Diabetes, hemoglobin A1c, and cognitive performance in older adults: is there any impact of frailty? Evidence from the ELSI-Brazil study
In conclusion, higher hemoglobin A1c levels were associated with lower cognitive performance among non-frail participants. Higher hemoglobin A1c levels without a previous diagnosis of diabetes were also related to poor cognitive performance. Future longitudinal analyses of the ELSI-Brazil study will provide further information on the role of frailty in the association of diabetes and glycemic control with cognitive decline.PMID:38381882 | PMC:PMC10880886 | DOI:10.1590/1414-431X2023e12939 (Source: Braz J Med Biol Res)
Source: Braz J Med Biol Res - February 21, 2024 Category: Research Authors: J G Souza D S Farias-Itao M J R Aliberti T S Alexandre C Szlejf C P Ferri M F Lima-Costa C K Suemoto Source Type: research
Inhibition of anlotinib-induced autophagy attenuates invasion and migration by regulating epithelial-mesenchymal transition and cytoskeletal rearrangement through ATG5 in human osteosarcoma cells
Braz J Med Biol Res. 2024 Feb 19;57:e13152. doi: 10.1590/1414-431X2023e13152. eCollection 2024.ABSTRACTThe cure rates for osteosarcoma have remained unchanged in the past three decades, especially for patients with pulmonary metastasis. Thus, a new and effective treatment for metastatic osteosarcoma is urgently needed. Anlotinib has been reported to have antitumor effects on advanced osteosarcoma. However, both the effect of anlotinib on autophagy in osteosarcoma and the mechanism of anlotinib-mediated autophagy in pulmonary metastasis are unclear. The effect of anlotinib treatment on the metastasis of osteosarcoma was inv...
Source: Braz J Med Biol Res - February 21, 2024 Category: Research Authors: Bingxin Zheng Xiangchen Sun Li Zhang Guojian Qu Chongmin Ren Peng Yan Chuanli Zhou Bin Yue Source Type: research
Correlation analysis between peripheral blood dendritic cell subsets and PD-1 in patients with peritoneal adenocarcinoma
Braz J Med Biol Res. 2024 Feb 19;57:e13192. doi: 10.1590/1414-431X2023e13192. eCollection 2024.ABSTRACTThe aim of this study was to explore the association between differential percentages of dendritic cell (DC) subsets in peripheral blood and malignancy (grade and lymph node metastasis) of peritoneal adenocarcinoma patients and the frequencies of dendritic cell subsets in the normal controls. The peripheral blood of 30 patients with peritoneal adenocarcinoma and 12 healthy controls were collected for multicolor flow cytometry analysis. Peritoneal adenocarcinoma patients were grouped according to the malignant degree (grad...
Source: Braz J Med Biol Res - February 21, 2024 Category: Research Authors: Huihui Hu Man Zhang Source Type: research
Puerarin protects the fatty liver from ischemia-reperfusion injury by regulating the PI3K/AKT signaling pathway
In conclusion, puerarin could significantly protect the fatty liver against IRI by activating the PI3K-AKT signaling pathway.PMID:38381885 | PMC:PMC10880884 | DOI:10.1590/1414-431X2024e13229 (Source: Braz J Med Biol Res)
Source: Braz J Med Biol Res - February 21, 2024 Category: Research Authors: Faji Yang Hengjun Gao Zheyu Niu Qingqiang Ni Huaqiang Zhu Jianlu Wang Jun Lu Source Type: research
Protective effect of sterubin against neurochemical and behavioral impairments in rotenone-induced Parkinson's disease
This study was conducted to evaluate how sterubin affects rotenone-induced Parkinson's disease (PD) in rats. A total of 24 rats were distributed into 4 equal groups: normal saline control and rotenone control were administered saline or rotenone (ROT), respectively, orally; sterubin 10 received ROT + sterubin 10 mg/kg po; and sterubin alone was administered to the test group (10 mg/kg). Rats of the normal saline and sterubin alone groups received sunflower oil injection (sc) daily, 1 h after receiving the treatments cited above, while rats of the other groups received rotenone injection (0.5 mg/kg, sc). The treatment was c...
Source: Braz J Med Biol Res - February 15, 2024 Category: Research Authors: M M Alqurashi F A Al-Abbasi M Afzal A M Alghamdi M Zeyadi R A Sheikh S Alshehri S S Imam N Sayyed I Kazmi Source Type: research
Factors associated with non-treatment of hypertension and gender differences at baseline in the ELSA-Brasil cohort
Braz J Med Biol Res. 2024 Feb 9;57:e12937. doi: 10.1590/1414-431X2023e12937. eCollection 2024.ABSTRACTThe treatment of arterial hypertension (AH) contributes to the reduction of morbidity and mortality. Gender differences are likely to play a role, as non-treatment is associated with clinical and sociodemographic aspects. The aim of this study was to investigate the factors associated with non-treatment of AH and gender differences in hypertensive individuals from the ELSA-Brasil cohort. The study was conducted with 5,743 baseline hypertensive cohort participants. AH was considered if there was a previous diagnosis or if s...
