Update on Pediatric and Young Adult Mature Lymphomas
This article summarizes the epidemiologic, histopathologic, and molecular features of selected mature systemic B-cell and T-cell lymphomas encountered in this age group. (Source: Clinics in Laboratory Medicine)
Source: Clinics in Laboratory Medicine - July 1, 2021 Category: Laboratory Medicine Authors: Emily F. Mason, Alexandra E. Kovach Source Type: research
Inherited Bone Marrow Failure Syndromes
Inherited bone marrow failure syndromes are a group of genetic disorders associated with bone marrow production defects resulting in single or multiple cytopenias. Many of these disorders predispose the patient to hematologic and nonhematologic malignancies, requiring life-long follow-up. A positive family history of hematologic disorders or malignancies is frequent, as these disorders commonly run in families, and selection of family members as potential bone marrow donors should be performed with caution to avoid transplanting potentially defective stem cells. This review highlights the most common genetic disorders asso...
Source: Clinics in Laboratory Medicine - July 1, 2021 Category: Laboratory Medicine Authors: M. Tarek Elghetany, Jyotinder Nain Punia, Andrea N. Marcogliese Source Type: research
Pediatric Myelodysplastic Syndromes
Pediatric myelodysplastic syndromes (MDS) comprise less than 5% of childhood malignancies. Approximately 30% to 45% of pediatric MDS cases are associated with an underlying genetic predisposition syndrome. A subset of patients present with MDS/acute myeloid leukemia (AML) following intensive chemotherapy for an unrelated malignancy. A definitive diagnosis of MDS can often only be rendered pending a comprehensive clinical and laboratory-based evaluation, which frequently includes ancillary testing in a reference laboratory. Clinical subtypes, the current diagnostic schema, and the results of more recently performed next-gen...
Source: Clinics in Laboratory Medicine - June 24, 2021 Category: Laboratory Medicine Authors: Sanjay S. Patel Source Type: research
Breath-Based Diagnosis of Infectious Diseases
This article discusses the current state of breath analysis for the diagnosis of infectious diseases. (Source: Clinics in Laboratory Medicine)
Source: Clinics in Laboratory Medicine - May 19, 2021 Category: Laboratory Medicine Authors: Chiranjit Ghosh, Armando Leon, Seena Koshy, Obadah Aloum, Yazan Al-Jabawi, Nour Ismail, Zoe Freeman Weiss, Sophia Koo Source Type: research
Bringing Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging to the Clinics
This article provides a brief introduction to MALDI MSI as well as clinical diagnostic workflows and opportunities to apply this powerful approach. It describes various MALDI MSI applications, from more clinically mature applications such as cancer to emerging applications such as infectious diseases and drug distribution. In addition, it discusses the analytical considerations that need to be considered when bringing these approaches to different diagnostic problems and settings. (Source: Clinics in Laboratory Medicine)
Source: Clinics in Laboratory Medicine - May 19, 2021 Category: Laboratory Medicine Authors: Sankha S. Basu, Nathalie Y.R. Agar Source Type: research
Beyond LC-MS: The Next Frontier in Clinical Mass Spectrometry
Clinical implementation of mass spectrometry (MS) has been relatively slow compared with nucleic acid and antibody-based methods. Although MS was first described in the early 1900s, it was not applied clinically until the 1970s with gas chromatography, and even then, in a limited capacity. MS saw wider deployment in the 1990s when soft-ionization techniques, such as electrospray ionization, brought together liquid chromatography (LC) and tandem mass spectrometry (MS/MS). The capacity of LC-MS/MS to measure multiple drugs and metabolites quickly and accurately in complex biological matrices solved several diagnostic challen...
