Donepezil's Effects on Brain Functions of Patients With Alzheimer Disease: A Regional Homogeneity Study Based on Resting-State Functional Magnetic Resonance Imaging
Conclusion
Donepezil-mediated improvement of cognitive function in AD patients is linked to spontaneous brain activities of the right gyrus rectus, right precentral gyrus, and left superior temporal gyrus, which could be used as potential biomarkers for monitoring the therapeutic effect of donepezil. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - March 1, 2019 Category: Neurology Tags: Original Articles Source Type: research
Real-World Experience With VMAT2 Inhibitors
Conclusions
The VMAT2 inhibitors are effective and safe in a range of hyperkinetic movement disorders but are not readily accessible by patients in the United States for indications not approved by the Food and Drug Administration. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - March 1, 2019 Category: Neurology Tags: Original Articles Source Type: research
CYP1A2 Genetic Polymorphism Is Associated With Treatment Remission to Antidepressant Venlafaxine in Han Chinese Population
Major depressive disorder (MDD) is a common mental disorder. Venlafaxine (VEN) is used to treat patients with MDD as an antidepressant of serotonin-norepinephrine reuptake inhibitor. In addition, current reports reveal that CYP enzymes mediate its metabolism, thereby affecting the treatment efficacy. The aim of this study was to test whether the genetic polymorphisms of CYP1A2 are associated with remission after VEN treatment for MDD. A total of 175 Han Chinese depressed patients have been recruited to accept a 6-week treatment with VEN. Three single-nucleotide polymorphisms of CYP1A2 were selected from dbSNP and previous ...
Source: Clinical Neuropharmacology - March 1, 2019 Category: Neurology Tags: Original Articles Source Type: research
Effect of Donepezil on Cognitive Deficits Associated With Electroconvulsive Therapy: A Randomized Triple-blind Clinical Trial
Conclusions
Despite a few evidence confirming the effect of acetylcholinesterase inhibitors in improving cognitive defects related to ECT, this study did not find such an effect in patients under ECT. Further studies are required to reach a clear conclusion. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - March 1, 2019 Category: Neurology Tags: Original Articles Source Type: research
Clinical Outcomes in Patients Taking Inhaled Loxapine, Haloperidol, or Ziprasidone in the Emergency Department
Objectives
Our objective was to compare outcomes of discharge disposition, need for additional medications, and restraint use for patients who received inhaled loxapine compared with patients receiving traditional antipsychotic drugs in the emergency department (ED).
Methods
A retrospective chart review was conducted on all patients who presented to the ED with agitation and received antipsychotic therapy, including loxapine, ziprasidone, or haloperidol from December 1, 2014, through October 31, 2016.
Results
The mean time from physician assignment to medical clearance was 7.9 hours for patients treated with inhale...
Source: Clinical Neuropharmacology - March 1, 2019 Category: Neurology Tags: Original Articles Source Type: research
Long-term Outcome of Adenosine A2A Receptor Antagonist on Lower Urinary Tract Symptoms in Male Parkinson Disease Patients: Erratum
No abstract available (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - January 1, 2019 Category: Neurology Tags: Erratum Source Type: research
Trichotillomania Triggered by Vitamin D Deficiency and Resolving Dramatically With Vitamin D Therapy
We report a case of a 4-year-old girl with TTM triggered by vitamin D deficiency resolving dramatically with vitamin D therapy. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - January 1, 2019 Category: Neurology Tags: Case Reports Source Type: research
Bupropion-Related Exacerbation of Tic Disorder in an Adult: A Case Report
We report for the first time a case of an older adult with a known tic disorder, which was in remission but exacerbated during treatment with bupropion. It has been reported that other dopaminergic compounds such as methylphenidate can exacerbate tic disorder. Clinicians should be aware of this potential adverse effect when prescribing bupropion to adults with tic and other motor disorders. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - January 1, 2019 Category: Neurology Tags: Case Reports Source Type: research
Possible Sertraline-Induced Hiccups in a Boy With Obsessive-Compulsive Disorder and Attention-Deficit/Hyperactivity Disorder
We present the case of a boy with obsessive-compulsive disorder and attention-deficit/hyperactivity disorder who displayed hiccup after sertraline therapy. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - January 1, 2019 Category: Neurology Tags: Case Reports Source Type: research
Blepharospasm as a Manifestation of Peak of Dose Dyskinesia in Parkinson Disease
Conclusions
Blepharospasm in the On period in patients with PD is extremely uncommon, and our series is the only one to describe such association. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - January 1, 2019 Category: Neurology Tags: Original Articles Source Type: research
Association Study Between Serotonin Transporter Gene and Fluoxetine Response in Mexican Patients With Major Depressive Disorder
Conclusions
Our findings showed an association between low activity alleles of SLC6A4 gene and fluoxetine nonresponse in patients with severe depression. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - January 1, 2019 Category: Neurology Tags: Original Articles Source Type: research
Single-Dose Pharmacokinetics and Pharmacodynamics of IPX203 in Patients With Advanced Parkinson Disease: A Comparison With Immediate-Release Carbidopa-Levodopa and With Extended-Release Carbidopa-Levodopa Capsules
Objective
IPX203 is an investigational oral extended-release capsule formulation of carbidopa-levodopa (CD-LD). The aim of this study was to characterize the single-dose pharmacodynamics, pharmacokinetics, and safety of IPX203 in subjects with advanced Parkinson disease compared with immediate-release (IR) CD-LD and extended-release CD-LD (Rytary).
Methods
This was a randomized, open-label, rater-blinded, multicenter, single-dose crossover study. Blinded clinicians assessed subject's motor state and Movement Disorders Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) part III scores for up to 10 hours postd...
Source: Clinical Neuropharmacology - January 1, 2019 Category: Neurology Tags: Original Articles Source Type: research
New Daily Persistent Headache and OnabotulinumtoxinA Therapy
Conclusions
Most therapies are unable to break the unremitting course of NDPH. In our investigation, at 1 year (3–4 cycles of onabot treatment), approximately half of the patients treated showed a reduction in headache frequency and approximately 75% demonstrated some improvement in headache severity. Evidence from this small-scale retrospective study suggests that onabot shows strong promise for the treatment of NDPH, which currently is resistant to most therapies, but a randomized controlled study should be the next step in confirmation of this therapy. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - January 1, 2019 Category: Neurology Tags: Original Articles Source Type: research
Adjunctive Donepezil for Anxiety Symptoms With Poor Response to Paroxetine in a Patient With Probable Mild Cognitive Impairment
No abstract available (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - November 1, 2018 Category: Neurology Tags: Letter to the Editor Source Type: research
Increased Risk of Ischemic Stroke in Multiple Myeloma Associated With Lenalidomide Treatment: A Case Report and Review of the Literature
Conclusions
Our case exemplifies the need to raise awareness about the risk of ischemic stroke associated with MM that might be increased by treatment with lenalidomide and to establish consistent recommendations regarding thromboprophylaxis to reduce comorbidities and mortality in these patients. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - November 1, 2018 Category: Neurology Tags: Case Reports Source Type: research
