Acknowledgement to Reviewers
Chemotherapy 2020;65:171 (Source: Chemotherapy)
Source: Chemotherapy - February 26, 2021 Category: Cancer & Oncology Source Type: research
Prognostic Value of the Albumin-to-Alkaline Phosphatase Ratio before Chemoradiotherapy in Patients with Nonmetastatic Nasopharyngeal Carcinoma
Conclusion: AAPR may be a reliable prognostic index for nonmetastatic NPC patients.Chemotherapy (Source: Chemotherapy)
Source: Chemotherapy - February 18, 2021 Category: Cancer & Oncology Source Type: research
Optimal Contact Concentration of Paclitaxel in the Collagen Gel Droplet-Embedded Culture Drug Sensitivity Test for Human Oral Squamous Cell Carcinoma and Evaluation of Combination with Cetuximab
Conclusion: The CD-DST results suggested that it was possible to predict the clinical effects of single-contact PTX and the enhancing effect of cMab + PTX.Chemotherapy (Source: Chemotherapy)
Source: Chemotherapy - February 9, 2021 Category: Cancer & Oncology Source Type: research
Rapid Response of Breast Cancer Cutaneous Metastasis to Single-Agent Palbociclib: A Case Report
We present a case of a woman with a history of infiltrating lobular cancer of the left breast, status post modified radical mastectomy 6 years prior, presenting with nodular erythematous lesions on the left arm and back. Histopathological examination confirmed the dia gnosis of recurrent metastatic breast adenocarcinoma. She had complete resolution of cutaneous metastasis with 1 cycle of Palbociclib. We believe our case is unique as the resolution of cutaneous metastasis with 1 cycle of single-agent Palbociclib is rare. Furthermore, it highlights the importance o f considering cutaneous metastasis as a possibility in patie...
Source: Chemotherapy - February 4, 2021 Category: Cancer & Oncology Source Type: research
Managing the Journey of Patients under Chemotherapy in a Pandemic Era: A Nursing Perspective
Background: During the COVID-19 pandemic, cancer patients ’ care needs to be reconsidered by integrating the patient’s clinical pathway with the hospital patient journey and the family context in a safe and patient-centered way. So far, no systematic reports are available regarding the impact of the COVID-19 pandemic on cancer care. This work gives a f irst overview of patients’ care needs undergoing chemotherapy treatment from a nursing perspective.Chemotherapy (Source: Chemotherapy)
Source: Chemotherapy - February 4, 2021 Category: Cancer & Oncology Source Type: research
Appropriate Number of Docetaxel Cycles in Castration-Resistant Prostate Cancer Patients Considering Peripheral Neuropathy and Oncological Control
Conclusion: The incidence of PN is high, and 8 treatment cycles are optimal for patients receiving docetaxel for CRPC.Chemotherapy (Source: Chemotherapy)
Source: Chemotherapy - January 22, 2021 Category: Cancer & Oncology Source Type: research
Rescue Therapy of Refractory Diffuse Large B-Cell Lymphomas BCL2 with Venetoclax: Case Report
Eleven years ago, a 64-year-old Caucasian man had LNH Follicular 3a, IV A stage, FLIPI 2 as a prognostic index of follicular lymphoma. He received 8 cycles of RCHOP followed by rituximab maintenance, with complete remission. Due to a systemic recurrence, a new treatment schedule (RCOMP, 6 cycles) was introduced with partial remission persisting during a long-term maintenance treatment with rituximab. Three years ago, LNH Follicular 3a progressed into GC type diffuse large B-cell lymphomas (DLBCL); 6 cycles of rituximab and bendamustine were followed by R-ICE and R OXALI DHAP treatments without beneficial effect. Due to the...
Source: Chemotherapy - January 21, 2021 Category: Cancer & Oncology Source Type: research
Minimal Residual Disease Eradication by Azacitidine Maintenance in a Patient with Core-Binding Factor Acute Myeloid Leukemia
Although core-binding factor AML (CBF-AML) has a favorable outcome, disease relapses occur in up to 35% of patients. Minimal residual disease (MRD) monitoring is one of the important tools to enable us to identify patients at high risk of relapse. Real-time quantitative PCR allows MRD to be measured with high sensitivity in CBF-AML. If the patient with CBF-AML is in complete morphologic remission but MRD positive at the end of treatment, what to do for those is still uncertain. Preemptive intervention approaches such as allogeneic hematopoietic stem cell transplantation or intensive chemotherapy could be an option or anoth...
