Clinical and morphological features of large-cell neuroendocrine carcinomas and small-cell lung carcinomas expressing the DLL3 and ASCL1 oncoproteins
Braz J Med Biol Res. 2023 Dec 22;56:e12921. doi: 10.1590/1414-431X2023e12921. eCollection 2023.ABSTRACTIntratumoral similarities and differences between large-cell neuroendocrine carcinomas (LCNECs) and small-cell lung carcinomas (SCLCs) are determined partially by the Notch signaling pathway, which controls the switch from neuroendocrine to slight/non-neuroendocrine cell fate. LCNECs are divided into two subgroups according to genomic alterations: type I LCNECs exhibit a neuroendocrine profile characterized by achaete-scute homolog 1 (ASCL1)high/delta-like protein 3 (DLL3)high/NOTCHlow and type II LCNECs show the pattern ...
Source: Braz J Med Biol Res - December 21, 2023 Category: Research Authors: T G Prieto C M Baldavira J Machado-Rugolo E H R Olivieri E C A da Silva V G Silva A M Ab'Saber T Y Takagaki V L Capelozzi Source Type: research
Quality of life and functional capacity in depressive patients on hemodialysis: a systematic review and meta-analysis
Braz J Med Biol Res. 2023 Dec 18;56:e12850. doi: 10.1590/1414-431X2023e12850. eCollection 2023.ABSTRACTDepression is a common disorder in patients with chronic kidney disease (CKD), and some data support its relationship with functional capacity and quality of life. However, to date, this has not been evaluated systematically or through meta-analysis. We sought to investigate the relationship of quality of life and functional capacity with depressive disorder in patients with CKD on hemodialysis. This systematic review considered studies published up to 2021 and included cross-sectional and cohort studies. PubMed, Embase, ...
Source: Braz J Med Biol Res - December 21, 2023 Category: Research Authors: M B Moreira N P Cavalli N C Righi F B Schuch L U Signori A M V da Silva Source Type: research
The level of Tim-3+CD8+ T cells can serve as a potential marker for evaluating the severity of acute graft-versus-host disease after haplo-PBSCT
In conclusion, the binding of Tim-3 with exogenous Galectin-9 can promote apoptosis of CD8+ T cells and affect the secretion of Granzyme B. Tim-3+CD8+ T cells have the potential to serve as immunological markers for assessing the severity of aGVHD after haplo-PBSCT and identifying patients at a higher risk for severe aGVHD.PMID:38126537 | PMC:PMC10729645 | DOI:10.1590/1414-431X2023e12997 (Source: Braz J Med Biol Res)
Source: Braz J Med Biol Res - December 21, 2023 Category: Research Authors: Nannan Pang Mingkai Yu Jianli Xu Hailong Yuan Gang Chen Dong Wang Chunxia Han Weiguo Wang Jianbing Ding Ming Jiang Source Type: research
Cellular and molecular mechanisms of Notch signal in pulmonary microvascular endothelial cells after acute lung injury
This study focused on the effect and mechanism of Notch signal on pulmonary microvascular endothelial cells (PMVECs) following acute lung injury. PMVECs were cultured in vitro and randomly divided into eight groups. Grouping was based on whether cells were co-cultured with T cells (splenic CD4+T cells were isolated using MACS microbeads) and the level of Notch expression: Normal group and Normal+T cells group, Model group and Model+T cells group, Notch low-expression group and Notch low-expression+T cells group, and Notch overexpression group and Notch overexpression+T cells group. Except for the Normal group and Normal+T ...
Source: Braz J Med Biol Res - December 21, 2023 Category: Research Authors: Zheng Yang Jilin Ma Zhihui Li Jie Wang Zhanli Shi Source Type: research
Clinical and morphological features of large-cell neuroendocrine carcinomas and small-cell lung carcinomas expressing the DLL3 and ASCL1 oncoproteins
Braz J Med Biol Res. 2023 Dec 22;56:e12921. doi: 10.1590/1414-431X2023e12921. eCollection 2023.ABSTRACTIntratumoral similarities and differences between large-cell neuroendocrine carcinomas (LCNECs) and small-cell lung carcinomas (SCLCs) are determined partially by the Notch signaling pathway, which controls the switch from neuroendocrine to slight/non-neuroendocrine cell fate. LCNECs are divided into two subgroups according to genomic alterations: type I LCNECs exhibit a neuroendocrine profile characterized by achaete-scute homolog 1 (ASCL1)high/delta-like protein 3 (DLL3)high/NOTCHlow and type II LCNECs show the pattern ...
