Light Responsive DNA Nanomaterials and Their Biomedical Applications
Chem Asian J. 2024 Mar 21:e202400226. doi: 10.1002/asia.202400226. Online ahead of print.ABSTRACTDNA nanomaterials have been widely employed for various biomedical applications. With rapid development of chemical modification of nucleic acid, serials of stimuli-responsive elements are included in the multifunctional DNA nanomaterials. In this review, we summarize the recent advances in light responsive DNA nanomaterials based on photocleavage/photodecage, photoisomerization, and photocrosslinking for efficient bioimaging (including imaging of small molecule, microRNA, and protein) and drug delivery (including delivery of s...
Source: Chemistry, an Asian Journal - March 21, 2024 Category: Chemistry Authors: Raja Muhammad Aqib Arsalan Umer Jialin Li Jianbing Liu Baoquan Ding Source Type: research
Quinone methide based self-immobilizing molecular fluorescent probes for in situ imaging of enzymes
Chem Asian J. 2024 Mar 21:e202400189. doi: 10.1002/asia.202400189. Online ahead of print.ABSTRACTEnzymes play important roles not only in normal physiological processes but in the development of many diseases. In situ imaging of enzymes with high-resolution in living systems would helpful for clinical diagnosis and treatment. However, many molecular fluorescent probes suffer from the drawback of diffusing away from the reaction site of enzymes even out of the cells, losing the in situ information and resulting in poor imaging resolution. Quinone methide (QM) based self-immobilizing probes allow the fluorescent signal to be...
Source: Chemistry, an Asian Journal - March 21, 2024 Category: Chemistry Authors: Yeru Miao Zhen-Qing Yu Shuai Xu Mei Yan Source Type: research
Sustainable Vat Photopolymerization-Based 3D-Printing through Dynamic Covalent Network Photopolymers
Chem Asian J. 2024 Mar 20:e202400183. doi: 10.1002/asia.202400183. Online ahead of print.ABSTRACTVat photopolymerization (VPP) based three-dimensional (3D) printing, including stereolithography (SLA) and digital light projection (DLP), is known for producing intricate, high-precision prototypes with superior mechanical properties. However, the challenge lies in the non-recyclability of covalently crosslinked thermosets used in these printing processes, limiting the sustainable utilization of printed prototypes. This review paper examines the recently explored avenue of VPP 3D-printed dynamic covalent network (DCN) polymers...
Source: Chemistry, an Asian Journal - March 20, 2024 Category: Chemistry Authors: Sirawit Pruksawan Yi Ting Chong Wylma Zen Terence Jun En Loh FuKe Wang Source Type: research
Sustainable Vat Photopolymerization-Based 3D-Printing through Dynamic Covalent Network Photopolymers
Chem Asian J. 2024 Mar 20:e202400183. doi: 10.1002/asia.202400183. Online ahead of print.ABSTRACTVat photopolymerization (VPP) based three-dimensional (3D) printing, including stereolithography (SLA) and digital light projection (DLP), is known for producing intricate, high-precision prototypes with superior mechanical properties. However, the challenge lies in the non-recyclability of covalently crosslinked thermosets used in these printing processes, limiting the sustainable utilization of printed prototypes. This review paper examines the recently explored avenue of VPP 3D-printed dynamic covalent network (DCN) polymers...
Source: Chemistry, an Asian Journal - March 20, 2024 Category: Chemistry Authors: Sirawit Pruksawan Yi Ting Chong Wylma Zen Terence Jun En Loh FuKe Wang Source Type: research
Metal-Organic Frameworks-Derived Nanocarbon Materials and Nanometal Oxides for Photocatalytic Applications
Chem Asian J. 2024 Mar 18:e202400161. doi: 10.1002/asia.202400161. Online ahead of print.ABSTRACTHarnessing low-density solar energy and converting it into high-density chemical energy through photocatalysis has emerged as a promising avenue for the production of chemicals and remediation of environmental pollution, which contributes to alleviating the overreliance on fossil fuels. In recent years, metal-organic frameworks (MOFs) have gained widespread application in the field of photocatalysis due to their photostability, tunable structures, and responsiveness in the visible light range. However, most MOFs exhibit relativ...
Source: Chemistry, an Asian Journal - March 19, 2024 Category: Chemistry Authors: Jun-Qing Ye Shu-Ying Xu Qian Liang Yan-Zi Dai Ming-Yang He Source Type: research
Structural Insights on the Role of Halogen Bonding in Protein MEK Kinase-Inhibitor Complexes
Chem Asian J. 2024 Mar 19:e202301033. doi: 10.1002/asia.202301033. Online ahead of print.ABSTRACTKinases are enzymes that play a critical role in governing essential biological processes. Due to their pivotal involvement in cancer cell signaling, they have become key targets in the development of anti-cancer drugs. Among these drugs, those containing the 2,4-dihalophenyl moiety demonstrated significant potential. Here we show how this moiety, particularly the 2-fluoro-4-iodophenyl one, is crucial for the structural stability of the formed drug-enzyme complexes. Crystallographic analysis of reported kinase-inhibitor complex...