Source: Chemotherapy - December 14, 2020 Category: Cancer & Oncology Source Type: research
“Door to Treatment” Outcomes of Cancer Patients during the COVID-19 Pandemic
Conclusion: The effective shift of workers and accurate regulations have not resulted in apparent delays in patient care. While a decrease in the number of patients has detected, faster healthcare service was introduced to newly diagnosed patients. The reason for the decrease in the number of patients should be investigated with new studies.Chemotherapy (Source: Chemotherapy)
Source: Chemotherapy - December 4, 2020 Category: Cancer & Oncology Source Type: research
Oncologic Outcomes of Salvage Chemotherapy in Patients with Recurrent or Metastatic Lesions after Radical Nephroureterectomy: A Multi-Institutional Retrospective Study
Conclusion: Two or more risk factors defined the high-risk group for patients with recurrence or metastasis after RNU. SC was associated with improved survival in patients with high-risk UTUC.Chemotherapy (Source: Chemotherapy)
Source: Chemotherapy - November 30, 2020 Category: Cancer & Oncology Source Type: research
Protein Disulfide Isomerase 4 Drives Docetaxel Resistance in Prostate Cancer
Conclusions: Our study indicates that PDIA4 is a negative regulator of PCa cell apoptosis and plays a critical role in PCa DTX resistance by activating the Akt-signaling pathway. Thereby, it implies that targeting PDIA4 could be a potential adjuvant therapeutic approach against DTX resistance in PCa.Chemotherapy (Source: Chemotherapy)
Source: Chemotherapy - November 25, 2020 Category: Cancer & Oncology Source Type: research
Diet and Chemotherapy: The Effects of Fasting and Ketogenic Diet on Cancer Treatment
Conclusions: All comparatives studies have demonstrated that even fasting then KD results in a reduction of collateral effects of adjuvant chemotherapy (due to reduction of drugs toxicity) and a better QoL than in patients that follow no diet. Unfortunately, despite the fact that various laboratory and animal studies confirm advantages from KD and fasting, few data are today disposable on humans: further studies are needed to confirm data exposed in this review.Chemotherapy (Source: Chemotherapy)
Source: Chemotherapy - November 16, 2020 Category: Cancer & Oncology Source Type: research
Modern Radiotherapy and Risk of Cardiotoxicity
Despite the advancements of modern radiotherapy, radiation-induced heart disease remains a common cause of morbidity and mortality amongst cancer survivors. This review outlines the basic mechanism, clinical presentation, risk stratification, early detection, possible mitigation, and treatment of this condition.Chemotherapy (Source: Chemotherapy)
Source: Chemotherapy - October 13, 2020 Category: Cancer & Oncology Source Type: research
HDAC3 Silencing Enhances Acute B Lymphoblastic Leukaemia Cells Sensitivity to MG-132 by Inhibiting the JAK/Signal Transducer and Activator of Transcription 3 Signaling Pathway
Conclusions: Silencing of HDAC3 enhanced the sensitivity of B-ALL cells to MG-132. The combination of targeting HDAC3 and MG-132 may provide a new avenue for clinical treatment of acute B lymphocytic leukaemia and improve the poor survival of leukaemia patients.Chemotherapy (Source: Chemotherapy)
Source: Chemotherapy - September 23, 2020 Category: Cancer & Oncology Source Type: research
White Blood Cell Count Nadir and Duration of Aplasia Do Not Associate with Treatment Outcome in Adult Patients with Acute Myeloid Leukemia Undergoing Intensive Chemotherapy
Discussion: The present study evaluated the potential prognostic role of WBC count nadir and duration of aplasia, demonstrating that they are not associated with treatment outcomes in adult patients with AML treated with intensive chemotherapy. Therefore, a short duration of aplasia seems not linked to poor therapeutic efficacy in clearing bone marrow blasts. Our findings, although needing validation in larger and more homogeneous cohorts, may offer helpful clues in the management of aplasia of AML patients.Chemotherapy (Source: Chemotherapy)
Source: Chemotherapy - September 18, 2020 Category: Cancer & Oncology Source Type: research
