Diabetes, hemoglobin A1c, and cognitive performance in older adults: is there any impact of frailty? Evidence from the ELSI-Brazil study
In conclusion, higher hemoglobin A1c levels were associated with lower cognitive performance among non-frail participants. Higher hemoglobin A1c levels without a previous diagnosis of diabetes were also related to poor cognitive performance. Future longitudinal analyses of the ELSI-Brazil study will provide further information on the role of frailty in the association of diabetes and glycemic control with cognitive decline.PMID:38381882 | PMC:PMC10880886 | DOI:10.1590/1414-431X2023e12939 (Source: Braz J Med Biol Res)
Source: Braz J Med Biol Res - February 21, 2024 Category: Research Authors: J G Souza D S Farias-Itao M J R Aliberti T S Alexandre C Szlejf C P Ferri M F Lima-Costa C K Suemoto Source Type: research

Inhibition of anlotinib-induced autophagy attenuates invasion and migration by regulating epithelial-mesenchymal transition and cytoskeletal rearrangement through ATG5 in human osteosarcoma cells
Braz J Med Biol Res. 2024 Feb 19;57:e13152. doi: 10.1590/1414-431X2023e13152. eCollection 2024.ABSTRACTThe cure rates for osteosarcoma have remained unchanged in the past three decades, especially for patients with pulmonary metastasis. Thus, a new and effective treatment for metastatic osteosarcoma is urgently needed. Anlotinib has been reported to have antitumor effects on advanced osteosarcoma. However, both the effect of anlotinib on autophagy in osteosarcoma and the mechanism of anlotinib-mediated autophagy in pulmonary metastasis are unclear. The effect of anlotinib treatment on the metastasis of osteosarcoma was inv...
Source: Braz J Med Biol Res - February 21, 2024 Category: Research Authors: Bingxin Zheng Xiangchen Sun Li Zhang Guojian Qu Chongmin Ren Peng Yan Chuanli Zhou Bin Yue Source Type: research

Correlation analysis between peripheral blood dendritic cell subsets and PD-1 in patients with peritoneal adenocarcinoma
Braz J Med Biol Res. 2024 Feb 19;57:e13192. doi: 10.1590/1414-431X2023e13192. eCollection 2024.ABSTRACTThe aim of this study was to explore the association between differential percentages of dendritic cell (DC) subsets in peripheral blood and malignancy (grade and lymph node metastasis) of peritoneal adenocarcinoma patients and the frequencies of dendritic cell subsets in the normal controls. The peripheral blood of 30 patients with peritoneal adenocarcinoma and 12 healthy controls were collected for multicolor flow cytometry analysis. Peritoneal adenocarcinoma patients were grouped according to the malignant degree (grad...
Source: Braz J Med Biol Res - February 21, 2024 Category: Research Authors: Huihui Hu Man Zhang Source Type: research

Puerarin protects the fatty liver from ischemia-reperfusion injury by regulating the PI3K/AKT signaling pathway
In conclusion, puerarin could significantly protect the fatty liver against IRI by activating the PI3K-AKT signaling pathway.PMID:38381885 | PMC:PMC10880884 | DOI:10.1590/1414-431X2024e13229 (Source: Braz J Med Biol Res)
Source: Braz J Med Biol Res - February 21, 2024 Category: Research Authors: Faji Yang Hengjun Gao Zheyu Niu Qingqiang Ni Huaqiang Zhu Jianlu Wang Jun Lu Source Type: research

Effect of MCH1, a fatty-acid amide hydrolase inhibitor, on the depressive-like behavior and gene expression of endocannabinoid and dopaminergic-signaling system in the mouse nucleus accumbens
Braz J Med Biol Res. 2024 Feb 19;57:e12857. doi: 10.1590/1414-431X2024e12857. eCollection 2024.ABSTRACTMCH1 is a synthetic macamide that has shown in vitro inhibitory activity on fatty acid amide hydrolase (FAAH), an enzyme responsible for endocannabinoid metabolism. This inhibition can modulate endocannabinoid and dopamine signaling in the nucleus accumbens (NAc), potentially having an antidepressant-like effect. The present study aimed to evaluate the effect of the in vivo administration of MCH1 (3, 10, and 30 mg/kg, ip) in 2-month-old BALB/c male mice (n=97) on forced swimming test (FST), light-dark box (LDB), and open ...
Source: Braz J Med Biol Res - February 21, 2024 Category: Research Authors: C Medina-Saldivar G V E Pardo L F Pacheco-Otalora Source Type: research

