Novel Tetrazoles against Acanthamoeba castellanii Belonging to the T4 Genotype
Background: Acanthamoeba castellanii is a pathogenic free-living amoeba responsible for blinding keratitis and fatal granulomatous amoebic encephalitis. However, treatments are not standardized but can involve the use of amidines, biguanides, and azoles. Objectives: The aim of this study was to synthesize a variety of synthetic tetrazole derivatives and test their activities against A. castellanii. Methods: A series of novel tetrazole compounds were synthesized by one-pot method and characterized by NMR and mass spectroscopy. These compounds were subjected to amoebicidal, and cytotoxicity assays against A. castellanii belo...
Source: Chemotherapy - November 1, 2021 Category: Cancer & Oncology Source Type: research
Isatuximab plus Pomalidomide and Dexamethasone in a Patient with Dialysis-Dependent Multiple Myeloma
The phase 3 ICARIA-MM trial showed that the addition of isatuximab improved the progression-free survival compared with pomalidomide/dexamethasone. However, the safety and efficacy of isatuximab for end-stage renal failure remains unclear. A 67-year-old man who started hemodialysis 5 years ago for diabetic nephropathy was diagnosed with International Staging System stage III multiple myeloma (MM) of IgD- λ type 3 years ago. After receiving a total of 7 treatment regimens, his free light chain (FLC) λ level increased from 419 to 2,070 mg/L, indicating progressive disease. Twelve days after starting isatuximab plus pomalid...
Source: Chemotherapy - October 28, 2021 Category: Cancer & Oncology Source Type: research
The Synergistic Inhibitory Effect of Combining MK-2206 and AZD 6244 in MARIMO Cells Harboring a Calreticulin Gene Mutation
Conclusions: AKT activation is a feature of MARIMO cells and co-targeting of AKT and MAPKs signaling pathways synergistically inhibits MARIMO cell growth.Chemotherapy (Source: Chemotherapy)
Source: Chemotherapy - October 19, 2021 Category: Cancer & Oncology Source Type: research
Metastatic Renal Cell Carcinoma Classified as Good Risk: The Easiest Choice Has Become the Hardest
Chemotherapy (Source: Chemotherapy)
Source: Chemotherapy - October 14, 2021 Category: Cancer & Oncology Source Type: research
S-Adenosylmethionine Supplementation May Reduce Cancer-Related Fatigue: A Prospective Evaluation Using the FACIT-F Questionnaire in Colon Cancer Patients Undergoing Oxaliplatin-Based Chemotherapy Regimens
Conclusions: Mechanisms and strategies for managing CRF are not fully understood. This work aimed at investigating the possible role of S-adenosylmethionine supplementation in improving fatigue scores in a specific setting of cancer patients, using a FACIT-F questionnaire, a well-validated quality of life instrument widely used for the assessment of CRF in clinical trials.Chemotherapy (Source: Chemotherapy)
Source: Chemotherapy - October 13, 2021 Category: Cancer & Oncology Source Type: research
Occupational Safety in Chemosensitivity Tests: A Method to Minimize the Risk of Contamination While Maximizing the Safety for the Examiner
In vitro chemosensitivity tests are a widely used and established method in research. In laboratory environments, work safety is particularly important when working with carcinogenic, mutagenic, or reprotoxic (CMR) substances. When working with cell cultures, minimizing the risk of contamination with CMR substances and protecting the experimenter must be in the foreground of the experimental setup since risk minimization and occupational safety when handling CMR substances are mandatory. To minimize any personnel risk, studies with solid CMR substances should be carried out in a closed system. However, publications on occu...
