Erratum
Chemotherapy (Source: Chemotherapy)
Source: Chemotherapy - May 19, 2020 Category: Cancer & Oncology Source Type: research
Exploring the Role of Piperacillin and Tazobactam in Combination with Vancomycin against Methicillin-Resistant < b > < i > Staphylococcus aureus < /i > < /b >
Previous studies have demonstrated synergy between piperacillin (PIP)-tazobactam (TAZ) (TZP) and vancomycin (VAN) against methicillin-resistantStaphylococcus aureus (MRSA). However, it is unknown whether PIP and/or TAZ synergizes with VAN against MRSA. We sought to determine whether PIP and/or TAZ synergizes with VAN against MRSA in vitro. The activity of PIP and/or TAZ with and without VAN (1/2 the minimum inhibitory concentration) was tested against 5 clinical MRSA isolates using a 24-h time-kill methodology. Antibiotic susceptibilities, accessory gene regulator (agr) operon functionality, and US strain type were also de...
Source: Chemotherapy - May 12, 2020 Category: Cancer & Oncology Source Type: research
Stereotactic Body Radiotherapy Combined with Transcatheter Arterial Chemoembolization versus Stereotactic Body Radiotherapy Alone as the First-Line Treatment for Unresectable Hepatocellular Carcinoma: A Meta-Analysis and Systematic Review
Conclusion: SBRT + TACE appears to be more effective than SBRT alone in treating unresectable HCC. However, its higher incidence rate of leukopenia and fever need to be monitored.Chemotherapy 2019;64:248 –258 (Source: Chemotherapy)
Source: Chemotherapy - April 22, 2020 Category: Cancer & Oncology Source Type: research
Efficacy and Safety of Cetuximab plus Radiotherapy in Cisplatin-Unfit Elderly Patients with Advanced Squamous Cell Head and Neck Carcinoma: A Retrospective Study
Conclusion: Cetuximab plus radiotherapy appears to be feasible and active in elderly patients unsuitable for cisplatin treatment. The treatment was supported by a favorable toxicity profile.Chemotherapy (Source: Chemotherapy)
Source: Chemotherapy - June 26, 2019 Category: Cancer & Oncology Source Type: research
Essential Oils for the Treatment of Herpes Simplex Virus Infections
Infections with herpes simplex virus type (HSV)-1 and HSV-2 are distributed worldwide. Although standard therapies with acyclovir and other synthetic drugs are available, the safety and efficacy of these drugs are limited due to the development of drug resistance and adverse side effects. The literature on essential oils and isolated compounds was reviewed regarding their antiviral activities against HSV-1 and HSV-2. The present overview aims to review experimental data and clinical trials focusing on the antiviral activity of selected essential oils and isolated oil components. HSV was found to be susceptible to many esse...
Source: Chemotherapy - June 24, 2019 Category: Cancer & Oncology Source Type: research
Inhibition of Pantothenate Synthetase by Analogs of β-Alanine Precursor Ineffective as an Antibacterial Strategy
Conclusions: Upon revision of the literature, we conclude that high enzyme selectivity or external salvage mechanisms may render this strategy futile against most bacteria.Chemotherapy (Source: Chemotherapy)
Source: Chemotherapy - June 5, 2019 Category: Cancer & Oncology Source Type: research
Pharmacokinetics of Benzylpenicillin (Penicillin G) during Prolonged Intermittent Renal Replacement Therapy
Prolonged intermittent renal replacement therapy (PIRRT) is an increasingly adopted method of renal replacement in critically ill patients. Like continuous renal replacement therapy, PIRRT can alter the pharmacokinetics (PK) of many drugs. In this setting, dosing data for antibiotics like benzylpenicillin are lacking. In order to enable clinicians to prescribe benzylpenicillin safely and effectively, knowledge of the effects of PIRRT on the plasma PK of benzylpenicillin is required. Herein, we describe the PK of benzylpenicillin in 2 critically ill patients on PIRRT for the treatment of penicillin-susceptibleStaphylococcus...
Source: Chemotherapy - June 5, 2019 Category: Cancer & Oncology Source Type: research
Efficacy of Combination Therapy with Actinomycin D and Methotrexate in the Treatment of Low-Risk Gestational Trophoblastic Neoplasia
Conclusion: Combined ACT-D+MTX chemotherapy achieved overall better efficacy and showed less toxicity than ACT-D or MTX alone, and thus can be prioritized for the treatment of LR-GTN.Chemotherapy (Source: Chemotherapy)
Source: Chemotherapy - June 4, 2019 Category: Cancer & Oncology Source Type: research
Gonadal Function Recovery and Fertility in Women Treated with Chemo- and/or Radiotherapy for Hodgkin ’s and Non-Hodgkin Lymphoma
Conclusions: This study suggests a possible role of pharmacological prophylaxis with OCs and GnRH analogues.Chemotherapy (Source: Chemotherapy)
Source: Chemotherapy - May 22, 2019 Category: Cancer & Oncology Source Type: research
Levofloxacin for NIH Category II Chronic Bacterial Prostatitis: A Real-Life Study
Conclusion: Levofloxacin retained its therapeutic efficacy in patients assessed in a real-life setting, and high eradication rates were attained when it was administered as a single agent. A combination of an FQ with azithromycin induced a significant improvement of eradication rates. This strategy may be an interesting option in both first-referral and relapsing cases, although caution should be exercised when patients are at risk of developing arrhythmias, tendinitis, or other adverse effects.Chemotherapy (Source: Chemotherapy)
Source: Chemotherapy - May 21, 2019 Category: Cancer & Oncology Source Type: research
Acknowledgement to Reviewers
Chemotherapy 2018;63:352 (Source: Chemotherapy)
Source: Chemotherapy - May 5, 2019 Category: Cancer & Oncology Source Type: research
Contents Vol. 63, 2018
Chemotherapy 2018;63:I –VI (Source: Chemotherapy)
Source: Chemotherapy - May 5, 2019 Category: Cancer & Oncology Source Type: research
< b > < i > IL1RN < /i > < /b > Polymorphisms Are Associated with a Decreased Risk of Esophageal Cancer Susceptibility in a Chinese Population
Conclusions: Our study provided the first evidence thatIL1RN rs3181052, rs452204, and rs315919 are correlated with a decreased risk of esophageal cancer in a Northwest Han Chinese population. These findings may be useful for the development of early prognostics for esophageal cancer. However, further larger studies on different ethnic populations are warranted to verify these findings.Chemotherapy (Source: Chemotherapy)
Source: Chemotherapy - April 17, 2019 Category: Cancer & Oncology Source Type: research
Cancer Therapy-Related Cardiac Dysfunction: Are We Treating Echocardiograms, Patients, Neither, or Both?
Chemotherapy 2018;63:338 –339 (Source: Chemotherapy)
Source: Chemotherapy - April 15, 2019 Category: Cancer & Oncology Source Type: research
Osteolytic Lesions in Primary Myelofibrosis and Effect of Ruxolitinib Therapy: Report of a Case and Literature Review
In conclusion, with the present case report, we confirm ruxolitinib efficacy in reducing bone marrow fibrosis grade and assume its possible role in the resolution of osteolytic lesions in PMF. Obviously, further studies with a greater number of patients are needed to document the exact frequency of these unusual findings and the possible role of ruxolitinib in their treatment.Chemotherapy 2018;63:340 –344 (Source: Chemotherapy)
Source: Chemotherapy - April 15, 2019 Category: Cancer & Oncology Source Type: research