Source: Clinics in Laboratory Medicine - May 19, 2021 Category: Laboratory Medicine Authors: Sankha S. Basu Tags: Preface Source Type: research
Beyond LC-MS: The Next Frontier in Clinical Mass Spectrometry
CLINICS IN LABORATORY MEDICINE (Source: Clinics in Laboratory Medicine)
Source: Clinics in Laboratory Medicine - May 19, 2021 Category: Laboratory Medicine Authors: Sankha S. Basu Source Type: research
Copyright
Elsevier (Source: Clinics in Laboratory Medicine)
Source: Clinics in Laboratory Medicine - May 19, 2021 Category: Laboratory Medicine Source Type: research
Contributors
MILENKO JOVAN TANASIJEVIC, MD, MBA (Source: Clinics in Laboratory Medicine)
Source: Clinics in Laboratory Medicine - May 19, 2021 Category: Laboratory Medicine Source Type: research
Contents
Sankha S. Basu (Source: Clinics in Laboratory Medicine)
Source: Clinics in Laboratory Medicine - May 19, 2021 Category: Laboratory Medicine Source Type: research
Forthcoming Issues
Hematopathology of the Young (Source: Clinics in Laboratory Medicine)
Source: Clinics in Laboratory Medicine - May 19, 2021 Category: Laboratory Medicine Source Type: research
Implementation of Mass Spectrometry Imaging in Pathology
This article discusses the recent developments in the field that are paving the way for this technology to become accepted as an analytical tool in the clinical setting, its current limitations, and future directions. (Source: Clinics in Laboratory Medicine)
Source: Clinics in Laboratory Medicine - April 24, 2021 Category: Laboratory Medicine Authors: Juliana Pereira Lopes Gon çalves, Christine Bollwein, Wilko Weichert, Kristina Schwamborn Source Type: research
Clinical Mass Spectrometry Approaches to Myeloma and Amyloidosis
The diagnosis of myeloma and other plasma cell disorders has traditionally been done with the aid of electrophoretic methods, whereas amyloidosis has been characterized by immunohistochemistry. Mass spectrometry has recently been established as an alternative to these traditional methods and has been proved to bring added benefit for patient care. These newer mass spectrometry –based methods highlight some of the key advantages of modern proteomic methods and how they can be applied to the routine care of patients. (Source: Clinics in Laboratory Medicine)
Source: Clinics in Laboratory Medicine - April 24, 2021 Category: Laboratory Medicine Authors: David L. Murray, Surendra Dasari Source Type: research
Breaking Through the Barrier
Rapid characterization of tissue disorder using ambient mass spectrometry (MS) techniques, requiring little to no preanalytical preparations of sampled tissues, has been shown using a variety of ion sources and with many disease classes. A brief overview of ambient MS in clinical applications, the state of the art in regulatory affairs, and recommendations to facilitate adoption for use at the bedside are presented. Unique challenges in the validation of untargeted MS methods and additional safety and compliance requirements for deployment within a clinical setting are further discussed. Development of a harmonized validat...
Source: Clinics in Laboratory Medicine - April 24, 2021 Category: Laboratory Medicine Authors: Michael Woolman, Lauren Katz, Alessandra Tata, Sankha S. Basu, Arash Zarrine-Afsar Source Type: research
Glycan Imaging Mass Spectrometry
N-glycan imaging mass spectrometry (IMS) can rapidly and reproducibly identify changes in disease-associated N-linked glycosylation that are linked with histopathology features in standard formalin-fixed paraffin-embedded tissue samples. It can detect multiple N-glycans simultaneously and has been used to identify specific N-glycans and carbohydrate structural motifs as possible cancer biomarkers. Recent advancements in instrumentation and sample preparation are also discussed. The tissue N-glycan IMS workflow has been adapted to new glass slide –based assays for effective and rapid analysis of clinical biofluids, cultur...
Source: Clinics in Laboratory Medicine - April 24, 2021 Category: Laboratory Medicine Authors: Calvin R.K. Blaschke, Colin T. McDowell, Alyson P. Black, Anand S. Mehta, Peggi M. Angel, Richard R. Drake Source Type: research
