Modified Colistin Regimen for Critically Ill Patients with Acute Renal Impairment and Continuous Renal Replacement Therapy
We report on the potential value of a modified regimen that adopts a loading dose of CMS (bolus of 9 MU vs. conventional 3 MU every 8 h), followed by maintenance (3 MU every 8 h). Preliminary pharmacokinetic evidence for the feasibility and efficacy of this regimen is described for 2 patients.Chemotherapy 2018;63:35-38 (Source: Chemotherapy)
Source: Chemotherapy - December 21, 2017 Category: Cancer & Oncology Source Type: research
Optimal Trough Concentration of Teicoplanin in Febrile Neutropenic Patients with Hematological Malignancy
Conclusions: The authors propose a target teicoplanin Cmin of ≥15.2 mg/L for FN in patients with hematological malignancy.Chemotherapy 2018;63:29-34 (Source: Chemotherapy)
Source: Chemotherapy - November 23, 2017 Category: Cancer & Oncology Source Type: research
Antimicrobial Activity of Galangin and Its Effects on Murein Hydrolases of Vancomycin-Intermediate Staphylococcus aureus (VISA) Strain Mu50
This study aimed to investigate the antimicrobial activity of galangin againstS. aureus and its effects on the murein hydrolases of VISA strain Mu50. This is the first report on these effects of galangin, and it may help to improve the treatment for VISA infections by demonstrating the effective use of galangin.Methods: Firstly, the minimum inhibitory concentration (MIC) and growth curve were used to investigate the antimicrobial activity of galangin againstS. aureus. Secondly, transmission electron microscopy (TEM) was used to observe morphological changes of VISA strain Mu50. Thirdly, Triton X-100-induced autolysis and c...
Source: Chemotherapy - November 17, 2017 Category: Cancer & Oncology Source Type: research
Antimicrobial Activity of Galangin and Its Effects on Murein Hydrolases of Vancomycin-Intermediate < b > < i > Staphylococcus aureus < /i > < /b > (VISA) Strain Mu50
This study aimed to investigate the antimicrobial activity of galangin againstS. aureus and its effects on the murein hydrolases of VISA strain Mu50. This is the first report on these effects of galangin, and it may help to improve the treatment for VISA infections by demonstrating the effective use of galangin.Methods: Firstly, the minimum inhibitory concentration (MIC) and growth curve were used to investigate the antimicrobial activity of galangin againstS. aureus. Secondly, transmission electron microscopy (TEM) was used to observe morphological changes of VISA strain Mu50. Thirdly, Triton X-100-induced autolysis and c...
Source: Chemotherapy - November 16, 2017 Category: Cancer & Oncology Source Type: research
Considerations about the Use of a Loading Dose of Daptomycin in a Neutropenic Murine Thigh Infection Model with Methicillin-Resistant < b > < i > Staphylococcus aureus < /i > < /b > Infection
Previous clinical studies have showed the clinical benefits of the initiation of treatment with a daptomycin (DAP) loading dose, but only a few studies have evaluated its antimicrobial benefits. We evaluated the efficacy of a DAP loading dose against methicillin-resistantStaphylococcus aureus (MRSA) infections in a neutropenic murine thigh infection model. Three MRSA isolates (DAP MIC: 0.5, 1, and 2 mg/L) were tested. Four DAP regimens simulating human concentration-time profiles, i.e., (i) day 1: 8 mg/kg and day 2: 6 mg/kg, (ii) days 1 and 2: 6 mg/kg/day, (iii) day 1: 8 mg/kg and day 2: 4 mg/kg, and (iv) days 1 and 2: 4 m...
Source: Chemotherapy - November 10, 2017 Category: Cancer & Oncology Source Type: research
Acknowledgement to Reviewers
Chemotherapy 2017;62:381 (Source: Chemotherapy)
Source: Chemotherapy - November 2, 2017 Category: Cancer & Oncology Source Type: research
Contents Vol. 62, 2017
Chemotherapy 2017;62:I-VI (Source: Chemotherapy)
Source: Chemotherapy - November 2, 2017 Category: Cancer & Oncology Source Type: research
Effect of a Shortened Duration of FOLFOX Chemotherapy on the Survival Rate of Patients with Stage II and III Colon Cancer
Conclusions: Five-year overall and disease-free survival were not significantly different between the 2 groups. Large-scale prospective studies are necessary for the analysis of complications and survival rates.Chemotherapy 2018;63:8-12 (Source: Chemotherapy)
Source: Chemotherapy - November 1, 2017 Category: Cancer & Oncology Source Type: research
High-Sensitivity Troponin T and NT-proBNP Kinetics in Breast Cancer Chemotherapy
Background/Aims: Doxorubicin (DOX) and trastuzumab (TRA) are associated with cardiac dysfunction.Method: High-sensitivity troponin T (hs-TnT) and brain natriuretic peptide attached to the amino acid N-terminal fragment in the prohormone (NT-proBNP) were measured before and on days +1, +2, +3, and +7 during cycles 1 and 2 of therapy with DOX or TRA in breast cancer patients.Results: Five of eleven DOX-treated women, compared with 2/11 TRA-treated women, had undetectable baseline hs-TnT. By day +1 of cycle 2, all the DOX-treated women (p = 0.03) but only 7/11 TRA-treated women (p = ns) had detectible hs-TnT. Time to peak was...
