Serum TNF- α level and probing depth as a combined indicator for peri-implant disease
Braz J Med Biol Res. 2024 Jan 22;57:e12989. doi: 10.1590/1414-431X2023e12989. eCollection 2024.ABSTRACTPeri-implant disease (PID) is a general term for inflammatory diseases of soft and hard tissues that occur around implants, including peri-implant mucositis and peri-implantitis. Cytokines are a class of small molecule proteins, which have various functions such as regulating innate immunity, adaptive immunity, and repairing damaged tissues. In order to explore the characteristics and clinical significance of tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-10, and tumor growth factor (TGF)-β1 expression levels in ...
Source: Braz J Med Biol Res - January 24, 2024 Category: Research Authors: Huerxidai Yilihamujiang Xiaofeng Ni Mingkai Yu Shuya Dong Long Mei Yuxiang Zheng Lujin Cheng Nannan Pang Source Type: research
Occupational exposure to pesticides deregulates systemic cortisol levels in women with breast cancer and correlates with poor prognosis features
Braz J Med Biol Res. 2024 Jan 22;57:e13060. doi: 10.1590/1414-431X2023e13060. eCollection 2024.ABSTRACTPesticides have been pointed out as hormone disruptors and may significantly affect the prognosis of hormone-dependent diseases such as breast cancer (BC). Here, we investigated the impact of occupational pesticide exposure on systemic cortisol levels in female rural workers diagnosed with BC. Occupational exposure was assessed by interviews with a standardized questionnaire. Plasma samples (112 from pesticide-exposed women and 77 from unexposed women) were collected in the afternoon, outside the physiological cortisol pe...
Source: Braz J Med Biol Res - January 24, 2024 Category: Research Authors: J J Jumes H S Jaques M F Dalla Vecchia M O Ferreira J F G Orrut éa M G Machado M F Mezoni R G S da Silva R F Almeida D Rech A C B Kawassaki C Panis Source Type: research
Health literacy and diabetic retinopathy
In conclusion, HL is related to DR without the mediation of classical clinical variables.PMID:38265342 | PMC:PMC10802231 | DOI:10.1590/1414-431X2023e13066 (Source: Braz J Med Biol Res)
Source: Braz J Med Biol Res - January 24, 2024 Category: Research Authors: J C Breder I Breder J Barreto V Fernandes F Zanchetta B A Oliveira F Chaves A Sposito M H M Lima Source Type: research
Influence of the addition of nanohydroxyapatite to scaffolds on proliferation and differentiation of human mesenchymal stem cells: a systematic review of in vitro studies
Braz J Med Biol Res. 2024 Jan 22;57:e13105. doi: 10.1590/1414-431X2023e13105. eCollection 2024.ABSTRACTOne of the main challenges of tissue engineering in dentistry is to replace bone and dental tissues with strategies or techniques that simulate physiological tissue repair conditions. This systematic review of in vitro studies aimed to evaluate the influence of the addition of nanohydroxyapatite (NHap) to scaffolds on cell proliferation and osteogenic and odontogenic differentiation of human mesenchymal stem cells. In vitro studies on human stem cells that proliferated and differentiated into odontogenic and osteogenic ce...
Source: Braz J Med Biol Res - January 24, 2024 Category: Research Authors: E L de Melo P P A S Cavalcanti C L Pires B V A Tostes J M Miranda A A Barbosa S I S da Rocha N S Deama S Alves Junior M E M M Gerbi Source Type: research
Running intralimb coordination patterns after a foot core exercise program in recreational runners
This study investigated the effects of a foot core intervention on the coordination of foot joints in recreational runners. This was a secondary analysis from a randomized controlled trial conducted with 87 recreational runners allocated to the control group (CG), which followed a placebo lower limb stretching protocol, or the intervention group (IG), which underwent an 8-week (3 times/week) foot core training. The participants ran on a force-instrumented treadmill at a self-selected speed (9.5-10.5 km/h) while the foot segment motion was captured. The vector coding technique was used to assess inter-joint coordination for...
Source: Braz J Med Biol Res - January 24, 2024 Category: Research Authors: E Y Suda M F Vieira A B Matias R S Gomide I C N Sacco Source Type: research
Is near-infrared spectroscopy a promising predictor for early intracranial hemorrhage diagnosis in the Emergency Department?
