build to meet the needs of clinical laboratories; biosafety challenges of automated laboratory systems, facilities, personnel, and practices; and the relationship with occupational health. (Source: Clinics in Laboratory Medicine)
Source: Clinics in Laboratory Medicine - October 27, 2020 Category: Laboratory Medicine Authors: Michael A. Pentella Source Type: research
Point-of-Care Testing in Microbiology
Point-of-care (POC) or near patient testing for infectious diseases is a rapidly expanding space that is part of an ongoing effort to bring care closer to the patient. Traditional POC tests were known for their limited utility, but advances in technology have seen significant improvements in performance of these assays. The increasing promise of these tests is also coupled with their increasing complexity, which requires the oversight of qualified laboratory-trained personnel. (Source: Clinics in Laboratory Medicine)
Source: Clinics in Laboratory Medicine - October 27, 2020 Category: Laboratory Medicine Authors: Linoj Samuel Source Type: research
Update in Pediatric Diagnostic Microbiology
This article discusses laboratory aspects of several clinically significant pediatric pathogens that cause severe harm to patients and impact public health responses. (Source: Clinics in Laboratory Medicine)
Source: Clinics in Laboratory Medicine - October 27, 2020 Category: Laboratory Medicine Authors: James J. Dunn, Paula A. Revell Source Type: research
2020: A Year for Clinical Microbiology
We had originally intended this issue to provide an update in many dynamic areas of clinical microbiology practice, including the introduction of groundbreaking technologies and major logistical challenges, such as laboratory consolidation and design. As the issue started to come together, authored primarily by active clinical microbiology lab directors, we were collectively confronted with the COVID-19 pandemic. The warnings that we have heard over the past decade about the potential for a pandemic in the highly interconnected global economy were suddenly proven to be prescient, and yet, despite all of those warnings, we ...
Source: Clinics in Laboratory Medicine - October 27, 2020 Category: Laboratory Medicine Authors: Nicole D. Pecora, Matthew A. Pettengill Tags: Preface Source Type: research
Current Issues in Clinical Microbiology
CLINICS IN LABORATORY MEDICINE (Source: Clinics in Laboratory Medicine)
Source: Clinics in Laboratory Medicine - October 27, 2020 Category: Laboratory Medicine Authors: Nicole D. Pecora, Matthew A. Pettengill Source Type: research
Copyright
Elsevier (Source: Clinics in Laboratory Medicine)
Source: Clinics in Laboratory Medicine - October 27, 2020 Category: Laboratory Medicine Source Type: research
Contributors
MILENKO JOVAN TANASIJEVIC, MD, MBA (Source: Clinics in Laboratory Medicine)
Source: Clinics in Laboratory Medicine - October 27, 2020 Category: Laboratory Medicine Source Type: research
Contents
Nicole D. Pecora and Matthew A. Pettengill (Source: Clinics in Laboratory Medicine)
Source: Clinics in Laboratory Medicine - October 27, 2020 Category: Laboratory Medicine Source Type: research
Forthcoming Issues
Topics in Pediatric Transfusion Medicine (Source: Clinics in Laboratory Medicine)
Source: Clinics in Laboratory Medicine - October 27, 2020 Category: Laboratory Medicine Source Type: research
Antimicrobial Stewardship
Misuse of antibiotics, including unnecessary use or inappropriate selection, may result in side effects and poor outcome in individual patients, as well as contribute to the spread of antimicrobial resistance. Antimicrobial stewardship programs exist to reduce such misuse of antibiotics and ill effect in order to promote patient outcome. The importance of diagnostics, antibiogram data, possible interventions, and impact are reviewed. It is essential for clinical microbiologists and other health care members to understand the field and scope of antimicrobial stewardship, actively participate in, and understand the value the...
Source: Clinics in Laboratory Medicine - October 5, 2020 Category: Laboratory Medicine Authors: Diana Alame, Bryan Hess, Claudine El-Beyrouty Source Type: research
Fellowship Training for the Future Clinical Microbiology Laboratory Director
This article discusses the key components of a fellowship program and provides recommendations for incorporating educational best practices. (Source: Clinics in Laboratory Medicine)
Source: Clinics in Laboratory Medicine - October 5, 2020 Category: Laboratory Medicine Authors: Bobbi S. Pritt, Carrie A. Bowler, Elitza S. Theel Source Type: research
