Stimulation of mouse hematopoietic stem cells by angiogenin and DNA preparations
Braz J Med Biol Res. 2024 Mar 4;57:e13072. doi: 10.1590/1414-431X2024e13072. eCollection 2024.ABSTRACTImmature hematopoietic progenitors are a constant source for renewal of hemocyte populations and the basic component of the tissue and cell repair apparatus. A unique property of these cells of internalizing extracellular double-stranded DNA has been previously shown. The leukostimulatory effect demonstrated in our pioneering studies was considered to be due to the feature of this cell. In the present research, we have analyzed the effects of DNA genome reconstructor preparation (DNAgr), DNAmix, and human recombinant angio...
Source: Braz J Med Biol Res - March 7, 2024 Category: Research Authors: E A Potter E V Dolgova A S Proskurina V S Ruzanova Y R Efremov S S Kirikovich S G Oshikhmina A L Mamaev O S Taranov A S Bryukhovetskiy L U Grivtsova N A Kolchanov A A Ostanin E R Chernykh S S Bogachev Source Type: research
Wearable near-infrared spectroscopy: reliability and sensitivity among different endurance cycling exercise intensities
Braz J Med Biol Res. 2024 Mar 4;57:e13102. doi: 10.1590/1414-431X2024e13102. eCollection 2024.ABSTRACTThe present study investigated the reliability and sensitivity of a wearable near-infrared spectroscopy (wNIRS) device in moderate and heavy exercise intensity domains. On three separate days, eleven males performed an incremental test to exhaustion, and in the following visits, four submaximal constant-load bouts (i.e., test and retest) were performed in the moderate-intensity domain (100 and 130 W) and heavy-intensity domain (160 and 190 W). The local tissue oxygen saturation index (SmO2) and pulmonary oxygen uptake (V̇...
Source: Braz J Med Biol Res - March 7, 2024 Category: Research Authors: J S Hasegawa R A Azevedo A C Silveira A E Lima-Silva R Bertuzzi Source Type: research
Association among cardiopulmonary and metabolic rehabilitation, arrhythmias, and myocardial ischemia responses of patients with HFpEF or HFmrEF
Braz J Med Biol Res. 2024 Mar 4;57:e13174. doi: 10.1590/1414-431X2024e13174. eCollection 2024.ABSTRACTThere's limited evidence of the potential benefits of cardiopulmonary and metabolic rehabilitation (CPMR) in patients with heart failure with preserved ejection fraction (HFpEF) or mildly reduced ejection fraction (HFmrEF) and coronary artery disease (CAD). The aim of this study was to investigate the impact of CPMR on the myocardial ischemia response (MIR), exercise-induced arrhythmias (EIA), New York Heart Association (NYHA) functional class, heart rate recovery (HRR), Borg CR10 perceived symptoms, and the SF-36 physical...
Source: Braz J Med Biol Res - March 7, 2024 Category: Research Authors: C A C Hossri F C Araujo B G Baldi R Otterstetter V R Uemoto C R R Carvalho L E Mastrocola A L P Albuquerque Source Type: research
Phospholipase D regulates ferroptosis signal transduction in mouse spleen hypoxia response
This study aimed to establish a hypoxia animal model. Combined transcriptomic and proteomic analyses showed that 95 predicted target genes (proteins) were significantly differentially expressed under hypoxic conditions. Key genes in phospholipase D and ferroptosis pathways under hypoxic exposure were identified by combining Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis techniques. Gene set enrichment analysis (GSEA) showed that the differential gene sets of the phospholipase D and ferroptosis signaling pathways were upregulated in the high-altitude hypoxia group. The genes in the...
Source: Braz J Med Biol Res - March 7, 2024 Category: Research Authors: Jiayang Wang Ying Hu Yuzhen Xu Qifu Long Cunlin Gu Chaoqun Tang Ru Wang Sheng Yong Source Type: research
Stimulation of mouse hematopoietic stem cells by angiogenin and DNA preparations
Braz J Med Biol Res. 2024 Mar 4;57:e13072. doi: 10.1590/1414-431X2024e13072. eCollection 2024.ABSTRACTImmature hematopoietic progenitors are a constant source for renewal of hemocyte populations and the basic component of the tissue and cell repair apparatus. A unique property of these cells of internalizing extracellular double-stranded DNA has been previously shown. The leukostimulatory effect demonstrated in our pioneering studies was considered to be due to the feature of this cell. In the present research, we have analyzed the effects of DNA genome reconstructor preparation (DNAgr), DNAmix, and human recombinant angio...
