Case Report of Probable Duloxetine-Induced Hyperosmia
No abstract available (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - March 1, 2020 Category: Neurology Tags: Letter to the Editor Source Type: research
Positive Magnetic Resonance Imaging Evidence of Transient Global Amnesia Following the Use of Sildenafil
Transient global amnesia (TGA) has been proposed as a possible adverse effect of sildenafil. There are rare cases in the literature, but none had strong evidence to support. Our case is the first to demonstrate a focal punctate diffusion-weighted imaging lesion at the right hippocampus after the use of sildenafil. This finding, which is suggestive of cytotoxic edema and is typical for TGA, may provide us evidence for the implication of sildenafil in TGA. We speculate that sildenafil may precipitate TGA by altering blood flow, inducing venous congestion or cortical spreading depression at the hippocampus. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - March 1, 2020 Category: Neurology Tags: Case Reports Source Type: research
A Severe Adverse Effect of Atomoxetine: Hypertensive Crisis
Atomoxetine, a selective norepinephrine (noradrenaline) reuptake inhibitor, is an effective medication in attention-deficit hyperactivity disorder with a generally well-tolerated adverse effect profile. However, unusual side effects may occur during treatment. Here we report a case of hypertensive crisis in an 8-year-old male patient with autism spectrum disorder and attention-deficit hyperactivity disorder receiving atomoxetine treatment. We plan to discuss the clinical picture of the subject and importance of close monitoring during atomoxetine treatment. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - March 1, 2020 Category: Neurology Tags: Case Reports Source Type: research
Olanzapine-Associated Pisa Syndrome in an Autistic Adolescent
Conclusions
In patients with balance problems and abnormal posture as a result of olanzapine use, the clinician should keep in mind Pisa syndrome. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - March 1, 2020 Category: Neurology Tags: Case Reports Source Type: research
Atomoxetine Induced Skin Picking: A Case Report
“Skin picking disorder,” also known as “dermatillomania” or “psychogenic excoriation,” is classified in the “Obsessive Compulsive and Related Disorders” category in Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition and characterized by repetitive skin picking behaviors resulting in skin lesions. Atomoxetine (ATX) is a selective norepinephrine (noradrenaline) reuptake inhibitor commonly used in the management of attention-deficit/hyperactivity disorder. Atomoxetine is considered to increase levels of noradrenaline and dopamine by inhibiting norepinephrine transporters. In this case report,...
Source: Clinical Neuropharmacology - March 1, 2020 Category: Neurology Tags: Case Reports Source Type: research
Prednisolone as Adjunctive Treatment to Risperidone in Children With Regressive Type of Autism Spectrum Disorder: A Randomized, Placebo-Controlled Trial
This study aimed to evaluate efficacy and safety of prednisolone as an adjunctive treatment to risperidone, in children with regressive autism spectrum disorder (ASD).
Methods
The current 12-week, randomized, single-blinded, placebo-controlled trial recruited 37 patients with regressive ASD. The participants were allocated to receive either 1 mg/kg per day prednisolone or matched placebo in addition to risperidone. The Aberrant Behavior Checklist-Community Edition (ABC-C) scale and Childhood Autism Rating Scale (CARS) were used to measure behavioral outcomes at weeks 0, 4, 8, and 12 of the study course. The primary outc...