Source: Braz J Med Biol Res - February 15, 2024 Category: Research Authors: A K M N éri R M F Xavier S M A Matos M C C Almeida R M Ladeira A A Lopes D O C Lino A P P L ázaro R V B M Cairutas J H Silva J únior J M O Lima M C Chaves R P Silva G B Silva J únior Source Type: research
"Penumbra sign" in knee pain: a case of distal femur osteomyelitis
Braz J Med Biol Res. 2024 Feb 9;57:e12976. doi: 10.1590/1414-431X2023e12976. eCollection 2024.ABSTRACT"Penumbra sign" is a characteristic finding in magnetic resonance imaging (MRI) of Brodie's abscess, a rare variant of subacute osteomyelitis. We aimed to discuss the imaging finding penumbra sign that will help in the diagnosis of osteomyelitis and may be useful to clinicians in differential diagnosis. A 26-year-old male patient presented to the emergency department with complaints of pain and limping in the right knee that did not go away. He had a history of arthroscopic debridement and percutaneous fixation surgery due...
Source: Braz J Med Biol Res - February 15, 2024 Category: Research Authors: Hakan Koray Tosyali Adem Çakir Source Type: research
Safety of a 90-min duration of intravenous infusion of obinutuzumab in patients with B-cell non-Hodgkin's lymphoma in a tertiary hospital in China: a prospective, open-label, exploratory clinical trial
This study aimed to analyze the safety and applicability of a 90-min duration of infusion (SDI) of obinutuzumab in patients with B-cell non-Hodgkin's lymphoma (NHL) in a tertiary hospital in China. This exploratory clinical trial was performed at Jiangsu Province Hospital. All patients were treated with the standard infusion regimen for the first infusion. If no grade ≥3 infusion-related reactions (IRRs) occurred, the subsequent infusions were given as SDI. The primary endpoint was the incidence of IRR during the standard infusion (3-4 h) and 90-min SDI regimens. This study enrolled 208 patients and all completed cycle 1...
Source: Braz J Med Biol Res - February 15, 2024 Category: Research Authors: Shuangshuang Xing Yiqin Pu Xiaoqian Zhao Yan Hu Feiyan Zhang Zejuan Gu Wei Xu Lei Fan Yi Miao Jianyong Li Source Type: research
Protective effect of sterubin against neurochemical and behavioral impairments in rotenone-induced Parkinson's disease
This study was conducted to evaluate how sterubin affects rotenone-induced Parkinson's disease (PD) in rats. A total of 24 rats were distributed into 4 equal groups: normal saline control and rotenone control were administered saline or rotenone (ROT), respectively, orally; sterubin 10 received ROT + sterubin 10 mg/kg po; and sterubin alone was administered to the test group (10 mg/kg). Rats of the normal saline and sterubin alone groups received sunflower oil injection (sc) daily, 1 h after receiving the treatments cited above, while rats of the other groups received rotenone injection (0.5 mg/kg, sc). The treatment was c...
Source: Braz J Med Biol Res - February 15, 2024 Category: Research Authors: M M Alqurashi F A Al-Abbasi M Afzal A M Alghamdi M Zeyadi R A Sheikh S Alshehri S S Imam N Sayyed I Kazmi Source Type: research
Factors associated with non-treatment of hypertension and gender differences at baseline in the ELSA-Brasil cohort
Braz J Med Biol Res. 2024 Feb 9;57:e12937. doi: 10.1590/1414-431X2023e12937. eCollection 2024.ABSTRACTThe treatment of arterial hypertension (AH) contributes to the reduction of morbidity and mortality. Gender differences are likely to play a role, as non-treatment is associated with clinical and sociodemographic aspects. The aim of this study was to investigate the factors associated with non-treatment of AH and gender differences in hypertensive individuals from the ELSA-Brasil cohort. The study was conducted with 5,743 baseline hypertensive cohort participants. AH was considered if there was a previous diagnosis or if s...