Source: Chemistry, an Asian Journal - March 19, 2024 Category: Chemistry Authors: Pietro Milesi Francesca Baldelli Bombelli Luisa Lanfrancone Rosa M Gomila Antonio Frontera Pierangelo Metrangolo Giancarlo Terraneo Source Type: research
The (o-p-o)-Terphenyl Embedded Calix[2]phyrin(2.2. 1 .1. 1 ) and Its Cu(II) Complex
Chem Asian J. 2024 Mar 19:e202400135. doi: 10.1002/asia.202400135. Online ahead of print.ABSTRACTThe introduction of a higher arene unit as a structural motif is unprecedented in calixphyrin chemistry. Herein, the syntheses, spectral and structural characterization of heretofore anonymous terphenylene unit (o-p-o) incorporated calixphyrin with fused sp2meso carbons is reported. The explicitly tailored macrocyclic core is utilized to stabilize the Cu(II) metal ion. The molecular structures of the calixbenziphyrin and Cu(II) complex are unambiguously confirmed by single-crystal X-ray analysis. Moreover, theoretical supports ...
Source: Chemistry, an Asian Journal - March 19, 2024 Category: Chemistry Authors: Sourav Ranjan Pradhan Chetan Kumar Prasad Mainak Das Alagar Srinivasan Source Type: research
Metal-Organic Frameworks-Derived Nanocarbon Materials and Nanometal Oxides for Photocatalytic Applications
Chem Asian J. 2024 Mar 18:e202400161. doi: 10.1002/asia.202400161. Online ahead of print.ABSTRACTHarnessing low-density solar energy and converting it into high-density chemical energy through photocatalysis has emerged as a promising avenue for the production of chemicals and remediation of environmental pollution, which contributes to alleviating the overreliance on fossil fuels. In recent years, metal-organic frameworks (MOFs) have gained widespread application in the field of photocatalysis due to their photostability, tunable structures, and responsiveness in the visible light range. However, most MOFs exhibit relativ...
Source: Chemistry, an Asian Journal - March 19, 2024 Category: Chemistry Authors: Jun-Qing Ye Shu-Ying Xu Qian Liang Yan-Zi Dai Ming-Yang He Source Type: research
Structural Insights on the Role of Halogen Bonding in Protein MEK Kinase-Inhibitor Complexes
Chem Asian J. 2024 Mar 19:e202301033. doi: 10.1002/asia.202301033. Online ahead of print.ABSTRACTKinases are enzymes that play a critical role in governing essential biological processes. Due to their pivotal involvement in cancer cell signaling, they have become key targets in the development of anti-cancer drugs. Among these drugs, those containing the 2,4-dihalophenyl moiety demonstrated significant potential. Here we show how this moiety, particularly the 2-fluoro-4-iodophenyl one, is crucial for the structural stability of the formed drug-enzyme complexes. Crystallographic analysis of reported kinase-inhibitor complex...
Source: Chemistry, an Asian Journal - March 19, 2024 Category: Chemistry Authors: Pietro Milesi Francesca Baldelli Bombelli Luisa Lanfrancone Rosa M Gomila Antonio Frontera Pierangelo Metrangolo Giancarlo Terraneo Source Type: research
Synthesis of R-GABA Derivatives via Pd(II) Catalyzed Enantioselective C(sp3)-H Arylation and Virtual Validation with GABAB1 Receptor for Potential leads
Chem Asian J. 2024 Mar 18:e202400064. doi: 10.1002/asia.202400064. Online ahead of print.ABSTRACTGABA (γ-amino butyric acid) analogues like baclofen, tolibut, phenibut, etc., are well-known GABAB1 inhibitors and pharmaceutically important drugs. However, there is a huge demand for more chiral GABA aryl analogues with promising pharmacological actions. Here, we demonstrate the chiral ligand acetyl-protected amino quinoline (APAQ) mediated enantioselective synthesis of GABAB1 inhibitor drug scaffolds from easily accessible GABA via Pd-catalyzed C(sp3)-H activation. The synthetic methodology shows moderate to good yields, up...