Source: Chemotherapy - October 25, 2017 Category: Cancer & Oncology Source Type: research
Clinical Manifestations and Prognostic Factors of Pneumocystis jirovecii Pneumonia without HIV
Conclusion: We suggest that poor PS is an independent risk factor in non-HIV PCP, and a patient's PS and disease activity may correlate with outcome.Chemotherapy 2017;62:343-349 (Source: Chemotherapy)
Source: Chemotherapy - October 25, 2017 Category: Cancer & Oncology Source Type: research
Colistin Resistance in KPC-2- and SHV-5-Producing Klebsiella pneumoniae Clinical Isolates in Bulgaria
Conclusions: Although colistin use in Bulgaria only started moderately during 2014, the findings of the current study notify the appearance of colistin resistance among carbapenemase-producingKlebsiella species in another European region.Chemotherapy 2017;62:339-342 (Source: Chemotherapy)
Source: Chemotherapy - October 25, 2017 Category: Cancer & Oncology Source Type: research
Disappearance of Bone Marrow Fibrosis in a Patient with Chronic Myeloid Leukemia Treated with Dasatinib
We report a case of a chronic myeloid leukemia patient showing progressive bone marrow fibrosis and anemia during imatinib therapy. Given the loss of major molecular response, we switched treatment to dasatinib 100 mg daily, observing a reduction in BCR-ABL transcript, a significant improvement of anemia, and a gradual disappearance of fibrosis. After 7 years of dasatinib therapy the patient maintains a complete cytogenetic response and a deep molecular response; the last bone biopsy confirmed the absence of fibrosis.Chemotherapy 2017;62:350-352 (Source: Chemotherapy)
Source: Chemotherapy - October 25, 2017 Category: Cancer & Oncology Source Type: research
Ponatinib-Induced Graft-versus-Host Disease/Graft-versus-Leukemia Effect in a Patient with Philadelphia-Positive Acute Lymphoblastic Leukemia without the T315I Mutation Relapsing after Allogeneic Transplant
We describe the case of a patient with Philadelphia-positive acute lymphoblastic leukemia treated with dasatinib plus steroids as first-line therapy, who achieved a major molecular response (MMR) before undergoing matched, unrelated donor allogeneic stem cell transplant. Eleven months after the transplant, she experienced molecular relapse. Mutational screening showed negativity for the T315I mutation, The patient underwent a salvage chemotherapy regimen with clofarabine + cyclophosphamide + steroids and ponatinib (clofarabine 70 mg i.v., days 1-5, cyclophosphamide 700 mg i.v., days 1-5, and ponatinib 45 mg p.o., daily sta...
Source: Chemotherapy - October 25, 2017 Category: Cancer & Oncology Source Type: research
The Effect of Tegafur-Uracil on Survival in T Categories as Defined in the Eighth Edition of the TNM Classification: An Exploratory Analysis of Postoperative Adjuvant Tegafur-Uracil on Survival in Patients with Adenocarcinoma of the Lung
Background: Tegafur-uracil (UFT) improves survival in patients with stage I adenocarcinoma of the lung. We evaluated the effect of UFT on survival in maximum primary tumor diameter (T) categories as defined in the eighth edition of the TNM Classification (TNM8).Methods: Tumors were subgrouped on the basis of T category (TNM8) as follows: T1a, T ≤1 cm; T1b, 1 (Source: Chemotherapy)
Source: Chemotherapy - October 25, 2017 Category: Cancer & Oncology Source Type: research
Combination Therapy with Capecitabine and Cisplatin as Second-Line Chemotherapy for Advanced Biliary Tract Cancer
Conclusions: Combination therapy with capecitabine and cisplatin may be an option for second-line chemotherapy in some of patients with advanced BTC.Chemotherapy 2017;62:361-366 (Source: Chemotherapy)
Source: Chemotherapy - October 25, 2017 Category: Cancer & Oncology Source Type: research