Source: Clinical Neuropharmacology - March 1, 2020 Category: Neurology Tags: Original Articles Source Type: research
Fingolimod for Relapsing-Remitting Multiple Sclerosis: The Experience From Saudi Arabia
Conclusions
Our multicenter study provides further evidence for the efficacy of fingolimod in reducing clinical and radiological disease activity in patients with RRMS. The reduction in relapse rate, stabilization of the EDSS score, and improvement in magnetic resonance imaging images were similar to other observational studies conducted in different countries worldwide. Fingolimod seems to be well tolerated for our multiple sclerosis population. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - March 1, 2020 Category: Neurology Tags: Original Articles Source Type: research
Coma Reversal After Intravenous Lipid Emulsion Therapy in a Trazodone-Poisoned Patient
A 77-year-old woman developed a deep coma (Glasgow Coma Scale score at 3/15) after a trazodone overdose (maximal ingested dose, 4500 mg), and orotracheal intubation was required for mechanical ventilation. In addition, she presented sinus bradycardia ( (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - January 1, 2020 Category: Neurology Tags: Case Reports Source Type: research
Adolescent Polypharmacy and Serotonin Syndrome
Conclusions
Patients with ADHD often have comorbid psychiatric illness and are treated with multiple psychotropic medications. Given the effects of drug-drug interactions and the serotonergic effects of psychostimulants, clinicians should remain vigilant for the triad of altered mental status, neuromuscular abnormalities, and autonomic hyperactivity seen in serotonin syndrome. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - January 1, 2020 Category: Neurology Tags: Case Reports Source Type: research
Knee Buckling (Negative Myoclonus) Associated With Clozapine: Reports on 3 Cases
Conclusions
Since the number of reported cases on negative myoclonus is limited, there is still a lack of well-established consensus on the management of this disease. It can be concluded that myoclonic jerk may be dose-dependent, sudden dose changes may be effective, anticonvulsants are not effective in all cases, and treatment can be achieved by reducing the dose. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - January 1, 2020 Category: Neurology Tags: Case Reports Source Type: research
Systematic Evaluation of Levodopa Effect on Visual Improvement in Amblyopia: A Meta-analysis
This study aims to evaluate the effectiveness of levodopa as a therapeutic drug in the treatment of children and adults with amblyopia.
Methods
We performed a systematic review and meta-analysis with randomized controlled trials of levodopa and placebo in the treatment of amblyopia. All data were identified and extracted from the PubMed, EMBASE, Cochrane libraries, and the Chinese knowledge resource integration database.
Results
After screening the literature and evaluating the quality, 11 studies met the criteria from 308 studies. The mean difference of LogMAR visual acuity between levodopa and the placebo group was...
Source: Clinical Neuropharmacology - January 1, 2020 Category: Neurology Tags: Review Article Source Type: research
Contrast-Induced Encephalopathy Resulting From Use of Ioversol and Iopromide
Conclusions
Compared with ioversol, iopromide appeared more likely to lead to CIE. Acute cerebral infarction was an independent risk factor for CIE. The earliest CIE onset was within 5 minutes after injecting contrast. The characteristics of CIE varied significantly for different contrast media. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - January 1, 2020 Category: Neurology Tags: Original Articles Source Type: research
Experience of Using Adrenocorticotropic Hormone in the Treatment of Patients With Acute Neuromyelitis Optica Who Failed Systemic Steroids: A Case Series
Conclusions
Adrenocorticotropic hormone treatment for acute NMO was associated with clinical improvement, suggesting that ACTH could have a role in treating acute NMO patients failing IVMP and declining other treatments. Fewer/less severe AEs were observed with ACTH versus IVMP. Larger, controlled clinical studies are needed. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - January 1, 2020 Category: Neurology Tags: Original Articles Source Type: research
Psychiatric Patients on Neuroleptics: Evaluation of Parkinsonism and Quantified Assessment of Gait
Objectives
We aimed to characterize parkinsonian features and gait performance of psychiatric patients on neuroleptics (PPN) and to compare them to Parkinson's disease (PD) and healthy controls (HC).
Methods
Hospitalized PPN (n = 27) were recruited, examined, and rated for parkinsonian signs according to the motor part of the Movement Disorders Society Unified Parkinson's Disease Rating Scale and performed a 10-m “timed-up-and-go” (TUG) test with a smartphone-based motion capture system attached to their sternum. Gait parameters and mUPDRS scores were compared to those of consecutive age-matched PD patients (n = 1...
Source: Clinical Neuropharmacology - January 1, 2020 Category: Neurology Tags: Original Articles Source Type: research
A Preschooler Girl With Hyperekplexia Treated With Escitalopram
No abstract available (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - November 1, 2019 Category: Neurology Tags: Letter to the Editor Source Type: research