Source: Braz J Med Biol Res - March 7, 2024 Category: Research Authors: E A Potter E V Dolgova A S Proskurina V S Ruzanova Y R Efremov S S Kirikovich S G Oshikhmina A L Mamaev O S Taranov A S Bryukhovetskiy L U Grivtsova N A Kolchanov A A Ostanin E R Chernykh S S Bogachev Source Type: research
Wearable near-infrared spectroscopy: reliability and sensitivity among different endurance cycling exercise intensities
Braz J Med Biol Res. 2024 Mar 4;57:e13102. doi: 10.1590/1414-431X2024e13102. eCollection 2024.ABSTRACTThe present study investigated the reliability and sensitivity of a wearable near-infrared spectroscopy (wNIRS) device in moderate and heavy exercise intensity domains. On three separate days, eleven males performed an incremental test to exhaustion, and in the following visits, four submaximal constant-load bouts (i.e., test and retest) were performed in the moderate-intensity domain (100 and 130 W) and heavy-intensity domain (160 and 190 W). The local tissue oxygen saturation index (SmO2) and pulmonary oxygen uptake (V̇...
Source: Braz J Med Biol Res - March 7, 2024 Category: Research Authors: J S Hasegawa R A Azevedo A C Silveira A E Lima-Silva R Bertuzzi Source Type: research
Association among cardiopulmonary and metabolic rehabilitation, arrhythmias, and myocardial ischemia responses of patients with HFpEF or HFmrEF
Braz J Med Biol Res. 2024 Mar 4;57:e13174. doi: 10.1590/1414-431X2024e13174. eCollection 2024.ABSTRACTThere's limited evidence of the potential benefits of cardiopulmonary and metabolic rehabilitation (CPMR) in patients with heart failure with preserved ejection fraction (HFpEF) or mildly reduced ejection fraction (HFmrEF) and coronary artery disease (CAD). The aim of this study was to investigate the impact of CPMR on the myocardial ischemia response (MIR), exercise-induced arrhythmias (EIA), New York Heart Association (NYHA) functional class, heart rate recovery (HRR), Borg CR10 perceived symptoms, and the SF-36 physical...
Source: Braz J Med Biol Res - March 7, 2024 Category: Research Authors: C A C Hossri F C Araujo B G Baldi R Otterstetter V R Uemoto C R R Carvalho L E Mastrocola A L P Albuquerque Source Type: research
Phospholipase D regulates ferroptosis signal transduction in mouse spleen hypoxia response
This study aimed to establish a hypoxia animal model. Combined transcriptomic and proteomic analyses showed that 95 predicted target genes (proteins) were significantly differentially expressed under hypoxic conditions. Key genes in phospholipase D and ferroptosis pathways under hypoxic exposure were identified by combining Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis techniques. Gene set enrichment analysis (GSEA) showed that the differential gene sets of the phospholipase D and ferroptosis signaling pathways were upregulated in the high-altitude hypoxia group. The genes in the...
Source: Braz J Med Biol Res - March 7, 2024 Category: Research Authors: Jiayang Wang Ying Hu Yuzhen Xu Qifu Long Cunlin Gu Chaoqun Tang Ru Wang Sheng Yong Source Type: research
Stimulation of mouse hematopoietic stem cells by angiogenin and DNA preparations
Braz J Med Biol Res. 2024 Mar 4;57:e13072. doi: 10.1590/1414-431X2024e13072. eCollection 2024.ABSTRACTImmature hematopoietic progenitors are a constant source for renewal of hemocyte populations and the basic component of the tissue and cell repair apparatus. A unique property of these cells of internalizing extracellular double-stranded DNA has been previously shown. The leukostimulatory effect demonstrated in our pioneering studies was considered to be due to the feature of this cell. In the present research, we have analyzed the effects of DNA genome reconstructor preparation (DNAgr), DNAmix, and human recombinant angio...
Source: Braz J Med Biol Res - March 7, 2024 Category: Research Authors: E A Potter E V Dolgova A S Proskurina V S Ruzanova Y R Efremov S S Kirikovich S G Oshikhmina A L Mamaev O S Taranov A S Bryukhovetskiy L U Grivtsova N A Kolchanov A A Ostanin E R Chernykh S S Bogachev Source Type: research
Wearable near-infrared spectroscopy: reliability and sensitivity among different endurance cycling exercise intensities
Braz J Med Biol Res. 2024 Mar 4;57:e13102. doi: 10.1590/1414-431X2024e13102. eCollection 2024.ABSTRACTThe present study investigated the reliability and sensitivity of a wearable near-infrared spectroscopy (wNIRS) device in moderate and heavy exercise intensity domains. On three separate days, eleven males performed an incremental test to exhaustion, and in the following visits, four submaximal constant-load bouts (i.e., test and retest) were performed in the moderate-intensity domain (100 and 130 W) and heavy-intensity domain (160 and 190 W). The local tissue oxygen saturation index (SmO2) and pulmonary oxygen uptake (V̇...