This study found that a difference of more than 9 in cerebral right-left NIRS values can be a non-invasive, easy-to-administer, rapid, and reliable diagnostic test for early detection of intracranial bleeding. NIRS holds promise as an objective method in ED triage for patients with intracranial hemorrhage. However, further research is needed to fully understand the potential benefits and limitations of this method.PMID:38265345 | PMC:PMC10802232 | DOI:10.1590/1414-431X2023e13155 (Source: Braz J Med Biol Res)
Source: Braz J Med Biol Res - January 24, 2024 Category: Research Authors: O S Çınaroğlu E S Bora H Acar C Ar ıkan M K üçük S K ırık Source Type: research
Didymin protects against polystyrene nanoplastic-induced hepatic damage in male albino rats by modulation of Nrf-2/Keap-1 pathway
Braz J Med Biol Res. 2024 Jan 22;57:e13173. doi: 10.1590/1414-431X2023e13173. eCollection 2024.ABSTRACTPolystyrene nanoplastics (PS-NPs) are ubiquitous environmental pollutants that can cause oxidative stress in various organs, including the liver. Didymin is a dietary flavanone that displays multiple pharmacological activities. Therefore, the present study evaluated the palliative role of didymin against PS-NPs-induced hepatic damage in rats. Albino rats (n=48) were randomly distributed into 4 groups: control, PS-NPs treated group, PS-NPs + didymin co-administered group, and didymin supplemented group. After 30 days, PS-N...
Source: Braz J Med Biol Res - January 24, 2024 Category: Research Authors: M U Ijaz N Nadeem A Hamza M H Almutairi U Atique Source Type: research
Assessing the reaction to and efficacy of the Screener drug discovery and development board game as a pedagogical tool in postgraduate courses
In this study, we provided a comprehensive analysis of five critical aspects for evaluating the quality of educational games, namely: 1) description of the intervention; 2) underlying pedagogical theory; 3) identification of local educational gaps; 4) impact on diverse stakeholders; and 5) elucidation of iterative quality enhancement processes. We also present qualitative and quantitative assessments of the effectiveness of this game in 11 postgraduate courses. We employed the MEEGA+ online survey, comprising thirty-three close-ended unipolar items with 5-point Likert-type response scales, to assess student perceptions of ...
Source: Braz J Med Biol Res - January 24, 2024 Category: Research Authors: F No ël G Xex éo M A Martins E J R Silva A S Pupo P J C Magalh ães R C P Lima-J únior K K L Gadelha K Lima-Silva J M Raimundo P C Ghedini M E Crespo-Lopez G P Arrifano J Ferreira R D Prediger G C G Milit ão R B Oliveira A W Hollais L C M Rodrigues D Source Type: research
Quality of life and functional capacity in depressive patients on hemodialysis: a systematic review and meta-analysis
Braz J Med Biol Res. 2023 Dec 18;56:e12850. doi: 10.1590/1414-431X2023e12850. eCollection 2023.ABSTRACTDepression is a common disorder in patients with chronic kidney disease (CKD), and some data support its relationship with functional capacity and quality of life. However, to date, this has not been evaluated systematically or through meta-analysis. We sought to investigate the relationship of quality of life and functional capacity with depressive disorder in patients with CKD on hemodialysis. This systematic review considered studies published up to 2021 and included cross-sectional and cohort studies. PubMed, Embase, ...
Source: Braz J Med Biol Res - December 21, 2023 Category: Research Authors: M B Moreira N P Cavalli N C Righi F B Schuch L U Signori A M V da Silva Source Type: research
The level of Tim-3+CD8+ T cells can serve as a potential marker for evaluating the severity of acute graft-versus-host disease after haplo-PBSCT
In conclusion, the binding of Tim-3 with exogenous Galectin-9 can promote apoptosis of CD8+ T cells and affect the secretion of Granzyme B. Tim-3+CD8+ T cells have the potential to serve as immunological markers for assessing the severity of aGVHD after haplo-PBSCT and identifying patients at a higher risk for severe aGVHD.PMID:38126537 | PMC:PMC10729645 | DOI:10.1590/1414-431X2023e12997 (Source: Braz J Med Biol Res)
Source: Braz J Med Biol Res - December 21, 2023 Category: Research Authors: Nannan Pang Mingkai Yu Jianli Xu Hailong Yuan Gang Chen Dong Wang Chunxia Han Weiguo Wang Jianbing Ding Ming Jiang Source Type: research
Cellular and molecular mechanisms of Notch signal in pulmonary microvascular endothelial cells after acute lung injury
This study focused on the effect and mechanism of Notch signal on pulmonary microvascular endothelial cells (PMVECs) following acute lung injury. PMVECs were cultured in vitro and randomly divided into eight groups. Grouping was based on whether cells were co-cultured with T cells (splenic CD4+T cells were isolated using MACS microbeads) and the level of Notch expression: Normal group and Normal+T cells group, Model group and Model+T cells group, Notch low-expression group and Notch low-expression+T cells group, and Notch overexpression group and Notch overexpression+T cells group. Except for the Normal group and Normal+T ...