Source: Braz J Med Biol Res - December 21, 2023 Category: Research Authors: T G Prieto C M Baldavira J Machado-Rugolo E H R Olivieri E C A da Silva V G Silva A M Ab'Saber T Y Takagaki V L Capelozzi Source Type: research
Quality of life and functional capacity in depressive patients on hemodialysis: a systematic review and meta-analysis
Braz J Med Biol Res. 2023 Dec 18;56:e12850. doi: 10.1590/1414-431X2023e12850. eCollection 2023.ABSTRACTDepression is a common disorder in patients with chronic kidney disease (CKD), and some data support its relationship with functional capacity and quality of life. However, to date, this has not been evaluated systematically or through meta-analysis. We sought to investigate the relationship of quality of life and functional capacity with depressive disorder in patients with CKD on hemodialysis. This systematic review considered studies published up to 2021 and included cross-sectional and cohort studies. PubMed, Embase, ...
Source: Braz J Med Biol Res - December 21, 2023 Category: Research Authors: M B Moreira N P Cavalli N C Righi F B Schuch L U Signori A M V da Silva Source Type: research
The level of Tim-3+CD8+ T cells can serve as a potential marker for evaluating the severity of acute graft-versus-host disease after haplo-PBSCT
In conclusion, the binding of Tim-3 with exogenous Galectin-9 can promote apoptosis of CD8+ T cells and affect the secretion of Granzyme B. Tim-3+CD8+ T cells have the potential to serve as immunological markers for assessing the severity of aGVHD after haplo-PBSCT and identifying patients at a higher risk for severe aGVHD.PMID:38126537 | PMC:PMC10729645 | DOI:10.1590/1414-431X2023e12997 (Source: Braz J Med Biol Res)
Source: Braz J Med Biol Res - December 21, 2023 Category: Research Authors: Nannan Pang Mingkai Yu Jianli Xu Hailong Yuan Gang Chen Dong Wang Chunxia Han Weiguo Wang Jianbing Ding Ming Jiang Source Type: research
Cellular and molecular mechanisms of Notch signal in pulmonary microvascular endothelial cells after acute lung injury
This study focused on the effect and mechanism of Notch signal on pulmonary microvascular endothelial cells (PMVECs) following acute lung injury. PMVECs were cultured in vitro and randomly divided into eight groups. Grouping was based on whether cells were co-cultured with T cells (splenic CD4+T cells were isolated using MACS microbeads) and the level of Notch expression: Normal group and Normal+T cells group, Model group and Model+T cells group, Notch low-expression group and Notch low-expression+T cells group, and Notch overexpression group and Notch overexpression+T cells group. Except for the Normal group and Normal+T ...
Source: Braz J Med Biol Res - December 21, 2023 Category: Research Authors: Zheng Yang Jilin Ma Zhihui Li Jie Wang Zhanli Shi Source Type: research
Clinical and morphological features of large-cell neuroendocrine carcinomas and small-cell lung carcinomas expressing the DLL3 and ASCL1 oncoproteins
Braz J Med Biol Res. 2023 Dec 22;56:e12921. doi: 10.1590/1414-431X2023e12921. eCollection 2023.ABSTRACTIntratumoral similarities and differences between large-cell neuroendocrine carcinomas (LCNECs) and small-cell lung carcinomas (SCLCs) are determined partially by the Notch signaling pathway, which controls the switch from neuroendocrine to slight/non-neuroendocrine cell fate. LCNECs are divided into two subgroups according to genomic alterations: type I LCNECs exhibit a neuroendocrine profile characterized by achaete-scute homolog 1 (ASCL1)high/delta-like protein 3 (DLL3)high/NOTCHlow and type II LCNECs show the pattern ...
Source: Braz J Med Biol Res - December 21, 2023 Category: Research Authors: T G Prieto C M Baldavira J Machado-Rugolo E H R Olivieri E C A da Silva V G Silva A M Ab'Saber T Y Takagaki V L Capelozzi Source Type: research
Quality of life and functional capacity in depressive patients on hemodialysis: a systematic review and meta-analysis
Braz J Med Biol Res. 2023 Dec 18;56:e12850. doi: 10.1590/1414-431X2023e12850. eCollection 2023.ABSTRACTDepression is a common disorder in patients with chronic kidney disease (CKD), and some data support its relationship with functional capacity and quality of life. However, to date, this has not been evaluated systematically or through meta-analysis. We sought to investigate the relationship of quality of life and functional capacity with depressive disorder in patients with CKD on hemodialysis. This systematic review considered studies published up to 2021 and included cross-sectional and cohort studies. PubMed, Embase, ...
