Core decompression combined with local DFO administration loaded on polylactic glycolic acid scaffolds for the treatment of osteonecrosis of the femoral head: a pilot study
CONCLUSION: In short-term follow-up, combined core decompression and local DFO administration not only prevent the progression of ONFH but also reduces the rate of osteonecrosis significantly. However, future controlled studies are required to confirm the present results.TRIAL REGISTRATION: IRCT20161121031003N3, 16/04/2019.PMID:37670365 | DOI:10.1186/s40360-023-00682-x (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - September 5, 2023 Category: Drugs & Pharmacology Authors: Kaveh Gharanizadeh Ali Mohammad Sharifi Hamed Tayyebi Razieh Heidari Shayan Amiri Sajad Noorigaravand Source Type: research
Drugs and gut microbiome interactions-an emerging field of tailored medicine
BMC Pharmacol Toxicol. 2023 Aug 30;24(1):43. doi: 10.1186/s40360-023-00684-9.ABSTRACTGut dwelling microbes provide profound biochemical advantages to the host, including nutrient and drug absorption, metabolism, and excretion. It is an emerging understanding that drug-response bias (particularly for orally intake medicine) is related to variation in the microbial composition in the gut. This Editorial at BMC Pharmacology and Toxicology introduces our collection which is discussing the role of gut microbes in modulating drugs' efficacy and bioavailability.PMID:37649091 | PMC:PMC10469409 | DOI:10.1186/s40360-023-00684-9 (Sou...
Source: BMC Pharmacology and Toxicology - August 30, 2023 Category: Drugs & Pharmacology Authors: Imran Khan Source Type: research
Drugs and gut microbiome interactions-an emerging field of tailored medicine
BMC Pharmacol Toxicol. 2023 Aug 30;24(1):43. doi: 10.1186/s40360-023-00684-9.ABSTRACTGut dwelling microbes provide profound biochemical advantages to the host, including nutrient and drug absorption, metabolism, and excretion. It is an emerging understanding that drug-response bias (particularly for orally intake medicine) is related to variation in the microbial composition in the gut. This Editorial at BMC Pharmacology and Toxicology introduces our collection which is discussing the role of gut microbes in modulating drugs' efficacy and bioavailability.PMID:37649091 | DOI:10.1186/s40360-023-00684-9 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - August 30, 2023 Category: Drugs & Pharmacology Authors: Imran Khan Source Type: research
Berberine-loaded albumin nanoparticles reverse aflatoxin B1-induced liver hyperplasia
BMC Pharmacol Toxicol. 2023 Aug 10;24(1):42. doi: 10.1186/s40360-023-00683-w.ABSTRACTHepatocellular carcinoma (HCC) can be produced from aflatoxin B1 (AFB1) administration. Although berberine (BER) acts as an anticancer agent and can counteract the AFB1 effect, it has low bioavailability. Nanotechnology can overcome this problem. This research aimed to synthesize berberine nanoparticles (NPs) and then estimate their therapeutic effect compared to that of berberine against aflatoxin-induced hepatotoxicity. The desolvation method was used to prepare BER-NPs. Aflatoxicosis was induced by 5 consecutive intraperitoneal injectio...
Source: BMC Pharmacology and Toxicology - August 9, 2023 Category: Drugs & Pharmacology Authors: Sarah M Khedr Doaa A Ghareeb Shadia A Fathy Germine M Hamdy Source Type: research