Source: Braz J Med Biol Res - March 7, 2024 Category: Research Authors: J S Hasegawa R A Azevedo A C Silveira A E Lima-Silva R Bertuzzi Source Type: research
Association among cardiopulmonary and metabolic rehabilitation, arrhythmias, and myocardial ischemia responses of patients with HFpEF or HFmrEF
Braz J Med Biol Res. 2024 Mar 4;57:e13174. doi: 10.1590/1414-431X2024e13174. eCollection 2024.ABSTRACTThere's limited evidence of the potential benefits of cardiopulmonary and metabolic rehabilitation (CPMR) in patients with heart failure with preserved ejection fraction (HFpEF) or mildly reduced ejection fraction (HFmrEF) and coronary artery disease (CAD). The aim of this study was to investigate the impact of CPMR on the myocardial ischemia response (MIR), exercise-induced arrhythmias (EIA), New York Heart Association (NYHA) functional class, heart rate recovery (HRR), Borg CR10 perceived symptoms, and the SF-36 physical...
Source: Braz J Med Biol Res - March 7, 2024 Category: Research Authors: C A C Hossri F C Araujo B G Baldi R Otterstetter V R Uemoto C R R Carvalho L E Mastrocola A L P Albuquerque Source Type: research
Phospholipase D regulates ferroptosis signal transduction in mouse spleen hypoxia response
This study aimed to establish a hypoxia animal model. Combined transcriptomic and proteomic analyses showed that 95 predicted target genes (proteins) were significantly differentially expressed under hypoxic conditions. Key genes in phospholipase D and ferroptosis pathways under hypoxic exposure were identified by combining Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis techniques. Gene set enrichment analysis (GSEA) showed that the differential gene sets of the phospholipase D and ferroptosis signaling pathways were upregulated in the high-altitude hypoxia group. The genes in the...
Source: Braz J Med Biol Res - March 7, 2024 Category: Research Authors: Jiayang Wang Ying Hu Yuzhen Xu Qifu Long Cunlin Gu Chaoqun Tang Ru Wang Sheng Yong Source Type: research
Stimulation of mouse hematopoietic stem cells by angiogenin and DNA preparations
Braz J Med Biol Res. 2024 Mar 4;57:e13072. doi: 10.1590/1414-431X2024e13072. eCollection 2024.ABSTRACTImmature hematopoietic progenitors are a constant source for renewal of hemocyte populations and the basic component of the tissue and cell repair apparatus. A unique property of these cells of internalizing extracellular double-stranded DNA has been previously shown. The leukostimulatory effect demonstrated in our pioneering studies was considered to be due to the feature of this cell. In the present research, we have analyzed the effects of DNA genome reconstructor preparation (DNAgr), DNAmix, and human recombinant angio...
Source: Braz J Med Biol Res - March 7, 2024 Category: Research Authors: E A Potter E V Dolgova A S Proskurina V S Ruzanova Y R Efremov S S Kirikovich S G Oshikhmina A L Mamaev O S Taranov A S Bryukhovetskiy L U Grivtsova N A Kolchanov A A Ostanin E R Chernykh S S Bogachev Source Type: research
Wearable near-infrared spectroscopy: reliability and sensitivity among different endurance cycling exercise intensities
Braz J Med Biol Res. 2024 Mar 4;57:e13102. doi: 10.1590/1414-431X2024e13102. eCollection 2024.ABSTRACTThe present study investigated the reliability and sensitivity of a wearable near-infrared spectroscopy (wNIRS) device in moderate and heavy exercise intensity domains. On three separate days, eleven males performed an incremental test to exhaustion, and in the following visits, four submaximal constant-load bouts (i.e., test and retest) were performed in the moderate-intensity domain (100 and 130 W) and heavy-intensity domain (160 and 190 W). The local tissue oxygen saturation index (SmO2) and pulmonary oxygen uptake (V̇...
Source: Braz J Med Biol Res - March 7, 2024 Category: Research Authors: J S Hasegawa R A Azevedo A C Silveira A E Lima-Silva R Bertuzzi Source Type: research
Association among cardiopulmonary and metabolic rehabilitation, arrhythmias, and myocardial ischemia responses of patients with HFpEF or HFmrEF
Braz J Med Biol Res. 2024 Mar 4;57:e13174. doi: 10.1590/1414-431X2024e13174. eCollection 2024.ABSTRACTThere's limited evidence of the potential benefits of cardiopulmonary and metabolic rehabilitation (CPMR) in patients with heart failure with preserved ejection fraction (HFpEF) or mildly reduced ejection fraction (HFmrEF) and coronary artery disease (CAD). The aim of this study was to investigate the impact of CPMR on the myocardial ischemia response (MIR), exercise-induced arrhythmias (EIA), New York Heart Association (NYHA) functional class, heart rate recovery (HRR), Borg CR10 perceived symptoms, and the SF-36 physical...
Source: Braz J Med Biol Res - March 7, 2024 Category: Research Authors: C A C Hossri F C Araujo B G Baldi R Otterstetter V R Uemoto C R R Carvalho L E Mastrocola A L P Albuquerque Source Type: research
