Carboplatin Dosing Accuracy by Estimation of Glomerular Filtration versus Creatinuria in Cancer Patients
Conclusions: GFR formulae and calculation of the carboplatin dose have good accuracy with the GFR obtained based on the 24-h creatinine clearance, with the Wright formula being the one with best performance and CG the one with worst performance.Chemotherapy 2018;63:137 –142 (Source: Chemotherapy)
Source: Chemotherapy - May 16, 2018 Category: Cancer & Oncology Source Type: research
Second International Colloquium on Cardio-Oncology, Krakow, May 3 - 4, 2018
Chemotherapy 2018;63:111 –111 (Source: Chemotherapy)
Source: Chemotherapy - April 26, 2018 Category: Cancer & Oncology Source Type: research
Sustained Erythroid Response in a Patient with Myelofibrosis Receiving Concomitant Treatment with Ruxolitinib and Deferasirox
Iron overload (IOL) due to transfusion-dependent anemia is a serious adverse effect in patients with myelofibrosis (MF). Recent studies have shown that the oral iron chelator deferasirox may prevent multiple organ damage due to IOL in MF. However, it is not clear whether deferasirox may contribute to revert transfusion-dependent anemia. Here, we present a patient with transfusion-dependent intermediate-2 MF according to the International Prognostic Scoring System treated with ruxolitinib in combination with deferasirox. In addition to a reduced serum ferritin level, the patient required less blood transfusions, ultimately ...
Source: Chemotherapy - April 25, 2018 Category: Cancer & Oncology Source Type: research
Identification of Risk Factors in High-Dose Methotrexate-Induced Acute Kidney Injury in Childhood Acute Lymphoblastic Leukemia
Conclusion: Increasing age, higher MTX dose per BSA, lower baseline serum protein, and first HDMTX course were significant risk factors for developing HDMTX-induced AKI in childhood ALL. The threshold of 48-h MTX plasma concentration is valuable for the prediction of HDMTX-induced AKI.Chemotherapy 2018;63:101 –107 (Source: Chemotherapy)
Source: Chemotherapy - April 19, 2018 Category: Cancer & Oncology Source Type: research
In vitro Antichlamydial Activity of 1,2,3,5-Tetrasubstituted Pyrrole Derivatives
Conclusion: Our findings highlight the potential of 1,2,3,5-tetrasubstituted pyrrole derivatives as promising lead molecules for the development of antichlamydial agents.Chemotherapy 2018;63:96 –100 (Source: Chemotherapy)
Source: Chemotherapy - April 12, 2018 Category: Cancer & Oncology Source Type: research
Erratum
Chemotherapy 2018;63:64 –64 (Source: Chemotherapy)
Source: Chemotherapy - April 10, 2018 Category: Cancer & Oncology Source Type: research
A Complete Pathological Response to Pembrolizumab following ex vivo Liver Resection in a Patient with Colorectal Liver Metastases
Advances in the systemic treatment of stage IV colorectal cancer with liver metastases has offered improved survival rates for patients who otherwise face a dismal prognosis. However, a pathologically complete response (PCR) to chemotherapy for colorectal liver metastases is still rare, and its significance is not fully understood. In this case report, we describe a patient who achieved PCR after neoadjuvant immunotherapy with pembrolizumab and a left hepatectomy using an ex vivo resection technique.Chemotherapy 2018;63:90 –94 (Source: Chemotherapy)
Source: Chemotherapy - April 5, 2018 Category: Cancer & Oncology Source Type: research
Efficacy of a Propolis-Based Syrup (FARINGEL) in Preventing Radiation-Induced Esophagitis in Locally Advanced Lung Cancer
Conclusion: FARINGEL was well-tolerated and delayed esophagitis that was induced by CRT for locally advanced lung cancer.Chemotherapy 2018;63:76 –82 (Source: Chemotherapy)
Source: Chemotherapy - March 19, 2018 Category: Cancer & Oncology Source Type: research
Radiotherapy and Vascular Endothelial Growth Factor Receptor-Tyrosine Kinase Inhibitors in Renal Cancer
This article reviews the literature behind the preclinical and clinical data of the combination of RT with VEGFR-TKIs currently approved for RCC (sunitinib, sorafenib, pazopanib, and axitinib), with a focus on dose schedules as well as efficacy and toxicity.Chemotherapy 2018;63:83 –89 (Source: Chemotherapy)
Source: Chemotherapy - March 19, 2018 Category: Cancer & Oncology Source Type: research
Beneficial and Detrimental Effects of Antiretroviral Therapy on HIV-Associated Immunosenescence
Since the introduction of highly active antiretroviral therapy more than 2 decades ago, HIV-related deaths have dramatically decreased and HIV infection has become a chronic disease. Due to the inability of antiretroviral drugs to eradicate the virus, treatment of HIV infection requires a systemic lifelong therapy. However, even when successfully treated, HIV patients still show increased incidence of age-associated co-morbidities compared with uninfected individuals. Virus- induced immunosenescence, a process characterized by a progressive decline of immune system function, contributes to the premature ageing observed in ...
Source: Chemotherapy - March 13, 2018 Category: Cancer & Oncology Source Type: research
Editorial: The Journal < b > < i > Chemotherapy < /i > < /b > Is for Cardio-Oncologists Too
Chemotherapy 2018;63:53 –54 (Source: Chemotherapy)
Source: Chemotherapy - February 9, 2018 Category: Cancer & Oncology Source Type: research
Early Diastolic Dysfunction after Cancer Chemotherapy: Primary Endpoint Results of a Multicenter Cardio-Oncology Study
Asymptomatic diastolic dysfunction (DD) with preserved left ventricular ejection fraction (LVEF) is suspected to precede late cardiac events in cancer survivors treated by chemotherapy. We conducted the first multicenter study of early DD induced by chemotherapy. Patients who were candidates for standard dose chemotherapy were screened for the absence of cardiovascular risk factors, LVEF ≥50%, normal-for-age diastolic function at echocardiography (E/A ratio, E wave deceleration time; DT), normal levels of potential DD biomarkers like Nt-proBNP (≤125 pg/mL), and cardiac troponin I (cTnI, ≤0.05 ng/mL). Mitral Doppler (...
Source: Chemotherapy - February 9, 2018 Category: Cancer & Oncology Source Type: research
Antitumor Efficacy of Combination Therapy Consisting of S-1, Leucovorin, and Oxaliplatin against Human Gastric Cancer Xenografts
This study examined the antitumor efficacy of combination therapy consisting of S-1, LV, and oxaliplatin against 4 human gastric cancer xenografts: NUGC-4, St-40, SC-2, and SC-4.Methods: The antitumor efficacy was evaluated using human gastric cancer xenograft-bearing nude mice. S-1 and LV were administered orally once daily on days 1-7 at doses of 6.9 and 10 mg/kg, respectively. Oxaliplatin was administered intravenously at a dose of 8.3 mg/kg on day 1. The tumor volume was measured on day 15, and the relative tumor volume (RTV) was calculated.Results: In all 4 xenograft models, S-1 alone and oxaliplatin alone, but not LV...
Source: Chemotherapy - January 23, 2018 Category: Cancer & Oncology Source Type: research
Pazopanib-Induced Hepatotoxicity in an Experimental Rat Model
This study is the first that reports the biochemical and histopathological evaluation of pazopanib-related hepatic toxicity.Chemotherapy 2018;63:39-45 (Source: Chemotherapy)
Source: Chemotherapy - January 23, 2018 Category: Cancer & Oncology Source Type: research