Source: Braz J Med Biol Res - February 15, 2024 Category: Research Authors: A K M N éri R M F Xavier S M A Matos M C C Almeida R M Ladeira A A Lopes D O C Lino A P P L ázaro R V B M Cairutas J H Silva J únior J M O Lima M C Chaves R P Silva G B Silva J únior Source Type: research
"Penumbra sign" in knee pain: a case of distal femur osteomyelitis
Braz J Med Biol Res. 2024 Feb 9;57:e12976. doi: 10.1590/1414-431X2023e12976. eCollection 2024.ABSTRACT"Penumbra sign" is a characteristic finding in magnetic resonance imaging (MRI) of Brodie's abscess, a rare variant of subacute osteomyelitis. We aimed to discuss the imaging finding penumbra sign that will help in the diagnosis of osteomyelitis and may be useful to clinicians in differential diagnosis. A 26-year-old male patient presented to the emergency department with complaints of pain and limping in the right knee that did not go away. He had a history of arthroscopic debridement and percutaneous fixation surgery due...
Source: Braz J Med Biol Res - February 15, 2024 Category: Research Authors: Hakan Koray Tosyali Adem Çakir Source Type: research
Safety of a 90-min duration of intravenous infusion of obinutuzumab in patients with B-cell non-Hodgkin's lymphoma in a tertiary hospital in China: a prospective, open-label, exploratory clinical trial
This study aimed to analyze the safety and applicability of a 90-min duration of infusion (SDI) of obinutuzumab in patients with B-cell non-Hodgkin's lymphoma (NHL) in a tertiary hospital in China. This exploratory clinical trial was performed at Jiangsu Province Hospital. All patients were treated with the standard infusion regimen for the first infusion. If no grade ≥3 infusion-related reactions (IRRs) occurred, the subsequent infusions were given as SDI. The primary endpoint was the incidence of IRR during the standard infusion (3-4 h) and 90-min SDI regimens. This study enrolled 208 patients and all completed cycle 1...
Source: Braz J Med Biol Res - February 15, 2024 Category: Research Authors: Shuangshuang Xing Yiqin Pu Xiaoqian Zhao Yan Hu Feiyan Zhang Zejuan Gu Wei Xu Lei Fan Yi Miao Jianyong Li Source Type: research
Protective effect of sterubin against neurochemical and behavioral impairments in rotenone-induced Parkinson's disease
This study was conducted to evaluate how sterubin affects rotenone-induced Parkinson's disease (PD) in rats. A total of 24 rats were distributed into 4 equal groups: normal saline control and rotenone control were administered saline or rotenone (ROT), respectively, orally; sterubin 10 received ROT + sterubin 10 mg/kg po; and sterubin alone was administered to the test group (10 mg/kg). Rats of the normal saline and sterubin alone groups received sunflower oil injection (sc) daily, 1 h after receiving the treatments cited above, while rats of the other groups received rotenone injection (0.5 mg/kg, sc). The treatment was c...
Source: Braz J Med Biol Res - February 15, 2024 Category: Research Authors: M M Alqurashi F A Al-Abbasi M Afzal A M Alghamdi M Zeyadi R A Sheikh S Alshehri S S Imam N Sayyed I Kazmi Source Type: research
Factors associated with non-treatment of hypertension and gender differences at baseline in the ELSA-Brasil cohort
Braz J Med Biol Res. 2024 Feb 9;57:e12937. doi: 10.1590/1414-431X2023e12937. eCollection 2024.ABSTRACTThe treatment of arterial hypertension (AH) contributes to the reduction of morbidity and mortality. Gender differences are likely to play a role, as non-treatment is associated with clinical and sociodemographic aspects. The aim of this study was to investigate the factors associated with non-treatment of AH and gender differences in hypertensive individuals from the ELSA-Brasil cohort. The study was conducted with 5,743 baseline hypertensive cohort participants. AH was considered if there was a previous diagnosis or if s...
Source: Braz J Med Biol Res - February 15, 2024 Category: Research Authors: A K M N éri R M F Xavier S M A Matos M C C Almeida R M Ladeira A A Lopes D O C Lino A P P L ázaro R V B M Cairutas J H Silva J únior J M O Lima M C Chaves R P Silva G B Silva J únior Source Type: research
"Penumbra sign" in knee pain: a case of distal femur osteomyelitis
Braz J Med Biol Res. 2024 Feb 9;57:e12976. doi: 10.1590/1414-431X2023e12976. eCollection 2024.ABSTRACT"Penumbra sign" is a characteristic finding in magnetic resonance imaging (MRI) of Brodie's abscess, a rare variant of subacute osteomyelitis. We aimed to discuss the imaging finding penumbra sign that will help in the diagnosis of osteomyelitis and may be useful to clinicians in differential diagnosis. A 26-year-old male patient presented to the emergency department with complaints of pain and limping in the right knee that did not go away. He had a history of arthroscopic debridement and percutaneous fixation surgery due...
Source: Braz J Med Biol Res - February 15, 2024 Category: Research Authors: Hakan Koray Tosyali Adem Çakir Source Type: research
