Intravenous Valproic Acid Add-On Therapy in Acute Agitation Adolescents With Suspected Substance Abuse: A Report of Six Cases
The aim of this study was to test efficacy and safety of intravenous (IV) valproate for aggression in children and adolescents with mood or conduct disorder and concomitant substance abuse. Six patients received a 20 mg/kg dose of IV valproic acid as an add-on therapy to their standard therapy with second-generation antipsychotics and benzodiazepines. Agitation and general psychopathology were measured at baseline and after the first injection using the Modified Overt Aggression Scale, the Brief Psychiatric Rating Scale, and the Children’s Global Assessment Scale. The findings suggested that in emergency psychiatry clini...
Source: Clinical Neuropharmacology - January 1, 2018 Category: Neurology Tags: Case Reports Source Type: research
Drug-Associated Spontaneous Orgasm: A Case Report and Systematic Review of Literature
Conclusions
It appears that 5HT1A has a key role in generating orgasm. Orgasms may be activated through arousal-independent or arousal-dependent pathways, and both orgasms and sexual arousal are bidirectionally activated. This double-bidirectional model of sexual response cycle may promote the success of sexual procreation and recreation, and further research on this pathway could offer an innovative method to manage anorgasmia in the future. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - January 1, 2018 Category: Neurology Tags: Case Reports Source Type: research
Newly Developed Skin Picking After Methylphenidate Treatment in Attention Deficit Hyperactivity Disorder: Possible Mechanisms
We describe a case of skin picking developing after methylphenidate therapy for ADHD. Possible explanations of methylphenidate and skin picking are reviewed in the light of the current literature. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - January 1, 2018 Category: Neurology Tags: Case Reports Source Type: research
Prescribing Trends of Atypical Antipsychotic Drugs in an Outpatient Unit of a Child and Adolescent Clinic in Turkey
Conclusions
Our results support the prevalence of off-label use of AP agents in managing various childhood psychopathologies also in Turkey. Further studies from multiple centers and using reliable and valid measurements are needed to determine the extent and predictors of AP use in outpatient samples from different child and adolescent centers. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - January 1, 2018 Category: Neurology Tags: Original Articles Source Type: research
Open-Access Electronic Diary for Motor Fluctuation and Dyskinesia Evaluation in Parkinson Disease: Comparison With Paper Diary
Conclusions
This electronic motor diary proved to be reliable for ON-OFF state and dyskinesia identification and classification. However, no advantage to paper diary has been observed in terms of number of erroneous entries. Based on these results, to improve home motor fluctuations, detection efforts should be directed toward the development of automatic wearable devices rather than digital versions of current available ON-OFF diaries. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - January 1, 2018 Category: Neurology Tags: Original Articles Source Type: research
Effect of Pharmacist-Led Interventions on (Non)Motor Symptoms, Medication-Related Problems, and Quality of Life in Parkinson Disease Patients: A Pilot Study
Conclusions
Our data did not support the added value of UDP alone or in combination with PKG. Only the combined intervention of UDP, PKG, and MR showed significant improvements in medication adherence, on time, and QoL. This supports the effectiveness of MR by a clinical pharmacist for PD patients in an outpatient setting. Therefore, this small scale study should be followed by larger-scale trials on this topic. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - January 1, 2018 Category: Neurology Tags: Original Articles Source Type: research
One-Year Retention Study of Adjunctive Perampanel Treatment in Epilepsy Patients
Conclusions
We showed that the retention rate and adverse events for adjunctive perampanel treatment in the Korean population were comparable with those in Western countries. Our study also suggests that adjuvant perampanel treatment may be effective in patients taking a higher number of concomitant AEDs and that psychiatric comorbidity may be a risk factor for perampanel-induced psychiatric reactions. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - January 1, 2018 Category: Neurology Tags: Original Articles Source Type: research
Anger Assessment in Patients Treated With Brivaracetam
Conclusions
This small, open study suggests that BRV increases anger measures less than LEV in epilepsy patients. However, larger, blinded control studies are required to establish whether this apparent difference can be confirmed. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - January 1, 2018 Category: Neurology Tags: Original Articles Source Type: research
The Association Between the Severity and Level of Understanding of Depression Among Patients Treated With Antidepressants: A Survey of 424 Outpatients in Japan
Conclusions
Items B and C were significantly negatively and positively associated with depression severity, respectively. Sufficient and suitable psychoeducation in and knowledge of depression might improve the treatment responses in patients with depression. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - January 1, 2018 Category: Neurology Tags: Original Articles Source Type: research
Inhaled Loxapine for Agitation in Intoxicated Patients: A Case Series
Conclusions
The acute agitation was effectively and quickly managed with inhaled loxapine in all intoxicated patients and enabled the appropriate clinical evaluation of the agitated state and the patient's management. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - November 1, 2017 Category: Neurology Tags: Case Reports Source Type: research
Subdural Instillation of a Thrombolytic Agent for Treatment of Recurrent Subdural Hematoma
This study aims to report the case of a patient with recurrent subdural hemorrhage (SDH) who was administered tissue plasminogen activator through a subdural drain to enhance drainage and prevent recurrence.
Methods
An 85-year-old man was treated for subacute over chronic SDH that kept on reaccumulating despite serial twist drill drainage, burr hole drainage, and craniotomy. No coagulopathy was identified with adequate blood pressure control.
Results
Treatment with tissue plasminogen activator resulted in successful drainage of the SDH, and the patient had no further recurrence at 9-month follow-up. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - November 1, 2017 Category: Neurology Tags: Case Reports Source Type: research
Aripiprazole for Post-traumatic Stress Disorder: A Systematic Review
Conclusions
Based on the reviewed literature, aripiprazole is a reasonable therapy option as monotherapy or adjunct therapy in patients with PTSD. Larger randomized controlled trials are needed to better understand the role of this atypical antipsychotic in patients with PTSD. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - November 1, 2017 Category: Neurology Tags: Review Article Source Type: research
Medical Cannabis in Parkinson Disease: Real-Life Patients' Experience
Conclusions
Medical cannabis was found to improve symptoms of PD in the initial stages of treatment and did not cause major adverse effects in this pilot, 2-center, retrospective survey. The extent of use and the reported effects lend support to further development of safer and more effective drugs derived from Cannabis sativa. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - November 1, 2017 Category: Neurology Tags: Original Articles Source Type: research
Pramipexole and Electroconvulsive Therapy in Treatment-Resistant Depression
Conclusions
Pramipexole is a therapeutic option for MDD resistant to ECT. It could be used jointly to ECT or after a partial remission with ECT. More studies are needed to precisely describe the optimal combination of sequential use of ECT and pramipexole in treatment-resistant MDD. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - November 1, 2017 Category: Neurology Tags: Original Articles Source Type: research
The Efficacy of Istradefylline for Treating Mild Wearing-Off in Parkinson Disease
Objectives
The adenosine A2A antagonist istradefylline has been used to treat Parkinson disease (PD) with symptoms of wearing-off since 2013 in Japan. Previous randomized controlled trials of istradefylline compared with placebo included PD patients experiencing an average daily OFF time of more than 2 hours. The purpose of this study is to assess the efficacy of 20 mg/d istradefylline in PD subjects experiencing an average daily OFF time of 3 hours or less.
Methods
Fifteen patients were enrolled into this retrospective study. They received 20 mg/d istradefylline for 12 weeks. Changes in the Unified Parkinson's Diseas...
Source: Clinical Neuropharmacology - November 1, 2017 Category: Neurology Tags: Original Articles Source Type: research
