Protein Disulfide Isomerase 4 Drives Docetaxel Resistance in Prostate Cancer

Conclusions: Our study indicates that PDIA4 is a negative regulator of PCa cell apoptosis and plays a critical role in PCa DTX resistance by activating the Akt-signaling pathway. Thereby, it implies that targeting PDIA4 could be a potential adjuvant therapeutic approach against DTX resistance in PCa.Chemotherapy
Source: Chemotherapy - Category: Cancer & Oncology Source Type: research