Source: Braz J Med Biol Res - December 21, 2023 Category: Research Authors: Zheng Yang Jilin Ma Zhihui Li Jie Wang Zhanli Shi Source Type: research
Clinical and morphological features of large-cell neuroendocrine carcinomas and small-cell lung carcinomas expressing the DLL3 and ASCL1 oncoproteins
Braz J Med Biol Res. 2023 Dec 22;56:e12921. doi: 10.1590/1414-431X2023e12921. eCollection 2023.ABSTRACTIntratumoral similarities and differences between large-cell neuroendocrine carcinomas (LCNECs) and small-cell lung carcinomas (SCLCs) are determined partially by the Notch signaling pathway, which controls the switch from neuroendocrine to slight/non-neuroendocrine cell fate. LCNECs are divided into two subgroups according to genomic alterations: type I LCNECs exhibit a neuroendocrine profile characterized by achaete-scute homolog 1 (ASCL1)high/delta-like protein 3 (DLL3)high/NOTCHlow and type II LCNECs show the pattern ...
Source: Braz J Med Biol Res - December 21, 2023 Category: Research Authors: T G Prieto C M Baldavira J Machado-Rugolo E H R Olivieri E C A da Silva V G Silva A M Ab'Saber T Y Takagaki V L Capelozzi Source Type: research
Quality of life and functional capacity in depressive patients on hemodialysis: a systematic review and meta-analysis
Braz J Med Biol Res. 2023 Dec 18;56:e12850. doi: 10.1590/1414-431X2023e12850. eCollection 2023.ABSTRACTDepression is a common disorder in patients with chronic kidney disease (CKD), and some data support its relationship with functional capacity and quality of life. However, to date, this has not been evaluated systematically or through meta-analysis. We sought to investigate the relationship of quality of life and functional capacity with depressive disorder in patients with CKD on hemodialysis. This systematic review considered studies published up to 2021 and included cross-sectional and cohort studies. PubMed, Embase, ...
Source: Braz J Med Biol Res - December 21, 2023 Category: Research Authors: M B Moreira N P Cavalli N C Righi F B Schuch L U Signori A M V da Silva Source Type: research
The level of Tim-3+CD8+ T cells can serve as a potential marker for evaluating the severity of acute graft-versus-host disease after haplo-PBSCT
In conclusion, the binding of Tim-3 with exogenous Galectin-9 can promote apoptosis of CD8+ T cells and affect the secretion of Granzyme B. Tim-3+CD8+ T cells have the potential to serve as immunological markers for assessing the severity of aGVHD after haplo-PBSCT and identifying patients at a higher risk for severe aGVHD.PMID:38126537 | PMC:PMC10729645 | DOI:10.1590/1414-431X2023e12997 (Source: Braz J Med Biol Res)
Source: Braz J Med Biol Res - December 21, 2023 Category: Research Authors: Nannan Pang Mingkai Yu Jianli Xu Hailong Yuan Gang Chen Dong Wang Chunxia Han Weiguo Wang Jianbing Ding Ming Jiang Source Type: research
Cellular and molecular mechanisms of Notch signal in pulmonary microvascular endothelial cells after acute lung injury
This study focused on the effect and mechanism of Notch signal on pulmonary microvascular endothelial cells (PMVECs) following acute lung injury. PMVECs were cultured in vitro and randomly divided into eight groups. Grouping was based on whether cells were co-cultured with T cells (splenic CD4+T cells were isolated using MACS microbeads) and the level of Notch expression: Normal group and Normal+T cells group, Model group and Model+T cells group, Notch low-expression group and Notch low-expression+T cells group, and Notch overexpression group and Notch overexpression+T cells group. Except for the Normal group and Normal+T ...
Source: Braz J Med Biol Res - December 21, 2023 Category: Research Authors: Zheng Yang Jilin Ma Zhihui Li Jie Wang Zhanli Shi Source Type: research