Source: Chemotherapy - September 8, 2021 Category: Cancer & Oncology Source Type: research
Detection of NDM-1 and VIM Genes in Carbapenem-Resistant < b > < i > Klebsiella pneumoniae < /i > < /b > Isolates from a Tertiary Health-Care Center in Kathmandu, Nepal
Conclusions: Molecular detection of resistant genes provides greater specificity and sensitivity than those with conventional techniques, thus aiding in accurate identification of antimicrobial resistance and clinical management of the disease.Chemotherapy (Source: Chemotherapy)
Source: Chemotherapy - August 31, 2021 Category: Cancer & Oncology Source Type: research
The Role of Hepatic Arterial Infusion Chemotherapy in the Treatment of Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis
Conclusion: HAIC improved long-term survival for both resectable and unresectable HCC patients in comparison with other therapies. However, the clinical effect of HAIC needs to be ascertained by large-scale well-designed studies.Chemotherapy (Source: Chemotherapy)
Source: Chemotherapy - August 26, 2021 Category: Cancer & Oncology Source Type: research
A Relapsing Meningeal Acute Myeloid Leukaemia FLT3-ITD+ Responding to Gilteritinib
A patient with a therapy-related acute myeloid leukaemia (AML), NPM1mut, and FLT3-ITD+ was treated with induction and consolidation with CPX-351, obtaining a complete response (CR) but minimal residual disease persisted positive. Later, she complained progressive burning leg pain, weakening of the right hand and leg muscles, associated with absence of osteotendinous leg reflexes. Examination of cerebrospinal fluid (CSF) showed a meningeal relapse of AML. Moreover, a magnetic resonance imaging (MRI) showed 2 right meningeal implants of myeloid sarcoma and bone marrow revealed haematologic relapse of disease. She was treated...
Source: Chemotherapy - August 24, 2021 Category: Cancer & Oncology Source Type: research
Topotecan plus Platinum-Based Chemotherapy versus Etoposide plus Platinum-Based Chemotherapy for Small-Cell Lung Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Conclusions: Compared with TP, EP was noticeably better in OS and PFS, but EP was toxic in terms of anemia and alopecia. More multicenter, better planned RCTs are needed.Chemotherapy (Source: Chemotherapy)
Source: Chemotherapy - August 19, 2021 Category: Cancer & Oncology Source Type: research
Treatment and Outcomes of Metastatic Pancreatic Cancer in Elderly Patients
Conclusions: Our results showed that older patients with metastatic pancreatic cancer were less likely to receive chemotherapy. However, the survival benefit from chemotherapy was comparable to that of younger patients ’ counterpart. Thus, further study involving identification of older patients who would benefit from cytotoxic chemotherapy is needed.Chemotherapy (Source: Chemotherapy)
Source: Chemotherapy - August 4, 2021 Category: Cancer & Oncology Source Type: research
Investigation of the Physical Properties and Clinical Application of Embosphere Microspheres
Conclusions: Embosphere microspheres can be used to embolize patients with rupture and hemorrhage of HCC. Embosphere microsphere embolization is superior to iodinated oil and iodinated oil + microsphere for HCC.Chemotherapy (Source: Chemotherapy)
Source: Chemotherapy - August 3, 2021 Category: Cancer & Oncology Source Type: research
Two Novel Mutations Associated with Polymyxin-B Resistance in a Pandemic Lineage of Uropathogenic < b > < i > Escherichia coli < /i > < /b > of the Sequence Type 69
Conclusions: The occurrence of non-mcr polymyxin resistance inE. coli from extraintestinal infections underscores the need of a continuous surveillance of this evolving pathogen.Chemotherapy (Source: Chemotherapy)
Source: Chemotherapy - July 29, 2021 Category: Cancer & Oncology Source Type: research
Gemcitabine Plus Nab-Paclitaxel as Second-Line Chemotherapy following FOLFIRINOX in Patients with Unresectable Pancreatic Cancer: A Single-Institution, Retrospective Analysis
Conclusions: GnP after FOLFIRINOX is expected to be one of the second-line recommendations for patients with unresectable pancreatic cancer.Chemotherapy (Source: Chemotherapy)
Source: Chemotherapy - July 20, 2021 Category: Cancer & Oncology Source Type: research
Safety and Survival Outcomes in Lung Cancer Patients Receiving Carboplatin: Impact of Uncapped Dosage
This study compared hematologic toxicity occurrence and survival outcomes in lung cancer patients receiving carboplatin #x3e; or #x3c;800 mg based on the Calvert formula (target area under the curve = 5 mg/mL min). Our results show more severe cytopenia in patients receiving carboplatin #x3e;800 mg with significant difference for all grades of thrombocytopenia in the uncapped group (37% patients vs. 3%,p = 0.02). For metastatic non-small-cell lung cancer patients, we also observed hematologic toxicity in the uncapped group with more severe anemia (30% of patients vs. 0%,p = 0.03) and all grades of thrombocytopenia (39 vs. ...
Source: Chemotherapy - July 19, 2021 Category: Cancer & Oncology Source Type: research
