Successful Treatment of a Locally Recurrent and Metastatic Malignant Phyllodes Tumor with Accelerated Radiotherapy and Nab-Paclitaxel, Cisplatin, and Liposomal Doxorubicin Chemotherapy
We present a case of a 62-year-old woman with a recurrent malignant phyllodes tumor of the breast and lung metastases. The patient was originally presented with a borderline phyllodes tumor (7.4 cm) of the left breast, treated with wide local excision. A year later, the patient returned with palpable left breast masses. On PET-CT, increased uptake of18F-FDG by large breast tumors was evident. A right lung lesion of metastatic origin was also present. A simple left breast mastectomy was performed. Histopathological report described 2 malignant phyllodes tumors (7 cm and 6.5 cm). One month later, during the CT simulation for...
Source: Chemotherapy - July 7, 2021 Category: Cancer & Oncology Source Type: research
Durable Molecular Remission in an Elderly Patient Affected by Relapsed Ph & apos;+ Acute Lymphoblastic Leukemia with T315I and Concomitant p190 and p210 Expression Achieved by Inotuzumab and Ponatinib
An unmet clinical need currently exists for elderly patients with relapsed/resistant (R/R) Philadelphia (Ph) positive acute lymphoblastic leukemia (ALL), nearly all who have a very poor prognosis. This includes patients already exposed to the first or second generation tyrosine kinase inhibitors (TKIs) and therefore has few treatment options available. New immunotherapies and targeted agents have shown encouraging activity in R/R ALL irrespective of age. Inotuzumab (InO), a humanized anti-CD22 monoclonal antibody, has potentially beneficial clinical effects in patients with resistant and difficult-to-treat disease in whom ...
Source: Chemotherapy - June 8, 2021 Category: Cancer & Oncology Source Type: research
Quo Vadis COVID? Lessons from a Focus Topic Issue of Chemotherapy
Chemotherapy (Source: Chemotherapy)
Source: Chemotherapy - May 25, 2021 Category: Cancer & Oncology Source Type: research
The Impact of COVID-19 Pandemic on Cancer ’s Patients and Their Access to Chemotherapy in Iraq
Chemotherapy (Source: Chemotherapy)
Source: Chemotherapy - May 20, 2021 Category: Cancer & Oncology Source Type: research
Viral Replication and Antibody Kinetics in the Recognition of Asymptomatic COVID-19 Patients
Following the discovery of COVID-19 disease caused by the SARS-CoV-2 coronavirus, different studies have been carried out to recognize the stages of the disease and the methods of achieving correct diagnosis. Investigations of cases and their contacts have revealed different degrees in the symptomatology of the disease, with asymptomatic patients gaining relevance because of the controversy regarding their role in the spread of the disease. Recognition and assessment of asymptomatic patients is essential to carry out containment actions such as public health measures for affected patients and contacts. In this review, we a...
Source: Chemotherapy - May 7, 2021 Category: Cancer & Oncology Source Type: research
Efficacy and Safety of Anti-Programed Death-1 Blockade in Previously Treated Large-Cell Neuroendocrine Carcinoma
Conclusion: Anti-PD-1 blockade monotherapy as a subsequent line for previously treated advanced LCNEC exhibited usefulness and tolerability and was identified as a valid treatment option.Chemotherapy (Source: Chemotherapy)
Source: Chemotherapy - April 7, 2021 Category: Cancer & Oncology Source Type: research
Molecular Characterization of Tigecycline Non-Susceptibility among Extensively Drug-Resistant < b > < i > Acinetobacter baumannii < /i > < /b > Isolates of Clinical Origin
Conclusion: It can be concluded from our results that reduced susceptibility to TGC in the studied isolates was mainly mediated by genetic alterations in the AdeRS system, which resulted in overexpression of AdeABC efflux pump. Emergence of TGC non-susceptibility among isolates that had not been previously exposed to TGC is an issue of great concern.Chemotherapy (Source: Chemotherapy)
Source: Chemotherapy - April 6, 2021 Category: Cancer & Oncology Source Type: research
Isolated Nodal TBC Reactivation in a Patient with Post-Thrombocythemia Myelofibrosis Treated with Ruxolitinib: Case Report and Review of the Literature
Ruxolitinib side effects include the most frequent hematological toxicity along with a more recently evidenced immunosuppressive activity, interfering both with the innate and adaptive immunity, and several cases of reactivation of latent infections by opportunistic agents in patients in treatment with ruxolitinib have been published in the last years. Several pathophysiological mechanisms may explain an association between ruxolitinib and opportunistic infections. From what we know, the only case of an isolated lymph node TBC reactivation in a ruxolitinib-treated myelofibrosis (MF) patient was reported by Patil et al. in ...