Source: Chemistry, an Asian Journal - March 18, 2024 Category: Chemistry Authors: Smitha Mohanlal Diprupa Saha Shubhant Pandey Rudresh Acharya Nagendra K Sharma Source Type: research
Nucleophilic Selenocyclization Reaction of Benzodiynes Promoted by Sodium Selenide: Synthesis of Isoselenochromenes
We describe here the synthesis of isoselenochromenes via a nucleophilic selenocyclization reaction of benzodiynes with sodium selenide. The central parameters that affect this cyclization reaction were studied, and the best reaction conditions were applied to different substrates to determine the scope of the method. The results indicated that isoselenochromenes were obtained in higher yields when the reactions were performed by the addition of NaBH4 (3 equiv), at room temperature, under nitrogen atmosphere, to a solution of elemental selenium (2 equiv) in dimethylformamide (2 mL). After 1 h, a benzodiynes (0.25 mmol) solu...
Source: Chemistry, an Asian Journal - March 18, 2024 Category: Chemistry Authors: Adriano Maroneze Fab íola Caldeira Davi Back Cristina Nogueira Gilson Zeni Source Type: research
Revisiting Stereoselective Propene Polymerization Mechanisms: Insights through the Activation Strain Model
Chem Asian J. 2024 Mar 17:e202400155. doi: 10.1002/asia.202400155. Online ahead of print.ABSTRACTThe stereoelectronic factors responsible for stereoselectivity in propene polymerization with several metallocene and post-metallocene transition metal catalysts have been revisited using a combined approach of DFT calculations, the Activation Strain Model, Natural Energy Decomposition Analysis and a molecular descriptor (%VBur). There are in most cases two different paths leading to the formation of stereoerrors (SE), and the classical model does not suffice to fully understand stereoregulation. Improving stereoselectivity req...
Source: Chemistry, an Asian Journal - March 17, 2024 Category: Chemistry Authors: Eugenio Romano Vincenzo Barone Peter H M Budzelaar Claudio De Rosa Giovanni Talarico Source Type: research
Revisiting Stereoselective Propene Polymerization Mechanisms: Insights through the Activation Strain Model
Chem Asian J. 2024 Mar 17:e202400155. doi: 10.1002/asia.202400155. Online ahead of print.ABSTRACTThe stereoelectronic factors responsible for stereoselectivity in propene polymerization with several metallocene and post-metallocene transition metal catalysts have been revisited using a combined approach of DFT calculations, the Activation Strain Model, Natural Energy Decomposition Analysis and a molecular descriptor (%VBur). There are in most cases two different paths leading to the formation of stereoerrors (SE), and the classical model does not suffice to fully understand stereoregulation. Improving stereoselectivity req...
Source: Chemistry, an Asian Journal - March 17, 2024 Category: Chemistry Authors: Eugenio Romano Vincenzo Barone Peter H M Budzelaar Claudio De Rosa Giovanni Talarico Source Type: research
Dual Functional Microcapsule based on Monodisperse Short PEG Amphiphile for Drug Encapsulation and Protein Affinity Controlled Release
Chem Asian J. 2024 Mar 15:e202400144. doi: 10.1002/asia.202400144. Online ahead of print.ABSTRACTA short monodisperse poly(ethylene glycol) (PEG) and a neutral organic rotamer conjugate TEG-BTA-2 amphiphile was designed for the construction of a stimuli-responsive switchable self-assembled structure for drug encapsulation by noncovalent interaction and targeted controlled delivery. A short PEG, tetraethylene glycol (TEG) was covalently attached with a neutral organic rotamer benzothiazole dye (BTA-2) affording the neutral TEG-BTA-2 (<500 D). The TEG-BTA-2 is self-assembled into a microsphere in an aqueous medium, but re...
Source: Chemistry, an Asian Journal - March 15, 2024 Category: Chemistry Authors: Rohit N Ketkar Paritosh Dey Triveni Sodnawar Shilpy Sharma Manikandan M Sharmistha Dutta Choudhury Nabanita Sadhukhan Source Type: research
Electro-oxidative methylation of 2-isocyanobiaryls using N,N-dimethylformamide (DMF) as carbon source: Synthesis of 6-methylphenanthridines
Chem Asian J. 2024 Mar 15:e202400176. doi: 10.1002/asia.202400176. Online ahead of print.ABSTRACTA benign electrochemical method to access 6-methylphenanthridines from 2-isocyanobiaryls using N,N-dimethylformamide (DMF) as a methyl source is reported. The protocol operates at ambient temperature without the need for harmful methylating reagents. Mechanistic studies suggested that DMF delivered a methylene synthon, followed by reduction at the cathode and tautomerization. The method offers environmental benefits by avoiding metal-based reagents and harsh conditions.PMID:38489229 | DOI:10.1002/asia.202400176 (Source: Chemist...
Source: Chemistry, an Asian Journal - March 15, 2024 Category: Chemistry Authors: Kannika La-Ongthong Teera Chantarojsiri Darunee Soorukram Pawaret Leowanawat Vichai Reutrakul Chutima Kuhakarn Source Type: research