Source: Braz J Med Biol Res - December 21, 2023 Category: Research Authors: M B Moreira N P Cavalli N C Righi F B Schuch L U Signori A M V da Silva Source Type: research
The level of Tim-3+CD8+ T cells can serve as a potential marker for evaluating the severity of acute graft-versus-host disease after haplo-PBSCT
In conclusion, the binding of Tim-3 with exogenous Galectin-9 can promote apoptosis of CD8+ T cells and affect the secretion of Granzyme B. Tim-3+CD8+ T cells have the potential to serve as immunological markers for assessing the severity of aGVHD after haplo-PBSCT and identifying patients at a higher risk for severe aGVHD.PMID:38126537 | PMC:PMC10729645 | DOI:10.1590/1414-431X2023e12997 (Source: Braz J Med Biol Res)
Source: Braz J Med Biol Res - December 21, 2023 Category: Research Authors: Nannan Pang Mingkai Yu Jianli Xu Hailong Yuan Gang Chen Dong Wang Chunxia Han Weiguo Wang Jianbing Ding Ming Jiang Source Type: research
Cellular and molecular mechanisms of Notch signal in pulmonary microvascular endothelial cells after acute lung injury
This study focused on the effect and mechanism of Notch signal on pulmonary microvascular endothelial cells (PMVECs) following acute lung injury. PMVECs were cultured in vitro and randomly divided into eight groups. Grouping was based on whether cells were co-cultured with T cells (splenic CD4+T cells were isolated using MACS microbeads) and the level of Notch expression: Normal group and Normal+T cells group, Model group and Model+T cells group, Notch low-expression group and Notch low-expression+T cells group, and Notch overexpression group and Notch overexpression+T cells group. Except for the Normal group and Normal+T ...
Source: Braz J Med Biol Res - December 21, 2023 Category: Research Authors: Zheng Yang Jilin Ma Zhihui Li Jie Wang Zhanli Shi Source Type: research
Clinical and morphological features of large-cell neuroendocrine carcinomas and small-cell lung carcinomas expressing the DLL3 and ASCL1 oncoproteins
Braz J Med Biol Res. 2023 Dec 22;56:e12921. doi: 10.1590/1414-431X2023e12921. eCollection 2023.ABSTRACTIntratumoral similarities and differences between large-cell neuroendocrine carcinomas (LCNECs) and small-cell lung carcinomas (SCLCs) are determined partially by the Notch signaling pathway, which controls the switch from neuroendocrine to slight/non-neuroendocrine cell fate. LCNECs are divided into two subgroups according to genomic alterations: type I LCNECs exhibit a neuroendocrine profile characterized by achaete-scute homolog 1 (ASCL1)high/delta-like protein 3 (DLL3)high/NOTCHlow and type II LCNECs show the pattern ...
Source: Braz J Med Biol Res - December 21, 2023 Category: Research Authors: T G Prieto C M Baldavira J Machado-Rugolo E H R Olivieri E C A da Silva V G Silva A M Ab'Saber T Y Takagaki V L Capelozzi Source Type: research
Quality of life and functional capacity in depressive patients on hemodialysis: a systematic review and meta-analysis
Braz J Med Biol Res. 2023 Dec 18;56:e12850. doi: 10.1590/1414-431X2023e12850. eCollection 2023.ABSTRACTDepression is a common disorder in patients with chronic kidney disease (CKD), and some data support its relationship with functional capacity and quality of life. However, to date, this has not been evaluated systematically or through meta-analysis. We sought to investigate the relationship of quality of life and functional capacity with depressive disorder in patients with CKD on hemodialysis. This systematic review considered studies published up to 2021 and included cross-sectional and cohort studies. PubMed, Embase, ...
Source: Braz J Med Biol Res - December 21, 2023 Category: Research Authors: M B Moreira N P Cavalli N C Righi F B Schuch L U Signori A M V da Silva Source Type: research
The level of Tim-3+CD8+ T cells can serve as a potential marker for evaluating the severity of acute graft-versus-host disease after haplo-PBSCT
In conclusion, the binding of Tim-3 with exogenous Galectin-9 can promote apoptosis of CD8+ T cells and affect the secretion of Granzyme B. Tim-3+CD8+ T cells have the potential to serve as immunological markers for assessing the severity of aGVHD after haplo-PBSCT and identifying patients at a higher risk for severe aGVHD.PMID:38126537 | PMC:PMC10729645 | DOI:10.1590/1414-431X2023e12997 (Source: Braz J Med Biol Res)
Source: Braz J Med Biol Res - December 21, 2023 Category: Research Authors: Nannan Pang Mingkai Yu Jianli Xu Hailong Yuan Gang Chen Dong Wang Chunxia Han Weiguo Wang Jianbing Ding Ming Jiang Source Type: research