Diabetes, hemoglobin A1c, and cognitive performance in older adults: is there any impact of frailty? Evidence from the ELSI-Brazil study
In conclusion, higher hemoglobin A1c levels were associated with lower cognitive performance among non-frail participants. Higher hemoglobin A1c levels without a previous diagnosis of diabetes were also related to poor cognitive performance. Future longitudinal analyses of the ELSI-Brazil study will provide further information on the role of frailty in the association of diabetes and glycemic control with cognitive decline.PMID:38381882 | PMC:PMC10880886 | DOI:10.1590/1414-431X2023e12939 (Source: Braz J Med Biol Res)
Source: Braz J Med Biol Res - February 21, 2024 Category: Research Authors: J G Souza D S Farias-Itao M J R Aliberti T S Alexandre C Szlejf C P Ferri M F Lima-Costa C K Suemoto Source Type: research

Inhibition of anlotinib-induced autophagy attenuates invasion and migration by regulating epithelial-mesenchymal transition and cytoskeletal rearrangement through ATG5 in human osteosarcoma cells
Braz J Med Biol Res. 2024 Feb 19;57:e13152. doi: 10.1590/1414-431X2023e13152. eCollection 2024.ABSTRACTThe cure rates for osteosarcoma have remained unchanged in the past three decades, especially for patients with pulmonary metastasis. Thus, a new and effective treatment for metastatic osteosarcoma is urgently needed. Anlotinib has been reported to have antitumor effects on advanced osteosarcoma. However, both the effect of anlotinib on autophagy in osteosarcoma and the mechanism of anlotinib-mediated autophagy in pulmonary metastasis are unclear. The effect of anlotinib treatment on the metastasis of osteosarcoma was inv...
Source: Braz J Med Biol Res - February 21, 2024 Category: Research Authors: Bingxin Zheng Xiangchen Sun Li Zhang Guojian Qu Chongmin Ren Peng Yan Chuanli Zhou Bin Yue Source Type: research

Correlation analysis between peripheral blood dendritic cell subsets and PD-1 in patients with peritoneal adenocarcinoma
Braz J Med Biol Res. 2024 Feb 19;57:e13192. doi: 10.1590/1414-431X2023e13192. eCollection 2024.ABSTRACTThe aim of this study was to explore the association between differential percentages of dendritic cell (DC) subsets in peripheral blood and malignancy (grade and lymph node metastasis) of peritoneal adenocarcinoma patients and the frequencies of dendritic cell subsets in the normal controls. The peripheral blood of 30 patients with peritoneal adenocarcinoma and 12 healthy controls were collected for multicolor flow cytometry analysis. Peritoneal adenocarcinoma patients were grouped according to the malignant degree (grad...
Source: Braz J Med Biol Res - February 21, 2024 Category: Research Authors: Huihui Hu Man Zhang Source Type: research

Puerarin protects the fatty liver from ischemia-reperfusion injury by regulating the PI3K/AKT signaling pathway
In conclusion, puerarin could significantly protect the fatty liver against IRI by activating the PI3K-AKT signaling pathway.PMID:38381885 | PMC:PMC10880884 | DOI:10.1590/1414-431X2024e13229 (Source: Braz J Med Biol Res)
Source: Braz J Med Biol Res - February 21, 2024 Category: Research Authors: Faji Yang Hengjun Gao Zheyu Niu Qingqiang Ni Huaqiang Zhu Jianlu Wang Jun Lu Source Type: research

Effect of MCH1, a fatty-acid amide hydrolase inhibitor, on the depressive-like behavior and gene expression of endocannabinoid and dopaminergic-signaling system in the mouse nucleus accumbens
Braz J Med Biol Res. 2024 Feb 19;57:e12857. doi: 10.1590/1414-431X2024e12857. eCollection 2024.ABSTRACTMCH1 is a synthetic macamide that has shown in vitro inhibitory activity on fatty acid amide hydrolase (FAAH), an enzyme responsible for endocannabinoid metabolism. This inhibition can modulate endocannabinoid and dopamine signaling in the nucleus accumbens (NAc), potentially having an antidepressant-like effect. The present study aimed to evaluate the effect of the in vivo administration of MCH1 (3, 10, and 30 mg/kg, ip) in 2-month-old BALB/c male mice (n=97) on forced swimming test (FST), light-dark box (LDB), and open ...
Source: Braz J Med Biol Res - February 21, 2024 Category: Research Authors: C Medina-Saldivar G V E Pardo L F Pacheco-Otalora Source Type: research