Source: Chemotherapy - March 30, 2021 Category: Cancer & Oncology Source Type: research
Animal Hosts and Experimental Models of SARS-CoV-2 Infection
Viruses arise through cross-species transmission and can cause potentially fatal diseases in humans. This is the case of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which recently appeared in Wuhan, China, and rapidly spread worldwide, causing the outbreak of coronavirus disease 2019 (COVID-19) and posing a global health emergency. Sequence analysis and epidemiological investigations suggest that the most likely original source of SARS-CoV-2 is a spillover from an animal reservoir, probably bats, that infected humans either directly or through intermediate animal hosts. The role of animals as reservoir...
Source: Chemotherapy - March 26, 2021 Category: Cancer & Oncology Source Type: research
Targeting Microbiome: An Alternative Strategy for Fighting SARS-CoV-2 Infection
Respiratory and gastrointestinal symptoms are the predominant clinical manifestations of the coronavirus disease 2019 (COVID-19). Infecting intestinal epithelial cells, the severe acute respiratory syndrome coronavirus-2 may impact on host ’s microbiota and gut inflammation. It is well established that an imbalanced intestinal microbiome can affect pulmonary function, modulating the host immune response (“gut-lung axis”). While effective vaccines and targeted drugs are being tested, alternative pathophysiology-based options to p revent and treat COVID-19 infection must be considered on top of the limited evidence-bas...
Source: Chemotherapy - March 23, 2021 Category: Cancer & Oncology Source Type: research
SARS-CoV-2 Infection and the COVID-19 Pandemic Emergency: The Importance of Diagnostic Methods
Background: Currently, a pandemic of coronavirus disease 2019 (COVID-19) caused by the novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is underway, resulting in high morbidity and mortality across the globe.Summary: A prompt and effective diagnosis is crucial to identify infected individuals, to monitor the infection, to perform contact tracing, and to limit the spread of the virus. Since the announcement of this public health emergency, several diagnostic methods have been developed including molecular and serological assays, and more recently biosensors. Here, we present the use of these as...
Source: Chemotherapy - March 19, 2021 Category: Cancer & Oncology Source Type: research
Analysis of Three Mutations in Italian Strains of SARS-CoV-2: Implications for Pathogenesis
Conclusion: The mutations analyzed in this article can be useful to evaluate the evolution of SARS-CoV-2.Chemotherapy (Source: Chemotherapy)
Source: Chemotherapy - March 18, 2021 Category: Cancer & Oncology Source Type: research
SARS-CoV-2 Lineages and Sub-Lineages Circulating Worldwide: A Dynamic Overview
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) originated in Wuhan, China, in early December 2019 has rapidly widespread worldwide, becoming one of the major global public health issues of the last centuries.Key Messages: Over the course of the pandemic, due to the advanced whole-genome sequencing technologies, an unprecedented amount of genomes have been generated, providing invaluable insights into the ongoing evolution and epidemiology of the virus during the pandemic. Therefore, this large amount of data played an important role in the SARS-CoV-2 mitigation and control strategies.Key Messages:...
Source: Chemotherapy - March 18, 2021 Category: Cancer & Oncology Source Type: research
Choosing Antifungals for the Midostaurin-Treated Patient: Does CYP3A4 Outweigh Recommendations? A Brief Insight from Real Life
Discussion: In real-life scenarios, concerns about CYP3A4 inhibition may outweigh compliance with recommendations. Large studies are needed to survey the risk:benefit of hematologist ’s decision to replace posaconazole with other antifungals.Chemotherapy (Source: Chemotherapy)
Source: Chemotherapy - March 5, 2021 Category: Cancer & Oncology Source Type: research
Contents Vol. 65, 2020
Chemotherapy 2020;65:I –IV (Source: Chemotherapy)
Source: Chemotherapy - February 26, 2021 Category: Cancer & Oncology Source Type: research