Diabetes, hemoglobin A1c, and cognitive performance in older adults: is there any impact of frailty? Evidence from the ELSI-Brazil study
In conclusion, higher hemoglobin A1c levels were associated with lower cognitive performance among non-frail participants. Higher hemoglobin A1c levels without a previous diagnosis of diabetes were also related to poor cognitive performance. Future longitudinal analyses of the ELSI-Brazil study will provide further information on the role of frailty in the association of diabetes and glycemic control with cognitive decline.PMID:38381882 | PMC:PMC10880886 | DOI:10.1590/1414-431X2023e12939 (Source: Braz J Med Biol Res)
Source: Braz J Med Biol Res - February 21, 2024 Category: Research Authors: J G Souza D S Farias-Itao M J R Aliberti T S Alexandre C Szlejf C P Ferri M F Lima-Costa C K Suemoto Source Type: research

Inhibition of anlotinib-induced autophagy attenuates invasion and migration by regulating epithelial-mesenchymal transition and cytoskeletal rearrangement through ATG5 in human osteosarcoma cells
Braz J Med Biol Res. 2024 Feb 19;57:e13152. doi: 10.1590/1414-431X2023e13152. eCollection 2024.ABSTRACTThe cure rates for osteosarcoma have remained unchanged in the past three decades, especially for patients with pulmonary metastasis. Thus, a new and effective treatment for metastatic osteosarcoma is urgently needed. Anlotinib has been reported to have antitumor effects on advanced osteosarcoma. However, both the effect of anlotinib on autophagy in osteosarcoma and the mechanism of anlotinib-mediated autophagy in pulmonary metastasis are unclear. The effect of anlotinib treatment on the metastasis of osteosarcoma was inv...
Source: Braz J Med Biol Res - February 21, 2024 Category: Research Authors: Bingxin Zheng Xiangchen Sun Li Zhang Guojian Qu Chongmin Ren Peng Yan Chuanli Zhou Bin Yue Source Type: research

Correlation analysis between peripheral blood dendritic cell subsets and PD-1 in patients with peritoneal adenocarcinoma
Braz J Med Biol Res. 2024 Feb 19;57:e13192. doi: 10.1590/1414-431X2023e13192. eCollection 2024.ABSTRACTThe aim of this study was to explore the association between differential percentages of dendritic cell (DC) subsets in peripheral blood and malignancy (grade and lymph node metastasis) of peritoneal adenocarcinoma patients and the frequencies of dendritic cell subsets in the normal controls. The peripheral blood of 30 patients with peritoneal adenocarcinoma and 12 healthy controls were collected for multicolor flow cytometry analysis. Peritoneal adenocarcinoma patients were grouped according to the malignant degree (grad...
Source: Braz J Med Biol Res - February 21, 2024 Category: Research Authors: Huihui Hu Man Zhang Source Type: research

Puerarin protects the fatty liver from ischemia-reperfusion injury by regulating the PI3K/AKT signaling pathway
In conclusion, puerarin could significantly protect the fatty liver against IRI by activating the PI3K-AKT signaling pathway.PMID:38381885 | PMC:PMC10880884 | DOI:10.1590/1414-431X2024e13229 (Source: Braz J Med Biol Res)
Source: Braz J Med Biol Res - February 21, 2024 Category: Research Authors: Faji Yang Hengjun Gao Zheyu Niu Qingqiang Ni Huaqiang Zhu Jianlu Wang Jun Lu Source Type: research

Effect of MCH1, a fatty-acid amide hydrolase inhibitor, on the depressive-like behavior and gene expression of endocannabinoid and dopaminergic-signaling system in the mouse nucleus accumbens
Braz J Med Biol Res. 2024 Feb 19;57:e12857. doi: 10.1590/1414-431X2024e12857. eCollection 2024.ABSTRACTMCH1 is a synthetic macamide that has shown in vitro inhibitory activity on fatty acid amide hydrolase (FAAH), an enzyme responsible for endocannabinoid metabolism. This inhibition can modulate endocannabinoid and dopamine signaling in the nucleus accumbens (NAc), potentially having an antidepressant-like effect. The present study aimed to evaluate the effect of the in vivo administration of MCH1 (3, 10, and 30 mg/kg, ip) in 2-month-old BALB/c male mice (n=97) on forced swimming test (FST), light-dark box (LDB), and open ...
Source: Braz J Med Biol Res - February 21, 2024 Category: Research Authors: C Medina-Saldivar G V E Pardo L F Pacheco-Otalora Source Type: research